[Form 4] Annovis Bio, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Michael B. Hoffman, a director of Annovis Bio, Inc. (ANVS), reported purchases of company common stock on 08/29/2025. He acquired three blocks of 5,000 shares each at prices of $2.28, $2.29, and $2.30, increasing his direct holdings from 1,469,929 to 1,479,929 shares. The filing also discloses indirect beneficial ownership of 223,357 shares held in the 2018 Jane and Michael Hoffman Descendants Trust, over which he has voting and investment power. The Form 4 is signed by an attorney-in-fact on behalf of the reporting person.

Positive

• Insider purchases of 15,000 shares on 08/29/2025 at prices between $2.28 and $2.30
• Increased direct ownership reported to 1,479,929 shares after the transactions
• Transparency on indirect holdings: 223,357 shares held in the 2018 Jane and Michael Hoffman Descendants Trust with voting and investment power disclosed

Negative

• None.

Insights

Financial Analyst

TL;DR: Insider purchases totaling 15,000 shares on 08/29/2025, modestly increasing direct stake.

The reported transactions show three small-market purchases totaling 15,000 common shares at prices between $2.28 and $2.30. Post-transactions direct ownership is reported as 1,479,929 shares, plus 223,357 shares held indirectly through a family trust. These are explicit, contemporaneous purchases by a director rather than option exercises or dispositions. From a financial-analysis perspective, the filing documents additional insider accumulation but does not include company financials, material corporate actions, or indications of size relative to outstanding shares, so its standalone market impact is likely limited.

Corporate Governance Expert

TL;DR: Director reported routine open-market buys and disclosed trust-held indirect ownership and control.

The Form 4 complies with Section 16 reporting by showing the director's acquisitions and clarifies the nature of indirect ownership via the 2018 family trust, stating the reporting person has voting and investment power. Transactions are clearly dated and priced, and the filing is signed by an attorney-in-fact. There are no disclosures of departures, new arrangements, or other governance actions. This is a standard insider transaction disclosure without governance red flags in the form itself.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Hoffman Michael B

(Last) (First) (Middle)

C/O ANNOVIS BIO, INC.

101 LINDENWOOD DR, SUITE 225

(Street)

MALVERN PA 19355

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Annovis Bio, Inc. [ ANVS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
08/29/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	08/29/2025		A		5,000	A	$2.28	1,469,929	D
Common Stock	08/29/2025		A		5,000	A	$2.29	1,474,929	D
Common Stock	08/29/2025		A		5,000	A	$2.3	1,479,929	D
Common Stock								223,357	I	The 2018 Jane and Michael Hoffman Descendants Trust(1)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares.

	/s/ Maria Maccecchini Attorney-in-Fact	09/03/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What transactions did Michael B. Hoffman report on Form 4 for ANVS?

He reported three open-market acquisitions on 08/29/2025 totaling 15,000 common shares at prices of $2.28, $2.29, and $2.30.

How many ANVS shares does Hoffman beneficially own after these transactions?

The filing reports 1,479,929 shares held directly following the reported transactions, plus 223,357 shares held indirectly via a family trust.

What is the nature of Hoffman's indirect ownership disclosed in the Form 4?

The indirect holdings are in the 2018 Jane and Michael Hoffman Descendants Trust, and the reporting person has voting and investment power over those shares.

Was this Form 4 signed by the reporting person?

The filing shows a signature block executed by Maria Maccecchini, Attorney-in-Fact dated 09/03/2025 on behalf of the reporting person.

Are there any dispositions or derivative transactions reported in this filing?

No dispositions or derivative security transactions are reported; the filing lists only the non-derivative acquisitions and the indirect trust holding.