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Amylyx Pharmaceuticals Co-Chief Executive Officer and director Justin B. Klee reported option exercises and related share sales. On January 15, 2026, he exercised stock options for 197,153 shares of common stock at an exercise price of $7.57 per share, then sold 136,193 shares at a weighted average price of $13.5827 per share. On January 16, 2026, he exercised options for an additional 2,847 shares at $7.57 and sold 1,995 shares at a weighted average price of $13.8853 per share. According to the footnotes, these sales were made to cover option cost and tax obligations under a preset sales plan adopted on November 12, 2025. After these transactions, Klee directly held 3,379,398 shares of Amylyx common stock.
AMLX filed a Rule 144 notice for a planned insider stock sale. The filing covers the proposed sale of 1,995 shares of the issuer’s common stock through Morgan Stanley Smith Barney LLC on NASDAQ, with an aggregate market value of $26,972.40 as of the filing details.
The shares to be sold were acquired on January 16, 2026 via an exercise of stock options paid in cash on the same date. The notice also lists prior sales of the issuer’s common stock during the past three months for the account of Justin Klee, including 136,193 shares sold on January 15, 2026 for gross proceeds of $1,849,860.26 and 7,715 shares sold on January 6, 2026 for gross proceeds of $85,589.44.
AMLX insider Joshua Barry Cohen has filed a notice of proposed sale of company stock under Rule 144. The filing covers the planned sale of 1,974 common shares through Morgan Stanley Smith Barney LLC on the NASDAQ, with an aggregate market value of $26,688.48 based on the figures provided. The shares relate to an exercise of stock options on 01/16/2026, paid for in cash and acquired from the issuer on the same date.
The notice states that AMLX had 109,819,569 shares of common stock outstanding. Over the prior three months, sales for Cohen’s account included 136,193 common shares on 01/15/2026 for gross proceeds of $1,850,794.52 and 7,715 common shares on 01/06/2026 for gross proceeds of $85,596.38. By signing, the seller represents that he is not aware of undisclosed material adverse information about the issuer.
An insider of Amylyx filed a Form 144 notice outlining a planned sale of company stock. The filing covers up to 136,193 common shares to be sold through Morgan Stanley Smith Barney LLC on or after January 15, 2026 on the NASDAQ, with an indicated aggregate market value of $1,916,235.51. These shares were acquired the same day through a cash exercise of stock options. The filing also notes that 109,819,569 common shares were outstanding and that the same individual sold 7,715 shares of common stock for $85,596.38 on January 6, 2026. The signer represents that they are not aware of any material adverse, nonpublic information about Amylyx.
An insider of the company with ticker AMLX has filed a notice of intent to sell 136,193 shares of common stock through broker Morgan Stanley Smith Barney LLC on or about 01/15/2026, with an indicated aggregate market value of $1,916,235.51. The filing notes that these shares were acquired on the same date via a cash exercise of stock options from the issuer.
As context, the filing lists 109,819,569 shares of common stock outstanding and discloses that Justin Klee sold 7,715 shares of common stock on 01/06/2026 for gross proceeds of $85,589.44 during the prior three months. The seller also represents that they are not aware of any undisclosed material adverse information about the issuer’s current or prospective operations.
Amylyx Pharmaceuticals director reports stock gift. Director George M. Milne Jr filed a Form 4 showing a bona fide gift of 17,780 shares of Amylyx Pharmaceuticals, Inc. common stock on January 12, 2026. The shares were transferred for no consideration, meaning he did not receive payment for them. After this gift, he directly beneficially owned 812,881 shares of the company’s common stock.
Amylyx Pharmaceuticals, Inc. Chief Financial Officer James M. Frates reported an automatic sale of common stock. On January 6, 2026, he sold 3,326 shares of Amylyx common stock at a weighted average price of $11.1106 per share. According to the filing, these shares were sold solely to cover tax withholding obligations arising from the vesting of restricted stock units, and the sale was not at his discretion.
After this transaction, Frates directly beneficially owned 177,104 shares of Amylyx common stock. He also had indirect holdings through trusts, including 100,000 shares held by the JAMES M. FRATES 2025 GRAT No. 1 and additional blocks of 15,459 shares and 11,072 shares in other family trusts. For these trust holdings, he serves as trustee and disclaims beneficial ownership except to the extent of any pecuniary interest.
Amylyx Pharmaceuticals, Inc. director and Co-Chief Executive Officer Joshua B. Cohen reported an automatic sale of common stock. On January 6, 2026, he sold 7,715 shares of Amylyx common stock at a weighted average price of $11.0948 per share. According to the disclosure, these shares were required to be sold to cover tax withholding obligations arising from the vesting of restricted stock units, and the sales were automatic and not at his discretion.
After this transaction, Cohen beneficially owned 3,317,632 shares of Amylyx common stock, held directly.
Amylyx Pharmaceuticals Co-Chief Executive Officer Justin B. Klee reported an automatic sale of 7,715 shares of common stock on January 6, 2026. The shares were sold at a weighted average price of $11.0939 per share to cover tax withholding obligations arising from the vesting of restricted stock units, and the sale was not made at his discretion.
After this tax-related sale, Klee beneficially owned 3,317,586 shares of Amylyx Pharmaceuticals, Inc. common stock directly.
Amylyx Pharmaceuticals reported that it has selected AMX0318, a long-acting GLP-1 receptor antagonist, as a new development candidate for treating post-bariatric hypoglycemia and other rare diseases. AMX0318 was discovered through a research collaboration with Gubra A/S, which specializes in peptide-based drug discovery and preclinical research.
Under this collaboration, Gubra is eligible to receive more than $50 million in success-based development and commercialization milestone payments, plus mid-single digit royalties on worldwide net sales if AMX0318 progresses successfully. The selection and handover of the development candidate immediately triggers $4 million in milestone payments to Gubra.
Amylyx also updated its corporate presentation for use with investors and analysts, furnishing the new presentation as Exhibit 99.1.