Structure Therapeutics (NASDAQ: GPCR) shows 16% weight loss in Phase 2 oral GLP-1 trial
Rhea-AI Filing Summary
Structure Therapeutics reported strong Phase 2 obesity data for its once-daily oral GLP‑1 receptor agonist aleniglipron from the ACCESS program. In the ACCESS II trial, placebo‑adjusted mean weight loss at 44 weeks reached 16.3% (39 lbs) at 180 mg and 16.0% (37 lbs) at 240 mg, with no evidence of weight‑loss plateau. An open‑label extension showed continued loss up to 16.2% (40.5 lbs) at 120 mg by week 56. Interim results from a body composition study using a lower 2.5 mg starting dose showed about 6.8% weight loss at a 20‑week median follow‑up and substantially fewer adverse‑event‑related discontinuations versus a 5 mg start. Across more than 625 participants, aleniglipron showed no drug‑induced liver injury, no persistent liver enzyme elevations, and no QTc prolongation. The company has an End‑of‑Phase 2 FDA meeting scheduled in the second quarter of 2026 and expects to start Phase 3 in the second half of 2026.
Positive
- Aleniglipron shows high oral GLP‑1 efficacy, with placebo‑adjusted mean weight loss of 16.3% at 180 mg and 16.0% at 240 mg at 44 weeks, alongside continued loss up to 16.2% at 120 mg by 56 weeks, positioning it as a potentially best‑in‑class oral obesity therapy.
Negative
- None.
Insights
Robust Phase 2 weight loss, clean safety, and clear Phase 3 path make this a meaningfully positive clinical update.
Structure Therapeutics now has multi-study evidence that oral GLP‑1 agonist aleniglipron delivers placebo‑adjusted weight loss of 16.3% at 180 mg over 44 weeks, with continued loss to 56 weeks at 120 mg. That places efficacy in the range described as comparable to injectable GLP‑1 therapies while remaining oral.
Tolerability is a key differentiator. Using a 2.5 mg starting dose and slower titration, interim data show adverse‑event‑related discontinuations of only 2.0% in the open‑label extension and 3.4% in the body composition study, versus higher rates at a 5 mg start. More than 625 participants have been treated with no drug‑induced liver injury, sustained liver enzyme elevations, or QTc issues reported.
From an investment perspective, this looks like a thesis‑relevant milestone: a potentially best‑in‑class oral GLP‑1 with a broad dose range, durable efficacy beyond 36 weeks, and a safety profile suitable for chronic obesity treatment. The scheduled End‑of‑Phase 2 FDA meeting in Q2 2026 and targeted Phase 3 initiation in 2H 2026 define the next major catalysts, with Phase 3 design and execution becoming central to future value.
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Item 7.01 Regulation FD Disclosure.
On March 16, 2026, Structure Therapeutics Inc. (the Company) issued a press release announcing Structure Therapeutics Reports Positive Topline Data from Phase 2 ACCESS II Trial with Once-Daily Oral Small Molecule GLP-1 Receptor Agonist, Aleniglipron. A copy of the press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K.
On March 16, 2026, the Company made available on its website an investor presentation to be shared with investors and others from time to time. A copy of this presentation is being furnished as Exhibit 99.2 to this Current Report on Form 8-K.
The information set forth in this Item 7.01 and in the press release and investor presentation attached hereto as Exhibits 99.1 and 99.2, respectively, is deemed to be “furnished” and shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the Exchange Act), or otherwise subject to the liabilities of that Section. The information set forth in this Item 7.01, including Exhibits 99.1 and 99.2, shall not be deemed incorporated by reference into any filing under the Exchange Act or the Securities Act of 1933, as amended, except to the extent that the Company specifically incorporates it by reference.
Item 8.01 Other Events.
ACCESS II Study - Evaluating higher doses up to 240 mg
ACCESS II is a randomized, double-blind, placebo-controlled, clinical study of aleniglipron that enrolled 85 adult participants living with obesity or overweight (defined as a BMI of greater than 25 kg/m2) with at least one weight-related comorbidity. The 44-week study was designed to evaluate two higher doses of aleniglipron. Participants started at 5 mg of aleniglipron (or placebo) and followed a 4-week titration schedule up to target doses of 120 mg, 180 mg and 240 mg.
As reported in December 2025, at 36 weeks, each of the three dose cohorts in the ACCESS II study met statistical significance compared to placebo. Results from the primary efficacy estimandi at 44 weeks are as follows:
|
Aleniglipron 120 mg |
Aleniglipron 180 mg |
Aleniglipron 240 mg |
Placebo | |
| Mean percent change in body weight at 44 weeks compared to baseline | -13.6 | -15.3 | -15.0 | +1.1 |
| Placebo-adjusted mean percent change in body weight at 44 weeks compared to baseline | -14.7 | -16.3 | -16.0 | - |
| P-value | p<0.0001 | p<0.0001 | p<0.0001 | - |
Aleniglipron demonstrated a tolerability profile consistent with the GLP-1 receptor agonist class following repeated, once-daily dosing of up to 240 mg. As expected for the GLP-1 receptor agonist drug class, the most common AEs were gastrointestinal (GI)-related, and the two most common AEs in the titration phase were nausea and vomiting.
i The primary efficacy estimand represents efficacy had all randomized participants remained on study treatment (with possible dose interruptions and/or dose modifications) for 44 weeks without initiating rescue weight management treatments or surgeries.
Body Composition Study - Evaluating lower 2.5 mg starting dose
Structure Therapeutics is conducting a randomized, placebo-controlled body composition study that enrolled 71 adult participants to assess the effect of aleniglipron (up to 120 mg) on body fat loss over a 40-week evaluation period. Participants in the aleniglipron treatment arm start at a 2.5 mg dose, and titrate up monthly to a target dose of 120 mg.
Data from a pre-specified interim analysis after a median follow-up of 20 weeks demonstrated that starting at a lower dose of 2.5 mg for the first four weeks supported a manageable tolerability profile with meaningful improvements in AE-related discontinuations compared to what was observed at a starting titration dose of 5 mg in the ACCESS and ACCESS II studies. Additionally, at a 2.5 mg start and after a median follow up of 20 weeks (~ 30 mg titration step) aleniglipron showed a 6.8% weight loss.
ACCESS Open-Label Extension Study - Following randomized 36-week period, evaluating lower 2.5mg starting dose in the placebo crossover arm and efficacy beyond 36 weeks in previously treated participants
Following the 36-week randomized controlled portion of the Phase 2b ACCESS study, participants were provided an option to roll over into the OLE and receive aleniglipron for an additional 36 weeks. A pre-specified interim analysis after a median follow-up of 20 weeks (a total of 56 weeks) demonstrated continuing weight loss in all dose cohorts, with no evidence of weight loss plateau. Patients who received aleniglipron in the three active dose arms during the initial double-blind portion were titrated to a maximum dose of 120mg during the OLE. These patients achieved continued weight loss of up to 16.2% from baseline out to 56 weeks.
Participants who received placebo in the initial double-blind portion transitioned to aleniglipron at a starting dose of 2.5 mg and titrated monthly to a target dose of 120 mg. Initial data from this group of participants after a median follow-up of 20 weeks are consistent with the findings from the body composition study, showing that starting at a 2.5 mg and titrating slowly was associated with a meaningful improvement in key tolerability markers compared to what was observed in the starting 5 mg titration dose in ACCESS and ACCESS II studies.
Aleniglipron Safety
Aleniglipron demonstrated a compelling safety profile in more than 625 participants across all studies. Importantly, to date, there have been no cases of drug-induced liver injury, no persistent liver enzyme elevations, and no QTc prolongation across all aleniglipron studies.
Phase 3 Preparation
Data from ACCESS, ACCESS II, body composition, and the ACCESS OLE studies continue to provide a strong foundation to advance aleniglipron into Phase 3 clinical development. The Company has a Type B End-of-Phase 2 meeting with the United States Food and Drug Administration (FDA) scheduled in the second quarter of 2026 to finalize the Phase 3 design, which is currently designed with a starting titration dose of 2.5 mg with the intent to evaluate multiple doses up to 240 mg. Structure Therapeutics anticipates initiating the Phase 3 program in the second half of 2026.
Forward-Looking Statements
This Current Report on Form 8-K contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including, without limitation, statements concerning: the Company’s future plans and prospects; any expectations regarding the potential benefits, tolerability and safety profile, accessibility, scalability, combinability, capability, efficacy, convenience, expected effects and future application of aleniglipron; the belief that data to date from the ACCESS, ACCESS II, body composition, and the ACCESS OLE studies support and inform advancement of the Phase 3 clinical development of aleniglipron; the belief that aleniglipron represents a potentially best-in-class oral small molecule GLP1 and may be a backbone therapy for obesity; the expected timing for the meeting with the FDA to finalize the Phase 3 trial design and the Phase 3 program initiation of aleniglipron; any presumption that topline, interim or preliminary data will be representative of final data or data in later clinical trials; and the belief that the results from ACCESS program represent a promising advance in the therapeutic landscape and brings the Company closer to a future where people living with obesity have multiple, accessible options to address their needs. In addition, when or if used in this Current Report on Form 8-K, the words and phrases “anticipated,” “believe,” “expect,” “may,” “on track,” “plan,” “potential,” “suggests,” “to be,” “to begin,” “will,” and similar expressions and their variants, as they relate to the Company may identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Although the Company believes the expectations reflected in such forward-looking statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. Readers are cautioned that actual results, levels of activity, safety, performance or events and circumstances could differ materially from those expressed or implied in the Company’s forward-looking statements due to a variety of risks and uncertainties, which include, without limitation: risks and uncertainties related to topline results that the Company reports are based on preliminary analysis of key efficacy and safety data, and such data may change following a more comprehensive review of the data related to the clinical trial and such topline data may not accurately reflect the complete results of a clinical trial, the preliminary nature of the results due to the length of the study and sample size and the results from earlier clinical studies not necessarily being predictive of future results; the reported efficacy and safety data is not based on head-to-head studies and therefore may not be comparable to other oral or injectable GLP-1’s due to differences in study design, participant characteristics and how companies quantify or qualify eligibility criteria, and how results are recorded; aleniglipron is in clinical development and even if the Company is successful in obtaining regulatory approval, there can be no guarantees that aleniglipron will outperform other therapies in terms of efficacy or tolerability; potential delays in the commencement, enrollment and completion of the Company’s planned Phase 3 clinical program and other clinical studies, whether as a result of feedback from the End-of-Phase 2 meeting with FDA or otherwise; the Company’s ability to advance aleniglipron, ACCG-2671, ACCG-3535, ANPA-0073, LTSE-2578, and its other therapeutic candidates, obtain regulatory approval of, and ultimately commercialize the Company’s therapeutic candidates; competitive products or approaches limiting the commercial value of the Company’s product candidates; the timing and results of preclinical and clinical studies; the Company’s ability to fund development activities and achieve development goals; the Company's reliance on third parties, including clinical research organizations, manufacturers, suppliers and collaborators, over which it may not always have full control; general geopolitical and macroeconomic conditions, including as a result of tariffs and various global conflicts; the Company’s ability to protect its intellectual property; and other risks and uncertainties described in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s latest Annual Report on Form 10-K and future reports the Company may file with the SEC from time to time. All forward-looking statements contained in this Current Report on Form 8-K speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
|
Exhibit No. |
Description | |
| 99.1 | Press Release, dated March 16, 2026. | |
| 99.2 | Investor Presentation, dated March 16, 2026. | |
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
| Structure Therapeutics Inc. | ||
| Date: March 16, 2026 | By: | /s/ Raymond Stevens |
| Raymond Stevens, Ph.D. | ||
| Chief Executive Officer | ||
Exhibit 99.1
Structure Therapeutics Reports Positive Topline Data from Phase 2 ACCESS II Trial with
Once-Daily Oral Small Molecule GLP-1 Receptor Agonist, Aleniglipron
Placebo-adjusted mean weight loss of 16.3% (39 lbs) at 180 mg and 16.0% (37 lbs) at 240 mg
at 44 weeks with no evidence of weight loss plateau in ACCESS II, demonstrating
highest efficacy among oral GLP-1RAs and comparable efficacy to injectable GLP1-RAs
Continued weight loss up to 16.2% (40.5 lbs) observed with 120 mg dose in the ACCESS Open
Label Extension (OLE) study at 56 weeks, with no evidence of weight loss plateau
Updated interim data from ACCESS OLE and Body Composition studies continue to support
improved tolerability and low (2.0 – 3.4%) study drug discontinuations due to adverse events
with the lower 2.5 mg starting dose
End-of-Phase 2 meeting with FDA scheduled in the second quarter of 2026;
Phase 3 initiation remains on track for 2H 2026
Company to host conference call today at 8:30 a.m. Eastern Time
SAN FRANCISCO, March 16, 2026– Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic diseases, with a focus on obesity, today announced positive topline data from the ACCESS clinical program of aleniglipron for the treatment of people living with obesity and/or overweight with at least one weight related co-morbidity. This includes 44-week data from the Phase 2 ACCESS II study and interim data from the ongoing body composition study and the ACCESS open label extension (OLE) study. Aleniglipron is an investigational orally-available, once-daily, nonpeptide small molecule agonist of the glucagon-like-peptide-1 (GLP-1) receptor designed to address patient needs and accessibility.
In the Phase 2 ACCESS II study, aleniglipron achieved clinically meaningful and statistically significant placebo-adjusted mean weight loss of 16.3% (39 lbs; p<0.0001) at the 180 mg dose and 16.0% (37 lbs; p<0.0001) at the 240 mg dose at 44 weeks. In the ACCESS OLE study, aleniglipron achieved continued weight loss from 36 weeks, up to 16.2% (40.5 lbs) with 120 mg at 56 weeks. Both studies continue to demonstrate no evidence of weight loss plateau.
Aleniglipron continues to demonstrate a tolerability profile that is consistent with the GLP-1 receptor agonist class and a compelling safety profile with no off-target events. In ACCESS II, across all active arms in participants who reached doses 120 mg or higher from 28 to 44 weeks, there was only one (3.7%) adverse event (AE)-related treatment discontinuation.
With a median follow-up of 20 weeks, the tolerability data as of the February 20, 2026 cutoff date from the interim analyses of the OLE and the body composition studies provide further support that the use of 2.5 mg as a lower starting dose very meaningfully reduces the rate of AE-related discontinuations during the titration phase. In the OLE, with a median follow-up of 20 weeks, there was an overall AE-related discontinuation rate of 2%. In the body composition study, with a median follow-up of 20 weeks, there was an overall AE-related discontinuation rate of 3.4% in the aleniglipron arm.
Together, these positive efficacy, tolerability and safety findings continue to support the advancement of aleniglipron into Phase 3 clinical development, with initiation anticipated in the second half of 2026.
“The totality of efficacy and tolerability data across the Phase 2 program continue to demonstrate clear differentiation of aleniglipron, with the highest weight loss observed for an oral GLP-1RA to date and a safety profile appropriate for chronic use in a disease that impacts millions of people,” said Raymond Stevens, Ph.D., CEO of Structure Therapeutics. “The consistent weight loss observed across multiple studies to date reaffirms aleniglipron’s potential to be a best-in-class oral GLP-1, with injectable-like efficacy that could become a backbone oral small molecule therapy for obesity.”
“The weight-lowering data from these ACCESS studies, without apparent plateau by Week 56, are encouraging—particularly the weight loss from baseline of up to -15.3% vs +1.1% at 180 mg in ACCESS II that hopefully will be confirmed in larger, longer-term studies,” said Julio Rosenstock, MD, Chair of the ACCESS program Steering Committee and Clinical Professor of Medicine, Univ. of Texas, Southwestern Medical Center. “In addition, the tolerability profile of starting at a low dose of 2.5 mg and the slow titration, positions the program ready for Phase 3 studies.”
ACCESS II Study - Evaluating higher doses up to 240 mg
ACCESS II is a randomized, double-blind, placebo-controlled, clinical study of aleniglipron that enrolled 85 adult participants living with obesity or overweight (defined as a BMI of greater than 25 kg/m2) with at least one weight-related comorbidity. The 44-week study was designed to evaluate two higher doses of aleniglipron. Participants started at 5 mg of aleniglipron (or placebo) and followed a 4-week titration schedule up to target doses of 120 mg, 180 mg and 240 mg.
As reported in December 2025, at 36 weeks, each of the three dose cohorts in the ACCESS II study met statistical significance compared to placebo. Results from the primary efficacy estimandi at 44 weeks are as follows:
|
Aleniglipron 120 mg |
Aleniglipron 180 mg |
Aleniglipron 240 mg |
Placebo | |
| Mean percent change in body weight at 44 weeks compared to baseline | -13.6 | -15.3 | -15.0 | +1.1 |
| Placebo-adjusted mean percent change in body weight at 44 weeks compared to baseline | -14.7 | -16.3 | -16.0 | - |
| P-value | p<0.0001 | p<0.0001 | p<0.0001 | - |
Aleniglipron demonstrated a tolerability profile consistent with the GLP-1 receptor agonist class following repeated, once-daily dosing of up to 240 mg. As expected for the GLP-1 receptor agonist drug class, the most common AEs were gastrointestinal (GI)-related, and the two most common AEs in the titration phase were nausea and vomiting.
Body Composition Study - Evaluating lower 2.5 mg starting dose
Structure Therapeutics is conducting a randomized, placebo-controlled body composition study that enrolled 71 adult participants to assess the effect of aleniglipron (up to 120 mg) on body fat loss over a 40-week evaluation period. Participants in the aleniglipron treatment arm start at a 2.5 mg dose, and titrate up monthly to a target dose of 120 mg.
Data from a pre-specified interim analysis after a median follow-up of 20 weeks demonstrated that starting at a lower dose of 2.5 mg for the first four weeks supported a manageable tolerability profile with meaningful improvements in AE-related discontinuations compared to what was observed at a starting titration dose of 5 mg in the ACCESS and ACCESS II studies. Additionally, at a 2.5 mg start and after a median follow up of 20 weeks (~ 30 mg titration step) aleniglipron showed a 6.8% weight loss.
ACCESS Open-Label Extension Study - Following randomized 36-week period, evaluating lower 2.5mg starting dose in the placebo crossover arm and efficacy beyond 36 weeks in previously treated participants
Following the 36-week randomized controlled portion of the Phase 2b ACCESS study, participants were provided an option to roll over into the OLE and receive aleniglipron for an additional 36 weeks. A pre-specified interim analysis after a median follow-up of 20 weeks (a total of 56 weeks) demonstrated continuing weight loss in all dose cohorts, with no evidence of weight loss plateau. Patients who received aleniglipron in the three active dose arms during the initial double-blind portion were titrated to a maximum dose of 120mg during the OLE. These patients achieved continued weight loss of up to 16.2% from baseline out to 56 weeks.
Participants who received placebo in the initial double-blind portion transitioned to aleniglipron at a starting dose of 2.5 mg and titrated monthly to a target dose of 120 mg. Initial data from this group of participants after a median follow-up of 20 weeks are consistent with the findings from the body composition study, showing that starting at a 2.5 mg and titrating slowly was associated with a meaningful improvement in key tolerability markers compared to what was observed in the starting 5 mg titration dose in ACCESS and ACCESS II studies.
Aleniglipron Safety
Aleniglipron demonstrated a compelling safety profile in more than 625 participants across all studies. Importantly, to date, there have been no cases of drug-induced liver injury, no persistent liver enzyme elevations, and no QTc prolongation across all aleniglipron studies.
Phase 3 Preparation
Data from ACCESS, ACCESS II, body composition, and the ACCESS OLE studies continue to provide a strong foundation to advance aleniglipron into Phase 3 clinical development. The Company has a Type B End-of-Phase 2 meeting with the United States Food and Drug Administration (FDA) scheduled in the second quarter of 2026 to finalize the Phase 3 design, which is currently designed with a starting titration dose of 2.5 mg with the intent to evaluate multiple doses up to 240 mg. Structure Therapeutics anticipates initiating the Phase 3 program in the second half of 2026.
Conference Call and Webcast Information
Structure Therapeutics will host a conference call and webcast today, March 16, 2026 at 8:30 a.m. Eastern Time. A live webcast of the call will be available on the Investor Relations page of Structure Therapeutics’ website at https://ir.structuretx.com/events-presentations/events. To access the call by phone, participants should visit this link to receive dial-in details. The webcast will be made available for replay on Structure Therapeutics’ website beginning approximately two hours after the live event. The replay of the webcast will be available for 90 days.
About Aleniglipron and Structure Therapeutics’ Oral Metabolic Franchise
Aleniglipron (GSBR-1290) is an investigational orally-available, small molecule agonist of the glucagon-like-peptide-1 (GLP-1) receptor, a validated drug target for the treatment of obesity and type 2 diabetes mellitus (T2DM). Through Structure Therapeutics’ structure-based drug discovery platform, aleniglipron was designed to be a biased G Protein-Coupled Receptor (GPCR) agonist, which selectively activates the G-protein signaling pathway. Beyond aleniglipron, Structure Therapeutics is developing next generation oral small molecules including amylin receptor agonists, and other combination GLP-1 receptor agonists candidates such as glucose-dependent insulinotropic polypeptide (GIP), glucagon and apelin oral small molecules.
About Structure Therapeutics
Structure Therapeutics is a science-driven clinical-stage biopharmaceutical company focused on discovering and developing innovative oral small molecule treatments for chronic metabolic conditions with significant unmet medical needs. Utilizing its next generation structure-based drug discovery platform, the Company has established a robust GPCR-targeted pipeline, featuring multiple wholly-owned proprietary clinical-stage oral small molecule compounds designed to surpass the scalability limitations of traditional biologic and peptide therapies and be accessible to more people living with obesity around the world. For additional information, please visit www.structuretx.com.
Forward Looking Statements
This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including, without limitation, statements concerning: the Company’s future plans and prospects; any expectations regarding the potential benefits, tolerability and safety profile, accessibility, scalability, combinability, capability, efficacy, convenience, expected effects and future application of aleniglipron; the belief that data to date from the ACCESS, ACCESS II, body composition, and the ACCESS OLE studies support and inform advancement of the Phase 3 clinical development of aleniglipron; the belief that aleniglipron represents a potentially best-in-class oral small molecule GLP1 and may be a backbone therapy for obesity; the expected timing for the meeting with the FDA to finalize the Phase 3 trial design and the Phase 3 program initiation of aleniglipron; any presumption that topline, interim or preliminary data will be representative of final data or data in later clinical trials; and the belief that the results from ACCESS program represent a promising advance in the therapeutic landscape and brings the Company closer to a future where people living with obesity have multiple, accessible options to address their needs. In addition, when or if used in this press release, the words and phrases “anticipated,” “believe,” “expect,” “may,” “on track,” “plan,” “potential,” “suggests,” “to be,” “to begin,” “will,” and similar expressions and their variants, as they relate to the Company may identify forward-looking statements. Forward-looking statements are neither historical facts nor assurances of future performance. Although the Company believes the expectations reflected in such forward-looking statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. Readers are cautioned that actual results, levels of activity, safety, performance or events and circumstances could differ materially from those expressed or implied in the Company’s forward-looking statements due to a variety of risks and uncertainties, which include, without limitation: risks and uncertainties related to topline results that the Company reports are based on preliminary analysis of key efficacy and safety data, and such data may change following a more comprehensive review of the data related to the clinical trial and such topline data may not accurately reflect the complete results of a clinical trial, the preliminary nature of the results due to the length of the study and sample size and the results from earlier clinical studies not necessarily being predictive of future results; the reported efficacy and safety data is not based on head-to-head studies and therefore may not be comparable to other oral or injectable GLP-1’s due to differences in study design, participant characteristics and how companies quantify or qualify eligibility criteria, and how results are recorded; aleniglipron is in clinical development and even if the Company is successful in obtaining regulatory approval, there can be no guarantees that aleniglipron will outperform other therapies in terms of efficacy or tolerability; potential delays in the commencement, enrollment and completion of the Company’s planned Phase 3 clinical program and other clinical studies, whether as a result of feedback from the End-of-Phase 2 meeting with FDA or otherwise; the Company’s ability to advance aleniglipron, ACCG-2671, ACCG-3535, ANPA-0073, LTSE-2578, and its other therapeutic candidates, obtain regulatory approval of, and ultimately commercialize the Company’s therapeutic candidates; competitive products or approaches limiting the commercial value of the Company’s product candidates; the timing and results of preclinical and clinical studies; the Company’s ability to fund development activities and achieve development goals; the Company's reliance on third parties, including clinical research organizations, manufacturers, suppliers and collaborators, over which it may not always have full control; general geopolitical and macroeconomic conditions, including as a result of tariffs and various global conflicts; the Company’s ability to protect its intellectual property; and other risks and uncertainties described in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s latest Annual Report on Form 10-K and future reports the Company may file with the SEC from time to time. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.
Investors:
Corey Davis, Ph.D.
LifeSci Advisors, LLC
212-915-2577
cdavis@lifesciadvisors.com
Jun Yoon
Structure Therapeutics Inc.
ir@structuretx.com
Media:
Dan Budwick
1AB
Dan@1abmedia.com
#####
i The primary efficacy estimand represents efficacy had all randomized participants remained on study treatment (with possible dose interruptions and/or dose modifications) for 44 weeks without initiating rescue weight management treatments or surgeries.
Exhibit 99.2
1 March 16, 2026 Aleniglipron Topline ACCESS II and Supplementary Studies
2 This presentation contains “forward - looking statements” within the meaning of the “safe harbor” provisions of the Private Securi ties Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be deemed forward - looking statements, including, without limitation, statements concerning: the estimated addressable patient population, market, and revenue opportunity for aleniglipron; any expectations regarding the potential benefits, tolerability and safety profile, accessibility, dose flexibility, scalability, co st, combinability, capability, efficacy, convenience, expected effects, and future application of aleniglipron; the Company’s belief that data to date from the ACCESS, ACCESS II, Body Composition and Open Label Extension st udi es provide a strong foundation for the Phase 3 clinical development of aleniglipron; the belief that all key questions have been answered by the studies to date; the belief that aleniglipron represents a potentiall y b est - in - class oral small molecule GLP - 1 and may be a backbone therapy for obesity; the expected size and design for the Phase 3 trial; any presumption that topline, interim or preliminary data will be representative of fi nal data or data in later clinical trials; the belief that the Company is well positioned to lead with a differentiated and highly scalable pipeline of oral small molecule medicines designed to address the significant unmet needs in obesity and related metabolic diseases; the belief that there is potential for expansion beyond obesity, including chronic kidney disease, metabolic associated steatohepatitis, heart failure, sleep apnea, type 2 diabetes mel litus, osteoarthritis, and addiction; plans to conduct FDA regulatory interactions; the expected timing of topline data readouts from the Open Label Extension, ACCESS II Extension, Body Composition, SWITCH and T2DM studies ; t he planned initiation of the ACCG - 3535 Phase 1 study and the timing thereof; the expected timing of study results from the Phase 1 ACCG - 2671 study; and the Company’s future plans and prospects. In addition, wh en or if used, the words and phrases “believe,” “may,” “potential,” “to be,” “will,” and similar expressions and their variants, as they relate to the Company may identify forward - looking statements. Forward - looking s tatements are neither historical facts nor assurances of future performance. Although the Company believes the expectations reflected in such forward - looking statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. Readers are cautioned that actual results, levels of activity, safety, performance or events and circumstances could differ materially from those expressed or imp lied in the Company’s forward - looking statements due to a variety of risks and uncertainties, which include, without limitation: risks and uncertainties related to topline results that the Company reports is based on pr eli minary analysis of key efficacy and safety data, and such data may change following a more comprehensive review of the data related to the clinical trial and such topline data may not accurately reflect the complete res ults of a clinical trial, the preliminary nature of the results due to the length of the study and sample size and results from earlier clinical studies not necessarily being predictive of future results; the reported effica cy and safety data is not based on head - to - head studies and therefore may not be comparable to other oral or injectable GLP - 1's due to differences in study design, participant characteristics and how companies quantify or qualify eligibility criteria, and how results are recorded; aleniglipron is in clinical development and even if the Company is successful in obtaining regulatory approval, there can be no guarantees that aleniglipron will outperform o the r therapies in terms of efficacy or tolerability; potential delays in the commencement, enrollment and completion of the Company’s planned Phase 3 clinical program and other clinical studies, whether as a result of feedback fro m the End - of - Phase 2 meeting with FDA or otherwise; the Company’s ability to advance aleniglipron, ACCG - 2671, ACCG - 3535, ANPA - 0073, LTSE - 2578, and its other therapeutic candidates, obtain regulatory approval of, a nd ultimately commercialize the Company’s therapeutic candidates; competitive products or approaches limiting the commercial value of the Company’s product candidates; the timing and results of preclinic al and clinical studies; the Company’s ability to fund development activities and achieve development goals; the Company's reliance on third parties, including clinical research organizations, manufacturers, supplie rs and collaborators, over which it may not always have full control; general geopolitical and macroeconomic conditions, including as a result of tariffs and various global conflicts; the Company’s ability to protect its in tellectual property; and other risks and uncertainties described in the Company’s filings with the Securities and Exchange Commission (SEC), including the Company’s latest Annual Report on Form 10 - K and future reports the Compa ny may file with the SEC from time to time. All forward - looking statements contained in this presentation speak only as of the date on which they were made and are based on management’s assumptions and estimate s a s of such date. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law. This presentation discusses product candidates that are under clinical study and which have not yet been approved for marketi ng by the U.S. Food and Drug Administration. No representation is made as to the safety or effectiveness of these product candidates for the use for which such product candidates are being studied. This presentation may incorporate publicly - available third - party data that we have not independently verified. There are risks i nherent in conducting cross - trial comparisons and the results should be interpreted with caution. The presentation of such third - party data does not represent a head - to - head comparison of how our product candidates performed a gainst any other third - party product candidate or study. Rather, such third - party data has been pulled by us from publicly - available sources for supplemental informational purposes, only. We caution you that any compari sons against third - party data set forth herein should not be viewed as a side - by - side comparison, and you should not rely on the completeness or accuracy of our presentation of the results of any third - party drug c andidate in these slides, due to differences in study design, how other companies quantify or qualify eligibility criteria, and how results are recorded, among other distinguishing factors and uncertainties. Because we may be unaware of or may not adequately present various distinguishing factors and uncertainties, the comparisons set forth herein may not properly present such third - party data, which may differ materially from the data as pr esented here. Investors are encouraged to independently review third party data and should not rely on our presentation of such data as a single measure to evaluate our business. Structure Therapeutics,” the Structure Therapeutics logo and other trademarks, trade names or service marks of the Company ap pea ring in this presentation are the property of the Company. All other trademarks, trade names and service marks appearing in this presentation are the property of their respective owners. Solely for convenience, t he trademarks and trade names in this presentation may be referred to without the ® and symbols, but such references should not be construed as any indicator that their respective owners will not assert their righ ts thereto. Forward - Looking Statements
3 Closing Raymond Stevens Interim Data from ACCESS OLE and Body Composition Studies Blai Coll Topline 44 - week Data from ACCESS II Study Blai Coll, M.D., Ph.D, Chief Medical Officer Today’s Update Introduction Raymond Stevens, Ph.D, Chief Executive Officer 1 2 3 4 Q&A Blai Coll, Raymond Stevens Jun Yoon, Chief Financial Officer 5 ORAL SMALL MOLECULE GLP - 1 Receptor Agonist ALENIGLIPRON
4 March 2026 ACCESS OLE continuing at 120 mg: 56 week body weight loss: o Up to 16.2%; n o evidence of plateauing o 2% AE - related treatment discontinuations ACCESS II: 44 week p lacebo - adjusted mean weight loss: o 16.3% at 180 mg and 16.0% at 240 mg; no evidence of plateauing For those participants who achieved re - randomization: o 3.7% AE - related treatment discontinuations ACCESS OLE & Body Composition at 2.5 mg start: Interim timepoint (median of 20 weeks): o Improvement in tolerability starting at 2.5 mg compared to 5 mg o 2% and 3.7% AE - related treatment discontinuations, respectively >625 participants treated across all studies up to 56 weeks at 120 mg and 44 weeks at 240 mg: o No events of drug induced liver injury o No off - target safety signals across all dose levels o No events of QTc prolongation Aleniglipron Obesity Data Summary Differentiated Selective Oral Small Molecule GLP - 1 Receptor Agonist (GLP - 1 RA) December 2025 ACCESS: 36 week placebo - adjusted mean weight loss: o Up to 11.3% at 120 mg; no evidence of plateauing o Overall 10.4% AE - related treatment discontinuations ACCESS II: 36 week p lacebo - adjusted mean weight loss: o Up to 15.3% at 180 and 240 mg; no evidence of plateauing For those participants who achieved re - randomization: o No AE - related treatment discontinuations up to 240 mg dose ACCESS OLE & Body Composition at 2.5 mg start: Interim timepoint (median of 10 weeks): o Improvement in tolerability starting at 2.5 mg compared to 5 mg o No discontinuations >500 participants treated across all studies up to 44 weeks: o No events of drug induced liver injury o No off - target safety signals across all dose levels o No events of QTc prolongation OLE = open label extension
5 Aleniglipron Patient Journey to Chronic Weight Management Key Questions 44 weeks 120 mg 180 mg 240 mg ACCESS OLE Interim – Week 36 to 56 2.5 mg start 3 0 mg 45/90/120mg 120 mg Body Composition Interim through Week 20 2.5 mg start to 30 mg March 2026 1. What is the top dose? 2. Does weight loss continue beyond 36 weeks? 3 . Is there weight loss at low doses? 5. Does aleniglipron maintain absence of off - target safety? 4 . Does tolerability improve starting at 2.5 mg?
6 Aleniglipron Patient Journey to Chronic Weight Management 44 weeks 120 mg 180 mg 240 mg 1. What is the top dose? 2. Does weight loss continue beyond 36 weeks?
7 ACCESS II Focused on 180 mg and 240 mg Doses at 44 Weeks 240 mg 180 mg Weeks 0 20 24 28 32 36 Baseline 180 mg 120 mg 90 mg 60 mg 30 mg 15 mg 5 mg Study Details N= 73 Participants with: • Body mass index (BMI) ≥ 30 kg/m 2 or • BMI ≥ 27 kg/m 2 with ≥ 1 weight - related comorbidity Number of sites: 10 Clinicaltrials.gov ID: NCT06703021 ; 120 mg 8 - Week Extension 44 Re - Randomization N=61 Titration Phase 180 mg and 240 mg Dose Phase Pooled Placebo N=12 First Randomization Interim Dec 2025 Topline Mar 2026 Key Secondary Endpoints • % of participants who achieve ≥ 5%, ≥ 10% and ≥ 15% reduction in body weight at week 44 • Safety and tolerability profile Primary Endpoint • % change in body weight at week 44 compared to baseline (active vs. placebo) • Statistical analysis based on the Primary Efficacy Estimand* *T he primary efficacy estimand represents efficacy had all randomized participants remained on study treatment (with possible d ose interruptions and/or dose modifications) for 44 weeks without initiating rescue weight management treatments or surgeries.
8 Placebo N=12 Aleniglipron Overall N=61 Characteristics Mean (SD) or N (%) 51.8 (12.9) 49.8 (14.5) Age, years 8 (66.7) 38 (62.3) Sex, female 104.3 (12.38) 116.2 (31.9) Weight, kg 36.8 (5.1) 39.9 (8.4) Body mass index, kg/m 2 5.4 (0.36) 5.6 (0.35) HbA1c, % 122.6 (11.4) 122.2 (12.2) Systolic Blood Pressure, mmHg 82.3 (9.2) 78.7 (7.0) Diastolic Blood Pressure, mmHg 3 (25.0) 15 (24.6) Ethnicity (Hispanic or Latino) Baseline Demographics and Characteristics
9 Aleniglipron Achieved Greater Weight Loss at 44 weeks Least - Squares Mean (LSM) Change (%) Body Weight *LS Mean Difference based on Primary Efficacy Estimand and MMRM model 37 lbs 39 lbs 33 lbs - 14.7% ( - 20.3 to - 9.1) P<0.0001 - 16.3% ( - 21.7 to - 10.9) P<0.0001 - 16.0% ( - 21.5 to - 10.6) P<0.0001 LSM (95% CI) 120 mg 180 mg 240 mg Placebo Placebo - adjusted Mean Body Weight Loss (%) • No evidence of weight loss plateau across all dose ranges • 16.3%* placebo - adjusted mean weight loss with 180 mg at 44 weeks 0.4 lbs Interim Dec 2025 Topline Mar 2026
10 Aleniglipron Achieved Secondary Efficacy Endpoints • 180 mg dose cohort: o 9 3% achieved ≥ 10% body weight reduction o 61% achieved ≥ 15% body weight reduction o 32% of participants achieved ≥ 20% body weight reduction based on additional exploratory analysis
11 Tolerability in Re - Randomized Participants over Weeks 28 - 44 * Post Re - Randomization • Higher vomiting in the 240 mg cohort compared to 120 mg and 180 mg • 3.7% (1/27) AE - related treatment discontinuation across all doses ** *O ne participant in the 180 mg dose discontinued due to an AE on week 42 **One vomiting event previously entered in week 32 was recategorized during data base lock
12 Tolerability Profile in the ACCESS II – post re - randomization Post Re - Randomization (Weeks 28 – 44)* Placebo N=10 Aleniglipron 240 mg N=9 Aleniglipron 180 mg N=10 Aleniglipron 120 mg N=8 N (%) Reporting at least one event 3 (30) 5 (55.6) 5 (50) 2 (25) Any TEAE 0 0 0 0 Any SAE 0 0 1 (10) 0 Any TEAE leading to Treatment Discontinuation 6 (60) 7 (77.8) 7 (70) 8 (100) Participants completing study at target dose ** 0 3 (33) 2 (20) 0 Nausea 0 4 (44.4) 4 (44.4) 0 1 (10) 1 (10) 0 1 (12.5) 1 (12.5) 0 Vomiting (Overall) Mild and Moderate Severe 0 0 0 0 Diarrhea 0 0 0 0 Constipation 3.7% (1/27) AE - related treatment discontinuation across all doses in re - randomized participants *Data from baseline to Week 28 presented in December 2025. E-diary reporting is associated with an increase in the number of reported events. **Actual maintenance dose for at least 80% of the dosing period during Week 32 - Week 44 of treatment post re - randomization.
13 Summary of Topline Data from ACCESS II • Efficacy o Potential best - in - class efficacy for an oral GLP - 1RA with 180 mg dose achieving 16.3% weight loss (placebo - adjusted) at 44 weeks • Tolerability o Low number (3.7%) of AEs leading to discontinuations across all doses in re - randomized participants o Incidence of GI events at 180 mg comparable to 120 mg 44 weeks 120 mg 180 mg 240 mg 1. What is the top dose? 2. Does weight loss continue beyond 36 weeks?
14 Aleniglipron Patient Journey to Chronic Weight Management ACCESS OLE Interim – Week 36 to 56 2.5 mg start 3 0 mg 45/90/120mg 120 mg 2. Does weight loss continue beyond 36 weeks? 4. Does tolerability improve starting at 2.5 mg?
15 120 mg ACCESS OLE Beyond 36 weeks and 2.5 mg Starting Dose Baseline Titration Phase (every 4 weeks) Maintenance Phase (at target dose) ACCESS Primary Endpoint 30 15 5 N=45 N=65 N=64 N=56 *OLE is ongoing up to 72 weeks 45 mg 90 mg 60 30 15 5 120 mg 60 30 15 5 90 Pooled Placebo 75 120 mg 90 60 30 20 10 5 2.5 120 mg 120 mg 60 90 End of OLE Pre - specified interim analysis with a median follow up of ~20 weeks Study Details N=151 Participants who: • Completed the double blind treatment period from ACCESS and • Signed informed consent to continue on the ACCESS OLE Number of sites: 36 ACCESS Open Label Extension Study Objectives • Long - term safety • Durability and maintenance of weight loss from Week 0 to 72 (full study), and Week 36 to 72 (OLE portion) *Study ongoing and interim data from a pre - specified analysis. Interim data as of February 20th, 2026 Double Blind Treatment Period N=28 N=42 N=43 N=38 Weeks 0 20 36 44 56 72 ACCESS OLE* Study Ongoing Reported in Dec 2025
16 Aleniglipron Continued to Demonstrate Weight Loss Beyond 36 weeks *Study ongoing and interim data as of February 20 th , 2026. No statistical model applied Descriptive Body Weight Reduction ACCESS OLE Period Interim: Week 36 – 56 ACCESS Double Blind (DB) Treatment Period Baseline to Week 36 Mean Change (%) Body Weight Placebo Cross - Over 2.5 mg 5 mg 10 mg 20 mg 30 mg ACCESS OLE* (Interim: Weeks 36 to 56) 45 mg OLE Starting Dose 45 mg 75 mg 90 mg 120 mg 90 mg OLE Starting Dose 90 mg 120 mg 120 mg OLE Starting Dose 120 mg 120 mg
17 Improved Tolerability with the 2.5 mg Starting Dose • Occasional events of nausea reported and no events of vomiting • No study drug discontinuations in participants starting the OLE at 2.5 mg of aleniglipron after a median follow up of 20 weeks Study ongoing Study ongoing Nausea - Aleniglipron (N=38) Vomiting - Aleniglipron (N=38) Placebo - crossover Participants
18 Tolerability Profile in ACCESS OLE: Weeks 36 to 56 Study Ongoing Aleniglipron in the OLE (median follow up of 20 weeks after finalization of the double - blind treatment period) N (%) Reporting at least one event Placebo - cross over * 120 mg 90 mg 45 mg Arm in the double - blind treatment period 2.5 mg 120 mg 120 mg 60 mg Starting dose in OLE 38 43 42 28 Sample size 31 (81.6) 23 (53.5) 27 (64.3) 16 (57.1) Any TEAE 0 1 (2.3) 2 (4.8) 0 Any TEAE leading to discontinuation of treatment 15 (39.9) 5 (11.6) 5 (11.9) 5 (17.9) Nausea 0 7 (16.3) 5 (11.9) 2 (7.1) Vomiting 10 (26.3) 3 (7) 7 (16.7) 2 (7.1) Diarrhea 12 (31.6) 1 (2.3) 6 (14.3) 3 (10.7) Constipation • 2.0 % (3/151) AE - related treatment discontinuation across all arms *Some GI events may be optimized by following dietary/healthy lifestyle during 36w before starting on aleniglipron. Use of da ily e - diary to capture participant symptomatology.
19 Summary of Interim Data of ACCESS OLE • Efficacy o Clinically relevant and additional body weight loss beyond 36 weeks, achieving up to 16.2% weight loss at 120 mg • Tolerability o Very low (2.0%) AE - related treatment discontinuations o Tolerability improved with 2.5 mg starting dose with no vomiting events and no discontinuations in that group after a median of 20 weeks ACCESS OLE Interim – Week 36 to 56 2.5 mg start 3 0 mg 45/90/120mg 120 mg 2. Does weight loss continue beyond 36 weeks? 4. Does tolerability improve starting at 2.5 mg? * Study ongoing and pre - specified interim data as of February 20 th , 2026. No statistical model applied
20 Aleniglipron Patient Journey to Chronic Weight Management Body Composition Interim through Week 20 2.5 mg start to 30 mg 3 . Is there weight loss at low doses? 4 . Does tolerability improve starting at 2.5 mg?
21 Body Composition Study to Further Evaluate Improved Tolerability with 2.5 mg Starting Dose Body Composition Study Objectives • Assess body fat loss over 40 weeks to inform body composition endpoints in Phase 3 • Evaluate tolerability with 2.5 mg starting dose Study Details N=71 Participants with: • Body mass index (BMI) ≥ 30 kg/m 2 Number of sites: 11 * Clinicaltrials.gov ID: NCT06693843 *Study ongoing and interim data from a pre - specified analysis. Interim data as of February 20 th , 2026 Study Ongoing Pre - specified interim analysis with a median follow up of ~20 weeks * 120 mg 90 mg 0 28 40 6 0 mg 3 0 mg 2 0 mg 10 mg 5 mg 2.5 mg N=59 N=12 Placebo
22 Baseline Demographics and Characteristics (Body Composition Study) Placebo N=12 Aleniglipron N=59 Characteristics Mean (SD) or N (%) 48.8 (16.4) 54.5 (11.4) Age, years, mean 8 (66.7) 38 (64.4) Sex, female 111.2 (20.8) 108.0 (20.2) Weight, kg 39.6 (6.8) 38.1 (6.2) Body mass index, kg/m 2 5.6 (0.4) 5.7 (0.4) HbA1c (%) 4 (33.3) 4 (6.8) Ethnicity (Hispanic or Latino) *Study ongoing and interim data from a pre - specified analysis. Interim data as of February 20, 2026
23 Aleniglipron Continued to Demonstrate Weight Loss Body with 2.5 mg Starting Dose Percent Change in Body Weight, % * Study ongoing and pre - specified interim data as of February 20 th , 2026. No statistical model applied • Clinically significant body weight reduction up to 30 mg in participants starting at 2.5 mg dose Descriptive Body Weight Reduction
24 Low Prevalence of Nausea and Vomiting Over Time Study ongoing Study ongoing Study ongoing Study ongoing • Events of nausea reported at the titration steps (<10%) • No events of vomiting while at the 2.5 mg starting dose • Very low occurrence of vomiting over time • 2 (3.4%) AE - related treatment discontinuation *Treatment Discontinuations due to AEs (not limited to nausea) * * Nausea - Aleniglipron (N=59) Nausea - Placebo (N=12) Vomiting - Aleniglipron (N=59) Vomiting - Placebo (N=12)
25 Tolerability Profile in the Body Composition Study * Study Ongoing Placebo N=12 Aleniglipron N=59 N (%) Reporting at least one event NA 2.5 mg Starting Dose 10 (83.3) 50 (84.7) Any TEAE 0 2 (3.4) Any TEAE leading to discontinuation of treatment 3 (33.3) 30 (50.8) Nausea 1 (8.3) 14 (23.7) Vomiting 6 (50) 19 (32.2) Diarrhea 3 (25.0) 21 (35.6) Constipation • 3.4% (2/59) treatment discontinuations due to AEs after a median treatment of ~20 weeks *Study ongoing and interim data from a pre - specified analysis. Interim data as of February 20 th , 2026. E-diary reporting is associated with an increase in the number of reported events.
26 Summary of Interim Data of Body Composition • Efficacy o Initial signs of body weight reduction up to 6.8% at 20 - week median follow up • Tolerability o Clinically manageable tolerability profile and very low (3.4%) study drug discontinuations due to AEs Body Composition Interim through Week 20 2.5 mg start to 30 mg 3 . Is there weight loss at low doses? 4 . Does tolerability improve starting at 2.5 mg? * Study ongoing and pre - specified interim data as of February 20 th , 2026. No statistical model applied
27 55.3% 24.4% 8.3% 45.4% 14.4% 2.1% 0% 10% 20% 30% 40% 50% 60% % of participants Tolerability Improvement Observed with Start Low (2.5 mg) and Go Slow Titration Strategy *Studies ongoing and interim data from a pre - specified analysis. Interim data as of February 20 th , 2026 Nausea Vomiting Discontinuations ACCESS and ACCESS II (n=244) Body Comp and ACCESS OLE (n=97) 5 mg 30 mg over 12 weeks 2.5 mg 30 mg over 20 weeks ACCESS and ACCESS II (n=244) Body Comp and ACCESS OLE (n=97) ACCESS and ACCESS II (n=244) Body Comp and ACCESS OLE (n=97)
28 Aleniglipron Patient Journey to Chronic Weight Management Body Composition Interim through Week 20 2.5 mg start to 30 mg 5. Does aleniglipron maintain absence of off - target safety? 44 weeks 120 mg 180 mg 240 mg ACCESS OLE Interim – Week 36 to 56 2.5 mg start 3 0 mg 45/90/120mg 120 mg
29 Aleniglipron Continues to Demonstrate Favorable Off - Target Safety Results • No cases of drug - induced liver injury (DILI) • No cases of ALT or AST ≥ 10x upper limit of normal (ULN) • All cases of elevated ALT and AST resolved without treatment modification or discontinuation * Interim data as of February 20th, 2026 Body Composition* Exploratory ACCESS II (up to 240 mg) ACCESS OLE * Phase 2b ACCESS (up to 120 mg) N (%) Placebo N=12 N=59 Placebo N=10 N=61 N=151 Placebo N=56 120 mg N=63 90 mg N=65 45 mg N=45 0 1 (1.8) 0 2 (3.3) 3 (2.0) 1 (1.8) 2 (3.2) 3 (4.8) 1 (2.3) ALT ≥ 3x ULN 0 0 0 0 2 (1.3) 0 0 1 (1.6) 0 ALT ≥ 5x ULN 0 0 0 0 0 0 0 0 0 ALT ≥ 10x ULN 0 1 (1.8) 0 2 (3.3) 1 (0.7) 1 (1.8) 0 0 0 AST ≥ 3x ULN 0 0 0 1 (1.7) 0 0 0 0 0 AST ≥ 5x ULN 0 0 0 0 0 0 0 0 0 AST ≥ 10x ULN 0 0 0 0 0 0 0 0 0 ALT or AST ≥ 3 x ULN and Total Bilirubin ≥ 2 x ULN
30 Aleniglipron Patient Journey to Chronic Weight Management Key Questions 1. What is the top dose? Potential best - in - class efficacy – 16.3% weight loss at 180 mg dose March 2026 2. Does weight loss continue beyond 36 weeks? ACCESS II and ACCESS OLE No evidence of plateauing at 44 weeks (ACCESS II) and 56 weeks (ACCESS OLE) 4 . Does tolerability improve starting at 2.5 mg? ACCESS OLE and Body Composition Low number of AE leading to study drug discontinuations (<4%) 5. Does aleniglipron maintain absence of off - target safety? ACCESS, ACCESS II, ACCESS OLE and Body Composition No drug - induced liver injury (DILI) 3 . Is there weight loss at low doses? ACCESS OLE and Body Composition Weight loss is observed starting at 2.5 mg and continues at increasing doses and ACCESS OLE
31 Closing Raymond Stevens
32 Phase 3 Phase 2 Phase 1 IND - enabling/ DC Lead Opt Discovery Study / Focus Molecule(s) Program Phase 3 Registrational Aleniglipron (GSBR - 1290) Selective GLP - 1 Receptor Agonist Backbone ACCESS (+ OLE) ACCESS II (+ Extension) Diabetes/Obesity SWITCH Study Body Composition ACCG - 2671 (DACRA) Amylin Amylin Receptor Agonists Backbone ACCG - 3535 (DACRA) SARA GLP - 1RA + Amylin GLP - 1RA + Amylin Combinations GLP - 1RA + GIPR Amylin + GIPR Backbone + GIPR Backbone + GCGR Backbone + GIPR + GCGR Backbone + GCGR Ongoing : Phase 1 SAD data 2H 2026 IND - enabling studies underway and Phase 1 initiation anticipated Q4 2026 2026: A Transformational Year as Aleniglipron Advances into Phase 3 Discovery and Development of a Strong and Broad Portfolio of Obesity related Oral Assets Phase 3 initiation anticipated 2H 2026 ACCESS Positive Results + OLE Ongoing ACCESS II Positive Topline Results Ongoing: D ata anticipated 2H 2026 Ongoing: D ata anticipated 2H 2026 Ongoing: D ata anticipated 2H 2026 End of Phase 2 Meeting Q2 2026
33 1. August 2025 Symphony Health prescriptio n data and 2025 Evaluate Pharma sales data ; Morgan Stanley Mounjaro+Zepbound Script tracker . March 2026 2. Trust for America’s Health Rep ort https://www.tfah .org/report - details/stateofobesity2019/#:~:text=Obesity%20is%20a%20growing%20epidemic,100%20million%20p eople%20%E2%80%93%20have%20ob es 3. Goldman Sachs Report https://www.goldmansachs.com/insights/articles/anti - obesity - drug - market 4. World Obesity 2024 https:// www.worldobesity.org/about/about - obesity/prevalence - of - obesity >5 million in US 1 >$100 billion Total Addressable Marke t 3 (obesity or overweight with at least one weight - related comorbid condition) >100 million in US 2 Overweight & Obesity Current Injectable Peptide GLP - 1s for O verweight & Obesity <5% of addressable US market Access to Obesity Treatments Remains a Worldwide Unmet Need Only oral small molecules can scale to meet the needs of the global obesity patient population >1 billion worldwide 4 Obesity 3.0 billion people Overweight & Obesity
34 Q&A
35 Our Mission Making medicines more accessible to all
FAQ
What did Structure Therapeutics (GPCR) report from the Phase 2 ACCESS II obesity trial?
How durable was aleniglipron’s weight-loss effect in the ACCESS open-label extension?
How did starting at a 2.5 mg dose affect aleniglipron’s tolerability?
What safety profile has aleniglipron shown across the ACCESS program?
When does Structure Therapeutics plan to start Phase 3 trials of aleniglipron?
What level of weight loss was seen at lower aleniglipron doses in the body composition study?
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