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Alto Neuroscience (NYSE: ANRO) estimates $244.2M cash and plans added ALTO-207 Phase 3

Filing Impact
(Moderate)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Alto Neuroscience, Inc. reported a preliminary estimate of its cash, cash equivalents and restricted cash of approximately $244.2 million as of June 30, 2026. This figure is based on management’s estimates, has not been audited, reviewed or compiled by the independent registered public accounting firm, and may change after completion of accounting procedures for the quarter ended June 30, 2026; any differences may be material.

The company also outlined a pipeline update, stating that it intends to accelerate and expand clinical development of its ALTO-207 program, including conducting an additional planned Phase 3 trial of ALTO-207 as monotherapy for treatment-resistant depression.

Positive

  • None.

Negative

  • None.
Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 8.01 Other Events Other
Voluntary disclosure of events the company deems important to shareholders but not covered by other items.
Cash, cash equivalents and restricted cash $244.2 million Preliminary estimate as of June 30, 2026
Form type Form 8-K Current report filed under the Securities Exchange Act of 1934
Phase of new ALTO-207 trial Phase 3 Planned additional monotherapy trial for treatment-resistant depression
restricted cash financial
"it estimates that its cash, cash equivalents and restricted cash were approximately"
Cash that a company holds but cannot use for day-to-day operations because it is set aside for a specific purpose—such as meeting loan covenants, serving as collateral, funding an escrow, or complying with regulations. Like money in a locked savings account earmarked for a bill, restricted cash reduces the cash available to run the business and pay dividends or debts, so investors treat it differently when assessing a company’s true short-term financial strength.
treatment-resistant depression medical
"Phase 3 trial of ALTO-207 as monotherapy for the treatment of treatment-resistant depression"
A form of major depression that does not improve after a person has tried standard treatments such as common antidepressant medications and therapy; think of it as a stubborn problem that doesn’t respond to the usual fixes. It matters to investors because it represents a large unmet medical need and a higher-risk, higher-reward area for drug developers, with potential for premium pricing, regulatory scrutiny, and durable demand if an effective new therapy is approved.
Phase 3 trial medical
"conduct an additional planned Phase 3 trial of ALTO-207 as monotherapy"
A Phase 3 trial is a large, late-stage test of a new drug or medical treatment done on many people to make sure it really works and is safe. For investors, it matters because a successful Phase 3 usually means the company can ask regulators to sell the product and could earn lots of money, while failure can sharply reduce the company’s value.
forward-looking statements regulatory
"contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act"
Forward-looking statements are predictions or plans that companies share about what they expect to happen in the future, like estimating sales or profits. They matter because they help investors understand a company's outlook, but since they are based on guesses and assumptions, they can sometimes be wrong.
emerging growth company regulatory
"Emerging growth company x"
An emerging growth company is a recently public or smaller public firm that qualifies for temporary, lighter regulatory and disclosure rules to reduce the cost and effort of being public. For investors, it means the company may provide less historical financial detail and face fewer reporting requirements than larger firms, so it can grow more quickly but also carries higher uncertainty—like buying a promising early-stage product with fewer user reviews.
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FAQ

What cash balance did Alto Neuroscience (ANRO) estimate as of June 30, 2026?

Alto Neuroscience estimated cash, cash equivalents and restricted cash of approximately $244.2 million as of June 30, 2026. This amount is preliminary, unaudited, and may change after full quarter-end accounting procedures are completed.

Is Alto Neuroscience’s $244.2 million cash figure for ANRO audited?

No. The $244.2 million cash, cash equivalents and restricted cash estimate has not been audited, reviewed, or compiled by Alto Neuroscience’s independent registered public accounting firm and may differ materially once full accounting is completed.

What pipeline update did Alto Neuroscience (ANRO) provide for ALTO-207?

Alto Neuroscience stated it intends to accelerate and expand clinical development of ALTO-207, including an additional planned Phase 3 trial of ALTO-207 as monotherapy for the treatment of treatment-resistant depression.

What indication is Alto Neuroscience’s ALTO-207 program targeting according to this 8-K?

The ALTO-207 program is being developed for treatment-resistant depression. Alto Neuroscience plans an additional Phase 3 monotherapy trial to further evaluate ALTO-207 in this patient population.

Does Alto Neuroscience (ANRO) commit to updating its forward-looking statements about ALTO-207?

Alto Neuroscience states that its forward-looking statements speak only as of the date of the report and it disclaims any obligation to update them, except as may be required by law.
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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

 

 

FORM 8-K

 

 

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

 

Date of Report (Date of earliest event reported): July 13, 2026

 

 

 

ALTO NEUROSCIENCE, INC.

(Exact Name of Registrant as Specified in its Charter)

 

 

 

Delaware    001-41944   83-4210124
(State or Other Jurisdiction
of Incorporation)
  (Commission
File Number)
  (IRS Employer
Identification No.)

 

650 Castro Street, Suite 450, Mountain View, CA 94041
(Address of principal executive offices) (Zip Code)

 

Registrant’s telephone number, including area code: (650) 200-0412

 

N/A

(Former name or former address, if changed since last report)

 

 

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

¨ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
   
¨ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
   
¨ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
   
¨ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class   Trading
Symbol(s)
  Name of each exchange
on which registered
Common Stock, $0.0001 par value per share   ANRO   New York Stock Exchange

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

 

Emerging growth company x

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

 

 

 

 

 

Item 2.02.Results of Operations and Financial Condition.

 

The information disclosed under the heading “Cash, Cash Equivalents and Restricted Cash as of June 30, 2026” under Item 8.01 of this Current Report on Form 8-K is incorporated herein by reference and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

 

Item 8.01Other Events.

 

Cash, Cash Equivalents and Restricted Cash as of June 30, 2026

 

On July 13, 2026, Alto Neuroscience, Inc. (the “Company”) announced that, based upon preliminary estimates and information available to the Company, it estimates that its cash, cash equivalents and restricted cash were approximately $244.2 million as of June 30, 2026. This amount has not been audited, reviewed, or compiled by the Company’s independent registered public accounting firm. The Company’s actual cash, cash equivalents and restricted cash as of June 30, 2026 may differ from these amounts after it completes its comprehensive accounting procedures for the quarter ended June 30, 2026, and any such differences may be material.

 

Pipeline Update

 

The Company intends to accelerate and expand the clinical development of its most advanced program, ALTO-207, including to conduct an additional planned Phase 3 trial of ALTO-207 as monotherapy for the treatment of treatment-resistant depression.

 

Forward-Looking Statements

 

This Current Report on Form 8-K contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “anticipates,” “believes,” “expects,” “intends,” “projects,” “plans,” and “future” or similar expressions are intended to identify forward-looking statements. Forward-looking statements include statements concerning the Company’s clinical development plans for ALTO-207, and other statements that are not historical fact. Forward-looking statements are based on management’s current expectations and are subject to various risks and uncertainties that could cause actual results to differ materially and adversely from those expressed or implied by such forward-looking statements. Accordingly, these forward-looking statements do not constitute guarantees of future performance, and you are cautioned not to place undue reliance on these forward-looking statements. Risks regarding the Company’s business are described in detail in its SEC filings, including in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 and other filings that the Company may make with the SEC, which are available on the SEC’s website at www.sec.gov. Additional information will be made available in other filings that the Company makes from time to time with the SEC. These forward-looking statements speak only as of the date hereof, and the Company disclaims any obligation to update these statements except as may be required by law.

 

 

 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

  ALTO NEUROSCIENCE, INC.
     
Dated: July 13, 2026 By: /s/ Amit Etkin
    Amit Etkin, M.D., Ph.D.
    President and Chief Executive Officer

 

 

 

Filing Exhibits & Attachments

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