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Castle Biosciences (CSTL) CEO sells 4,172 shares via family trusts

Filing Impact
(Neutral)
Filing Sentiment
(Negative)
Form Type
4

Rhea-AI Filing Summary

Castle Biosciences Inc. President and Chief Executive Officer Derek J. Maetzold reported open-market sales of 4,172 shares of common stock on July 14, 2026 at a weighted-average price of about $22.92 per share, executed largely through family trusts and related entities.

He also exercised stock options for 550 shares at an exercise price of $2.39 per share. The sales were carried out under a Rule 10b5-1 trading plan adopted on December 3, 2025, and many positions are reported as indirect holdings through various Maetzold family trusts and grantor retained annuity trusts.

Positive

  • None.

Negative

  • None.
Insider MAETZOLD DEREK J
Role Pres. & Chief Exec. Officer
Sold 4,172 shs ($96K)
Type Security Shares Price Value
Exercise Stock option (right to buy) 550 $0.00 --
Exercise Common Stock 550 $2.39 $1K
Sale Common Stock 550 $22.92 $13K
Sale Common Stock 1,357 $22.92 $31K
Sale Common Stock 1,153 $22.92 $26K
Sale Common Stock 278 $22.92 $6K
Sale Common Stock 278 $22.92 $6K
Sale Common Stock 278 $22.92 $6K
Sale Common Stock 278 $22.92 $6K
holding Common Stock -- -- --
holding Common Stock -- -- --
holding Common Stock -- -- --
Holdings After Transaction: Stock option (right to buy) — 85,117 shares (Direct); Common Stock — 22,029 shares (Direct); Common Stock — 39,353 shares (Indirect, By The Maetzold Descendants 2020 Trust)
Footnotes (1)
  1. These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 3, 2025. This transaction was executed in multiple trades at prices ranging from $22.62 to $23.15, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries. Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries. Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary. Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary. Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary. Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary. Held by DJM Grantor Retained Annuity Trust No. 6 of which the Reporting Person is the trustee and the beneficiaries are The Maetzold 2018 Remainder Trust FBO John Derek Maetzold, The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk, The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold and The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold. Held by DJM Grantor Retained Annuity Trust No. 7 of which the Reporting Person is the trustee and beneficiary. Held by DJM Grantor Retained Annuity Trust No. 8 of which the Reporting Person is the trustee and beneficiary. The shares subject to the option are fully vested.
Common shares sold 4,172 shares Total non-derivative common shares sold on July 14, 2026
Weighted-average sale price $22.9200 per share Price reported for open-market sales of CSTL common stock
Sale price range $22.62 to $23.15 per share Range of execution prices for the reported common stock sales
Options exercised into common stock 550 shares Common shares acquired through stock option exercise on July 14, 2026
Option exercise price $2.3900 per share Exercise price of the stock option converted into common shares
Maetzold Descendants 2020 Trust holding 39,353 shares Common shares shown following the reported sale for that trust
Derek Maetzold 2020 Irrevocable Trust holding 33,449 shares Common shares shown following the reported sale for that trust
Rule 10b5-1 plan regulatory
"These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person."
A Rule 10b5-1 plan is a prearranged, written schedule that lets corporate insiders buy or sell company stock at set times or amounts, even if they later learn material nonpublic information. Think of it like setting an automatic thermostat for trades: it creates a clear record that trades were planned in advance, reducing the risk of insider-trading accusations and helping investors trust that insider transactions are routine rather than based on secret information.
Grantor Retained Annuity Trust financial
"Held by DJM Grantor Retained Annuity Trust No. 7 of which the Reporting Person is the trustee."
A grantor retained annuity trust (GRAT) is an estate-planning tool where the person who creates the trust transfers assets into it but receives fixed cash payments (an annuity) from the trust for a set number of years; whatever remains after that term passes to designated beneficiaries. It matters to investors because it can shift future appreciation of assets out of the creator’s taxable estate—like putting an asset into a timed vending machine that pays you fixed amounts while any extra value that grows inside the machine goes to heirs with reduced gift or estate tax consequences.
Stock option (right to buy) financial
"Security title is Stock option (right to buy) with an expiration date in 2028."
weighted-average sale price financial
"The price reported above reflects the weighted-average sale price for the trades."
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FAQ

What insider transactions did Castle Biosciences (CSTL) CEO Derek Maetzold report?

Derek Maetzold reported open-market sales of 4,172 Castle Biosciences shares on July 14, 2026 at a weighted-average price of $22.92 per share, and separately exercised stock options for 550 shares at an exercise price of $2.39 per share.

How many Castle Biosciences (CSTL) shares were sold and at what prices?

Reported sales totaled 4,172 CSTL shares of common stock. The transactions were executed at prices ranging from $22.62 to $23.15 per share, with a reported weighted-average sale price of $22.92 across the multiple trades on July 14, 2026.

Were Derek Maetzold’s Castle Biosciences (CSTL) trades under a Rule 10b5-1 plan?

Yes. A footnote states these transactions were made pursuant to a Rule 10b5-1 plan adopted by Derek Maetzold on December 3, 2025, indicating the trades were pre-arranged rather than discretionary in timing, which affects how investors may interpret their significance.

Did Derek Maetzold exercise Castle Biosciences (CSTL) stock options in this filing?

Yes. He exercised stock options for 550 shares of Castle Biosciences common stock at an exercise price of $2.39 per share. A footnote explains that the shares subject to the option are fully vested, and the option is described as a stock option right to buy common stock.

How are Castle Biosciences (CSTL) shares held after the reported transactions?

Holdings are reported both directly and through trusts. For example, after the reported trades, the filing shows 39,353 shares held by The Maetzold Descendants 2020 Trust and 33,449 shares held by the Derek Maetzold 2020 Irrevocable Trust, with the reporting person or spouse serving as trustee.

What types of entities held the Castle Biosciences (CSTL) shares involved in these trades?

Many positions are indirect holdings in family estate-planning vehicles. These include Maetzold 2018 remainder trusts, Derek Maetzold 2020 irrevocable and descendants trusts, and several DJM Grantor Retained Annuity Trusts, where Derek Maetzold or his spouse serves as trustee for family beneficiaries.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
MAETZOLD DEREK J

(Last)(First)(Middle)
C/O CASTLE BIOSCIENCES, INC.
1500 W. PARKWOOD AVE SUITE 400

(Street)
FRIENDSWOOD TEXAS 77546

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
CASTLE BIOSCIENCES INC [ CSTL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
Pres. & Chief Exec. Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
07/14/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock07/14/2026M(1)550A$2.3922,029D
Common Stock07/14/2026S(1)550D$22.92(2)21,479D
Common Stock07/14/2026S(1)1,357D$22.92(2)39,353IBy The Maetzold Descendants 2020 Trust(3)
Common Stock07/14/2026S(1)1,153D$22.92(2)33,449IBy Derek Maetzold 2020 Irrevocable Trust(4)
Common Stock07/14/2026S(1)278D$22.92(2)12,090IBy The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk(5)
Common Stock07/14/2026S(1)278D$22.92(2)12,090IBy The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold(6)
Common Stock07/14/2026S(1)278D$22.92(2)12,090IBy The Maetzold 2018 Remainder Trust FBO John Derek Maetzold(7)
Common Stock07/14/2026S(1)278D$22.92(2)12,090IBy The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold(8)
Common Stock18,718IBy DJM Grantor Retained Annuity Trust No. 6(9)
Common Stock44,323IBy DJM Grantor Retained Annuity Trust No. 7(10)
Common Stock40,935IBy DJM Grantor Retained Annuity Trust No. 8(11)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock option (right to buy)$2.3907/14/2026M(1)550 (12)05/09/2028Common Stock550$085,117D
Explanation of Responses:
1. These transactions were made pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on December 3, 2025.
2. This transaction was executed in multiple trades at prices ranging from $22.62 to $23.15, inclusive. The price reported above reflects the weighted-average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.
3. Held by The Maetzold Descendants 2020 Trust of which the Reporting Person's spouse is the trustee and the Reporting Person's spouse and their children are beneficiaries.
4. Held by Derek Maetzold 2020 Irrevocable Trust of which the Reporting Person is the trustee and his children are beneficiaries.
5. Held by The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk of which the Reporting Person is the trustee and his child is the beneficiary.
6. Held by The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
7. Held by The Maetzold 2018 Remainder Trust FBO John Derek Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
8. Held by The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold of which the Reporting Person is the trustee and his child is the beneficiary.
9. Held by DJM Grantor Retained Annuity Trust No. 6 of which the Reporting Person is the trustee and the beneficiaries are The Maetzold 2018 Remainder Trust FBO John Derek Maetzold, The Maetzold 2018 Remainder Trust FBO Emily Carol Kirk, The Maetzold 2018 Remainder Trust FBO Peter Douglas Maetzold and The Maetzold 2018 Remainder Trust FBO Hannah Elizabeth Maetzold.
10. Held by DJM Grantor Retained Annuity Trust No. 7 of which the Reporting Person is the trustee and beneficiary.
11. Held by DJM Grantor Retained Annuity Trust No. 8 of which the Reporting Person is the trustee and beneficiary.
12. The shares subject to the option are fully vested.
Remarks:
/s/ Frank Stokes, Attorney-in-fact07/16/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)