Check the appropriate box below if the Form 8-K filing is intended
to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction
A.2. below):
On November 5, 2026, Cryoport, Inc. (the “Company”)
issued a press release announcing its financial results for the third quarter ended September 30, 2026. A copy of the press release issued
by the Company is attached hereto as Exhibit 99.1.
The information, including the exhibit attached
hereto, in this Current Report on Form 8-K shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange
Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that Section, nor shall it be deemed
incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, except as otherwise expressly stated in
such filing.
Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Exhibit 99.1

Cryoport
Reports Third Quarter 2026 Financial Results
| · | Third
quarter revenue grew 14% year-over-year to $50.2 million |
| · | Commercial
Cell and Gene Therapy revenue increased 20% year-over-year |
| · | Supporting
a record 788 global clinical trials and 23 commercially approved cell and gene therapies
as of September 30, 2026 |
| · | Raises
full-year 2026 revenue guidance to $197 million - $199 million |
NASHVILLE,
Tennessee, November 5, 2026, - Cryoport, Inc. (NASDAQ: CYRX) (“Cryoport” or
the “Company”), a leading global provider of integrated temperature-controlled supply chain solutions for the life sciences,
today announced financial results for its third quarter (Q3) and first nine months (9M) of 2026.
Jerrell
Shelton, CEO of Cryoport, stated, “Cryoport delivered third quarter revenue of $50.2 million, reflecting continued momentum across
our core cell and gene therapy (CGT) business. Revenue from commercial CGT clients increased 20% year over year, BioStorage/BioServices
revenue expanded 25%, and total Life Sciences Services revenue grew 18%, underscoring the strength of our integrated platform and the
growing demand for our solutions. These results reflect both the increasing number of patients worldwide receiving CGT treatments and
the continued adoption of our end-to-end temperature-controlled supply chain solutions. We also achieved 8% year over year growth in
Life Sciences Products revenue, supported by MVE Biological Solutions’ (MVE) position as the global market leader in cryogenic
systems.”
“During
the quarter, we further strengthened our leadership position within the CGT ecosystem, ending the period supporting 23 commercial therapies
and a record of 788 clinical trials worldwide. Our integrated platform, disciplined execution, and growing utilization of our Global
Supply Chain Center Network continue to enhance scalability and operating leverage, advancing our progress toward sustained profitability.
This momentum was reflected in our positive adjusted EBITDA of $1.1 million for the quarter, representing another important milestone
in our pathway to profitability initiative.
“Our
strong year-to-date performance, combined with expanding support of commercial therapies, deepening customer relationships, a robust
clinical trial pipeline, and continued demand for MVE’s industry-leading products, gives us confidence in our outlook. As a result,
we are increasing our full-year 2026 revenue guidance to a range of $197 million to $199 million,” concluded Mr. Shelton.
The following table
presents Q3 2026 revenue compared with Q3 2025:
Cryoport, Inc. and Subsidiaries
Revenue
| | |
Three Months Ended September 30, (unaudited) | | |
Nine Months Ended September 30, (unaudited) | |
| (in thousands) | |
2026 | | |
2025 | | |
% Change | | |
2026 | | |
2025 | | |
% Change | |
| Life Sciences Services | |
$ | 28,564 | | |
$ | 24,258 | | |
| 18 | % | |
$ | 83,431 | | |
$ | 71,492 | | |
| 17 | % |
| BioLogistics Solutions | |
| 22,522 | | |
| 19,428 | | |
| 16 | % | |
| 66,549 | | |
| 57,832 | | |
| 15 | % |
| BioStorage/BioServices | |
| 6,042 | | |
| 4,830 | | |
| 25 | % | |
| 16,882 | | |
| 13,660 | | |
| 24 | % |
| Life Sciences Products | |
$ | 21,656 | | |
$ | 19,975 | | |
| 8 | % | |
$ | 63,558 | | |
$ | 59,235 | | |
| 7 | % |
| Total Revenue | |
$ | 50,220 | | |
$ | 44,233 | | |
| 14 | % | |
$ | 146,989 | | |
$ | 130,727 | | |
| 12 | % |
BioLogistics
Solutions revenue increased 16% year-over-year in Q3 2026, driven by continued commercial therapies development, and clinical trial progress
within the CGT market. BioStorage/BioServices revenue grew 25% year-over-year, reflecting another strong quarter of demand for our expanded,
integrated services offering, which provides seamless, secure handling of temperature-sensitive materials across our global network.
As
of September 30, 2026, the number of commercial cell and gene therapies we support increased to 23 and our total global clinical trial
count that we support rose to 788 clinical trials, a net increase of 43 clinical trials over September 30, 2025, with 99 of these clinical
trials in Phase 3. The number of trials by phase and region are as follows:
Cryoport
Supported Clinical Trials by Phase
| | |
September 30, | |
| Clinical Trials | |
2024 | | |
2025 | | |
2026 | |
| Phase 1 | |
| 295 | | |
| 309 | | |
| 319 | |
| Phase 2 | |
| 317 | | |
| 353 | | |
| 370 | |
| Phase 3 | |
| 79 | | |
| 83 | | |
| 99 | |
| Total | |
| 691 | | |
| 745 | | |
| 788 | |
Cryoport
Supported Clinical Trials by Region
| | |
September 30, | |
| Clinical Trials | |
2024 | | |
2025 | | |
2026 | |
| Americas | |
| 531 | | |
| 559 | | |
| 589 | |
| EMEA | |
| 112 | | |
| 137 | | |
| 143 | |
| APAC | |
| 48 | | |
| 49 | | |
| 56 | |
| Total | |
| 691 | | |
| 745 | | |
| 788 | |
In
Q3 2026, Cryoport’s customer, Replimune, received accelerated U.S. Food and Drug Administration (FDA) approval for TUDRIQEV™
for the treatment of adults with unresectable advanced cutaneous melanoma, a skin cancer that has spread too widely or deeply to be safely
or completely removed with surgery. Also, during the quarter Crispr Therapeutics and their partner Vertex Pharmaceuticals received FDA
supplemental approval to expand the label of CASGEVY® for treatment of people 2 years of age and older with either Sickle
Cell Disease (SCD) or Transfusion-dependent Beta Thalassemia (TDT). CASGEVY is the first approved genetic therapy indicated for children
as young as 2 years for both SCD and TDT .

Two
of Cryoport’s customers filed Biologics License Applications (BLA) with the FDA in the third quarter and we anticipate another
five possible BLA or Marketing Authorization
Applications (MAA) in 2026. Cryoport also anticipates two possible additional new therapy approvals (both of which have received Prescription
Drug User Fee Act (PDUFA) dates from the FDA for Q4 2026), and one possible additional supplemental approval for geographic expansion
from our customer base this year.
Operational
Milestones
| · | Cryoport
Systems initiated BioLogistics services at its new state-of-the-art Global Supply Chain Center
located in Santa Ana, California. |
| | | |
| · | Cryoport
Systems’ Global Supply Chain Center in Paris, France, received ISO 9001 and ISO 21973
certifications. ISO 21973 certification is the first international standard developed specifically
to address the transportation risks associated with human cells for therapeutic use. |
| | | |
| · | CRYOGENE
secured new BioStorage and service contracts with customers including Houston Methodist Medical
Center, Sonic Clinical Trials, and XenoSTART. |
Financial
Highlights
On
June 11, 2025, the Company completed the divestiture of its CRYOPDP specialty courier business to DHL Group. The results of CRYOPDP,
a former business within Cryoport’s Life Sciences Services segment, are presented as discontinued operations for all periods and
are excluded from the non-GAAP financial measures in this release.
Revenue
| · | Total
revenue for Q3 2026 was $50.2 million, compared to $44.2 million for Q3 2025, a year-over-year
increase of 14%, or $6.0 million. |
| o | Life
Sciences Services revenue for Q3 2026 (representing 57% of our total revenue) was $28.6 million,
compared to $24.3 million for Q3 2025, up 18% year-over-year, including BioStorage/BioServices
revenue of $6.0 million, up 25% year-over-year. |
| o | Life
Sciences Products revenue for Q3 2026 (representing 43% of our total revenue) was $21.7 million,
compared to $20.0 million for Q3 2025. |
| · | Total
revenue for 9M 2026 was $147.0 million, compared to $130.7 million for 9M 2025. |
| o | Life
Sciences Services revenue for 9M 2026 was $83.4 million, compared to $71.5 million for 9M
2025, including BioStorage/BioServices revenue of $16.9 million, compared to $13.7 million
for 9M 2025. |
| o | Life
Sciences Products revenue for 9M 2026 was $63.6 million, compared to $59.2 million for 9M
2025. |

Gross
Margin
| · | Total
gross margin was 47.5% for Q3 2026, compared to 48.2% for Q3 2025. |
| o | Gross
margin for Life Sciences Services was 50.4% for Q3 2026, compared to 49.7% for Q3 2025. |
| o | Gross
margin for Life Sciences Products was 43.6% for Q3 2026, compared to 46.4% for Q3 2025. |
| · | Total
gross margin was 46.7% for 9M 2026, compared to 46.9% for 9M 2025. |
| o | Gross
margin for Life Sciences Services was 49.7% for 9M 2026, compared to 48.8% for 9M 2025. |
| o | Gross
margin for Life Sciences Products was 42.6% for 9M 2026, compared to 44.6% for 9M 2025. |
Operating
Costs and Expenses
| · | Operating
costs and expenses were $32.6 million for Q3 2026, compared to $31.3 million for Q3 2025.
Operating costs and expenses were $97.0 million for 9M 2026, compared to $88.1 million for
9M 2025. |
Loss
from Continuing Operations
| · | Loss
from continuing operations was $10.9 million for Q3 2026, compared to a loss of $6.7 million
for Q3 2025. Loss from continuing operations was $28.5 million for 9M 2026, compared to a
loss of $25.4 million for 9M 2025. |
Net
Income (Loss) – including Discontinued Operations
| · | Net
loss was $10.9 million for Q3 2026, compared to net loss of $6.9 million for Q3 2025. Net
loss for 9M 2026 was $29.7 million, compared to net income of $89.9 million for 9M 2025.
Net income for 9M 2025 was primarily driven by the sale of our CRYOPDP specialty courier
business during Q2 2025, which contributed $115.4 million, net of taxes, to income from discontinued
operations. |
| · | Net
loss attributable to common stockholders for Q3 2026 was $12.9 million, or $0.25 per share.
Net loss attributable to common stockholders for 9M 2026 was $35.7 million, or $0.71 per
share. This compares to net loss attributable to common stockholders of $8.9 million, or
$0.18 per share, and net income attributable to common stockholders of $83.9 million, or
$1.68 per share, for Q3 2025 and 9M 2025, respectively. |
Adjusted
EBITDA from Continuing Operations
| · | Adjusted
EBITDA from continuing operations was $1.1 million for Q3 2026, compared to a negative $0.6
million for Q3 2025. Adjusted EBITDA from continuing operations for 9M 2026 was $0.9 million,
compared to a negative $4.4 million for 9M 2025. |
Cash,
Cash equivalents, and Short-Term Investments
| · | Cryoport
held $393.1 million in cash, cash equivalents, and short-term investments as of September
30, 2026. |
Revenue
Guidance for Full-Year 2026
| · | The
Company is providing updated full-year 2026 revenue guidance in the range of $197 million
to $199 million. The Company's 2026 revenue guidance is dependent on its current business
and expectations, which may be impacted by, among other things, factors that are outside
of our control, such as national economic factors, the global macroeconomic and geopolitical
environment, supply chain constraints, inflationary pressures, tariffs and other trade restrictions
and/or the effects of foreign currency fluctuations, as well as the other factors described
in the Company's filings with the Securities and Exchange Commission ("SEC"), including
in the "Risk Factors" section of its most recently filed periodic reports on Form
10-K and Form 10-Q, as well as in its subsequent filings with the SEC. |
Note:
All reconciliations of GAAP to adjusted (non-GAAP) figures above are detailed in the reconciliation tables included later in the press
release.
Additional
Information
Further
information on Cryoport’s financial results is included in the attached condensed consolidated balance sheets and statements of
operations, and additional explanations of Cryoport’s financial performance are provided in the Company’s Quarterly Report
on Form 10-Q for the quarter ended September 30, 2026, which is expected to be filed with the Securities and Exchange Commission ("SEC")
on November 5, 2026. Additionally, the full report will be available in the SEC Filings section of the Investor Relations section of
Cryoport’s website at www.cryoportinc.com.
Earnings
Conference Call Information
IMPORTANT
INFORMATION: In addition to the earnings release, a document titled “Cryoport Third Quarter 2026 in Review,” providing
a review of Cryoport’s business update, will be issued at 4:05 p.m. ET on Thursday, November 5, 2026. The document is designed
to be read in advance of the questions and answers conference call and will be accessible at https://ir.cryoportinc.com/news-events/ir-calendar.
Cryoport
management will host a conference call at 5:00 p.m. ET on November 5, 2026. The conference call will be in the format of a questions
and answers session and will address any queries investors have regarding the Company’s reported results. A slide deck will accompany
the call.
Conference
Call Information
| Date: |
Thursday,
November 5, 2026 |
| |
|
| Time: |
5:00
p.m. ET |
| |
|
| Dial-in
numbers: |
1-800-717-1738
(U.S.), 1-646-307-1865 (International) |
| |
|
| Confirmation
code: |
Request
the “Cryoport Call” or Conference ID: 1107312 |
| |
|
| Live
webcast: |
‘Investor
Relations’ section at www.cryoportinc.com or click here.
Please
allow 10 minutes prior to the call to visit this site to download and install any necessary audio software. |

The
questions and answers call will be recorded and available approximately three hours after completion of the live event in the Investor
Relations section of the Company's website at www.cryoportinc.com for a limited time. To access the replay of the questions and
answers click here. A dial-in replay of the call will also be available to those interested, until November 12, 2026. To access
the replay, dial 1-844-512-2921 (United States) or 1-412-317-6671 (International) and enter replay entry code: 1107312#.
About
Cryoport, Inc.
Cryoport,
Inc. (Nasdaq: CYRX) is a leading global provider of integrated temperature-controlled supply chain solutions for the life sciences,
with an emphasis on regenerative medicine. We support biopharmaceutical companies, contract manufacturers (CDMOs), contract research
organizations (CROs), developers, and researchers with a comprehensive suite of services and products designed to minimize risk and maximize
reliability across the temperature-controlled supply chain for the life sciences. Our integrated supply chain platform includes the Cryoportal®
Logistics Management Platform, advanced temperature-controlled packaging, informatics, specialized BioLogistics, BioStorage, BioServices,
cryopreservation services, and cryogenic systems, which in varying combinations deliver end-to-end solutions that meet the rigorous demands
of the life sciences. With innovation, regulatory compliance, and agility at our core, we are "Enabling the Future of Medicine™."
Headquartered
in Nashville, Tennessee, our company maintains a strong global presence with operations across the Americas, EMEA, and APAC.
For
more information, visit www.cryoportinc.com or follow via LinkedIn at https://www.linkedin.com/company/cryoportinc or @cryoport
on X, formerly known as Twitter at https://x.com/cryoport for live updates.

Forward-Looking
Statements
Statements
in this press release which are not purely historical, including statements regarding the Company's intentions, hopes, beliefs, expectations,
representations, projections, plans or predictions of the future, are forward-looking statements within the meaning of the Private Securities
Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, those related to the Company's industry,
business, long-term growth prospects, plans, strategies, acquisitions, future financial results and financial condition, such as the
Company's outlook and guidance for full-year 2026 revenue and the related assumptions and factors expected to drive revenue, projected
growth trends in the markets in which the Company operates, the Company's plans and expectations regarding the launch of new products
and services, such as the expected timing and benefits of such products and services launches, the Company’s expectations about
future benefits of its acquisitions, and anticipated regulatory filings, approvals, label/geographic expansions or moves to earlier lines
of treatment approved with respect to the products of the Company's clients. Forward-looking statements also include those related to
the Company’s plans regarding its Global Supply Chain Centers, including expected timing of future openings, the Company’s
anticipation that it will benefit from its operating leverage, the Company’s belief that it is well positioned to further expand
margins, enhance operating efficiency and deliver sustainable, profitable long-term growth for its shareholders, and the Company’s
expectation that upcoming growth catalysts in its business segments will drive the Company to new heights in market position, growth,
and productivity. It is important to note that the Company's actual results could differ materially from those in any such forward-looking
statements. Factors that could cause actual results to differ materially include, but are not limited to, risks and uncertainties associated
with the effects of changing economic and geopolitical conditions, such as those resulting from the war with Iran, supply chain constraints,
inflationary pressures, the effects of foreign currency fluctuations, trends in the products markets, variations in the Company’s
cash flow, market acceptance risks, the effects of tariffs and other trade restrictions, and technical development risks. The Company's
business could be affected by other factors discussed in the Company's SEC reports, including in the "Risk Factors" section
of its most recently filed periodic reports on Form 10-K and Form 10-Q, as well as in its subsequent filings with the SEC. The forward-looking
statements contained in this press release speak only as of the date hereof and the Company cautions investors not to place undue reliance
on these forward-looking statements. Except as required by law, the Company disclaims any obligation and does not undertake to update
or revise any forward-looking statements in this press release.
Cryoport
Investor Contacts:
Todd
Fromer / Scott Eckstein
KCSA
Strategic Communications
cryoport@kcsa.com

Cryoport, Inc. and Subsidiaries
Condensed Consolidated Statements of Operations
| | |
Three Months Ended September 30, (unaudited) | | |
Nine Months Ended September 30, (unaudited) | |
| (in thousands, except share and per share data) | |
2026 | | |
2025 | | |
2026 | | |
2025 | |
| Revenue | |
| | |
| | |
| | |
| |
| Life Sciences Services revenue | |
$ | 28,564 | | |
$ | 24,258 | | |
$ | 83,431 | | |
$ | 71,492 | |
| Life Sciences Products revenue | |
| 21,656 | | |
| 19,975 | | |
| 63,558 | | |
| 59,235 | |
| Total revenue | |
| 50,220 | | |
| 44,233 | | |
| 146,989 | | |
| 130,727 | |
| Cost of revenue: | |
| | | |
| | | |
| | | |
| | |
| Cost of services revenue | |
| 14,181 | | |
| 12,201 | | |
| 41,936 | | |
| 36,570 | |
| Cost of products revenue | |
| 12,205 | | |
| 10,707 | | |
| 36,482 | | |
| 32,814 | |
| Total cost of revenue | |
| 26,386 | | |
| 22,908 | | |
| 78,418 | | |
| 69,384 | |
| Gross margin | |
| 23,834 | | |
| 21,325 | | |
| 68,571 | | |
| 61,343 | |
| Operating costs and expenses: | |
| | | |
| | | |
| | | |
| | |
| Selling, general and administrative | |
| 27,904 | | |
| 26,734 | | |
| 83,535 | | |
| 75,543 | |
| Engineering and development | |
| 4,734 | | |
| 4,523 | | |
| 13,493 | | |
| 12,575 | |
| Total operating costs and expenses | |
| 32,638 | | |
| 31,257 | | |
| 97,028 | | |
| 88,118 | |
| Loss from operations | |
| (8,804 | ) | |
| (9,932 | ) | |
| (28,457 | ) | |
| (26,775 | ) |
| Other income (expense): | |
| | | |
| | | |
| | | |
| | |
| Investment income | |
| 3,027 | | |
| 3,402 | | |
| 9,249 | | |
| 6,441 | |
| Interest expense | |
| (517 | ) | |
| (526 | ) | |
| (1,467 | ) | |
| (1,727 | ) |
| Other income (expense), net | |
| (4,364 | ) | |
| 525 | | |
| (7,057 | ) | |
| (2,714 | ) |
| Loss before provision for income taxes | |
| (10,658 | ) | |
| (6,531 | ) | |
| (27,732 | ) | |
| (24,775 | ) |
| Provision for income taxes | |
| (194 | ) | |
| (165 | ) | |
| (807 | ) | |
| (673 | ) |
| Loss from continuing operations | |
$ | (10,852 | ) | |
$ | (6,696 | ) | |
$ | (28,539 | ) | |
$ | (25,448 | ) |
| Income (loss) from discontinued operations, net | |
| - | | |
| (247 | ) | |
| (1,112 | ) | |
| 115,393 | |
| Net income (loss) | |
$ | (10,852 | ) | |
$ | (6,943 | ) | |
$ | (29,651 | ) | |
$ | 89,945 | |
| Paid-in-kind dividend on Series C convertible preferred stock | |
| (2,000 | ) | |
| (2,000 | ) | |
| (6,000 | ) | |
| (6,000 | ) |
| Net income (loss) attributable to common stockholders | |
$ | (12,852 | ) | |
$ | (8,943 | ) | |
$ | (35,651 | ) | |
$ | 83,945 | |
| Net income (loss) per share attributable to common stockholders - basic and diluted | |
$ | (0.25 | ) | |
$ | (0.18 | ) | |
$ | (0.71 | ) | |
$ | 1.68 | |
| Weighted average common shares issued and outstanding - basic and diluted | |
| 50,653,987 | | |
| 50,125,268 | | |
| 50,335,554 | | |
| 50,110,450 | |
| | |
| | | |
| | | |
| | | |
| | |
| Gross margin - Total [%] | |
| 47.5 | % | |
| 48.2 | % | |
| 46.7 | % | |
| 46.9 | % |
| Gross margin - Services [%] | |
| 50.4 | % | |
| 49.7 | % | |
| 49.7 | % | |
| 48.8 | % |
| Gross margin - Products [%] | |
| 43.6 | % | |
| 46.4 | % | |
| 42.6 | % | |
| 44.6 | % |

Cryoport, Inc. and Subsidiaries
Condensed Consolidated Balance Sheets
| | |
September 30, | | |
December 31, | |
| | |
2026 | | |
2025 | |
| (in thousands) | |
(unaudited) | | |
| |
| Current assets | |
| | | |
| | |
| Cash and cash equivalents | |
$ | 279,179 | | |
$ | 250,494 | |
| Short-term investments | |
| 113,897 | | |
| 160,714 | |
| Accounts receivable, net | |
| 36,004 | | |
| 33,359 | |
| Inventories | |
| 22,438 | | |
| 23,188 | |
| Prepaid expenses and other current assets | |
| 5,186 | | |
| 8,419 | |
| Total current assets | |
| 456,704 | | |
| 476,174 | |
| Property and equipment, net | |
| 96,367 | | |
| 85,448 | |
| Operating lease right-of-use assets | |
| 39,473 | | |
| 39,720 | |
| Intangible assets, net | |
| 133,277 | | |
| 138,082 | |
| Goodwill | |
| 22,030 | | |
| 22,400 | |
| Deposits | |
| 1,998 | | |
| 2,092 | |
| Deferred tax assets | |
| 1,096 | | |
| 1,073 | |
| Total assets | |
$ | 750,945 | | |
$ | 764,989 | |
| | |
| | | |
| | |
| Current liabilities | |
| | | |
| | |
| Accounts payable and other accrued expenses | |
$ | 16,347 | | |
$ | 15,283 | |
| Accrued compensation and related expenses | |
| 14,731 | | |
| 12,980 | |
| Deferred revenue | |
| 1,455 | | |
| 943 | |
| Current portion of operating lease liabilities | |
| 4,378 | | |
| 4,133 | |
| Current portion of finance lease liabilities | |
| 448 | | |
| 422 | |
| Current portion of convertible senior notes, net | |
| 185,986 | | |
| 185,094 | |
| Current portion of notes payable | |
| 159 | | |
| 163 | |
| Current portion of contingent consideration | |
| 674 | | |
| - | |
| Total current liabilities | |
| 224,178 | | |
| 219,018 | |
| Notes payable, net | |
| 947 | | |
| 1,087 | |
| Operating lease liabilities, net | |
| 38,905 | | |
| 39,078 | |
| Finance lease liabilities, net | |
| 688 | | |
| 741 | |
| Deferred tax liabilities | |
| 1,748 | | |
| 1,354 | |
| Other long-term liabilities | |
| 965 | | |
| 444 | |
| Contingent consideration | |
| - | | |
| 629 | |
| Total liabilities | |
| 267,431 | | |
| 262,351 | |
| Total stockholders' equity | |
| 483,514 | | |
| 502,638 | |
| Total liabilities and stockholders' equity | |
$ | 750,945 | | |
$ | 764,989 | |

Note Regarding Use of Non-GAAP
Financial Measures
To supplement
our financial statements, which are presented on the basis of U.S. generally accepted accounting principles (GAAP), the following non-GAAP
measure of financial performance as defined in Regulation G of the Securities Exchange Act of 1934 is included in this release: adjusted
EBITDA from continuing operations. Non-GAAP financial measures are not calculated in accordance with GAAP, are not based on any comprehensive
set of accounting rules or principles and may be different from non-GAAP financial measures presented by other companies. Non-GAAP financial
measures, including adjusted EBITDA from continuing operations, should not be considered as a substitute for, or superior to, measures
of financial performance prepared in accordance with GAAP.
Adjusted
EBITDA from continuing operations is defined as loss from continuing operations adjusted for net interest expense, income taxes, depreciation
and amortization expense, stock-based compensation expense, acquisition and integration costs, cost reduction initiatives, investment
income, unrealized (gain)/loss on investments, foreign currency loss, changes in fair value of contingent consideration and charges or
gains resulting from non-recurring events, as applicable.
Management
believes that adjusted EBITDA from continuing operations provides a useful measure of Cryoport's operating results, a meaningful comparison
with historical results and with the results of other companies, and insight into Cryoport's ongoing operating performance. Further,
management and the Company’s board of directors utilize adjusted EBITDA from continuing operations to gain a better understanding
of Cryoport's comparative operating performance from period to period and as a basis for planning and forecasting future periods. Adjusted
EBITDA from continuing operations is also a significant performance measure used by Cryoport in connection with its incentive compensation
programs. Management believes adjusted EBITDA from continuing operations, when read in conjunction with Cryoport's GAAP financials, is
useful to investors because it provides a basis for meaningful period-to-period comparisons of Cryoport's ongoing operating results,
including results of operations, against investor and analyst financial models, helps identify trends in Cryoport's underlying business
and in performing related trend analyses, and it provides a better understanding of how management plans and measures Cryoport's underlying
business.

Cryoport, Inc. and Subsidiaries
Reconciliation of GAAP loss from continuing operations to adjusted EBITDA
(unaudited)
| | |
Three Months Ended September 30, | | |
Nine Months Ended September 30, | |
| (in thousands) | |
2026 | | |
2025 | | |
2026 | | |
2025 | |
| GAAP loss from continuing operations | |
$ | (10,852 | ) | |
$ | (6,696 | ) | |
$ | (28,539 | ) | |
$ | (25,448 | ) |
| Non-GAAP adjustments to loss: | |
| | | |
| | | |
| | | |
| | |
| Depreciation and amortization expense | |
| 6,467 | | |
| 6,415 | | |
| 19,458 | | |
| 18,798 | |
| Acquisition and integration costs | |
| 25 | | |
| 38 | | |
| 25 | | |
| 69 | |
| Cost reduction initiatives | |
| 857 | | |
| 160 | | |
| 997 | | |
| 642 | |
| Investment income | |
| (3,027 | ) | |
| (3,402 | ) | |
| (9,249 | ) | |
| (6,441 | ) |
| Unrealized (gain) loss on investments | |
| 4,171 | | |
| (655 | ) | |
| 6,064 | | |
| 620 | |
| Foreign currency loss | |
| 380 | | |
| 274 | | |
| 1,485 | | |
| 2,521 | |
| Interest expense, net | |
| 517 | | |
| 526 | | |
| 1,467 | | |
| 1,727 | |
| Stock-based compensation expense | |
| 2,346 | | |
| 2,526 | | |
| 7,143 | | |
| 7,635 | |
| Change in fair value of contingent consideration | |
| 25 | | |
| — | | |
| 67 | | |
| (5,178 | ) |
| Income taxes | |
| 194 | | |
| 165 | | |
| 807 | | |
| 673 | |
| Other adjustments | |
| — | | |
| — | | |
| 1,142 | | |
| — | |
| Adjusted EBITDA from continuing operations | |
$ | 1,103 | | |
$ | (649 | ) | |
$ | 867 | | |
$ | (4,382 | ) |