[Form 3] Bicycle Therapeutics plc American Initial Statement of Beneficial Ownership

Rhea-AI Filing Summary

Herve Hoppenot submitted an Initial Statement of Beneficial Ownership (Form 3) for Bicycle Therapeutics plc (BCYC) reporting the event date 09/08/2025. The filing identifies Mr. Hoppenot as a Director and states no securities are beneficially owned by him. The form is signed on behalf of the reporting person by an attorney-in-fact, Travis Thompson, dated 09/10/2025. The filing contains no equity holdings or derivative positions.

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Hoppenot Herve

(Last) (First) (Middle)

C/O BICYCLE THERAPEUTICS PLC

BLOCKS A & B, PORTWAY BUILDING

(Street)

CAMBRIDGE X0 CB21 6GS

(City) (State) (Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
09/08/2025

3. Issuer Name and Ticker or Trading Symbol
BICYCLE THERAPEUTICS PLC [ BCYC ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

No securities are beneficially owned.

	/s/ Travis Thompson, Attorney-in-Fact	09/10/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did the Form 3 filed for Bicycle Therapeutics (BCYC) disclose?

The Form 3 filed for BCYC by Herve Hoppenot dated 09/08/2025 discloses that he is a Director and that no securities are beneficially owned.

Does the filing show any stock or option holdings for Hoppenot at BCYC?

No. The filing explicitly states "No securities are beneficially owned."

When was the Form 3 signed and by whom?

The signature block shows the form was signed by attorney-in-fact Travis Thompson on 09/10/2025.

What is the reporting relationship of Herve Hoppenot to BCYC?

The form checks the box indicating the reporting person is a Director of Bicycle Therapeutics plc.

Is this a joint filing or filed by one reporting person?

The form indicates it was filed by one reporting person.