Annovis Bio director buys 45,000 shares in open-market purchases

Annovis Bio, Inc. director reported open-market purchases of the company’s common stock.

Rhea-AI Filing Summary

Annovis Bio, Inc. director reported open-market purchases of the company’s common stock. On 12/08/2025, the reporting person bought 30,000 shares at $4.3398 per share and an additional 15,000 shares at $4.24 per share. After these transactions, the reporting person beneficially owned 2,574,739 shares of Annovis Bio common stock directly. An additional 223,357 shares are held indirectly through The 2018 Jane and Michael Hoffman Descendants Trust, over which the reporting person has voting and investment power.

Insider Trade Summary

Net Buyer: 45,000 shares

Net Buy 3 txns

Insider Hoffman Michael B

Role Director

Bought 45,000 shs ($194K)

Type	Security	Shares	Price	Value
Purchase	Common Stock	30,000	$4.3398	$130K
Purchase	Common Stock	15,000	$4.24	$64K
holding	Common Stock	--	--	--

Holdings After Transaction: Common Stock — 2,574,739 shares (Direct); Common Stock — 223,357 shares (Indirect, The 2018 Jane and Michael Hoffman Descendants Trust)

Footnotes (1)

1. F1. The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did Annovis Bio (ANVS) report on this Form 4?

The filing reports that a director of Annovis Bio purchased a total of 45,000 shares of common stock in the open market on 12/08/2025.

At what prices did the Annovis Bio (ANVS) director buy shares?

The director bought 30,000 shares at $4.3398 per share and 15,000 shares at $4.24 per share.

How many Annovis Bio (ANVS) shares does the reporting person now own directly?

Following the reported transactions, the reporting person directly beneficially owns 2,574,739 shares of Annovis Bio common stock.

What indirect holdings in Annovis Bio (ANVS) does the reporting person have?

The reporting person indirectly holds 223,357 shares of Annovis Bio common stock through The 2018 Jane and Michael Hoffman Descendants Trust.

What is the relationship of the reporting person to Annovis Bio (ANVS)?

The reporting person is identified as a director of Annovis Bio, Inc. on the Form 4.

Who controls voting and investment decisions for the trust holding Annovis Bio (ANVS) shares?

The filing states that the shares in the family trust are held by a trust formed by the reporting person and that the reporting person has voting and investment power over those shares.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 12/08/2025 - 08:05 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Hoffman Michael B

(Last) (First) (Middle)

C/O ANNOVIS BIO, INC.

101 LINDENWOOD DR, SUITE 225

(Street)

MALVERN PA 19355

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Annovis Bio, Inc. [ ANVS ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
12/08/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	12/08/2025		P		30,000	A	$4.3398	2,559,739	D
Common Stock	12/08/2025		P		15,000	A	$4.24	2,574,739	D
Common Stock								223,357	I	The 2018 Jane and Michael Hoffman Descendants Trust(1)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. The shares are held in a family trust formed by the reporting person and the reporting person has voting and investment power over such shares.

	/s/ Maria Maccecchini Attorney-in-Fact	12/08/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.