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Biotech leader Andrew Miller joins Alto Neuroscience (ANRO) board and governance committee

Filing Impact
(Moderate)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Alto Neuroscience, Inc. appointed Andrew Miller, Ph.D. to its Board of Directors as a Class III director, filling a seventh board seat for a term ending at the 2027 annual stockholder meeting. He was also named to the Nominating and Corporate Governance Committee and deemed independent under NYSE and SEC rules.

As a non-employee director, Dr. Miller will receive an initial stock option for up to 48,200 shares or options valued at up to $400,000 by Black‑Scholes, plus ongoing annual option grants and cash retainers for board and committee service under the company’s Non-Employee Director Compensation Policy.

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Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers Governance
Key personnel changes including departures, elections, or appointments of directors and executive officers.
Initial option grant cap 48,200 shares Maximum shares under initial non-employee director stock option
Initial option value cap $400,000 Maximum aggregate Black-Scholes Value for initial option
Annual option grant cap 24,100 shares Maximum shares under each annual director option grant
Annual option value cap $200,000 Maximum aggregate Black-Scholes Value for each annual option
Board cash retainer $40,000 per year Annual cash retainer for board service
Committee cash retainer $5,000 per year Annual cash retainer for Nominating and Corporate Governance Committee
Board size 7 directors Board size after increase effective March 16, 2026
Director age 44 years Age of Andrew Miller, Ph.D.
Non-Employee Director Compensation Policy financial
"As a non-employee director of the Company, Dr. Miller is eligible to participate in the Company’s Non-Employee Director Compensation Policy"
Black-Scholes Value financial
"the largest whole number of shares of Common Stock that results in such option having an aggregate Black-Scholes Value not exceeding $400,000"
indemnification agreement regulatory
"the Company and Dr. Miller entered into the Company’s standard form of indemnification agreement"
An indemnification agreement is a contract in which one party promises to cover losses, costs, or legal claims that another party might face, acting like a tailored safety net or private insurance policy. For investors, it matters because such agreements shift potential financial risk away from a company or its officers and onto the indemnifier, which can affect a company’s future liabilities, cash flow and how risky the investment appears during deal-making or litigation.
emerging growth company regulatory
"Emerging growth company x"
An emerging growth company is a recently public or smaller public firm that qualifies for temporary, lighter regulatory and disclosure rules to reduce the cost and effort of being public. For investors, it means the company may provide less historical financial detail and face fewer reporting requirements than larger firms, so it can grow more quickly but also carries higher uncertainty—like buying a promising early-stage product with fewer user reviews.
Class III director regulatory
"Dr. Miller was appointed as a Class III director for a term expiring at the Company’s 2027 Annual Meeting of Stockholders."
A Class III director is a board member placed in one of the numbered groups used by companies with a staggered (or “classified”) board; that director’s seat typically comes up for election in the third year of a three-year rotation. For investors this matters because staggered terms create continuity but also make it harder to replace the whole board quickly, affecting shareholder influence, takeover dynamics and how fast new strategy or accountability can be implemented — like replacing only some players on a sports team each season instead of the whole roster at once.
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FAQ

What did Alto Neuroscience (ANRO) announce about its board of directors?

Alto Neuroscience appointed Andrew Miller, Ph.D. as a Class III director, expanding its board to seven members. His term runs until the 2027 annual stockholder meeting, and he will also serve on the Nominating and Corporate Governance Committee.

Who is Andrew Miller, Ph.D., newly appointed to Alto Neuroscience (ANRO)’s board?

Andrew Miller, Ph.D. founded Karuna Therapeutics and held senior roles there, including President of Research and Development and Chief Operating Officer. He also serves on Kyverna Therapeutics’ board and several private biotech boards, bringing extensive biotechnology and drug development experience.

How will Alto Neuroscience (ANRO) compensate Andrew Miller as a director?

Under its Non-Employee Director Compensation Policy, Alto Neuroscience will grant Dr. Miller an initial stock option for up to 48,200 shares or options valued up to $400,000, plus cash retainers and future annual option grants for ongoing board and committee service.

What annual cash retainers will Andrew Miller receive from Alto Neuroscience (ANRO)?

Dr. Miller will receive a $40,000 annual cash retainer for board service and a $5,000 annual cash retainer for serving on the Nominating and Corporate Governance Committee. These amounts are paid quarterly in arrears and prorated for partial service periods.

Is Andrew Miller considered independent on Alto Neuroscience (ANRO)’s board?

Yes. The board determined that Andrew Miller is independent under New York Stock Exchange rules and current SEC regulations. This means he meets specified standards for director independence, which helps support objective oversight of Alto Neuroscience’s management and governance.

What equity awards will Andrew Miller receive in future years from Alto Neuroscience (ANRO)?

On each annual stockholder meeting date, Dr. Miller will receive an option to buy up to 24,100 shares or options valued up to $200,000. Each annual option vests by the first anniversary of grant or the next annual meeting, subject to continued service.
0001999480False00019994802026-05-272026-05-27

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
_____________________
FORM 8-K
_____________________

CURRENT REPORT
Pursuant to Section 13 or 15(d)
of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): May 27, 2026
_____________________
ALTO NEUROSCIENCE, INC.
(Exact Name of Registrant as Specified in its Charter)
_____________________
Delaware
 001-41944
83-4210124
(State or Other Jurisdiction
of Incorporation)
(Commission
File Number)
(IRS Employer
Identification No.)
650 Castro Street, Suite 450, Mountain View, CA
94041
(Address of principal executive offices)(Zip Code)
Registrant’s telephone number, including area code: (650) 200-0412
N/A
(Former name or former address, if changed since last report)
_____________________
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
oWritten communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
oSoliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
oPre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
oPre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))


Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading
Symbol(s)
Name of each exchange
on which registered
Common Stock, $0.0001 par value per shareANRONew York Stock Exchange

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company x
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. o



Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

Appointment of Andrew Miller, Ph.D. to the Board

On May 27, 2026, the Board of Directors (the “Board”) of Alto Neuroscience, Inc. (the “Company”), following the recommendation of the Board’s Nominating and Corporate Governance Committee (the “NCGC”), unanimously appointed Andrew Miller, Ph.D. to serve as a member of the Board. Effective March 16, 2026, the Board had increased its size from six to seven directors, and Dr. Miller will join the board and fill the resulting vacancy. Dr. Miller was appointed as a Class III director for a term expiring at the Company’s 2027 Annual Meeting of Stockholders. The Board also appointed Dr. Miller to the NCGC, replacing Christopher Nixon Cox. The Board has determined that Dr. Miller is “independent” pursuant to the rules of the New York Stock Exchange (“NYSE”) and the current rules and regulations of the Securities and Exchange Commission (the “SEC”).

Dr. Miller, age 44, founded Karuna Therapeutics, Inc. (previously Nasdaq: KRTX), a biopharmaceutical company, and most recently served as its President of Research and Development from January 2024 to March 2024 when it was acquired by Bristol Myers Squibb. He previously served as Chief Operating Officer of Karuna from August 2018 to January 2024, its President and Chief Executive Officer from July 2016 to August 2018 and as a member of its board of directors from April 2012 to March 2019. Prior to that, Dr. Miller held senior and executive level positions at PureTech Health plc, Tal Medical and Entrega, Inc. Dr. Miller has served on the board of directors of Kyverna Therapeutics, Inc. (Nasdaq: KYTX), a clinical-stage biopharmaceutical company, since February 2026. He also serves on the board of directors of multiple privately held biotechnology companies. Dr. Miller received a B.S. in Chemical Engineering from the University of Illinois with highest honors and completed his Ph.D. in Chemical Engineering at the Massachusetts Institute of Technology. The Board believes that Dr. Miller’s extensive experience in biotechnology leadership, drug development, and corporate strategy qualify him to serve on our Board.

There is no arrangement or understanding between Dr. Miller and any other person pursuant to which he was selected as a director. There are no transactions between Dr. Miller and the Company that would be required to be reported under Item 404(a) of Regulation S-K.

As a non-employee director of the Company, Dr. Miller is eligible to participate in the Company’s Non-Employee Director Compensation Policy, as such policy may be amended from time to time (the “Policy”). Pursuant to the Policy, Dr. Miller will receive an initial option to purchase the lesser of (1) 48,200 shares of Common Stock or (2) the largest whole number of shares of Common Stock that results in such option having an aggregate Black-Scholes Value not exceeding $400,000, which option will vest and become exercisable in equal monthly installments over a three-year period, subject to continuous service through each vesting date. On the date of each annual stockholder meeting thereafter, Dr. Miller will receive an annual option grant to purchase the lesser of (1) 24,100 shares of Common Stock or (2) the largest whole number of shares of Common Stock that results in such option having an aggregate Black-Scholes Value not exceeding $200,000, which option will vest and become exercisable on the earlier of the first anniversary of the date of grant or the next annual stockholder meeting, subject to continuous service through the vesting date. In addition, Dr. Miller will be paid a $40,000 annual cash retainer for his service on the Board, plus a $5,000 annual cash retainer for his service on the NCGC, plus additional amounts for service on any additional committee(s) to which he may be appointed, paid in equal quarterly installments, payable in arrears on the last day of each fiscal quarter in which the service occurred and pro-rated based on the number of actual days served by him during such quarter. Under the Policy, Dr. Miller may elect to receive some or all of his eligible cash compensation in the form of stock options.

In connection with Dr. Miller’s election to the Board, the Company and Dr. Miller entered into the Company’s standard form of indemnification agreement (the “Indemnification Agreement”), a copy of which was filed as Exhibit 10.7 to the Company’s Registration Statement on Form S-1 (File No. 333-276495), filed with the SEC on January 29, 2024. The Indemnification Agreement requires the Company to indemnify Dr. Miller, to the fullest extent permitted by Delaware law, for certain liabilities to which he may become subject as a result of his affiliation with the Company.




Board Committee Structure

Following Dr. Miller’s appointment, as of May 27, 2026, the composition of the committees of the Board were as follows:

NameAudit CommitteeCompensation and Management Development CommitteeNominating and Corporate Governance Committee
Husseini ManjiX (Chair)
Christopher Nixon CoxXX (Chair)
Gwill YorkX (Chair)X
Andrew DreyfusXX
Raymond SanchezX
Andrew MillerX




SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
ALTO NEUROSCIENCE, INC.
Dated: May 28, 2026By:/s/ Amit Etkin
Amit Etkin, M.D., Ph.D.
President and Chief Executive Officer

Filing Exhibits & Attachments

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