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#1 RGC leads with +9,999% 2025 YTD

RGC (Regencell Bioscience Holdings Limited) is the best performing stock in 2025 year-to-date. Following are AXTI (+3,496%) and HYMC (+1,829%). Top performing sectors: Healthcare (+885% avg, 6 in top 10), Industrials (+555% avg), Technology (+548% avg, 2 in top 10).

Top Performing Stocks 2025 - Year-to-Date Gainers Ranked

Discover the best US stocks of 2025 ranked by year-to-date performance. This ranking tracks YTD gains and highest YTD returns from January 1st, 2025 to today, featuring the top stock gainers with market caps over $100 million on Nasdaq and NYSE.

This ranking shows the top performing US stocks and biggest stock gainers of 2025, calculated from January 1st to the most recent trading day. See which stocks delivered the highest YTD returns this year. Using split-adjusted data ensures accurate performance calculations that account for stock splits and corporate actions.

Year-to-date performance helps investors identify stocks that have been outperforming the market in the current year, revealing trends and momentum that may continue through the rest of 2025.

Looking for a specific Symbol?

Data as of April 20, 2026 at 7:52 PM EDT

Rank
Symbol
Company Name
YTD Gain
Market Cap
Price
Country
Sector
1
22060.88%
14.18 B
$ 28.67
Hong Kong
Healthcare
2
3496.35%
4.59 B
$ 82.56
United States
Technology
3
1828.51%
4.02 B
$ 44.17
United States
Basic Materials
4
1537.41%
784.58 M
$ 7.48
United States
Healthcare
5
1477.23%
9.78 B
$ 120.16
France
Healthcare
6
1099.73%
349.89 M
$ 3.54
United States
Healthcare
7
1000.34%
1.64 B
$ 33.79
France
Healthcare
8
977.75%
1.86 B
$ 130.01
United States
Healthcare
9
945.69%
63.84 B
$ 894.07
United States
Technology
10
901.01%
197.80 M
$ 9.89
France
Financial Services
11
856.07%
2.49 B
$ 18.36
United States
Industrials
12
844.58%
13.32 B
$ 38.48
United States
Industrials
13
833.98%
59.07 B
$ 207.86
United States
Industrials
14
830.16%
6.08 B
$ 52.65
United States
Healthcare
15
814.62%
5.92 B
$ 122.46
United States
Healthcare
16
743.13%
3.80 B
$ 26.64
United States
Healthcare
17
704.07%
5.91 B
$ 19.01
United States
Healthcare
18
694.91%
319.56 M
$ 5.365
Hong Kong
Industrials
19
685.61%
1.31 B
$ 7.75
Canada
Basic Materials
20
656.84%
17.45 B
$ 493.86
United States
Industrials
21
647.75%
255.74 M
$ 1.58
United States
Basic Materials
22
599.3%
109.76 M
$ 10.98
United States
Healthcare
23
596.15%
2.43 B
$ 84.86
United States
Healthcare
24
589.66%
239.73 M
$ 73.87
Israel
Healthcare
25
585.96%
3.93 B
$ 70.43
United States
Technology
26
585.66%
2.56 B
$ 18.67
United States
Industrials
27
580.33%
849.77 M
$ 16.01
Cayman Islands
Healthcare
28
574.8%
122.06 M
$ 8.75
United States
Energy
29
572.4%
8.54 B
$ 62.85
United States
Technology
30
566.67%
2.13 B
$ 6.55
Canada
Basic Materials
31
556.48%
1.89 B
$ 12.54
United States
Basic Materials
32
551.24%
569.13 M
$ 7.53
United States
Healthcare
33
546.15%
1.26 B
$ 21.34
France
Healthcare
34
541.35%
421.28 M
$ 11.5
United States
Healthcare
35
524.78%
122.71 B
$ 547.75
Singapore
Technology
36
515.03%
1.52 B
$ 10.57
United States
Basic Materials
37
504.67%
127.36 B
$ 372.52
United States
Technology
38
504.6%
71.78 B
$ 507.43
United States
Technology
39
493.89%
38.48 B
$ 133.21
United States
Communication Services
40
447.77%
696.46 M
$ 2.62
Canada
Basic Materials
41
444.71%
2.64 B
$ 83.86
United States
Technology
42
440.23%
1.29 B
$ 88.23
United States
Healthcare
43
438.75%
2.78 B
$ 44.9
United States
Healthcare
44
422.3%
238.83 M
$ 16.33
Netherlands
Technology
45
419.47%
678.23 M
$ 41.23
United States
Financial Services
46
413.48%
513.20 B
$ 455.07
United States
Technology
47
411.84%
13.11 B
$ 126.24
United States
Technology
48
400.14%
150.03 M
$ 1.79
United States
Basic Materials
49
392.02%
2.75 B
$ 76.97
United States
Industrials
50
385.62%
970.94 M
$ 13.42
India
Communication Services
51
384.84%
1.89 B
$ 20.4
United States
Basic Materials
52
382.61%
938.67 M
$ 44.77
United States
Consumer Cyclical
53
378.77%
11.40 B
$ 81.87
Israel
Utilities
54
374.36%
6.05 B
$ 37.25
United States
Healthcare
55
371.67%
2.95 B
$ 5.32
Canada
Basic Materials
56
366.36%
937.42 M
$ 5.22
United States
Healthcare
57
366.22%
9.89 B
$ 218.05
United States
Technology
58
365.77%
15.96 B
$ 48.12
Australia
Financial Services
59
361.32%
1.04 B
$ 4.82
United States
Healthcare
60
359.19%
12.38 B
$ 159.42
United States
Technology
61
358.64%
548.68 M
$ 10.35
United States
Healthcare
62
349.36%
2.03 B
$ 18.36
United States
Healthcare
63
344.57%
6.50 B
$ 31.75
United States
Basic Materials
64
343.6%
472.24 M
$ 1.45
Canada
Basic Materials
65
343.18%
684.73 M
$ 43.32
United States
Basic Materials
66
339.68%
409.11 M
$ 5.75
United States
Healthcare
67
338.19%
1.62 B
$ 43.26
Singapore
Consumer Cyclical
68
337.51%
55.12 B
$ 109.15
United States
Basic Materials
69
337.22%
192.49 M
$ 9.47
United States
Industrials
70
335.48%
26.95 B
$ 226.45
Israel
Technology
71
333.33%
624.57 M
$ 9.16
United States
Healthcare
72
333.33%
1.01 B
$ 5.49
Canada
Basic Materials
73
330.99%
45.57 B
$ 396.01
Canada
Technology
74
330.8%
9.54 B
$ 342.5
United States
Healthcare
75
326.47%
8.34 B
$ 597.88
United States
Industrials
76
321.05%
887.77 M
$ 6.22
United States
Basic Materials
77
320%
301.16 M
$ 3.97
United States
Technology
78
312.69%
9.01 B
$ 31.53
United States
Technology
79
307.98%
4.82 B
$ 10
United States
Technology
80
304.09%
10.84 B
$ 60.99
United States
Basic Materials
81
299.38%
7.85 B
$ 19.37
United States
Technology
82
297.13%
1.24 B
$ 25.56
United States
Technology
83
296.21%
5.08 B
$ 93.26
United States
Healthcare
84
294.92%
2.84 B
$ 12.84
Canada
Basic Materials
85
292.09%
58.07 B
$ 1650.47
United States
Industrials
86
290.59%
475.57 M
$ 9.63
Canada
Industrials
87
288.47%
9.98 B
$ 13.8
South Africa
Basic Materials
88
286.79%
1.08 B
$ 6
United States
Healthcare
89
285.5%
2.83 B
$ 7.73
Canada
Basic Materials
90
284.53%
470.65 M
$ 12.82
Japan
Technology
91
281.51%
778.60 M
$ 4.48
Canada
Basic Materials
92
281.4%
3.00 B
$ 16.76
United States
Healthcare
93
281.36%
1.94 B
$ 67.51
United States
Healthcare
94
280.56%
1.41 B
$ 3.98
United States
Healthcare
95
280.24%
277.38 M
$ 45.31
United States
Financial Services
96
278.7%
4.95 B
$ 20.49
United States
Energy
97
278.22%
2.84 B
$ 12.32
United States
Technology
98
277.31%
817.15 M
$ 14.16
United States
Technology
99
277.13%
324.68 M
$ 2.24
United States
Basic Materials
100
275.46%
8.75 B
$ 20.64
United States
Financial Services
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q What is the best stock of 2025?
A

RGC (Regencell Bioscience Holdings Limited) is the best performing stock of 2025 with a year-to-date gain of 9,999% from January 1st to today. The top 3 stocks of 2025 are RGC, AXTI, HYMC.

Q What are the top performing stocks in 2025?
A

The top performing stocks in 2025 YTD are: RGC (+9,999%), AXTI (+3,496%), HYMC (+1,829%), RLMD (+1,537%), ABVX (+1,477%). Performance is calculated from January 1, 2025 to the most recent trading day.

Q Which stocks have made the most money in 2025?
A

The biggest stock gainers of 2025 include RGC leading with +9,999%, followed by AXTI (+3,496%) and HYMC (+1,829%). These represent the best investment returns YTD.

Q What sectors are performing best in 2025?
A

In 2025, the best performing sectors based on top stock gains include Healthcare, Technology, Basic Materials. The top gainer RGC operates in the Healthcare sector.

Q Which US stocks have the highest YTD returns in 2025?
A

The US stocks with the highest year-to-date returns in 2025 include RGC (+9,999%), AXTI (+3,496%), HYMC (+1,829%). These top YTD gainers are ranked by total return from January 1st to today across NYSE and NASDAQ.

Understanding Year-to-Date Stock Performance

Year-to-date (YTD) performance measures how much a stock's price has changed since January 1st of the current year. This metric is valuable for several reasons:

  • Current Trend Identification: YTD performance reveals which stocks are leading or lagging in the current market cycle, helping identify emerging trends before they become widely recognized.
  • Benchmark Comparison: Compare individual stock performance against market indices like the S&P 500 to assess whether investments are outperforming or underperforming the broader market.
  • Tax Planning: YTD gains and losses are crucial for tax-loss harvesting strategies and estimating potential capital gains tax obligations before year-end.

Factors Driving YTD Performance

Several factors can influence a stock's year-to-date performance:

  • Earnings Reports: Quarterly earnings that beat or miss expectations can significantly impact stock prices throughout the year.
  • Industry Trends: Sector rotation and changing market preferences can drive entire industries higher or lower.
  • Macroeconomic Factors: Interest rates, inflation data, and economic indicators affect stock valuations across the market.
  • Company-Specific News: Product launches, management changes, M&A activity, and regulatory developments can move individual stocks.

Model Your Returns

See exactly how much a YTD top performer would have returned on your investment with our Stock Return Calculator. Planning regular investments? The DCA Calculator shows how dollar-cost averaging into these stocks would have performed.