[144] BICYCLE THERAPEUTICS PLC SEC Filing

Rhea-AI Filing Summary

Bicycle Therapeutics plc (BCYC) Form 144 notifies of a proposed sale of 2,264 shares of Common Stock through Stifel Nicolaus & Company Inc. on or about 10/02/2025, with an aggregate market value of $19,023. The filing lists total shares outstanding as 49,868,567, indicating the proposed sale is a small fraction of the company’s stock.

The securities were acquired as Restricted Stock Units from the issuer on 10/02/2025 (2,437 units) and 10/03/2025 (2,031 units) and paid as equity compensation. The filer (listed as Alistair Milnes at the address shown) previously sold 1,149 and 966 shares on 07/02/2025 and 07/03/2025, generating $8,148 and $7,184 respectively.

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK
Filer CCC
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer

SEC File Number

Address of Issuer

Phone

Name of Person for Whose Account the Securities are To Be Sold

See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.

Relationship to Issuer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common Stock	Stifel Nicolaus & Company Inc 501 N Broadway St. Louis MO 63102	2264	19023.00	49868567	10/02/2025	Nasdaq

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common Stock	10/02/2025	Restricted Stock Units	Issuer			2437	10/02/2025	Equity Compensation
Common Stock	10/03/2025	Restricted Stock Units	Issuer			2031	10/03/2025	Equity Compensation

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
Alistair Milnes Blocks A & B Portway Building Cambridge X0 CB21 6GS	Common Stock	07/02/2025	1149	8148.00
Alistair Milnes Blocks A & B Portway Building Cambridge X0 CB21 6GS	Common Stock	07/03/2025	966	7184.00

144: Remarks and Signature

Remarks

Date of Notice

ATTENTION:

The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.

Signature

ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)

FAQ

What is being proposed to be sold in the BCYC Form 144?

The notice proposes sale of 2,264 shares of BCYC common stock via Stifel Nicolaus & Company Inc.

When is the approximate sale date listed for the BCYC securities?

The approximate date of sale is listed as 10/02/2025.

What is the aggregate market value of the proposed sale in the filing?

The aggregate market value is stated as $19,023.

How and when were the securities being sold acquired?

They were acquired as Restricted Stock Units from the issuer on 10/02/2025 (2,437 units) and 10/03/2025 (2,031 units) and paid as equity compensation.

Has the filer sold BCYC shares recently?

Yes; the filer sold 1,149 shares on 07/02/2025 for $8,148 and 966 shares on 07/03/2025 for $7,184.

Who is the broker handling the proposed sale?

The broker named is Stifel Nicolaus & Company Inc, address 501 N Broadway St. Louis MO 63102.