STOCK TITAN

Castle Biosciences CEO sells 14.5K shares

CASTLE BIOSCIENCES INC (CSTL) reported insider activity by President & Chief Executive Officer Derek J. Maetzold.

(Moderate)
(Negative)
Form Type
4

Rhea-AI Filing Summary

CASTLE BIOSCIENCES INC (CSTL) reported insider activity by President & Chief Executive Officer Derek J. Maetzold. On September 11, 2026, he exercised options for 8,584 shares of common stock at $2.39 per share and, on the same date, entities associated with him sold a total of 14,518 shares of common stock in open-market transactions at prices including $32.00 and $32.78 per share. The option shares were fully vested, and the company reports that these transactions were made under a Rule 10b5-1 trading plan adopted on June 2, 2026.

Positive

  • None.

Negative

  • None.
Insider MAETZOLD DEREK J
Role Pres. & Chief Exec. Officer
Sold 14,518 shs ($465K)
Approx. gross sale proceeds $465K
Approx. exercise cost $21K
Type Security Shares Price Value
Exercise Stock option (right to buy) F1, F13 8,584 $0.00 $0.00
Exercise Common Stock F1 8,584 $2.39 $21K
Sale Common Stock F1, F2 8,361 $32.00 $268K
Sale Common Stock F1, F2, F3 3,124 $32.00 $100K
Sale Common Stock F1, F2, F4 2,656 $32.00 $85K
Sale Common Stock F1 223 $32.78 $7K
Sale Common Stock F1, F3 83 $32.78 $3K
Sale Common Stock F1, F4 71 $32.78 $2K
holding Common Stock F5 -- -- --
holding Common Stock F6 -- -- --
holding Common Stock F7 -- -- --
holding Common Stock F8 -- -- --
holding Common Stock F9 -- -- --
holding Common Stock F10 -- -- --
holding Common Stock F11 -- -- --
holding Common Stock F12 -- -- --
Holdings After Transaction: Stock option (right to buy) — 16,745 contracts (Direct); Common Stock — 21,479 shares (Direct); Common Stock — 14,434 shares (Indirect, By The Maetzold Descendants 2020 Trust); Common Stock — 12,268 shares (Indirect, By Derek Maetzold 2020 Irrevocable Trust); Common Stock — 11,256 shares (Indirect, By The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk); Common Stock — 11,256 shares (Indirect, By The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold); Common Stock — 11,256 shares (Indirect, By The Maetzold 2018 Remainder Trust FBO John Derek Maetzold); Common Stock — 11,256 shares (Indirect, By The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold); Common Stock — 11,963 shares (Indirect, By DJM Grantor Retained Annuity Trust No. 6); Common Stock — 27,862 shares (Indirect, By DJM Grantor Retained Annuity Trust No. 7); Common Stock — 40,935 shares (Indirect, By DJM Grantor Retained Annuity Trust No. 8); Common Stock — 23,216 shares (Indirect, DJM Grantor Retained Annuity Trust No. 9)
Footnotes (13)
  1. F1. These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on June 2, 2026.
  2. F2. This transaction was executed in multiple trades at prices ranging from $31.700 to $32.508, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
  3. F3. Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries.
  4. F4. Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries.
  5. F5. Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary.
  6. F6. Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
  7. F7. Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
  8. F8. Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
  9. F9. Held by DJM Grantor Retained Annuity Trust No. 6 of which the Reporting Person is the trustee and the beneficiaries are The Maetzold 2018 Remainder Trust FBO John Derek Maetzold, The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk, The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold and The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold.
  10. F10. Held by DJM Grantor Retained Annuity Trust No. 7 of which the Reporting Person is the trustee and beneficiary.
  11. F11. Held by DJM Grantor Retained Annuity Trust No. 8 of which the Reporting Person is the trustee and beneficiary.
  12. F12. Held by DJM Grantor Retained Annuity Trust No. 9 of which the Reporting Person is the trustee and beneficiary.
  13. F13. The shares subject to the option are fully vested.
Options exercised 8,584 shares Stock option exercise into common stock on September 11, 2026
Option exercise price $2.39 per share Exercise price for 8,584 options exercised on September 11, 2026
Shares sold 14,518 shares Total CSTL common shares sold in open-market transactions on September 11, 2026
Reported sale prices $32.00 and $32.78 per share Per-share sale prices for CSTL stock; trades occurred in a $31.700–$32.508 range
Remaining option shares 16,745 shares Option shares reported as outstanding after the 8,584-share exercise
Trust holding (example) 11,256 shares Common stock held by each Maetzold 2018 Remainder Trust FBO named beneficiaries
Largest GRAT holding 40,935 shares CSTL common stock held by DJM Grantor Retained Annuity Trust No. 8
Rule 10b5-1 plan regulatory
"These transactions were made pursuant to a Rule 10b5-1 plan adopted"
A Rule 10b5-1 plan is a prearranged, written schedule that lets corporate insiders buy or sell company stock at set times or amounts, even if they later learn material nonpublic information. Think of it like setting an automatic thermostat for trades: it creates a clear record that trades were planned in advance, reducing the risk of insider-trading accusations and helping investors trust that insider transactions are routine rather than based on secret information.
weighted-average sale price financial
"The price reported above reflects the weighted-average sale price"
Grantor Retained Annuity Trust financial
"Held by DJM Grantor Retained Annuity Trust No. 7 of which"
A grantor retained annuity trust (GRAT) is an estate-planning tool where the person who creates the trust transfers assets into it but receives fixed cash payments (an annuity) from the trust for a set number of years; whatever remains after that term passes to designated beneficiaries. It matters to investors because it can shift future appreciation of assets out of the creator’s taxable estate—like putting an asset into a timed vending machine that pays you fixed amounts while any extra value that grows inside the machine goes to heirs with reduced gift or estate tax consequences.
beneficiaries financial
"of which the Reporting Person is the trustee and the beneficiaries are"
Beneficiaries are the people or organizations designated to receive benefits, such as money or assets, from a financial arrangement like a trust, insurance policy, or retirement plan. They matter to investors because choosing the right beneficiaries ensures that assets are passed on according to their wishes, providing financial security or support to loved ones when needed. Think of beneficiaries as the intended recipients of a gift or inheritance.
derivative security financial
"Exercise or conversion of derivative security"
A derivative security is a financial contract whose value comes from the price or performance of something else, such as a stock, bond, commodity, or market index. For investors it acts like an insurance policy or a wager: it can be used to protect against losses, lock in prices, or amplify gains and losses, so it can change a portfolio’s risk and potential return without owning the underlying asset directly.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did CSTL’s CEO do in this Form 4 transaction?

Derek J. Maetzold, CEO of CSTL, exercised options for 8,584 shares of common stock at $2.39 per share and related accounts sold a total of 14,518 shares of common stock in open-market transactions on September 11, 2026.

At what prices were the CSTL shares sold in this Form 4?

The filing reports sales of CSTL common stock at $32.00 and $32.78 per share, with a footnote stating trades occurred in a range from $31.700 to $32.508 per share, with the reported prices reflecting weighted-average sale prices.

Were the CSTL insider transactions made under a Rule 10b5-1 plan?

Yes. A footnote states the transactions were made pursuant to a Rule 10b5-1 plan adopted by Derek J. Maetzold on June 2, 2026, and the filing’s Rule 10b5-1 checkbox is marked as affirming a trading plan.

How many CSTL options did the CEO exercise and what remains?

The CEO exercised options covering 8,584 shares of CSTL common stock at an exercise price of $2.39 per share. After this exercise, 16,745 option shares remain reported for this option series, which is fully vested and expires on May 9, 2028.

Which entities associated with the CSTL CEO sold shares?

Sales involved directly held shares and indirect holdings, including The Maetzold Descendants 2020 Trust and the Derek Maetzold 2020 Irrevocable Trust, each identified in the filing, with the CEO or his spouse serving as trustee as described in the footnotes.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
MAETZOLD DEREK J

(Last)(First)(Middle)
C/O CASTLE BIOSCIENCES, INC.
1500 W. PARKWOOD AVE SUITE 400

(Street)
FRIENDSWOOD TEXAS 77546

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
CASTLE BIOSCIENCES INC [ CSTL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
Pres. & Chief Exec. Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/11/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/11/2026M(1)8,584A$2.3930,063D
Common Stock09/11/2026S(1)8,361D$32(2)21,702D
Common Stock09/11/2026S(1)3,124D$32(2)14,517IBy The Maetzold Descendants 2020 Trust(3)
Common Stock09/11/2026S(1)2,656D$32(2)12,339IBy Derek Maetzold 2020 Irrevocable Trust(4)
Common Stock09/11/2026S(1)223D$32.7821,479D
Common Stock09/11/2026S(1)83D$32.7814,434IBy The Maetzold Descendants 2020 Trust(3)
Common Stock09/11/2026S(1)71D$32.7812,268IBy Derek Maetzold 2020 Irrevocable Trust(4)
Common Stock11,256IBy The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk(5)
Common Stock11,256IBy The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold(6)
Common Stock11,256IBy The Maetzold 2018 Remainder Trust FBO John Derek Maetzold(7)
Common Stock11,256IBy The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold(8)
Common Stock11,963IBy DJM Grantor Retained Annuity Trust No. 6(9)
Common Stock27,862IBy DJM Grantor Retained Annuity Trust No. 7(10)
Common Stock40,935IBy DJM Grantor Retained Annuity Trust No. 8(11)
Common Stock23,216IDJM Grantor Retained Annuity Trust No. 9(12)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock option (right to buy)$2.3909/11/2026M(1)8,584 (13)05/09/2028Common Stock8,584$016,745D
Explanation of Responses:
1. These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on June 2, 2026.
2. This transaction was executed in multiple trades at prices ranging from $31.700 to $32.508, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
3. Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries.
4. Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries.
5. Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary.
6. Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
7. Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
8. Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
9. Held by DJM Grantor Retained Annuity Trust No. 6 of which the Reporting Person is the trustee and the beneficiaries are The Maetzold 2018 Remainder Trust FBO John Derek Maetzold, The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk, The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold and The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold.
10. Held by DJM Grantor Retained Annuity Trust No. 7 of which the Reporting Person is the trustee and beneficiary.
11. Held by DJM Grantor Retained Annuity Trust No. 8 of which the Reporting Person is the trustee and beneficiary.
12. Held by DJM Grantor Retained Annuity Trust No. 9 of which the Reporting Person is the trustee and beneficiary.
13. The shares subject to the option are fully vested.
Remarks:
/s/ Frank Stokes, Attorney-in-fact09/15/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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