STOCK TITAN

Enliven CSO executes 10b5-1 sale of 4,000 ELVN shares at $20.25

Filing Impact
(Neutral)
Filing Sentiment
(Negative)
Form Type
4

Rhea-AI Filing Summary

Enliven Therapeutics insider sale by Chief Scientific Officer

Joseph P. Lyssikatos, Enliven Therapeutics' Chief Scientific Officer, reported a sale of 4,000 shares of the company's common stock on 09/26/2025 at a weighted average price of $20.2513 per share. The sales were effected under a Rule 10b5-1 trading plan adopted by the reporting person on 11/15/2024. After the reported disposition, the reporting person beneficially owns 927,688 shares indirectly through The Lyssikatos Revocable Trust dated 12/15/2011, for which he serves as trustee. The Form 4 was signed by power of attorney on 09/30/2025.

Positive

  • Sale executed under a Rule 10b5-1 trading plan, indicating it was pre-planned (adopted 11/15/2024).
  • Full post-transaction beneficial ownership disclosed: 927,688 shares held indirectly via The Lyssikatos Revocable Trust.
  • Transaction details include weighted average price ($20.2513) and price range disclosure offer upon request.

Negative

  • Disposition of 4,000 shares reduces the reporting person's direct/indirect holdings by that amount.

Insights

TL;DR: A routine, pre-planned insider sale of 4,000 shares under a 10b5-1 plan; holding remains substantial at 927,688 shares.

The reported transaction is a disposition executed under a Rule 10b5-1 trading plan, indicating the sale was pre-established and intended to avoid timing concerns associated with inside information. The sale size (4,000 shares) and the weighted average price ($20.2513) are disclosed; however, relative to the reported post-transaction beneficial ownership of 927,688 shares, the disposition appears modest. There is no other financial or operational information in the filing to suggest a change in company fundamentals.

TL;DR: Filing demonstrates standard disclosure and use of a 10b5-1 plan; signature by POA properly documented.

The Form 4 clearly identifies the reporting person, relationship to the issuer (Chief Scientific Officer), and the nature of indirect ownership via a revocable trust. The filing states the 10b5-1 plan adoption date (11/15/2024) and provides an undertaking to disclose trade-level prices on request. The signature executed by power of attorney on 09/30/2025 follows typical procedural practice for timely reporting. No governance issues or omissions are apparent from the document alone.

Insider Lyssikatos Joseph P
Role CHIEF SCIENTIFIC OFFICER
Sold 4,000 shs ($81K)
Type Security Shares Price Value
Sale Common Stock 4,000 $20.2513 $81K
Holdings After Transaction: Common Stock — 927,688 shares (Indirect, See footnote)
Footnotes (1)
  1. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 15, 2024. This transaction was executed in multiple trades at prices ranging from $20.015 to $20.285. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. The shares are held by The Lyssikatos Revocable Trust 12/15/2011 for which the Reporting Person serves as trustee.
SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Lyssikatos Joseph P

(Last) (First) (Middle)
C/O ENLIVEN THERAPEUTICS, INC.
6200 LOOKOUT ROAD

(Street)
BOULDER CO 80301

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
Enliven Therapeutics, Inc. [ ELVN ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
CHIEF SCIENTIFIC OFFICER
3. Date of Earliest Transaction (Month/Day/Year)
09/26/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/26/2025 S(1) 4,000 D $20.2513(2) 927,688 I See footnote(3)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 15, 2024.
2. This transaction was executed in multiple trades at prices ranging from $20.015 to $20.285. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price.
3. The shares are held by The Lyssikatos Revocable Trust 12/15/2011 for which the Reporting Person serves as trustee.
/s/ Ben Hohl, by power of attorney 09/30/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did ELVN report on this Form 4?

The Form 4 reports that Joseph P. Lyssikatos sold 4,000 shares of Enliven Therapeutics common stock on 09/26/2025.

At what price were the ELVN shares sold?

The sale was executed at a weighted average price of $20.2513 per share, with individual trades ranging from $20.015 to $20.285.

Was the sale part of a pre-arranged plan for ELVN insider Lyssikatos?

Yes. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted on 11/15/2024.

How many ELVN shares does the reporting person beneficially own after the sale?

After the reported transaction, the reporting person beneficially owns 927,688 shares indirectly through The Lyssikatos Revocable Trust dated 12/15/2011.

Who signed the Form 4 and when was it filed?

The Form 4 was signed by Ben Hohl by power of attorney on 09/30/2025.