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#1 RGC leads with +9,999% 2025 YTD

RGC (Regencell Bioscience Holdings Limited) is the best performing stock in 2025 year-to-date. Following are AXTI (+4,740%) and TOI (+1,516%). Top performing sectors: Healthcare (+1090% avg, 6 in top 10), Energy (+806% avg), Technology (+595% avg, 2 in top 10).

Top Performing Stocks 2025 - Year-to-Date Gainers Ranked

Discover the best US stocks of 2025 ranked by year-to-date performance. This ranking tracks YTD gains and highest YTD returns from January 1st, 2025 to today, featuring the top stock gainers with market caps over $100 million on Nasdaq and NYSE.

This ranking shows the top performing US stocks and biggest stock gainers of 2025, calculated from January 1st to the most recent trading day. See which stocks delivered the highest YTD returns this year. Using split-adjusted data ensures accurate performance calculations that account for stock splits and corporate actions.

Year-to-date performance helps investors identify stocks that have been outperforming the market in the current year, revealing trends and momentum that may continue through the rest of 2025.

Looking for a specific Symbol?

Data as of June 5, 2026 at 9:06 AM EDT

Rank
Symbol
Company Name
YTD Gain
Market Cap
Price
Country
Sector
1
17376.34%
10.96 B
$ 22.16
Hong Kong
Healthcare
2
4739.73%
6.93 B
$ 105.99
United States
Technology
3
1515.54%
473.92 M
$ 4.74
United States
Healthcare
4
1339.37%
8.36 B
$ 104.93
France
Healthcare
5
1301.91%
661.86 M
$ 6.31
United States
Healthcare
6
1229.82%
2.77 B
$ 30.32
United States
Basic Materials
7
1172.76%
1.87 B
$ 36.91
France
Healthcare
8
1146.77%
82.88 B
$ 291.37
United States
Industrials
9
1107.34%
172.63 M
$ 17.265
United States
Healthcare
10
1040.5%
1.12 T
$ 996
United States
Technology
11
1004.07%
73.53 B
$ 945.08
United States
Technology
12
996.47%
15.51 B
$ 43.53
United States
Industrials
13
977.46%
2.77 B
$ 18.64
United States
Industrials
14
971.87%
209.51 B
$ 925.99
Singapore
Technology
15
911.46%
3.24 B
$ 67.06
United States
Technology
16
905.05%
199.00 M
$ 9.95
France
Financial Services
17
856.83%
1.65 B
$ 114.82
United States
Healthcare
18
830.18%
198.36 B
$ 575.5
United States
Technology
19
809.51%
408.91 M
$ 6.865
Hong Kong
Industrials
20
805.69%
482.66 M
$ 11.14
United States
Energy
21
778.8%
7.27 B
$ 30.67
United States
Technology
22
744.86%
1.78 B
$ 9.04
United States
Healthcare
23
688.11%
3.19 B
$ 22.54
United States
Industrials
24
665.27%
9.96 B
$ 72.93
United States
Technology
25
651.99%
19.20 B
$ 184.84
United States
Technology
26
632.71%
243.11 M
$ 74.37
Israel
Healthcare
27
620.1%
4.22 B
$ 74.89
United States
Technology
28
607.67%
3.20 B
$ 22.15
United States
Healthcare
29
604.41%
3.67 B
$ 116.58
United States
Technology
30
604.27%
4.51 B
$ 92.47
United States
Healthcare
31
602.92%
1.19 B
$ 6.8
Canada
Basic Materials
32
543.48%
75.74 B
$ 535.63
United States
Technology
33
534.84%
13.95 B
$ 306.12
United States
Technology
34
498.36%
1.34 B
$ 91.25
United States
Healthcare
35
496.92%
1.90 B
$ 5.82
Canada
Basic Materials
36
492.46%
30.49 B
$ 993.74
United States
Industrials
37
491.4%
22.11 B
$ 61.86
Australia
Financial Services
38
483.65%
14.39 B
$ 127.76
United States
Financial Services
39
479.35%
6.23 B
$ 90.205
United States
Technology
40
476.98%
2.18 B
$ 58.16
Singapore
Consumer Cyclical
41
476.58%
207.22 M
$ 1.28
United States
Basic Materials
42
469.92%
16.28 B
$ 202.89
United States
Technology
43
468.85%
130.21 M
$ 20.82
United States
Industrials
44
466.03%
12.62 B
$ 44.15
United States
Technology
45
463.89%
1.88 B
$ 12.18
United States
Basic Materials
46
454.25%
1.23 B
$ 16.96
India
Communication Services
47
453.07%
3.13 B
$ 87.33
United States
Industrials
48
452.82%
561.81 B
$ 111.78
United States
Technology
49
451.57%
1.71 B
$ 128.24
United States
Technology
50
448.3%
13.24 B
$ 95.02
Israel
Utilities
51
447.87%
36.12 B
$ 124.64
United States
Communication Services
52
440.92%
1.04 B
$ 17.58
France
Healthcare
53
439.19%
9.99 B
$ 294.67
Hong Kong
Technology
54
429.55%
1.12 B
$ 9.32
United States
Technology
55
428.99%
10.45 B
$ 25.55
United States
Technology
56
428.66%
661.90 M
$ 2.49
Canada
Basic Materials
57
427.05%
624.74 M
$ 10.91
United States
Healthcare
58
426.85%
18.84 B
$ 180.5
United States
Technology
59
425%
468.13 M
$ 18.9
United States
Technology
60
416.86%
5.56 B
$ 62.54
United States
Healthcare
61
413.07%
1.65 B
$ 9.03
Brazil
Industrials
62
406.91%
31.09 B
$ 261.31
Israel
Technology
63
400%
1.28 B
$ 8.65
United States
Basic Materials
64
399.17%
3.34 B
$ 5.99
Canada
Basic Materials
65
395.79%
41.64 B
$ 107.29
United States
Technology
66
395.07%
224.40 M
$ 11.04
United States
Industrials
67
394.19%
4.45 B
$ 73.14
Israel
Technology
68
391.48%
4.13 B
$ 13.27
United States
Healthcare
69
390.3%
529.28 M
$ 13.14
United States
Technology
70
387.03%
1.54 B
$ 24.4
United States
Technology
71
386.82%
641.53 M
$ 16.99
Japan
Technology
72
386.25%
149.91 M
$ 7.78
United States
Technology
73
381.66%
198.98 M
$ 18.4
United States
Industrials
74
381.4%
8.44 B
$ 94.21
United States
Technology
75
381.04%
9.62 B
$ 689.43
United States
Industrials
76
380.57%
74.95 B
$ 119.95
United States
Industrials
77
379.67%
12.98 B
$ 26.19
United States
Financial Services
78
364.91%
1.11 B
$ 17.62
United States
Technology
79
364.4%
420.70 B
$ 336.41
United States
Technology
80
357.03%
48.90 B
$ 425.36
Canada
Technology
81
355.13%
6.10 B
$ 11.97
United States
Technology
82
353.19%
1.17 B
$ 6.39
United States
Technology
83
350.82%
708.38 M
$ 11
United States
Healthcare
84
346.83%
67.36 B
$ 1914.65
United States
Industrials
85
345.16%
206.43 M
$ 6.9
United States
Industrials
86
343.37%
666.38 M
$ 28.42
United States
Technology
87
338%
2.34 B
$ 73.19
United States
Technology
88
335.69%
550.03 M
$ 11.11
Canada
Industrials
89
333.72%
853.13 B
$ 523.2
United States
Technology
90
332.45%
128.13 M
$ 12.67
United States
Technology
91
323.25%
170.15 B
$ 197.7
United States
Technology
92
320.38%
5.60 B
$ 32.79
United States
Healthcare
93
319.43%
82.54 B
$ 421.9
United States
Technology
94
318.82%
17.64 B
$ 133.06
United States
Healthcare
95
313.02%
58.44 B
$ 159.51
United States
Technology
96
312.33%
200.43 M
$ 3.17
United States
Healthcare
97
311.45%
2.00 B
$ 59.31
United States
Healthcare
98
310.31%
6.11 B
$ 29.46
United States
Basic Materials
99
310.15%
344.49 M
$ 2.36
United States
Basic Materials
100
305.8%
237.39 M
$ 14
United States
Healthcare
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q What is the best stock of 2025?
A

RGC (Regencell Bioscience Holdings Limited) is the best performing stock of 2025 with a year-to-date gain of 9,999% from January 1st to today. The top 3 stocks of 2025 are RGC, AXTI, TOI.

Q What are the top performing stocks in 2025?
A

The top performing stocks in 2025 YTD are: RGC (+9,999%), AXTI (+4,740%), TOI (+1,516%), ABVX (+1,339%), RLMD (+1,302%). Performance is calculated from January 1, 2025 to the most recent trading day.

Q Which stocks have made the most money in 2025?
A

The biggest stock gainers of 2025 include RGC leading with +9,999%, followed by AXTI (+4,740%) and TOI (+1,516%). These represent the best investment returns YTD.

Q What sectors are performing best in 2025?
A

In 2025, the best performing sectors based on top stock gains include Healthcare, Technology. The top gainer RGC operates in the Healthcare sector.

Q Which US stocks have the highest YTD returns in 2025?
A

The US stocks with the highest year-to-date returns in 2025 include RGC (+9,999%), AXTI (+4,740%), TOI (+1,516%). These top YTD gainers are ranked by total return from January 1st to today across NYSE and NASDAQ.

Understanding Year-to-Date Stock Performance

Year-to-date (YTD) performance measures how much a stock's price has changed since January 1st of the current year. This metric is valuable for several reasons:

  • Current Trend Identification: YTD performance reveals which stocks are leading or lagging in the current market cycle, helping identify emerging trends before they become widely recognized.
  • Benchmark Comparison: Compare individual stock performance against market indices like the S&P 500 to assess whether investments are outperforming or underperforming the broader market.
  • Tax Planning: YTD gains and losses are crucial for tax-loss harvesting strategies and estimating potential capital gains tax obligations before year-end.

Factors Driving YTD Performance

Several factors can influence a stock's year-to-date performance:

  • Earnings Reports: Quarterly earnings that beat or miss expectations can significantly impact stock prices throughout the year.
  • Industry Trends: Sector rotation and changing market preferences can drive entire industries higher or lower.
  • Macroeconomic Factors: Interest rates, inflation data, and economic indicators affect stock valuations across the market.
  • Company-Specific News: Product launches, management changes, M&A activity, and regulatory developments can move individual stocks.

Model Your Returns

See exactly how much a YTD top performer would have returned on your investment with our Stock Return Calculator. Planning regular investments? The DCA Calculator shows how dollar-cost averaging into these stocks would have performed.