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#1 RGC leads with +9,999% 2025 YTD

RGC (Regencell Bioscience Holdings Limited) is the best performing stock in 2025 year-to-date. Following are AXTI (+3,517%) and RLMD (+1,571%). Top performing sectors: Healthcare (+871% avg, 6 in top 10), Technology (+587% avg, 2 in top 10), Industrials (+540% avg, 1 in top 10).

Top Performing Stocks 2025 - Year-to-Date Gainers Ranked

Discover the best US stocks of 2025 ranked by year-to-date performance. This ranking tracks YTD gains and highest YTD returns from January 1st, 2025 to today, featuring the top stock gainers with market caps over $100 million on Nasdaq and NYSE.

This ranking shows the top performing US stocks and biggest stock gainers of 2025, calculated from January 1st to the most recent trading day. See which stocks delivered the highest YTD returns this year. Using split-adjusted data ensures accurate performance calculations that account for stock splits and corporate actions.

Year-to-date performance helps investors identify stocks that have been outperforming the market in the current year, revealing trends and momentum that may continue through the rest of 2025.

Looking for a specific Symbol?

Data as of May 1, 2026 at 1:33 AM EDT

Rank
Symbol
Company Name
YTD Gain
Market Cap
Price
Country
Sector
1
22944.16%
14.45 B
$ 29.22
Hong Kong
Healthcare
2
3517.35%
5.18 B
$ 79.22
United States
Technology
3
1570.74%
788.77 M
$ 7.52
United States
Healthcare
4
1510.15%
9.31 B
$ 117.38
France
Healthcare
5
1499.12%
3.33 B
$ 36.46
United States
Basic Materials
6
1215.61%
381.52 M
$ 3.86
United States
Healthcare
7
1112.49%
80.60 B
$ 283.36
United States
Industrials
8
1093.79%
1.68 B
$ 34.62
France
Healthcare
9
969.33%
1.84 B
$ 128.32
United States
Healthcare
10
954.11%
64.43 B
$ 902.32
United States
Technology
11
900%
198.00 M
$ 9.9
France
Financial Services
12
833.51%
6.11 B
$ 52.93
United States
Healthcare
13
831.23%
12.80 B
$ 36.97
United States
Industrials
14
824.22%
5.87 B
$ 121.35
United States
Healthcare
15
805.2%
2.13 B
$ 15.66
United States
Industrials
16
749.23%
381.81 M
$ 6.41
Hong Kong
Industrials
17
747.28%
1.89 B
$ 129.21
United States
Healthcare
18
679.77%
151.05 B
$ 673.64
Singapore
Technology
19
673.17%
412.03 M
$ 9.51
United States
Energy
20
636.36%
2.89 B
$ 21.06
United States
Industrials
21
636.36%
105.26 M
$ 10.53
United States
Healthcare
22
629.46%
240.28 M
$ 74.04
Israel
Healthcare
23
602.31%
148.56 B
$ 434.52
United States
Technology
24
594.22%
1.72 B
$ 12.01
United States
Basic Materials
25
591.61%
8.95 B
$ 65.91
United States
Technology
26
590.73%
3.12 B
$ 21.62
United States
Healthcare
27
571.63%
3.94 B
$ 69.85
United States
Technology
28
565.7%
1.09 B
$ 6.44
Canada
Basic Materials
29
557.66%
236.31 M
$ 1.46
United States
Basic Materials
30
546.15%
1.24 B
$ 21
France
Healthcare
31
543.69%
16.43 B
$ 158.22
United States
Technology
32
535.19%
2.07 B
$ 13.72
United States
Basic Materials
33
533.81%
74.60 B
$ 527.58
United States
Technology
34
508.71%
256.20 M
$ 17.47
Netherlands
Technology
35
492.19%
583.22 B
$ 517.16
United States
Technology
36
490.91%
540.41 M
$ 7.15
United States
Healthcare
37
489.94%
2.87 B
$ 85.04
United States
Healthcare
38
486.67%
1.86 B
$ 5.72
Canada
Basic Materials
39
484.84%
918.96 M
$ 14.27
United States
Healthcare
40
458.42%
12.22 B
$ 269.27
United States
Technology
41
447.19%
2.85 B
$ 90.56
United States
Technology
42
441.27%
35.57 B
$ 123.14
United States
Communication Services
43
423.02%
12.63 B
$ 90.64
Israel
Utilities
44
412.06%
366.22 M
$ 9.98
United States
Healthcare
45
404.41%
2.70 B
$ 43.48
United States
Healthcare
46
403.59%
1.11 B
$ 15.41
India
Communication Services
47
403%
381.57 M
$ 5.03
United States
Technology
48
398.94%
624.69 M
$ 2.35
Canada
Basic Materials
49
391.99%
1.91 B
$ 65.73
United States
Healthcare
50
389.69%
221.96 M
$ 10.92
United States
Industrials
51
380.24%
140.92 M
$ 14.07
United States
Technology
52
372.78%
3.81 B
$ 16.5
United States
Technology
53
367.47%
9.35 B
$ 669.98
United States
Industrials
54
367.26%
474.86 B
$ 94.48
United States
Technology
55
362.62%
913.44 M
$ 4.95
United States
Healthcare
56
361.69%
13.16 B
$ 164.36
United States
Technology
57
358.85%
6.11 B
$ 35.79
United States
Healthcare
58
355.95%
762.84 M
$ 7.66
Hong Kong
Technology
59
352.18%
2.56 B
$ 71.4
United States
Industrials
60
350%
676.58 M
$ 41.13
United States
Financial Services
61
345.4%
1.43 B
$ 29.53
United States
Technology
62
343.99%
101.00 M
$ 16.25
United States
Industrials
63
340.09%
47.09 B
$ 409.59
Canada
Technology
64
339.1%
9.79 B
$ 34.25
United States
Technology
65
336.67%
2.92 B
$ 5.24
Canada
Basic Materials
66
335.09%
15.10 B
$ 45.51
Australia
Financial Services
67
329.46%
64.78 B
$ 1840.25
United States
Industrials
68
328.99%
424.18 M
$ 8.88
United States
Healthcare
69
328.81%
26.30 B
$ 221.05
Israel
Technology
70
323.04%
1.68 B
$ 18.14
United States
Basic Materials
71
321.43%
977.76 M
$ 5.31
Canada
Basic Materials
72
318.4%
416.53 M
$ 5.23
United States
Healthcare
73
309.21%
1.78 B
$ 16
United States
Healthcare
74
308.83%
1.55 B
$ 41.21
Singapore
Consumer Cyclical
75
307.27%
267.52 M
$ 43.7
United States
Financial Services
76
305.91%
473.40 M
$ 8.93
United States
Healthcare
77
305.56%
364.87 M
$ 5.11
United States
Healthcare
78
302.93%
11.73 B
$ 66.04
United States
Basic Materials
79
301.25%
5.90 B
$ 28.81
United States
Basic Materials
80
300.94%
8.88 B
$ 318.83
United States
Healthcare
81
300.33%
7.43 B
$ 218.78
Hong Kong
Technology
82
299.15%
666.24 M
$ 42.15
United States
Basic Materials
83
298.96%
115.66 M
$ 1.38
United States
Basic Materials
84
298.11%
912.27 M
$ 4.22
United States
Healthcare
85
297.99%
10.70 B
$ 21.73
United States
Financial Services
86
294.44%
3.31 B
$ 10.65
United States
Healthcare
87
293.47%
3.25 B
$ 65.67
United States
Energy
88
292.76%
852.08 M
$ 5.97
United States
Basic Materials
89
291.63%
732.17 M
$ 34.91
United States
Consumer Cyclical
90
289.05%
712.23 M
$ 62.87
United States
Energy
91
285.19%
1.47 B
$ 4.16
United States
Healthcare
92
285.09%
47.34 B
$ 93.73
United States
Basic Materials
93
284.6%
4.91 B
$ 92.92
United States
Industrials
94
281.75%
4.89 B
$ 10.04
United States
Technology
95
280.99%
5.37 B
$ 21.64
United States
Energy
96
280.63%
2.65 B
$ 11.99
Canada
Basic Materials
97
280.36%
157.13 M
$ 14.53
United States
Industrials
98
278.45%
4.78 B
$ 87.8
United States
Healthcare
99
275.39%
313.09 M
$ 2.16
United States
Basic Materials
100
273.94%
10.29 B
$ 73.48
United States
Healthcare
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q What is the best stock of 2025?
A

RGC (Regencell Bioscience Holdings Limited) is the best performing stock of 2025 with a year-to-date gain of 9,999% from January 1st to today. The top 3 stocks of 2025 are RGC, AXTI, RLMD.

Q What are the top performing stocks in 2025?
A

The top performing stocks in 2025 YTD are: RGC (+9,999%), AXTI (+3,517%), RLMD (+1,571%), ABVX (+1,510%), HYMC (+1,499%). Performance is calculated from January 1, 2025 to the most recent trading day.

Q Which stocks have made the most money in 2025?
A

The biggest stock gainers of 2025 include RGC leading with +9,999%, followed by AXTI (+3,517%) and RLMD (+1,571%). These represent the best investment returns YTD.

Q What sectors are performing best in 2025?
A

In 2025, the best performing sectors based on top stock gains include Healthcare, Technology, Basic Materials. The top gainer RGC operates in the Healthcare sector.

Q Which US stocks have the highest YTD returns in 2025?
A

The US stocks with the highest year-to-date returns in 2025 include RGC (+9,999%), AXTI (+3,517%), RLMD (+1,571%). These top YTD gainers are ranked by total return from January 1st to today across NYSE and NASDAQ.

Understanding Year-to-Date Stock Performance

Year-to-date (YTD) performance measures how much a stock's price has changed since January 1st of the current year. This metric is valuable for several reasons:

  • Current Trend Identification: YTD performance reveals which stocks are leading or lagging in the current market cycle, helping identify emerging trends before they become widely recognized.
  • Benchmark Comparison: Compare individual stock performance against market indices like the S&P 500 to assess whether investments are outperforming or underperforming the broader market.
  • Tax Planning: YTD gains and losses are crucial for tax-loss harvesting strategies and estimating potential capital gains tax obligations before year-end.

Factors Driving YTD Performance

Several factors can influence a stock's year-to-date performance:

  • Earnings Reports: Quarterly earnings that beat or miss expectations can significantly impact stock prices throughout the year.
  • Industry Trends: Sector rotation and changing market preferences can drive entire industries higher or lower.
  • Macroeconomic Factors: Interest rates, inflation data, and economic indicators affect stock valuations across the market.
  • Company-Specific News: Product launches, management changes, M&A activity, and regulatory developments can move individual stocks.

Model Your Returns

See exactly how much a YTD top performer would have returned on your investment with our Stock Return Calculator. Planning regular investments? The DCA Calculator shows how dollar-cost averaging into these stocks would have performed.