Codexis: Opaleye reports 2.37% ownership stake

The reported 2.37% position falls within the statement's 5%-or-less ownership category and is subject to shared voting and dispositive power.

Available on EDGAR 11/06/2026 - 04:05 PM EST Accepted by SEC EDGAR 11/06/2026 - 04:05 PM EST Learn about SEC filing dates

Rhea-AI Filing Summary

Codexis, Inc. (CDXS) is the issuer in Amendment No. 5 to a Schedule 13G, which reports 2,590,000 common shares beneficially owned by Opaleye Management Inc., Opaleye, L.P. and James Silverman. These entries refer to the same position, not three separate holdings: the statement says the shares are directly held by Opaleye, L.P. The reported position equals 2.37% of the class, based on 109,505,765 common shares outstanding as of August 6, 2026, as reported by Codexis on August 11, 2026, in its Form 10-Q.

All three reporting persons report shared voting and dispositive power over 2,590,000 shares and zero sole voting and dispositive power. Opaleye Management Inc. serves as investment adviser to Opaleye, L.P., and James Silverman controls the adviser. The statement identifies ownership of 5 percent or less and says the filing should not be construed as an admission that any reporting person is the beneficial owner for Section 13 purposes.

Key Figures

Beneficially owned common shares: 2,590,000 shares Percent of class: 2.37% Common shares outstanding: 109,505,765 shares +2 more

5 metrics

Beneficially owned common shares 2,590,000 shares Same position reported by Opaleye Management Inc., Opaleye, L.P. and James Silverman

Percent of class 2.37% Reported beneficial ownership

Common shares outstanding 109,505,765 shares As of August 6, 2026, as reported by Codexis on August 11, 2026

Shared voting power 2,590,000 shares Reported by each of the three reporting persons

Shared dispositive power 2,590,000 shares Reported by each of the three reporting persons

Key Terms

beneficially owned, shared voting power, shared dispositive power

3 terms

beneficially owned financial

"Amount beneficially owned: 2,590,000.00"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

shared voting power financial

"Shared Voting Power 2,590,000.00"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

shared dispositive power financial

"Shared Dispositive Power 2,590,000.00"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many Codexis (CDXS) shares did Opaleye and James Silverman report?

The three reporting persons each reported the same 2,590,000-share position, representing 2.37% of Codexis common stock. The shares are directly held by Opaleye, L.P.; the statement reports shared voting and dispositive power over 2,590,000 shares.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 5)

Codexis, Inc.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

192005106

(CUSIP Number)

09/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 192005106

1

Names of Reporting Persons

Opaleye Management Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 2,590,000.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 2,590,000.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

2,590,000.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.37 %

12

Type of Reporting Person (See Instructions)

IA, CO

SCHEDULE 13G

CUSIP Number(s): 192005106

1

Names of Reporting Persons

Opaleye, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 2,590,000.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 2,590,000.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

2,590,000.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.37 %

12

Type of Reporting Person (See Instructions)

PN

SCHEDULE 13G

CUSIP Number(s): 192005106

1

Names of Reporting Persons

James Silverman

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 2,590,000.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 2,590,000.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

2,590,000.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.37 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Codexis, Inc.
(b)	Address of issuer's principal executive offices: 200 Penobscot Drive, Redwood City, CA 94063
Item 2.
(a)	Name of person filing: Opaleye Management Inc. Opaleye, L.P. James Silverman This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund. The Adviser serves as investment adviser to the Fund. Mr. Silverman exercises control over the Adviser. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein.
(b)	Address or principal business office or, if none, residence: One Boston Place, 26th Floor, Boston, MA 02108
(c)	Citizenship: Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Delaware James Silverman - United States
(d)	Title of class of securities: Common Stock, par value $0.0001 per share
(e)	CUSIP No.: 192005106
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 2,590,000.00
(b)	Percent of class: 2.37 % Based on 109,505,765 Common Shares outstanding as of 08/06/2026 as reported by Codexis, Inc. on 08/11/2026, in its Form 10-Q Statement.
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 2,590,000.00
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 2,590,000.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Opaleye Management Inc.

Signature:	/s/ James Silverman
Name/Title:	President
Date:	11/06/2026

Opaleye, L.P.

Signature:	Opaleye GP LLC, its general partner /s/ James Silverman
Name/Title:	Managing Member
Date:	11/06/2026

James Silverman

Signature:	/s/ James Silverman
Name/Title:	Individually
Date:	11/06/2026

Exhibit Information

Exhibit 99.1 Joint Filing Agreement by and among the reporting persons