Cellectis S.A. filings document a foreign private issuer focused on clinical-stage gene-edited cell and gene therapies. Recent Form 6-K reports furnish press-release exhibits covering financial-results announcements, business updates, research presentations, and clinical program disclosures for the company's allogeneic CAR T and gene-editing platforms.
The filing record also reflects disclosure topics tied to Cellectis' Nasdaq and Euronext Growth listings, including its Form 20-F reporting status, pipeline updates for lasme-cel, eti-cel and cema-cel, license and collaboration references involving Servier, Allogene and AstraZeneca, and formal communications about strategy, research data and corporate developments.
Cellectis, a clinical-stage gene-editing company, announced that new clinical data on its allogeneic CAR-T candidates lasme-cel and eti-cel will be presented at the EHA 2026 congress in Stockholm. An oral presentation will cover full Phase 1 BALLI-01 results in relapsed or refractory B-cell acute lymphoblastic leukemia, which support a pivotal Phase 2 program now recruiting in Europe and North America. A poster will present preliminary Phase 1 NATHALI-01 data in relapsed or refractory B-cell non-Hodgkin lymphoma, exploring how alemtuzumab exposure and cytokine dynamics relate to expansion and response of the dual-targeting CD20/CD22 product. Interim BALLI-01 Phase 2 data and Phase 1 NATHALI-01 clinical data are planned to be disclosed in Q4 2026.
Cellectis reported a consolidated net loss attributable to shareholders of $17.8 million, or $0.18 per share, for the first quarter of 2026, similar to the prior year. Revenue and other income fell to $7.5 million from $12.0 million, mainly due to lower activity under the AstraZeneca collaboration, while R&D and SG&A expenses increased as the company invested in its pipeline.
The company ended March 31 2026 with $188 million in cash, cash equivalents, restricted cash and fixed-term deposits and believes this will fund operations into Q4 2027. Key programs include the pivotal Phase 2 BALLI‑01 trial of lasme‑cel in relapsed or refractory B‑ALL, with a first interim analysis expected in Q4 2026 and a planned BLA submission in 2028, and the Phase 1 NATHALI‑01 trial of eti‑cel in relapsed or refractory NHL, with a full Phase 1 dataset also expected in Q4 2026.
Cellectis highlighted interim pivotal ALPHA3 data from partner Allogene’s cema‑cel program, showing 58.3% MRD negativity in the cema‑cel arm versus 16.7% in the observation arm and a favorable safety profile. The company is also advancing a TALE‑based epigenetic editing platform and continues its AstraZeneca collaboration. Subsequently, Life Technologies Corporation, a Thermo Fisher subsidiary, purported to terminate certain license agreements and initiated arbitration over alleged underpaid royalties, which Cellectis contests.
Cellectis S.A. reported unaudited results for the three-month period ended March 31, 2026. Total revenues and other income were $7.5 million, down from $12.0 million a year earlier, mainly reflecting lower collaboration revenue recognized under its AstraZeneca joint research and collaboration agreement.
Research and development expenses rose to $27.2 million from $21.9 million, driven by higher personnel costs and clinical spending on the BALLI-01 and NATHALI-01 studies. The company posted an operating loss of $25.2 million and a net loss of $17.8 million, similar to the prior-year net loss, with earnings per share at $(0.18). A $6.5 million fair value gain on EIB warrants contributed to a net financial gain of $7.4 million. Cash and cash equivalents stood at $34.8 million, with an additional $150.6 million in fixed-term deposits classified as current financial assets, and management states these resources are sufficient to fund operations for at least twelve months after approval of the statements.
Cellectis S.A. filed a Form 6-K announcing it will release first quarter 2026 financial results, for the period ending March 31, 2026, on May 11, 2026 after the close of the U.S. market. The release will be posted in the Investors section of its website and no conference call will be held.
The filing also reiterates that Cellectis is a clinical-stage biotechnology company using its gene-editing platform to develop allogeneic CAR T immunotherapies and other cell and gene therapies, with headquarters in Paris and additional locations in New York and Raleigh.
Cellectis filed a Form 6-K sharing a press release on new epigenetic editing research presented at the ASGCT annual meeting. The work uses TALE-based epigenetic modulators (TALEM) to turn genes off without cutting or permanently changing DNA, which the company describes as a potentially safer genome-editing approach.
Cellectis developed a high-throughput screening system to rapidly assemble and test hundreds of TALEM constructs and identified combinations that strongly control specific genes. In hepatocytes and T-cells, the method achieved more than 90% sustained reduction in target gene activity, supporting Cellectis’ broader gene-editing and allogeneic CAR T therapy platform.
Cellectis reports interim data from Allogene’s pivotal ALPHA3 trial of cema-cel in first-line consolidation for large B‑cell lymphoma. In the futility analysis, 58.3% of patients in the cema‑cel arm achieved minimal residual disease negativity versus 16.7% in the observation arm, suggesting a strong signal for disease control. Allogene also reported that cema‑cel was generally well tolerated, with most patients treated as outpatients and no serious treatment‑related safety events at the cutoff. Cellectis notes that, under its Servier agreement, it may receive up to $340 million in milestones plus low double‑digit royalties if licensed CD19 products like cema‑cel reach the market.
Cellectis S.A. files its annual report on Form 20-F, outlining its gene-editing cell therapy business, capital structure and key risks. As of December 31, 2025, outstanding capital stock totaled 100,339,441 shares, including 72,339,441 ordinary shares and 28,000,000 convertible preferred shares.
The company remains a clinical-stage biopharmaceutical business focused on allogeneic CAR T-cell therapies and reports significant ongoing losses. For 2025, Cellectis recorded a net loss from continuing operations of $67.6 million, with research and development expenses of $93.5 million and an accumulated deficit of $334.1 million attributable to shareholders.
Liquidity is supported by cash and cash equivalents of $61.5 million and fixed-term deposits classified as current financial assets of $144.8 million as of December 31, 2025, which management believes will fund operations into the second half of 2027. The report emphasizes extensive risk factors around competition, funding needs, manufacturing complexity, regulatory approvals and dependence on partners and third parties.
Cellectis reported strong 2025 clinical progress but a wider annual loss. For the year ended December 31, 2025, total revenues and other income rose to $79.6 million from $49.2 million, mainly from its collaboration with AstraZeneca. Research and development and SG&A spending were broadly stable, yet a swing to a $34.9 million net financial loss from a $22.8 million gain drove the consolidated net loss attributable to shareholders to $67.6 million, or $0.67 per share, versus a $36.8 million loss, or $0.41 per share, in 2024.
Clinically, allogeneic CAR-T programs advanced. In r/r B-ALL, lasme-cel showed an 83% overall response rate at the recommended Phase 2 dose and 100% overall response rate in the target Phase 2 population, with all target patients becoming transplant-eligible. A pivotal Phase 2 BALLI-01 trial is ongoing, with first interim analysis expected in Q4 2026 and a BLA submission anticipated in 2028. In r/r NHL, eti-cel delivered an 88% overall response rate and 63% complete response rate at the current dose level, with a full Phase 1 dataset expected in Q4 2026.
Cash, cash equivalents and fixed-term deposits totaled $211 million as of December 31, 2025, which the company believes provides runway into H2 2027. Cellectis also highlighted progress on cssDNA non-viral templates, TALE base editor safety, and collaborations with AstraZeneca, Servier/Allogene and Iovance.
Cellectis S.A. filed a report stating it will release its fourth quarter and full year 2025 financial results on March 19, 2026, after the U.S. market close. An investor conference call and webcast will follow on March 20, 2026, at 8:00 AM ET / 1:00 PM CET to discuss the results and provide a business update.
Cellectis set out its 2026 strategy, centered on advancing its allogeneic CAR-T pipeline, key partnerships, and extending its cash runway. The company is executing a pivotal Phase 2 BALLI-01 trial of lasme-cel in relapsed/refractory B-ALL, targeting a first interim analysis for 40 patients in Q4 2026, after Phase 1 data showed a 68% overall response rate with Process 2, rising to 83% at the recommended Phase 2 dose and 100% in the target Phase 2 population, with strong MRD-negative complete remissions and a favorable safety profile.
For eti-cel in relapsed/refractory NHL, preliminary Phase 1 data from NATHALI-01 showed an 88% response rate and 63% complete remissions, with an IL-2 combination cohort starting enrollment in Q1 2026 and full Phase 1 data expected in Q4 2026. Cellectis highlighted progress under its AstraZeneca collaboration (up to 10 products), potential milestones and royalties from Servier/Allogene including up to $340 million tied to a CD19 program, and upcoming Iovance IOV-4001 data. The company believes its cash, cash equivalents, and fixed-term deposits will fund operations into H2 2027.