[Form 4] Clene Inc. Insider Trading Activity

Rhea-AI Filing Summary

Clene Inc. director Alison Mosca was granted a stock option for 5,674 shares of common stock under the Clene Inc. Amended 2020 Stock Plan with an exercise price of $3.60 per share. The option was granted on 08/14/2025, vests immediately upon grant, is exercisable through 08/13/2035, and, if exercised, represents 5,674 shares of common stock. The Form 4 was signed via power of attorney on 08/15/2025.

Positive

• Option grant documented: A stock option for 5,674 shares was granted and reported.
• Immediate vesting: The options vest immediately upon grant, as explicitly stated.
• Clear terms provided: Exercise price of $3.60 and expiration date of 08/13/2035 are disclosed.

Negative

• None.

Insights

Financial Analyst

TL;DR Director received immediately vested options for 5,674 shares at $3.60, creating a straightforward insider compensation disclosure.

The filing documents a one-time grant of a stock option to director Alison Mosca for 5,674 shares under the company’s Amended 2020 Stock Plan. Key, explicit terms are an exercise price of $3.60 per share, immediate vesting, and an expiration date of August 13, 2035. This is a routine governance disclosure showing director-level equity compensation; the direct facts reported do not include exercise activity or cash proceeds, only the grant.

Corporate Governance Expert

TL;DR The Form 4 records an immediately vested option grant to a director, a clear disclosure of director compensation under the equity plan.

The document explicitly shows Alison Mosca, a director, was granted an option for 5,674 shares under the Amended 2020 Stock Plan with immediate vesting and a $3.60 exercise price. The filing follows Section 16 reporting requirements; it is a clear, specific disclosure of insider beneficial ownership change. No additional governance actions or amendments to the plan are disclosed in this filing.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Mosca Alison

(Last) (First) (Middle)

6550 SOUTH MILLROCK DRIVE

SUITE G50

(Street)

SALT LAKE CITY UT 84121

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Clene Inc. [ CLNN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
08/14/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
stock option	$3.6	08/14/2025		A		5,674		(1)	08/13/2035	common stock	5,674	$0	5,674	D

Explanation of Responses:

1. This option was granted on August 14, 2025 as an option for 5,674 share of Common Stock under the Clene Inc. Amended 2020 Stock Plan at an exercise price of $3.60 per share. The options vest immediately upon grant.

	/s/ Jerome T. Miraglia POA	08/15/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Alison Mosca report on Form 4 for CLNN?

The Form 4 reports a grant of an option for 5,674 shares of Clene Inc. common stock to Alison Mosca.

What are the exercise price and expiration date of the option in the CLNN Form 4?

The option has an exercise price of $3.60 per share and an expiration date of 08/13/2035.

When was the option grant for CLNN made and when does it vest?

The option was granted on 08/14/2025 and the filing states the options vest immediately upon grant.

How many shares underlying the option were reported and how many are owned after the transaction?

The option covers 5,674 shares and the number of shares beneficially owned following the reported transaction is 5,674.

Who signed the Form 4 for the reporting person?

The Form 4 was signed by Jerome T. Miraglia as power of attorney on 08/15/2025.