[SCHEDULE 13G/A] aTYR PHARMA INC SEC Filing

Rhea-AI Filing Summary

Federated Hermes, Inc. and related reporting persons disclose beneficial ownership of 10,544,437 shares of aTyr Pharma, Inc. common stock, representing 10.76% of the class. The filing states the shares are held in the ordinary course of business and were not acquired to change or influence control. Ownership is reported across Federated Hermes, a Voting Shares Irrevocable Trust, and three individual reporting persons who each disclose shared voting and dispositive power over the same aggregate stake. The filing includes exhibits for reporting-person classification, a joint-filing agreement, and a power of attorney.

Positive

• Material passive stake disclosed: 10,544,437 shares representing 10.76%
• Clear intent statement: Securities stated as held in the ordinary course and not for control
• Required exhibits provided: Joint-filing agreement and power of attorney attached

Negative

• None.

Insights

Institutional Ownership Analyst

Federated Hermes reports a meaningful passive stake of 10.76%.

The ownership position totals 10,544,437 shares and is presented as held in the ordinary course of business with sole voting and dispositive power reported for Federated Hermes and shared power reflected for certain trustees and individuals.

This level of ownership is material to investors because it crosses the 5% reporting threshold and may affect liquidity and block-trade dynamics; monitor any subsequent amendments or Schedule 13D filings for changes in intent or coordination within 30/09/2025–10/07/2025.

Corporate Governance Specialist

Filing asserts non-control intent and supplies required joint-filing exhibits.

The certification states the securities were not acquired to influence control, and Exhibits include an agreement for joint filing and a power of attorney, which clarifies the administrative and voting arrangements among reporting persons.

Investors should note the formal declaration of passive intent and the attached exhibits; any future change in that declaration or additional coordination among reporting persons would be the next material governance signal to watch over the coming quarters.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 10)

aTYR PHARMA INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

002120202

(CUSIP Number)

09/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 002120202

1

Names of Reporting Persons

Federated Hermes, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 10,544,437.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 10,544,437.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

10.76 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

CUSIP No. 002120202

1

Names of Reporting Persons

Voting Shares Irrevocable Trust

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 10,544,437.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 10,544,437.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

10.76 %

12

Type of Reporting Person (See Instructions)

OO

SCHEDULE 13G

CUSIP No. 002120202

1

Names of Reporting Persons

Thomas R. Donahue

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,544,437.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,544,437.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

10.76 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

CUSIP No. 002120202

1

Names of Reporting Persons

Ann C. Donahue

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,544,437.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,544,437.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

10.76 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

CUSIP No. 002120202

1

Names of Reporting Persons

J. Christopher Donahue

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,544,437.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,544,437.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

10.76 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: aTYR PHARMA INC
(b)	Address of issuer's principal executive offices: 10240 Sorrento Valley Road, Suite 300 San Diego, CA 92121
Item 2.
(a)	Name of person filing: Federated Hermes, Inc.
(b)	Address or principal business office or, if none, residence: 1001 Liberty Avenue, Pittsburgh, PA 15222-3779
(c)	Citizenship: Pennsylvania
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 002120202
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 10,544,437
(b)	Percent of class: 10.76 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 10,544,437
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 10,544,437
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exhibit "1" Attached
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Federated Hermes, Inc.

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue, as President of Federated Hermes, Inc.
Date:	10/07/2025

Voting Shares Irrevocable Trust

Signature:	/s/Thomas R. Donahue
Name/Title:	Thomas R. Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2025

Signature:	/s/Ann C. Donahue
Name/Title:	Ann C. Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2025

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2025

Thomas R. Donahue

Signature:	/s/Thomas R. Donahue
Name/Title:	Thomas R. Donahue
Date:	10/07/2025

Ann C. Donahue

Signature:	/s/Ann C. Donahue
Name/Title:	Ann C. Donahue
Date:	10/07/2025

J. Christopher Donahue

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue
Date:	10/07/2025

Comments accompanying signature: SEE EXHIBITS 2 AND 3 ATTACHED Exhibit Information EXHIBIT 1 ITEM 3 CLASSIFICATION OF REPORTING PERSONS EXHIBIT 2 AGREEMENT FOR JOINT FILING OF SCHEDULE 13G EXHIBIT 3 POWER OF ATTORNEY

FAQ

How many aTyr Pharma (ATYR) shares does Federated Hermes own?

Federated Hermes and related reporting persons report beneficial ownership of 10,544,437 shares.

What percentage of aTyr Pharma does the reported stake represent?

The aggregate position represents 10.76% of aTyr Pharma's common stock.

Does the filing indicate an intent to influence control of aTyr Pharma (ATYR)?

The filing certifies the shares were not acquired and are not held for the purpose of changing or influencing control.

Who else is named as a reporting person in the Schedule 13G/A?

The filing lists Voting Shares Irrevocable Trust, Thomas R. Donahue, Ann C. Donahue, and J. Christopher Donahue as reporting persons.

What exhibits are included with this Schedule 13G/A?

Exhibits include an Item 3 classification, an agreement for joint filing, and a power of attorney.