Indicate by check mark whether the registrant
files or will file annual reports under cover of Form 20-F or Form 40-F.
On September 24, 2026, CollPlant Biotechnologies
Ltd. issued a press release entitled “LightSolver, a CollPlant Company, and HLRS Joint Research Demonstrated Photonic Computing Can significantly Accelerate
Fundamental HPC Workloads.” A copy of the press release is attached hereto as Exhibit 99.1 and is incorporated herein by reference.
Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.
Exhibit 99.1
LightSolver, a CollPlant Company, and HLRS Joint Research Demonstrated
Photonic Computing Can significantly Accelerate Fundamental HPC Workloads
Peer-reviewed study published by ACM: LightSolver’s
LPU architecture demonstrated significantly lower projected time-to-solution, compared to state-of-the-art algorithms running on a GPU
REHOVOT, Israel, September 24, 2026 — CollPlant Biotechnologies
Ltd. (Nasdaq: CLGN) today announced the publication of joint research conducted by its subsidiary LightSolver Ltd. (“LightSolver”),
a pioneer of pure photonic computing and developer of the
Laser Processing Unit (LPU), and the High-Performance Computing Center Stuttgart (HLRS), one of Europe’s premier supercomputing
institutions.
Published in the proceedings of the 23rd ACM International Conference
on Computing Frontiers, the research demonstrates the potential of LightSolver’s all-optical computing architecture to dramatically
accelerate one of the most fundamental and computationally intensive workloads in high-performance computing (HPC): solving large-scale
sparse systems of linear equations.
In the joint study, researchers from LightSolver and HLRS benchmarked
projected LPU performance, using an emulator of LightSolver’s LPU architecture, against established state-of-the-art iterative algorithms
running on a GPU. Across the benchmark problems evaluated, the study projected that the LPU could achieve time-to-solution acceleration
ranging from approximately 40× to more than 80,000×, depending on the algorithm and problem evaluated.
Large-scale linear systems sit at the mathematical core of some of
the world’s most demanding scientific and engineering simulations, including computational fluid dynamics, structural mechanics,
electromagnetics, molecular dynamics and materials science. Solving these systems can dominate runtime and energy consumption in HPC applications,
making them a critical computational bottleneck and an important target for next-generation computing architectures.
The findings highlight the potential for photonic processors to serve
as specialized accelerators for large-scale linear systems, particularly for structured problems and computational workloads in which
these mathematical operations must be solved repeatedly.
Executive Commentary
“This joint work demonstrates how an emerging photonic computing
architecture can be evaluated against established numerical methods and modern GPU platforms,” said Prof. Michael Resch, Director
of the High-Performance Computing Center Stuttgart (HLRS). “The results provide valuable insight into where photonic computing may
offer advantages for high-performance computing workloads and how it could be integrated into future hybrid computing systems.”
“This research marks an essential milestone in validating the
LPU as a transformative computing layer alongside traditional CPUs and GPUs,” said Dr. Ruti Ben-Shlomi, CEO and Co-Founder of
LightSolver. “Working with HLRS and its world-class researchers gave us an exceptional opportunity to benchmark and validate
our technology against established computing platforms and test it on some of the most demanding computational problems. Collaborations
like this are invaluable as we continue to expand the range of problems the LPU can address and demonstrate its potential across science,
engineering and high-performance computing. We look forward to continuing to work with leading research institutions around the world
to validate, challenge and advance this new computing architecture.”
The Future of HPC: Heterogeneous Hybrid Architectures
The published research reinforces LightSolver’s vision for the
future of enterprise and scientific computing: a heterogeneous hybrid architecture in which CPUs, GPUs and LPUs work together, each executing
the workloads best suited to its underlying architecture:
| ● | CPUs provide general-purpose processing, orchestration and system control. |
| ● | GPUs accelerate massively parallel digital computing and tensor-based workloads. |
| ● | LPUs serve as specialized photonic accelerators, offloading computationally intensive mathematical workloads, including linear
and differential equations and optimization-where LightSolver’s optical architecture can provide significant acceleration. |
This hybrid approach is designed to enable supercomputing centers,
data centers and cloud providers to integrate photonic acceleration into existing computing environments, potentially delivering dramatic
reductions in time-to-solution, energy consumption, computing costs and carbon footprint for targeted workloads.
Research Publication Details
The peer-reviewed paper, titled “Accelerating Sparse Linear Solvers
with an Optical Laser Processing Unit,” was presented and published in the proceedings of the 23rd ACM International Conference
on Computing Frontiers (Workshops and Special Sessions).
The full paper is available via the ACM Digital Library: https://dl.acm.org/doi/10.1145/3801488.3808041.
About HLRS
The High-Performance
Computing Center Stuttgart (HLRS) of the University of Stuttgart was established in
1996 as Germany’s first federal supercomputing center. As
a member of the Gauss Centre for Supercomputing (GCS), HLRS operates some
of the world’s most powerful supercomputing infrastructure, providing high-performance computing, artificial intelligence, and simulation
services to academic researchers and industrial partners across Europe.
About CollPlant
CollPlant Biotechnologies Ltd. (NASDAQ: CLGN) is an innovative technology
company operating at the intersection of deep-tech computing and advanced biotechnology. Through its subsidiary LightSolver, CollPlant
is advancing the development of proprietary all-optical laser based computing architectures designed to resolve the world’s most demanding
computational bottlenecks across artificial intelligence, aerospace, financial engineering, and high-performance computing. Concurrently,
CollPlant remains a leader in regenerative medicine, pioneering plant-derived recombinant human collagen (rhCollagen) technologies for
3D bioprinting of tissues and organs and medical aesthetics.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning
of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding
the future development, commercialization and market adoption of LightSolver’s Laser Processing Unit (LPU) technology; the extent to which
projected or emulated LPU performance may be replicated in physical hardware and real-world workloads; anticipated performance, capabilities
and applications of the LPU; potential integration of the LPU into hybrid computing environments; potential reductions in time-to-solution
and computing requirements; future research collaborations; and the future prospects, business plans and growth strategies of CollPlant
and LightSolver. Forward-looking statements can be identified by words such as “anticipate,” “believe,” “expect,”
“intend,” “plan,” “may,” “should,” “could,” “might,” “seek,” “target,”
“will,” “project,” “continue” and similar expressions or the negative of such terms. These forward-looking
statements are based on assumptions and assessments made in light of management’s experience and perception of historical trends, current
conditions, expected future developments and other factors believed to be appropriate. Forward-looking statements are not guarantees of
future performance and are subject to risks and uncertainties, many of which are outside of our control. Many factors could cause our
actual activities or results to differ materially from the activities and results anticipated in forward-looking statements, including,
but not limited to, the risk that the anticipated benefits of the transaction are not realized, or are not realized within the expected
timeframe; risks associated with integrating LightSolver’s business, operations and personnel; LightSolver’s ability to achieve anticipated
technological and commercial milestones; uncertainties regarding market acceptance and adoption of LightSolver’s technology; the ability
to develop and commercialize LightSolver’s products and technology successfully; the ability to establish and expand strategic collaborations
and commercial relationships; competition and technological developments; intellectual property risks; the availability of capital; CollPlant’s
ability to maintain compliance with Nasdaq listing requirements; general market, industry, economic and geopolitical conditions; and other
risks and uncertainties described in CollPlant’s filings with the U.S. Securities and Exchange Commission, including its most recent Annual
Report on Form 20-F and subsequent Reports on Form 6-K. Forward-looking statements speak only as of the date of this press release. CollPlant
undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or
otherwise, except as required by applicable law.
Contact Information:
CollPlant
Eran Rotem
Deputy CEO & CFO
eran@collplant.com
+972.73.232.5600
LightSolver
Dr. Ruti Ben Shlomi
Co-Founder & CEO
ruti@lightsolver.com
