GSK (NYSE: GSK) buys RAPT for $2.2B, adding food allergy antibody ozureprubart

Rhea-AI Filing Summary

GSK plc hat die zuvor angekündigte Übernahme von RAPT Therapeutics abgeschlossen und bewertet RAPT mit einem ungefähren aggregierten Eigenkapitalwert von $2.2 Milliarden, wobei GSKs anfängliche Barinvestition rund $1.9 Milliarden netto des übernommenen Bargelds beträgt.

Der Deal gewährt GSK globale Rechte an dem Kandidaten gegen Nahrungsmittelallergien ozureprubart, mit Ausschluss des chinesischen Festlandes, Macao, Taiwan und Hong Kong. Ozureprubart ist ein langwirkendes anti-IgE-Monoklonalantikoerper in Phase IIb-Entwicklung, das eine Dosierung alle 12 Wochen im Vergleich zu den aktuellen Injektionen alle 2–4 Wochen anstrebt und potenziell Patienten bedient, die derzeit für die bestehende anti‑IgE-Therapie nicht in Frage kommen.

Phase-IIb-Monotherapie-Daten aus der prestIgE-Studie werden voraussichtlich im 2027 erwartet, mit Phase-III-Studien, die bei risikobehafteten Erwachsenen- und pädiatrischen Populationen geplant sind. GSK wird zudem erfolgsabhängige Meilenstein- und Royalty-Verpflichtungen für ozureprubart übernehmen, die Shanghai Jeyou Pharmaceutical gegenüber entstehen.

Insights

Biopharmaceutical M&A and pipeline strategy analyst

GSK pays $2.2B to add a late-stage food-allergy antibody with global rights.

GSK is deploying about $1.9 billion in upfront cash (net of RAPT’s cash) for full global rights to ozureprubart outside greater China. The asset targets IgE, a clinically validated pathway in food allergy where current systemic options are limited and often burdensome.

Ozureprubart’s proposed 12‑week dosing contrasts with existing anti‑IgE injections every 2–4 weeks, and GSK highlights potential access for roughly 25% of patients not eligible for current therapy. Actual commercial value will depend on forthcoming prestIgE phase IIb data expected in 2027 and successful phase III programmes in adults and children.

GSK also assumes success‑based milestones and royalties to Shanghai Jeyou, adding contingent financial commitments tied to ozureprubart’s progress. Subsequent clinical readouts and any regulatory submissions after 2027 will be key to understanding whether this sizeable investment enhances GSK’s respiratory, immunology and inflammation portfolio as intended.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of March 2026

Commission File Number 001-15170

GSK plc

(Translation of registrant's name into English)

79 New Oxford Street, London, WC1A 1DG

(Address of principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F . . . .X. . . . Form 40-F . . . . . . . .

Issued: 3 March 2026, London UK

GSK completes acquisition of RAPT Therapeutics

GSK plc (LSE/NYSE: GSK) today announced the completion of its previously announced acquisition of RAPT Therapeutics, a California-based, clinical-stage biopharmaceutical company dedicated to developing novel therapies for patients living with inflammatory and immunologic diseases.

The acquisition includes ozureprubart, a long-acting anti-immunoglobulin E (IgE) monoclonal antibody, currently in phase IIb clinical development for prophylactic protection against food allergens. IgE is a clinically validated target and is the only approved systemic therapy shown to protect patients from a harmful allergic and inflammatory immune response. Around 94% of severe food allergies are caused by IgE-mediated reactions.1

Current anti-IgE treatment for food allergy involves injections every 2 to 4 weeks, which can be a significant burden, particularly since most patients are children. Ozureprubart's clinical profile offers the potential for less frequent dosing of every 12 weeks, supporting improved compliance and patient outcomes, as well as providing a new option to approximately 25% of patients currently ineligible for existing therapy. Ozureprubart complements GSK's extensive commercial footprint and prescriber base in allergy.

Data from the phase IIb trial (prestIgE) assessing use of ozureprubart as monotherapy is expected in 2027, with phase III trials to be focused on both at-risk adult and paediatric populations.

Kaivan Khavandi, SVP, R&D Head Respiratory, Immunology & Inflammation, and Head of GSK Translational & Development Sciences, GSK said: "Ozureprubart is a promising asset that complements our expanding RI&I pipeline. Food allergies continue to place a heavy burden on patients and their families, and we are committed to progressing this potential best-in-class monoclonal antibody to deliver longer-lasting protection."

Financial considerations

The total cash consideration for this acquisition amounts to an approximate aggregate equity value of $2.2 billion. Net of cash acquired, GSK's upfront investment is approximately $1.9 billion.

The transaction gives GSK the global rights to the ozureprubart programme, excluding mainland China, Macau, Taiwan and Hong Kong. GSK will also be responsible for success-based milestone and royalty payments for ozureprubart owed to RAPT's partner, Shanghai Jeyou Pharmaceutical Co., Ltd.

About food allergies

In the US, over 17 million people are diagnosed with food allergies, with more than 1.3 million people suffering severe reactions.2,3,4 Notably, 65% of severe food allergy patients are children and adolescents.1 This results in more than 3 million patient visits each year to hospital and emergency care.5 Disease burden is amplified by the frequency and complexity of allergic reactions, which can escalate to anaphylaxis, emergency care and impact a patient's wellbeing and participation in social activities. Collectively, food allergies cost US families an estimated $33 billion in 2024, underscoring the need for more effective and durable therapies.5

About RAPT Therapeutics

RAPT Therapeutics is a clinical-stage immunology-based biopharmaceutical company focused on discovering, developing and commercializing novel therapies for patients living with inflammatory and immunologic diseases. Utilizing deep and proprietary expertise in immunology, RAPT develops novel molecules that are designed to modulate the critical immune responses underlying these diseases.

About GSK

GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com.

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Cautionary statement regarding forward-looking statements

GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in the "Risk Factors" section in GSK's Annual Report on Form 20-F for 2024, and GSK's Q4 Results for 2025.

Registered in England & Wales:

No. 3888792

Registered Office:

79 New Oxford Street

London

WC1A 1DG

​

References

1. GSK Epi assessment based on MarketScan and Optum claims database

2. Warren CM, Aktas ON, Manalo LJ, Bartell TR, Gupta RS. The epidemiology of multifood allergy in the United States: a population-based study. Ann Allergy Asthma Immunol. 2023;130(5):637-648.e5.

3. US Census Bureau. Age and Sex, American Community Survey, ACS 1-Year Estimates Subject Tables, Table S0101, 2022. Accessed 9 January, 2026. https://data.census.gov/table/ACSST1Y2022.S0101.

4. MarketScan's overall prevalence, and Optum's age-stratified (<18; 18+) and overall prevalence. Severe FA defined as patients with ER/inpatient visit or under specialist care.

5. FARE Food Allergy Facts and Statistics for the US (April 2024).

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorised.

GSK plc

(Registrant)

Date: March 03, 2026

By:/s/ VICTORIA WHYTE

--------------------------

Victoria Whyte

Authorised Signatory for and on

behalf of GSK plc

&#xD;

FAQ

What did GSK (GSK) announce in this Form 6-K?

GSK announced completion of its acquisition of RAPT Therapeutics, a clinical-stage biopharma focused on inflammatory and immunologic diseases, securing global rights to the food-allergy antibody ozureprubart outside greater China as part of its respiratory, immunology and inflammation pipeline strategy.

How much is GSK paying to acquire RAPT Therapeutics?

GSK is paying total cash consideration representing an approximate aggregate equity value of $2.2 billion. Net of cash acquired from RAPT, GSK’s upfront cash investment is about $1.9 billion, with additional success-based milestone and royalty obligations tied to ozureprubart owed to Shanghai Jeyou Pharmaceutical.

What is ozureprubart and what stage of development is it in?

Ozureprubart is a long-acting anti-IgE monoclonal antibody being developed for prophylactic protection against food allergens. It is currently in phase IIb clinical development, with data from the prestIgE monotherapy trial expected in 2027 and phase III trials planned in at-risk adult and paediatric populations.

Why is ozureprubart important for food allergy treatment?

Ozureprubart targets IgE, the driver of about 94% of severe food allergies. Existing anti‑IgE treatments require injections every 2–4 weeks, often for children. Ozureprubart’s profile aims for dosing every 12 weeks and could serve roughly 25% of patients currently ineligible for existing anti‑IgE therapy.

What rights does GSK gain and what regions are excluded?

GSK gains global rights to the ozureprubart programme, strengthening its allergy franchise and RI&I pipeline. The rights exclude mainland China, Macau, Taiwan and Hong Kong, where existing partner Shanghai Jeyou Pharmaceutical retains its position, while GSK assumes related milestone and royalty obligations on ozureprubart.

How large is the food allergy burden described in GSK’s disclosure?

The disclosure notes that in the US over 17 million people have food allergies, with more than 1.3 million suffering severe reactions. Around 65% of severe cases are in children and adolescents, leading to over 3 million hospital and emergency visits yearly and an estimated $33 billion cost to families in 2024.