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2 stocks are withheld from this ranking because their price history is under review.
The gain covers the period; price, market cap, sector and country show each company as it is today.
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Over 2025, 56% of the 4,474 ranked companies finished higher and the median move was +3.7%; Basic Materials led on median (+34.9%) and Real Estate lagged (-6.1%). The S&P 500 fund (SPY) moved +16.35% between its Dec 31, 2024 and Dec 31, 2025 closes. A company that began trading during the period is measured from its first close, over a shorter window.
Among the 4,474 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, RGC (Regencell Bioscience Holdings Limited) has the highest gain in 2025 with +16,054%. Following are QMMM (+9,228%) and ABVX (+1,742%).
This ranking shows the top performing US stocks and biggest stock gainers of 2025, calculated from January 1st to the last trading day of 2025. See which stocks delivered the highest returns in 2025.
Year-to-date performance shows which names led in 2025. Gains use split-adjusted closing prices, so a stock split does not show up as a move; they measure price change only, and dividends are not added back.
Among the 4,474 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, RGC (Regencell Bioscience Holdings Limited) has the highest gain in 2025 with +16,054%. It is followed by QMMM (+9,228%) and ABVX (+1,742%). These are the largest gains in this ranking rather than recommendations.
Every figure runs from January 1 to December 31, 2025, measured on split-adjusted closing prices, so a split inside the year contributes nothing to the number. The window has a fixed start rather than a rolling one, which is what separates this board from the 52-week ranking: each year has its own board, so a year's page keeps its figures once the year closes, while the 52-week figures keep rolling forward.
4,474 companies with a market capitalization above $100 million traded on NYSE, Nasdaq and NYSE American, each with at least one trading day inside 2025. A company needs only one close inside the year to qualify here, whereas the 52-week board needs a close a full year back, which is why this board admits more companies than that one: every company listed during 2025 appears here and cannot appear there.
Because that company's return did not accrue over the whole period. A symbol whose current trading history began inside 2025, through a recent listing or a relisting, has no January price to measure from, so its figure runs from the day that history begins and the dagger says so. Reading such a row as a year-to-date return would compare a partial window against full ones.
The five highest-gaining companies sit in Healthcare, Communication Services and Consumer Cyclical, with the leader RGC in Healthcare. That describes the top of this list, not a sector ranking: the board orders individual companies by their own price change, and the market-context strip under the table reports the median move of each sector's ranked companies, across NYSE, Nasdaq and NYSE American.
Year-to-date (YTD) performance measures how much a stock's price has changed since January 1st of the current year. This metric is valuable for several reasons:
Several factors can influence a stock's year-to-date performance:
See exactly how much a YTD top performer would have returned on your investment with our Stock Return Calculator. Planning regular investments? The DCA Calculator shows how dollar-cost averaging into these stocks would have performed.
