Structure Therapeutics CMO sells 4,008 ADSs

Structure Therapeutics’ chief medical officer converted Ordinary Shares into ADSs and sold them under a Rule 10b5-1 plan, with additional shares withheld for tax on RSU vesting.

Rhea-AI Filing Summary

Structure Therapeutics Inc. (GPCR) reported that Chief Medical Officer Blas Coll Crespo converted and sold equity on September 21, 2026. He converted 12,024 Ordinary Shares into 4,008 American Depositary Shares (ADSs) and sold the 4,008 ADSs at $36.1459 per ADS, pursuant to a Rule 10b5-1 trading plan entered into on March 30, 2026. Each ADS is convertible at any time into three Ordinary Shares and has no expiration date. On September 18, 2026, 10,626 Ordinary Shares were withheld to satisfy income tax obligations related to a restricted share unit vesting.

Insider Trade Summary 10b5-1

Net Seller: 4,008 shares

Net Sell 4 txns

Insider Coll Crespo Blas

Role CHIEF MEDICAL OFFICER

Sold 4,008 shs ($145K)

Type	Security	Shares	Price	Value
Conversion	American Depositary Shares F5, F4	4,008	$0.00	$0.00
Sale	American Depositary Shares F5, F6	4,008	$36.1459	$145K
Conversion	Ordinary Shares F4	12,024	$0.00	$0.00
Tax Withholding	Ordinary Shares F1, F2, F3	10,626	$11.67	$124K

Holdings After Transaction: American Depositary Shares — 1,157 contracts (Direct); Ordinary Shares — 258,228 shares (Direct)

Footnotes (6)

1. F1. The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.
2. F2. Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.
3. F3. Reflects price per share in Ordinary Shares.
4. F4. 12,024 Ordinary Shares were converted into 4,008 American Depositary Shares as reported in Table II.
5. F5. Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.
6. F6. The American Depositary Shares were sold pursuant to a Rule 10b5-1 trading plan entered into on March 30, 2026.

Key Figures

ADSs sold: 4,008 American Depositary Shares Sale price per ADS: $36.1459 per ADS Ordinary Shares converted to ADSs: 12,024 Ordinary Shares +3 more

6 metrics

ADSs sold 4,008 American Depositary Shares Sold on September 21, 2026

Sale price per ADS $36.1459 per ADS Sale of 4,008 ADSs on September 21, 2026

Ordinary Shares converted to ADSs 12,024 Ordinary Shares Converted into 4,008 ADSs on September 21, 2026

ADS to Ordinary Share ratio 1 ADS : 3 Ordinary Shares Each ADS represents three Ordinary Shares; ADSs have no expiration date

Shares withheld for tax 10,626 Ordinary Shares Withheld on September 18, 2026 to satisfy tax on RSU vesting

Tax withholding price per Ordinary Share $11.67 per Ordinary Share Price used for 10,626 Ordinary Shares withheld for tax

Key Terms

American Depositary Shares, Rule 10b5-1 trading plan, restricted share unit award, Ordinary Shares

4 terms

American Depositary Shares financial

"The Ordinary Shares of the Issuer may be represented by American Depositary Shares"

American depositary shares (ADSs) are a way for investors in the United States to buy shares of foreign companies without dealing with international markets directly. They represent ownership in a foreign company's stock and are traded on U.S. stock exchanges, making it easier for American investors to buy, sell, and own parts of companies from around the world.

Rule 10b5-1 trading plan regulatory

"The American Depositary Shares were sold pursuant to a Rule 10b5-1 trading plan"

A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.

restricted share unit award financial

"income tax obligations associated with the vesting of a restricted share unit award"

Ordinary Shares financial

"The Ordinary Shares of the Issuer may be represented by American Depositary Shares"

Ordinary shares are a type of ownership stake in a company, giving shareholders a right to participate in the company’s profits and decision-making through voting. They are similar to owning a piece of a business, and their value can rise or fall based on the company's performance. Investors buy ordinary shares to potentially earn dividends and benefit from the company's growth over time.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transactions did GPCR’s chief medical officer report on this Form 4?

Blas Coll Crespo reported converting 12,024 Ordinary Shares into 4,008 ADSs and selling those 4,008 ADSs at $36.1459 per ADS on September 21, 2026, plus the withholding of 10,626 Ordinary Shares on September 18, 2026 to cover tax on a restricted share unit vesting.

At what price were the GPCR American Depositary Shares sold?

The 4,008 American Depositary Shares of Structure Therapeutics Inc. were sold at $36.1459 per ADS on September 21, 2026, as reported in the Form 4.

What is the conversion ratio between GPCR ADSs and Ordinary Shares?

Each American Depositary Share of Structure Therapeutics Inc. represents three Ordinary Shares. ADSs are convertible at any time, at the holder’s election, into three Ordinary Shares and have no expiration date.

Were the GPCR ADS sales made under a Rule 10b5-1 trading plan?

Yes. The sale of 4,008 ADSs on September 21, 2026 was made pursuant to a Rule 10b5-1 trading plan that Blas Coll Crespo entered into on March 30, 2026, and the filing affirms use of a Rule 10b5-1 plan.

Why were 10,626 Ordinary Shares of GPCR disposed of on September 18, 2026?

The 10,626 Ordinary Shares disposed of on September 18, 2026 were withheld by Structure Therapeutics Inc. to satisfy income tax obligations associated with the vesting of a restricted share unit award, with the price of $11.67 reflecting the Ordinary Share price.

Does the Form 4 state any remaining holdings for the GPCR insider?

The Form 4 reports the transactions and related share amounts but does not state a total number of shares held by Blas Coll Crespo following these transactions.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 09/22/2026 - 06:00 PM Accepted by SEC EDGAR 09/22/2026 - 05:59 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Coll Crespo Blas

(Last) (First) (Middle)

C/O STRUCTURE THERAPEUTICS INC.

601 GATEWAY BLVD., SUITE 900

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Structure Therapeutics Inc. [ GPCR ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	CHIEF MEDICAL OFFICER

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
09/18/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares(1)	09/18/2026		F		10,626(2)	D	$11.67(3)	270,252	D
Ordinary Shares	09/21/2026		C		12,024(4)	D	$0	258,228	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
American Depositary Shares	(5)	09/21/2026		C		4,008(4)		(5)	(5)	Ordinary Shares	12,024	$0	5,165	D
American Depositary Shares	(5)	09/21/2026		S(6)			4,008	(5)	(5)	Ordinary Shares	12,024	$36.1459	1,157	D

Explanation of Responses:

1. The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer.

2. Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award.

3. Reflects price per share in Ordinary Shares.

4. 12,024 Ordinary Shares were converted into 4,008 American Depositary Shares as reported in Table II.

5. Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date.

6. The American Depositary Shares were sold pursuant to a Rule 10b5-1 trading plan entered into on March 30, 2026.

	/s/ Jun Yoon, Attorney-in-Fact	09/22/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)