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#1 RGC leads with +9,999% 2025 YTD

RGC (Regencell Bioscience Holdings Limited) is the best performing stock in 2025 year-to-date. Following are AXTI (+3,145%) and RLMD (+1,537%). Top performing sectors: Healthcare (+866% avg, 6 in top 10), Industrials (+535% avg, 1 in top 10), Technology (+523% avg, 2 in top 10).

Top Performing Stocks 2025 - Year-to-Date Gainers Ranked

Discover the best US stocks of 2025 ranked by year-to-date performance. This ranking tracks YTD gains and highest YTD returns from January 1st, 2025 to today, featuring the top stock gainers with market caps over $100 million on Nasdaq and NYSE.

This ranking shows the top performing US stocks and biggest stock gainers of 2025, calculated from January 1st to the most recent trading day. See which stocks delivered the highest YTD returns this year. Using split-adjusted data ensures accurate performance calculations that account for stock splits and corporate actions.

Year-to-date performance helps investors identify stocks that have been outperforming the market in the current year, revealing trends and momentum that may continue through the rest of 2025.

Looking for a specific Symbol?

Data as of April 30, 2026 at 5:33 AM EDT

Rank
Symbol
Company Name
YTD Gain
Market Cap
Price
Country
Sector
1
22731.23%
14.32 B
$ 28.95
Hong Kong
Healthcare
2
3145.21%
4.56 B
$ 71.07
United States
Technology
3
1537.41%
773.04 M
$ 7.37
United States
Healthcare
4
1400.44%
3.13 B
$ 34.21
United States
Basic Materials
5
1357.34%
8.42 B
$ 106.24
France
Healthcare
6
1164.49%
366.69 M
$ 3.71
United States
Healthcare
7
1132.22%
81.91 B
$ 287.97
United States
Industrials
8
1037.59%
1.60 B
$ 32.99
France
Healthcare
9
920.33%
1.75 B
$ 122.44
United States
Healthcare
10
902.71%
61.28 B
$ 858.32
United States
Technology
11
900%
198.00 M
$ 9.9
France
Financial Services
12
833.33%
6.11 B
$ 52.92
United States
Healthcare
13
806.32%
5.75 B
$ 119
United States
Healthcare
14
798.25%
403.85 M
$ 6.78
Hong Kong
Industrials
15
758.44%
11.80 B
$ 34.08
United States
Industrials
16
754.34%
2.01 B
$ 14.78
United States
Industrials
17
718.49%
1.82 B
$ 124.82
United States
Healthcare
18
657.72%
403.80 M
$ 9.32
United States
Energy
19
644.65%
144.12 B
$ 643.3
Singapore
Technology
20
611.19%
2.79 B
$ 20.34
United States
Industrials
21
608.39%
101.26 M
$ 10.13
United States
Healthcare
22
604.79%
3.18 B
$ 22.06
United States
Healthcare
23
603.45%
231.71 M
$ 71.4
Israel
Healthcare
24
567.14%
141.12 B
$ 412.76
United States
Technology
25
543.99%
1.05 B
$ 6.23
Canada
Basic Materials
26
524.71%
3.66 B
$ 64.97
United States
Technology
27
524.62%
1.20 B
$ 20.3
France
Healthcare
28
522.04%
8.05 B
$ 59.28
United States
Technology
29
521.62%
223.37 M
$ 1.38
United States
Basic Materials
30
493.68%
584.68 B
$ 518.46
United States
Technology
31
485.95%
535.87 M
$ 7.09
United States
Healthcare
32
482.23%
245.05 M
$ 16.71
Netherlands
Technology
33
477.46%
907.37 M
$ 14.09
United States
Healthcare
34
477.18%
2.76 B
$ 83.2
United States
Healthcare
35
476.88%
1.43 B
$ 9.98
United States
Basic Materials
36
471.11%
67.22 B
$ 475.39
United States
Technology
37
464.1%
1.79 B
$ 5.5
Canada
Basic Materials
38
459.4%
14.28 B
$ 137.5
United States
Technology
39
444.44%
1.77 B
$ 11.76
United States
Basic Materials
40
432.35%
11.65 B
$ 256.7
United States
Technology
41
426.51%
34.60 B
$ 119.78
United States
Communication Services
42
407.44%
12.25 B
$ 87.94
Israel
Utilities
43
406.61%
2.71 B
$ 43.67
United States
Healthcare
44
394.32%
2.57 B
$ 81.81
United States
Technology
45
391.5%
1.09 B
$ 15.04
India
Communication Services
46
389.99%
350.44 M
$ 9.55
United States
Healthcare
47
379.83%
600.76 M
$ 2.26
Canada
Basic Materials
48
368.6%
476.21 B
$ 94.75
United States
Technology
49
366.62%
1.79 B
$ 62.34
United States
Healthcare
50
359.87%
6.13 B
$ 35.87
United States
Healthcare
51
354%
344.40 M
$ 4.54
United States
Technology
52
353.81%
205.70 M
$ 10.12
United States
Industrials
53
345.24%
744.92 M
$ 7.48
Hong Kong
Technology
54
343.55%
3.57 B
$ 15.48
United States
Technology
55
339.62%
8.80 B
$ 630.07
United States
Industrials
56
336.45%
861.77 M
$ 4.67
United States
Healthcare
57
329.3%
12.23 B
$ 152.83
United States
Technology
58
328.38%
281.38 M
$ 45.9647
United States
Financial Services
59
328.01%
643.52 M
$ 39.12
United States
Financial Services
60
325.61%
1.69 B
$ 18.25
United States
Basic Materials
61
324.26%
2.40 B
$ 66.99
United States
Industrials
62
324.15%
419.41 M
$ 8.78
United States
Healthcare
63
319.04%
9.34 B
$ 32.685
United States
Technology
64
313.17%
772.20 M
$ 36.83
United States
Consumer Cyclical
65
311.9%
955.67 M
$ 5.19
Canada
Basic Materials
66
310%
2.74 B
$ 4.92
Canada
Basic Materials
67
309.75%
14.22 B
$ 42.86
Australia
Financial Services
68
306.43%
9.00 B
$ 323.19
United States
Healthcare
69
304.58%
43.29 B
$ 376.54
Canada
Technology
70
302.37%
60.69 B
$ 1724.14
United States
Industrials
71
299.38%
731.15 M
$ 64.54
United States
Energy
72
298.98%
1.73 B
$ 15.6
United States
Healthcare
73
298.96%
115.66 M
$ 1.38
United States
Basic Materials
74
298.2%
3.29 B
$ 66.46
United States
Energy
75
297.99%
7.39 B
$ 217.5
Hong Kong
Technology
76
297.62%
1.50 B
$ 40.08
Singapore
Consumer Cyclical
77
292.34%
5.77 B
$ 28.17
United States
Basic Materials
78
292.27%
457.49 M
$ 8.63
United States
Healthcare
79
286.58%
1.24 B
$ 25.63
United States
Technology
80
286.38%
23.70 B
$ 199.18
Israel
Technology
81
282.08%
875.52 M
$ 4.05
United States
Healthcare
82
281.48%
1.46 B
$ 4.12
United States
Healthcare
83
280.23%
111.57 M
$ 11.14
United States
Technology
84
277.46%
630.04 M
$ 39.86
United States
Basic Materials
85
274.01%
10.89 B
$ 61.3
United States
Basic Materials
86
271.69%
45.69 B
$ 90.47
United States
Basic Materials
87
270.63%
333.45 M
$ 4.67
United States
Healthcare
88
267.11%
796.42 M
$ 5.58
United States
Basic Materials
89
266.67%
9.81 B
$ 20.02
United States
Financial Services
90
264.44%
2.54 B
$ 11.48
Canada
Basic Materials
91
262.64%
5.35 B
$ 5.58
United States
Real Estate
92
260.84%
4.59 B
$ 9.49
United States
Technology
93
259.91%
4.55 B
$ 83.5
United States
Healthcare
94
258.93%
9.88 B
$ 70.53
United States
Healthcare
95
256.13%
4.54 B
$ 86.04
United States
Industrials
96
254.54%
295.69 M
$ 2.04
United States
Basic Materials
97
253.49%
290.86 M
$ 2.9
China
Healthcare
98
252.94%
444.46 M
$ 9
Canada
Industrials
99
250.31%
6.87 B
$ 16.92
United States
Technology
100
248.5%
2.55 B
$ 6.97
Canada
Basic Materials
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q What is the best stock of 2025?
A

RGC (Regencell Bioscience Holdings Limited) is the best performing stock of 2025 with a year-to-date gain of 9,999% from January 1st to today. The top 3 stocks of 2025 are RGC, AXTI, RLMD.

Q What are the top performing stocks in 2025?
A

The top performing stocks in 2025 YTD are: RGC (+9,999%), AXTI (+3,145%), RLMD (+1,537%), HYMC (+1,400%), ABVX (+1,357%). Performance is calculated from January 1, 2025 to the most recent trading day.

Q Which stocks have made the most money in 2025?
A

The biggest stock gainers of 2025 include RGC leading with +9,999%, followed by AXTI (+3,145%) and RLMD (+1,537%). These represent the best investment returns YTD.

Q What sectors are performing best in 2025?
A

In 2025, the best performing sectors based on top stock gains include Healthcare, Technology, Basic Materials. The top gainer RGC operates in the Healthcare sector.

Q Which US stocks have the highest YTD returns in 2025?
A

The US stocks with the highest year-to-date returns in 2025 include RGC (+9,999%), AXTI (+3,145%), RLMD (+1,537%). These top YTD gainers are ranked by total return from January 1st to today across NYSE and NASDAQ.

Understanding Year-to-Date Stock Performance

Year-to-date (YTD) performance measures how much a stock's price has changed since January 1st of the current year. This metric is valuable for several reasons:

  • Current Trend Identification: YTD performance reveals which stocks are leading or lagging in the current market cycle, helping identify emerging trends before they become widely recognized.
  • Benchmark Comparison: Compare individual stock performance against market indices like the S&P 500 to assess whether investments are outperforming or underperforming the broader market.
  • Tax Planning: YTD gains and losses are crucial for tax-loss harvesting strategies and estimating potential capital gains tax obligations before year-end.

Factors Driving YTD Performance

Several factors can influence a stock's year-to-date performance:

  • Earnings Reports: Quarterly earnings that beat or miss expectations can significantly impact stock prices throughout the year.
  • Industry Trends: Sector rotation and changing market preferences can drive entire industries higher or lower.
  • Macroeconomic Factors: Interest rates, inflation data, and economic indicators affect stock valuations across the market.
  • Company-Specific News: Product launches, management changes, M&A activity, and regulatory developments can move individual stocks.

Model Your Returns

See exactly how much a YTD top performer would have returned on your investment with our Stock Return Calculator. Planning regular investments? The DCA Calculator shows how dollar-cost averaging into these stocks would have performed.