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Charles River (NYSE: CRL) posts Q1 loss but keeps 2026 EPS outlook

Filing Impact
(High)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Charles River Laboratories reported first-quarter 2026 revenue of $995.8 million, up 1.2% from a year earlier, but revenue declined 1.5% on an organic basis once currency and divestitures are excluded. GAAP results swung to a net loss of $14.8 million, or $(0.30) per share, mainly due to a $118.0 million loss on assets held for sale tied to the CDMO and Cell Solutions divestiture.

On a non-GAAP basis, operating margin fell to 16.3% from 19.1%, and net income decreased 14.6% to $101.7 million, or $2.06 per diluted share, versus $2.34 a year ago, largely from higher DSA study costs, unfavorable RMS mix, and higher stock-based compensation. Segment performance was mixed, with Manufacturing organic revenue up 2.9% and RMS and DSA down 5.5% and 1.4%, respectively.

The company completed the sale of its CDMO and Cell Solutions businesses on May 6, 2026, and expects to sell certain European Discovery Services sites in May 2026 to sharpen focus on core drug development testing. It also repurchased 1.1 million shares for $200 million, leaving $800 million under its $1.0 billion authorization. Management reaffirmed 2026 organic revenue and non-GAAP EPS guidance of $10.80–$11.30, while trimming reported revenue growth by about 50 basis points for foreign exchange and updating GAAP EPS guidance to $5.35–$5.85.

Positive

  • None.

Negative

  • None.

Insights

Mixed quarter: small revenue growth, strategic divestitures, and lower non-GAAP margins with guidance intact.

Charles River delivered modest reported revenue growth of 1.2% to $995.8M, but organic revenue fell 1.5%, reflecting softer trends in RMS and DSA. GAAP operating margin improved to 12.0%, yet a $118.0M loss on assets held for sale drove a GAAP loss per share of $(0.30).

Non-GAAP profitability softened: operating margin declined from 19.1% to 16.3%, and non-GAAP EPS fell 12.0% to $2.06, mainly from higher DSA study costs, unfavorable RMS mix, and increased stock-based compensation. These trends suggest near-term margin pressure even as core demand in DSA is described as “solid.”

Strategically, completion of the CDMO and Cell Solutions divestiture and the planned sale of certain European Discovery Services sites narrow the portfolio toward regulated drug development testing. The company executed $200M of buybacks and reaffirmed 2026 organic revenue and non-GAAP EPS guidance, while trimming reported revenue growth by about 50 basis points for foreign exchange. Subsequent filings may clarify how divestitures and restructuring initiatives flow through margins over the rest of 2026.

Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Q1 2026 revenue $995.8 million Total revenue, up 1.2% vs Q1 2025
Organic revenue growth -1.5% Q1 2026 organic revenue change vs prior year
GAAP EPS $(0.30) per share Q1 2026 GAAP diluted earnings per share
Non-GAAP EPS $2.06 per share Q1 2026 diluted non-GAAP EPS, down 12.0% YoY
Divestiture loss $118.0 million Loss on assets held for sale related to CDMO and Cell Solutions
Stock repurchases $200.0 million Cost to repurchase 1.1 million shares in Q1 2026
2026 GAAP EPS guidance $5.35–$5.85 Full-year 2026 GAAP earnings per share estimate
2026 non-GAAP EPS guidance $10.80–$11.30 Full-year 2026 non-GAAP EPS estimate, reaffirmed
organic revenue growth financial
"Excluding the effect of these items, revenue declined 1.5% on an organic basis."
Organic revenue growth is the increase in a company's sales that comes from its existing products and services, without including any gains from acquisitions or selling off parts of the business. It reflects the company’s ability to attract more customers or encourage existing customers to buy more over time. For investors, it indicates the company's underlying strength and efficiency in expanding its core operations.
non-GAAP earnings per share financial
"First-quarter diluted earnings per share on a non-GAAP basis were $2.06, a decrease of 12.0%."
Non-GAAP earnings per share is a company’s reported profit per share after removing certain items that management considers one-time, unusual, or not part of regular operations, such as restructuring costs, stock-based compensation, or asset write-downs. Investors use it like an “adjusted score” to see what management believes is the company’s ongoing, core profitability, but because the adjustments vary between firms it should be compared carefully across companies.
Operating margin financial
"On a non-GAAP basis, the first-quarter operating margin decreased to 16.3% from 19.1%."
Operating margin shows how much profit a company makes from its core business activities after paying for costs like wages and materials. It’s useful because it tells you how efficiently a company is running—higher margins mean it keeps more money from each dollar of sales, which can indicate better management or stronger products.
CDMO and Cell Solutions divestiture financial
"the CDMO and Cell Solutions divestiture totaling $118.0 million, or $1.53 per share."
stock repurchase authorization financial
"the Company had $800.0 million remaining under its $1.0 billion stock repurchase authorization."
A stock repurchase authorization is board approval for a company to buy back its own shares up to a stated amount or time period, using its cash or borrowed funds. For investors it matters because reducing the number of shares outstanding can increase each remaining share’s claim on profits and often signals management’s confidence, but it also uses cash that could have been spent on other priorities — like shrinking a pie so each slice is bigger.
restructuring and efficiency initiatives financial
"higher study-related direct costs in the DSA segment, unfavorable revenue mix in the RMS segment, and higher stock-based compensation expense related largely to executive transition."
Revenue $995.8 million +1.2% YoY
GAAP EPS $(0.30) vs $0.50 prior year
Non-GAAP EPS $2.06 -12.0% YoY
Organic revenue growth -1.5% decline vs prior year
Guidance

For 2026, Charles River expects reported revenue decline of 5.5%–4.0%, organic revenue decline of 1.5%–0.5%, GAAP EPS of $5.35–$5.85, and non-GAAP EPS of $10.80–$11.30.

0001100682false00011006822026-05-072026-05-07


UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 8-K


CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


May 7, 2026
Date of Report (Date of earliest event reported)


CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
(Exact Name of Registrant as Specified in Charter)
Delaware001-1594306-1397316
(State or Other
Jurisdiction of Incorporation)
(Commission File Number)(IRS Employer
Identification No.)

251 Ballardvale Street
Wilmington, Massachusetts 01887
(Address of Principal Executive Offices) (Zip Code)

781-222-6000
(Registrant’s Telephone Number, including Area Code)

Securities registered pursuant to Section 12(b) of the Act:
Title of each classTrading Symbol(s)Name of each exchange on which registered
Common stock, $0.01 par valueCRLNew York Stock Exchange
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
 Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2).

Emerging growth company  

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.





ITEM 2.02. Results of Operations and Financial Condition
The following information shall not be deemed "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.
On May 7, 2026, Charles River Laboratories International, Inc. issued a press release providing financial results for the first quarter ended March 28, 2026.
The press release, attached as an exhibit to this report, includes "safe harbor" language pursuant to the Private Securities Litigation Reform Act of 1995, as amended, indicating that certain statements contained in the press release are "forward-looking" rather than historic. The press release also states that these and other risks relating to Charles River are set forth in the documents filed by Charles River with the Securities and Exchange Commission.
ITEM 9.01. Financial Statements and Exhibits
(d) Exhibits.

Exhibit No.Description
99.1
Press release dated May 7, 2026
104Cover Page Interactive Data File (embedded within the Inline XBRL document)

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
 
Date:May 7, 2026By:/s/ Matthew L. Daniel
Matthew L. Daniel, Corporate Senior Vice President,
General Counsel, Corporate Secretary & Chief Compliance Officer

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Exhibit 99.1
image_0.jpg

NEWS RELEASE


CHARLES RIVER LABORATORIES ANNOUNCES
FIRST-QUARTER 2026 RESULTS

– Reports First-Quarter Revenue of $995.8 Million, GAAP Loss per Share
of $(0.30), and Non-GAAP Earnings per Share of $2.06 –

– Reaffirms 2026 Guidance for Organic Revenue
and Non-GAAP Earnings per Share –
– Repurchased $200 Million of Common Stock
in First Quarter of 2026 –

– Completed the Divestiture of the CDMO and Cell Solutions Businesses –


WILMINGTON, MA, May 7, 2026 – Charles River Laboratories International, Inc. (NYSE: CRL) today reported its results for the first quarter of 2026. For the quarter, revenue was $995.8 million, an increase of 1.2% from $984.2 million in the first quarter of 2025.
The impact of foreign currency translation increased reported revenue by 2.8%, while a divestiture reduced reported revenue by 0.1%. Excluding the effect of these items, revenue declined 1.5% on an organic basis. By segment, organic revenue growth in the Manufacturing Solutions (Manufacturing) segment was more than offset by organic revenue declines in the Research Models and Services (RMS) and Discovery and Safety Assessment (DSA) segments.
In the first quarter of 2026, the GAAP operating margin was 12.0%, compared to 7.6% in the first quarter of 2025. The increase in the GAAP operating margin was primarily driven by lower accelerated amortization expense related to certain CDMO client relationships. The GAAP net loss available to common shareholders for the first quarter of 2026 was $(14.8) million, or $(0.30) per diluted share, compared to GAAP net income of $25.5 million, or $0.50 per diluted share for the same period in 2025. The decrease was principally due to a loss on assets held for sale related to the CDMO and Cell Solutions divestiture totaling $118.0 million, or $1.53 per share.
On a non-GAAP basis, the first-quarter operating margin decreased to 16.3% from 19.1% in the first quarter of 2025, primarily as a result of higher study-related direct costs in the DSA segment, unfavorable revenue mix in the RMS segment, and higher stock-based compensation expense related largely to executive transition. Non-GAAP net income was $101.7 million for the first quarter of 2026, a decrease of 14.6% from $119.1 million for the same period in 2025. First-quarter diluted earnings per share on a non-GAAP basis were $2.06, a decrease of 12.0%
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from $2.34 per share in the first quarter of 2025. The non-GAAP net income and earnings per share decreases were driven primarily by the lower operating margin.
Birgit Girshick, Chief Executive Officer, said, “We are pleased to deliver on our first-quarter financial targets, and remain well positioned to generate improving results over the course of the year. Our confidence is supported by a DSA demand environment that is tracking to our expectations, resulting in solid bookings in the first quarter, as well as the successful execution of our strategy.”
“As we look to the future, our focus remains on enhancing our clients’ experience, strengthening our world-class scientific portfolio, achieving our financial and operational goals, and increasing long‑term shareholder value. We have already established a solid foundation and with a refreshed strategic focus aimed at modernizing the Company and the industry, we intend to continue to evolve and lead the way. By doing so, we will enable the Company to realize its full potential and ensure future success. I am energized to lead this great company into its next chapter of growth and am confident in the path we are taking to create the future for Charles River,” Ms. Girshick concluded.
First-Quarter Segment Results
Research Models and Services (RMS)
Revenue for the RMS segment was $208.4 million in the first quarter of 2026, a decrease of 2.2% from $213.1 million in the first quarter of 2025. The impact of foreign currency translation increased revenue by 3.3%. Organic revenue decreased by 5.5%, due primarily to lower revenue for small research models in North America, as well as for large research models. The decline was partially offset by higher revenue for small research models in China.
In the first quarter of 2026, the RMS segment’s GAAP operating margin increased to 23.9% from 20.5% in the first quarter of 2025, primarily due to a gain on the sale of real estate in Massachusetts. On a non-GAAP basis, the operating margin decreased to 24.7% from 27.1%. The non-GAAP operating margin decrease was primarily driven by the unfavorable revenue mix, principally related to small research models in North America and large research models.
Discovery and Safety Assessment (DSA)
Revenue for the DSA segment was $596.9 million in the first quarter of 2026, an increase of 0.7% from $592.6 million in the first quarter of 2025. The impact of foreign currency translation increased DSA revenue by 2.2%, while a divestiture reduced reported revenue by 0.1%. Organic revenue decreased by 1.4%, driven primarily by lower revenue for discovery services due in part to the impact of prior site consolidation activities.
In the first quarter of 2026, the DSA segment’s GAAP operating margin increased to 17.4% from 15.9% in the first quarter of 2025. The increase was primarily driven by lower third-party legal costs related to a non-human primate (NHP) supply matter, as well as lower costs associated with the Company's restructuring and efficiency initiatives. On a non-GAAP basis, the operating margin decreased to 21.0% from 23.9% in the first quarter of 2025. The non-GAAP operating
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margin decrease was primarily driven by higher study-related direct costs associated with large-model sourcing and study starts.
Manufacturing Solutions (Manufacturing)

Revenue for the Manufacturing segment was $190.5 million in the first quarter of 2026, an increase of 6.8% from $178.5 million in the first quarter of 2025. The impact of foreign currency translation increased Manufacturing revenue by 3.9%. Organic revenue increased 2.9%, driven by higher revenue in the Microbial Solutions business, partially offset by lower revenue in the CDMO business.
The Manufacturing segment’s GAAP operating margin was 24.6%, compared to (4.8)% in the first quarter of 2025. The increase was primarily the result of lower accelerated amortization expense related to certain CDMO client relationships. On a non-GAAP basis, the operating margin increased to 25.9% from 23.1% in the first quarter of 2025, driven primarily by the benefit of cost savings resulting from the Company's restructuring initiatives.
Divestiture Update

On May 6, 2026, the Company completed the previously announced divestiture of the CDMO and Cell Solutions businesses to GI Partners. In addition, the Company expects to complete the sale of certain European Discovery Services sites in May 2026. These strategic transactions will enable Charles River to refine and refocus its comprehensive portfolio on core competencies and drive synergistic growth in areas in which it has differentiated scientific expertise, including regulated drug development testing.
Stock Repurchase Update
During the first quarter of 2026, the Company repurchased 1.1 million shares for a total of $200.0 million. As of March 28, 2026, the Company had $800.0 million remaining under its $1.0 billion stock repurchase authorization that was approved by the Board of Directors on October 29, 2025.
2026 Guidance Update
The Company is reaffirming its 2026 organic revenue and non-GAAP earnings per share guidance, which was last updated on February 25, 2026, and previously included the expected impact of the completed divestiture of the CDMO and Cell Solutions businesses, as well as the planned divestiture of certain European Discovery Services sites in May 2026.
However, the Company is reducing its 2026 reported revenue outlook by approximately 50 basis points to reflect recent changes in assumptions for foreign exchange rates. The Company's GAAP earnings per share guidance has now been updated to primarily reflect the impact of the divestitures.
The Company’s 2026 guidance for revenue and earnings per share is as follows:
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2026 GUIDANCE (1)CURRENTPRIOR
Revenue growth/(decrease), reported
(5.5)% - (4.0)%
(5.0)% - (3.5)%
Less: Contribution from acquisitions
0.0% - (0.5)%
0.0% - (0.5)%
Add: Impact from divestitures
~5.0%
~5.0%
Less: Favorable impact of foreign exchange
(0.5)% - (1.0)%
(1.0)% - (1.5)%
Revenue growth/(decrease), organic (2)
(1.5)% - (0.5)%(1.5)% - (0.5)%
GAAP EPS estimate
$5.35 – $5.85
Acquisition-related amortization (3)
~$2.30
Acquisition- and divestiture-related costs (4)
~$2.30
Costs associated with restructuring and efficiency initiatives (5)
~$0.85
Other, net (6)
NM
Non-GAAP EPS estimate$10.80 – $11.30$10.80 – $11.30

Footnotes to Guidance Table:
(1) Revenue and earnings per share guidance assumes the planned divestiture of certain European Discovery Services sites will be completed in May 2026, and that the CDMO and Cell Solutions divestiture was completed on May 6, 2026.
(2) Organic revenue growth is defined as reported revenue growth adjusted for completed acquisitions and both completed and previously announced divestitures (including the CDMO and Cell Solutions businesses, as well as certain European Discovery Services sites), as well as foreign currency translation.
(3) These adjustments primarily include amortization related to intangible assets, as well as the purchase accounting step-up on inventory and certain long-term biological assets.
(4) These adjustments include costs related to the evaluation and integration of acquisitions and divestitures, as well as a loss on assets held for sale related to divestitures and other transaction-related tax adjustments.
(5) These adjustments primarily include site consolidation (including site transition costs), severance, impairment, third-party consulting and professional services, and other costs related to the Company’s restructuring actions and efficiency initiatives. These adjustments also include gains and/or losses on the sale of certain assets and real estate.
(6) These adjustments primarily include immaterial items related to: (i) certain venture capital and other strategic investment losses/(gains), net. This item only includes recognized gains or losses on certain investments. The Company does not forecast the future performance of these investments; and (ii) reductions to a previous $27 million inventory charge associated with an NHP supply matter. As a result of the resolution of the U.S. government investigations during fiscal year 2025, certain NHPs were subsequently utilized.


Webcast
Charles River has scheduled a live webcast on Thursday, May 7th, at 8:30 a.m. ET to discuss matters relating to this press release. To participate, please go to ir.criver.com and select the webcast link. You can also find the associated slide presentation and reconciliations of GAAP financial measures to non-GAAP financial measures on the website.
Non-GAAP Reconciliations
The Company reports non-GAAP results in this press release, which exclude often-one-time charges and other items that are outside of normal operations. A reconciliation of GAAP to non-GAAP results is provided in the schedules at the end of this press release.
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Use of Non-GAAP Financial Measures
This press release contains non-GAAP financial measures, such as non-GAAP earnings per share, non-GAAP operating income, non-GAAP operating margin, and non-GAAP net income. Non-GAAP financial measures exclude, but are not limited to, the amortization of intangible assets and the purchase accounting step-up adjustment on inventory and certain long term biological assets, and other charges and adjustments related to our acquisitions and divestitures, including expenses associated with evaluating and integrating acquisitions and divestitures, including advisory fees, certain transition costs, and certain other transaction-related costs, as well as fair value adjustments associated with contingent consideration; charges, gains, and losses attributable to businesses or properties we plan to close, consolidate, or divest, including the divestitures of our CDMO and Cell Solutions businesses, the sale of certain of our European Discovery Services sites, and the sale of certain assets including real estate; severance and other costs associated with our restructuring initiatives; investment gains or losses associated with our venture capital and certain other strategic equity investments; certain legal costs and adjustments related to an NHP inventory charge in our DSA segment related to now concluded U.S. government investigations into the NHP supply chain; legal and advisory costs related to entering into a Cooperation Agreement with a shareholder; tax effect of all of the aforementioned matters; and adjustments related to the derecognition of certain deferred tax assets due to the CDMO Gene Therapy intangible asset impairment charge, the recognition of deferred tax assets expected to be utilized as a result of changes to the Company's international financing structure, and the revaluation of deferred tax liabilities as a result of foreign tax legislation. This press release also refers to our revenue on both a GAAP and non-GAAP basis: on a non-GAAP basis, we define “organic revenue growth” as reported revenue growth adjusted for foreign currency translation, acquisitions, and divestitures. We exclude these items from the non-GAAP financial measures because they are outside our normal operations. There are limitations in using non-GAAP financial measures, as they are not presented in accordance with generally accepted accounting principles, and may be different than non-GAAP financial measures used by other companies. In particular, we believe that the inclusion of supplementary non-GAAP financial measures in this press release helps investors to gain a meaningful understanding of our core operating results and future prospects without the effect of these often-one-time charges, and is consistent with how management measures and forecasts the Company's performance, especially when comparing such results to prior periods or forecasts. We believe that the financial impact of our acquisitions and divestitures (and in certain cases, the evaluation of such acquisitions and divestitures, whether or not ultimately consummated) is often large relative to our overall financial performance, which can adversely affect the comparability of our results on a period-to-period basis. In addition, certain activities and their underlying associated costs, such as business acquisitions, generally occur periodically but on an unpredictable basis. We calculate non-GAAP integration costs to include third-party integration costs incurred post-acquisition. Presenting revenue on an organic basis allows investors to measure our revenue growth exclusive of acquisitions, divestitures, and foreign currency exchange fluctuations more clearly. Non-GAAP results also allow investors to compare the Company’s operations against the financial results of other companies in the industry who similarly provide non-GAAP results. The non-GAAP financial measures included in this press release are not meant to be considered superior to or a substitute for results of operations presented in accordance with GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules and regulations. Reconciliations of the non-GAAP financial measures used in this press release to the most directly comparable GAAP financial measures are set forth in this press release, and can also be found on the Company’s website at ir.criver.com.
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Caution Concerning Forward-Looking Statements
This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words such as “anticipate,” “believe,” “expect,” “intend,” “will,” “would,” “may,” “estimate,” “plan,” “outlook,” and “project,” and other similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These statements also include statements regarding: the projected and/or anticipated future financial performance of Charles River and our specific businesses, including as delineated in our forward-looking guidance, and particularly our expectations with respect to revenue, the impact of foreign exchange, interest rates, and enhanced efficiency initiatives; our expectations with respect to our ability to gain market share; our ability to create long-term value for our shareholders and successfully execute on our strategic initiatives, including the impact and results of the such initiatives; the Company’s plans or prospects, expectations and long-term goals associated with our business including the timing of previously announced planned divestiture of certain European Discovery Services sites; earnings per share; operating margin; client demand, particularly the future demand for drug discovery and development products and services, including our expectations for future revenue trends; our expectations with respect to booking trends and the impacts thereof; our expectations with respect to pricing of our products and services; our expectations with respect to future tax rates and the impact of such tax rates on our business; our expectations with respect to the impact of acquisitions, including the acquisition of the assets of K.F. (Cambodia) Ltd. and of PathoQuest SAS, and divestitures on the Company, our service offerings, client perception, strategic relationships, revenue, revenue growth rates, revenue growth drivers, and earnings; the development and performance of our services and products, including our investments in our portfolio; market and industry conditions including the outsourcing of services and identification of spending trends by our clients and funding available to them; ability to gain market share and capitalize on business and growth opportunities; the impact of our restructuring initiatives, including annualized savings; and the impact of our stock repurchase authorization. Forward-looking statements are based on Charles River’s current expectations and beliefs, and involve a number of risks and uncertainties that are difficult to predict and that could cause actual results to differ materially from those stated or implied by the forward-looking statements. Those risks and uncertainties include, but are not limited to: the impact of NHP supply constraints; changes and uncertainties in the global economy and financial markets, including disruptions in the global economy caused by geopolitical conflicts; the ability to successfully integrate businesses we acquire, and risks and uncertainties associated with businesses that we acquire; the timing and magnitude of our share repurchases; negative trends in research and development spending, negative trends in the level of outsourced services, or other cost reduction actions by our clients; the ability to convert backlog to revenue; demand and booking trends; special interest groups; contaminations; industry trends; new displacement technologies; USDA and FDA regulations; changes in law; continued availability of products and supplies; loss of key personnel; interest rate and foreign currency exchange rate fluctuations; changes in tax regulation and laws; changes in generally accepted accounting principles; and any changes in business, political, or economic conditions due to the threat of future terrorist activity in the U.S. and other parts of the world, and related U.S. military action overseas. A further description of these risks, uncertainties, and other matters can be found in the Risk Factors detailed in Charles River's Annual Report on Form 10-K as filed on February 18, 2026, as well as other filings we make with the Securities and Exchange Commission. Because forward-looking statements involve risks and uncertainties,
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actual results and events may differ materially from results and events currently expected by Charles River, and Charles River assumes no obligation and expressly disclaims any duty to update information contained in this press release except as required by law.

About Charles River

Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visit www.criver.com.

# # #

Investor Contact:    Media Contact:
Todd Spencer    Amy Cianciaruso
Corporate Vice President,    Corporate Senior Vice President,
Investor Relations    Chief Communications Officer
781.222.6455    781.222.6168
todd.spencer@crl.com    amy.cianciaruso@crl.com
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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
SCHEDULE 1
CONDENSED CONSOLIDATED STATEMENTS OF INCOME (LOSS) (UNAUDITED)
(in thousands, except for per share data)
Three Months Ended
March 28, 2026March 29, 2025
Service revenue$798,152 $797,923 
Product revenue197,678 186,245 
Total revenue995,830 984,168 
Costs and expenses:
Cost of services provided (excluding amortization of intangible assets)608,907 577,428 
Cost of products sold (excluding amortization of intangible assets)92,259 89,008 
Selling, general and administrative159,422 177,799 
Amortization of intangible assets15,345 65,264 
Operating income119,897 74,669 
Other income (expense):
Interest income1,033 1,404 
Interest expense(26,742)(27,884)
Other (expense) income, net(124,130)(12,211)
Income (loss) before income taxes(29,942)35,978 
Provision (benefit) for income taxes(15,140)10,100 
Net income (loss)(14,802)25,878 
Less: Net income attributable to noncontrolling interests41 409 
Net income (loss) attributable to common shareholders$(14,843)$25,469 
Earnings (loss) per common share
Basic$(0.30)$0.50 
Diluted$(0.30)$0.50 
Weighted-average number of common shares outstanding
Basic48,951 50,677 
Diluted48,951 50,853 
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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
SCHEDULE 2
CONDENSED CONSOLIDATED BALANCE SHEETS (UNAUDITED)
(in thousands, except per share amounts)
March 28, 2026December 27, 2025
Assets
Current assets:
Cash and cash equivalents$191,830 $213,770 
Trade receivables and contract assets, net of allowances for credit losses of $8,114 and $10,463, respectively700,251 708,856 
Inventories359,723 299,103 
Prepaid assets102,146 96,108 
Other current assets134,856 129,212 
Total current assets1,488,806 1,447,049 
Property, plant and equipment, net1,510,154 1,655,219 
Venture capital and strategic equity investments209,723 206,972 
Operating lease right-of-use assets, net317,840 361,415 
Goodwill3,040,032 2,764,253 
Intangible assets, net248,989 339,995 
Deferred tax assets88,599 67,334 
Other assets826,165 293,185 
Total assets$7,730,308 $7,135,422 
Liabilities, Redeemable Noncontrolling Interests and Equity
Current liabilities:
Accounts payable$133,952 $148,800 
Accrued compensation166,888 268,854 
Deferred revenue194,330 210,418 
Accrued liabilities372,397 270,085 
Other current liabilities226,137 222,158 
Total current liabilities1,093,704 1,120,315 
Long-term debt, net and finance leases2,663,133 2,136,360 
Operating lease right-of-use liabilities393,113 434,048 
Deferred tax liabilities81,399 95,203 
Other long-term liabilities510,646 138,302 
Total liabilities4,741,995 3,924,228 
Redeemable noncontrolling interests41,900 41,263 
Equity:
Preferred stock, $0.01 par value; 20,000 shares authorized; no shares issued and outstanding— — 
Common stock, $0.01 par value; 120,000 shares authorized; 49,342 shares issued and 48,167 shares outstanding as of March 28, 2026, and 49,217 shares issued and outstanding as of December 27, 2025
493 492 
Additional paid-in capital1,967,356 1,947,301 
Retained earnings1,373,777 1,388,620 
Treasury stock, at cost, 1,175 and zero shares, as of March 28, 2026 and December 27, 2025, respectively
(209,990)— 
Accumulated other comprehensive loss(191,042)(171,783)
Total Charles River Laboratories International, Inc. equity2,940,594 3,164,630 
Nonredeemable noncontrolling interest5,819 5,301 
Total equity2,946,413 3,169,931 
Total liabilities, redeemable noncontrolling interests and equity$7,730,308 $7,135,422 
9



CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
SCHEDULE 3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (UNAUDITED)
(in thousands)
Three Months Ended
March 28, 2026March 29, 2025
Cash flows relating to operating activities
Net income (loss)$(14,802)$25,878 
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Depreciation and amortization67,151 120,364 
Long-lived asset impairments15,863 10,576 
Stock-based compensation22,381 13,135 
Deferred income taxes (29,417)(19,041)
Write down of inventories1,489 6,762 
Losses and impairments on venture capital and strategic equity investments, net1,138 10,374 
Provision for credit losses47 2,007 
(Gain) loss on divestitures, net117,981 (3,376)
Other, net(34,675)3,731 
Changes in assets and liabilities:
Trade receivables and contract assets, net(65,319)(29,353)
Inventories26,004 (21,882)
Accounts payable20,455 25,251 
Accrued compensation(83,758)15,263 
Deferred revenue5,197 (1,213)
Customer contract deposits(135)9,167 
Other assets and liabilities, net(8,523)4,054 
Net cash provided by operating activities41,077 171,697 
Cash flows relating to investing activities
Acquisition of businesses and assets, net of cash acquired(405,006)— 
Capital expenditures(55,908)(59,324)
Purchases of investments and contributions to venture capital investments(8,492)(5,302)
Proceeds from sale of investments2,922 1,602 
Proceeds from sale of businesses, net60,096 17,441 
Other, net(1,457)104 
Net cash used in investing activities(407,845)(45,479)
Cash flows relating to financing activities
Proceeds from long-term debt and revolving credit facility912,462 416,341 
Payments on long-term debt, revolving credit facility, and finance lease obligations(355,676)(149,394)
Proceeds from exercises of stock options1,223 — 
Purchase of treasury stock(208,285)(353,132)
Purchase of remaining equity interests of other redeemable noncontrolling interest— (19,140)
Other, net(2,000)— 
Net cash provided by (used in) financing activities347,724 (105,325)
Effect of exchange rate changes on cash, cash equivalents, and restricted cash1,248 5,265 
Net change in cash, cash equivalents, and restricted cash(17,796)26,158 
Cash, cash equivalents, and restricted cash, beginning of period215,997 205,570 
Cash, cash equivalents, and restricted cash, end of period$198,201 $231,728 
10



CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
SCHEDULE 4
RECONCILIATION OF GAAP TO NON-GAAP
SELECTED BUSINESS SEGMENT INFORMATION (UNAUDITED)(1)
(in thousands, except percentages)
Three Months Ended
March 28, 2026March 29, 2025
Research Models and Services
Revenue$208,367 $213,073 
Operating income49,773 43,605 
Operating income as a % of revenue23.9 %20.5 %
Add back:
     Amortization related to acquisitions7,380 12,687 
     Acquisition, integration, and divestiture-related adjustments (3)
— 14 
     Severance789 229 
     Asset impairment15,561 319 
     Cost savings and efficiency initiatives (4)
(21,964)876 
Total non-GAAP adjustments to operating income$1,766 $14,125 
Operating income, excluding non-GAAP adjustments$51,539 $57,730 
Non-GAAP operating income as a % of revenue24.7 %27.1 %
Depreciation and amortization$16,140 $21,761 
Capital expenditures$11,568 $7,286 
Discovery and Safety Assessment
Revenue$596,923 $592,609 
Operating income103,875 93,952 
Operating income as a % of revenue17.4 %15.9 %
Add back:
     Amortization related to acquisitions16,497 18,171 
     Acquisition, integration, and divestiture-related adjustments (3)
2,542 1,061 
     Severance2,626 4,979 
     Asset impairment— 9,786 
     Cost savings and efficiency initiatives (4)
4,987 2,777 
     Third-party legal and advisory costs and certain related items (5)
(5,455)10,970 
Total non-GAAP adjustments to operating income$21,197 $47,744 
Operating income, excluding non-GAAP adjustments$125,072 $141,696 
Non-GAAP operating income as a % of revenue21.0 %23.9 %
Depreciation and amortization$39,914 $42,084 
Capital expenditures$37,509 $34,521 
Manufacturing Solutions
Revenue$190,540 $178,486 
Operating income (loss)46,839 (8,620)
Operating income (loss) as a % of revenue24.6 %(4.8)%
Add back:
     Amortization related to acquisitions (2)
1,945 46,077 
     Severance(868)2,204 
     Asset impairment— 201 
     Cost savings and efficiency initiatives (4)
1,371 1,306 
Total non-GAAP adjustments to operating income$2,448 $49,788 
Operating income, excluding non-GAAP adjustments$49,287 $41,168 
Non-GAAP operating income as a % of revenue25.9 %23.1 %
Depreciation and amortization$8,399 $54,623 
Capital expenditures$6,274 $17,279 
Unallocated Corporate Overhead$(80,590)$(54,268)
Add back:
     Acquisition, integration, and divestiture-related adjustments (3)
16,589 730 
     Severance3,671 1,002 
     Cost savings and efficiency initiatives (4)
(2,915)166 
Total non-GAAP adjustments to operating expense$17,345 $1,898 
Unallocated corporate overhead, excluding non-GAAP adjustments$(63,245)$(52,370)
Total
Revenue$995,830 $984,168 
Operating income119,897 74,669 
Operating income as a % of revenue12.0 %7.6 %
Add back:
     Amortization related to acquisitions (2)
25,822 76,935 
     Acquisition, integration, and divestiture-related adjustments (3)
19,131 1,805 
     Severance6,218 8,414 
     Asset impairment15,561 10,306 
     Cost savings and efficiency initiatives (4)
(18,521)5,125 
     Third-party legal and advisory costs and certain related items (5)
(5,455)10,970 
Total non-GAAP adjustments to operating income$42,756 $113,555 
Operating income, excluding non-GAAP adjustments$162,653 $188,224 
Non-GAAP operating income as a % of revenue16.3 %19.1 %
Depreciation and amortization$67,151 $120,364 
Capital expenditures$55,908 $59,324 
(1)
Charles River management believes that supplementary non-GAAP financial measures provide useful information to allow investors to gain a meaningful understanding of our core operating results and future prospects, without the effect of often-one-time charges and other items which are outside our normal operations, consistent with the manner in which management measures and forecasts the Company’s performance. The supplementary non-GAAP financial measures included are not meant to be considered superior to, or a substitute for results of operations prepared in accordance with U.S. GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules, regulations and guidance.
(2)
Amortization related to acquisitions for the three months ended March 29, 2025 includes $35.5 million of accelerated amortization of certain client relationships in the Biologics Solutions reporting unit within the Manufacturing Solutions reportable segment.
(3)
These adjustments are related to the evaluation and integration of acquisitions and divestitures, and primarily include transaction, advisory, certain third-party integration, certain compensation costs, and related costs; as well as fair value adjustments associated with contingent consideration arrangements.
(4)
Cost savings and efficiency initiatives in 2026 primarily include site consolidation charges related to recent site optimization activities, cost of professional services related to certain improvement initiatives, and a pre-tax gain of $38.5 million in connection with the sale of certain assets in Wilmington, Massachusetts. The gain was recognized within RMS reportable segment and unallocated corporate for $23.2 million and $15.3 million, respectively.
(5)
Within the DSA business, third‑party legal and advisory costs incurred during fiscal 2025 relate to U.S. government investigations into the NHP supply chain, which were concluded in fiscal 2025. Also included within DSA results for fiscal 2026 is the utilization of previously written‑down NHP inventory, resulting in partial reversals of the $27 million inventory charge recorded in fiscal 2024 following the resolution of the matter in fiscal 2025.
11



CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
SCHEDULE 5
RECONCILIATION OF GAAP EARNINGS TO NON-GAAP EARNINGS (UNAUDITED)(1)
(in thousands, except per share data)
Three Months Ended
March 28, 2026March 29, 2025
Net income (loss) available to Charles River Laboratories International, Inc. common shareholders$(14,843)$25,469 
Add back:
Non-GAAP adjustments to operating income (2)
41,710 112,393 
Venture capital and strategic equity investment losses and impairments, net1,752 9,969 
(Gain) loss on divestitures (3)
117,981 (3,376)
Tax effect of non-GAAP adjustments:
Tax impact of divestitures(43,069)— 
Interest on acquired uncertain tax positions4,969 — 
Tax effect of the remaining non-GAAP adjustments(6,804)(25,345)
Net income available to Charles River Laboratories International, Inc. common shareholders, excluding non-GAAP adjustments$101,696 $119,110 
Weighted average shares outstanding - Basic48,951 50,677 
Effect of dilutive securities:
Stock options, restricted stock units and performance share units 402 176 
Weighted average shares outstanding - Diluted49,353 50,853 
Earnings (loss) per share attributable to common shareholders:
Basic$(0.30)$0.50 
Diluted (4)
$(0.30)$0.50 
Basic, excluding non-GAAP adjustments$2.08 $2.35 
Diluted, excluding non-GAAP adjustments$2.06 $2.34 
(1)
Charles River management believes that supplementary non-GAAP financial measures provide useful information to allow investors to gain a meaningful understanding of our core operating results and future prospects, without the effect of often-one-time charges and other items which are outside our normal operations, consistent with the manner in which management measures and forecasts the Company’s performance. The supplementary non-GAAP financial measures included are not meant to be considered superior to, or a substitute for results of operations prepared in accordance with U.S. GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules, regulations and guidance.
(2)
This amount excludes non-GAAP adjustments attributable to noncontrolling interest holders.
(3)
The amount included in 2026 relates to a pre-tax loss on assets held for sale in connection with the CDMO and Cell Solutions Divestiture while the amount included in 2025 relates to a gain on the sale of a DSA site.
(4)
Net loss available to Charles River Laboratories International, Inc. per common share excludes the effect of dilution and is computed using basic weighted-average number of shares outstanding for the three month period ended March 28, 2026.
12



CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
SCHEDULE 6
RECONCILIATION OF GAAP REVENUE GROWTH
TO NON-GAAP REVENUE GROWTH, ORGANIC (UNAUDITED) (1)
Three Months Ended March 28, 2026Total CRLRMS SegmentDSA SegmentMS Segment
Revenue growth, reported1.2 %(2.2)%0.7 %6.8 %
(Increase) decrease due to foreign exchange(2.8)%(3.3)%(2.2)%(3.9)%
Impact of divestitures (2)
0.1 %— %0.1 %— %
Non-GAAP revenue growth, organic (3)
(1.5)%(5.5)%(1.4)%2.9 %
(1)
Charles River management believes that supplementary non-GAAP financial measures provide useful information to allow investors to gain a meaningful understanding of our core operating results and future prospects, without the effect of often-one-time charges and other items which are outside our normal operations, consistent with the manner in which management measures and forecasts the Company’s performance. The supplementary non-GAAP financial measures included are not meant to be considered superior to, or a substitute for results of operations prepared in accordance with U.S. GAAP. The Company intends to continue to assess the potential value of reporting non-GAAP results consistent with applicable rules, regulations and guidance.
(2)
Impact of divestitures relates to the sale of a site within DSA.
(3)
Organic revenue growth is defined as reported revenue growth adjusted for divestitures and foreign exchange.
13

FAQ

How did Charles River Laboratories (CRL) perform financially in Q1 2026?

Charles River generated revenue of $995.8 million in Q1 2026, up 1.2% year over year. However, organic revenue declined 1.5% after adjusting for currency and divestitures, and non-GAAP EPS fell to $2.06 from $2.34, reflecting margin pressure.

Why did Charles River report a GAAP loss in the first quarter of 2026?

The company reported a GAAP net loss of $14.8 million, or $(0.30) per share, mainly because of a $118.0 million loss on assets held for sale related to the divestiture of its CDMO and Cell Solutions businesses, despite higher GAAP operating margin.

What were the Q1 2026 results by segment for Charles River (CRL)?

In Q1 2026, RMS revenue was $208.4 million with organic revenue down 5.5%. DSA revenue was $596.9 million, organic down 1.4%. Manufacturing revenue was $190.5 million, with organic growth of 2.9%, driven by Microbial Solutions.

What strategic divestitures did Charles River complete or plan in 2026?

On May 6, 2026, Charles River completed the divestiture of its CDMO and Cell Solutions businesses to GI Partners and expects to sell certain European Discovery Services sites in May 2026, aiming to focus on core regulated drug development testing capabilities.

How much stock did Charles River repurchase in Q1 2026 and what remains authorized?

During Q1 2026, Charles River repurchased 1.1 million shares for $200.0 million. As of March 28, 2026, the company had $800.0 million remaining under its $1.0 billion stock repurchase authorization approved in October 2025.

What is Charles River’s 2026 guidance for revenue and earnings per share?

For 2026, Charles River guides to reported revenue decline of 5.5%–4.0% and organic revenue decline of 1.5%–0.5%. It expects GAAP EPS of $5.35–$5.85 and reaffirms non-GAAP EPS of $10.80–$11.30, incorporating divestiture effects.

Filing Exhibits & Attachments

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