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Cullgen deal gives Gyre Therapeutics (GYRE) holders new preferred and lock-up terms

(Moderate)
(Neutral)
Form Type
SCHEDULE 13D/A

Rhea-AI Filing Summary

Ying Luo and Ping Lan report beneficial ownership of 10,211,387 shares of Gyre Therapeutics common stock, representing 8.6% of the class. This includes 5,373,091 shares underlying Mr. Luo’s options, 2,575,541 shares held directly by Ms. Lan, and 2,262,755 shares underlying Ms. Lan’s options, all exercisable within 60 days.

The amendment reflects Gyre’s all‑stock acquisition of Cullgen Inc., which valued Cullgen at approximately $300 million and added 14,450,527 Gyre common shares issued in the merger. Cullgen holders received either common stock or Series B Preferred Stock, each preferred share being convertible into five common shares after stockholder approval of a Conversion Proposal, subject to a 19.99% cap and individual beneficial ownership limits.

Series B Preferred Stock carries voting rights and dividend participation similar to common stock and is subject to protective provisions until conversion is approved. Certain executives, directors and stockholders entered lock‑up agreements restricting transfers of one‑third of their shares for 180 days, one‑third for 12 months and one‑third for 18 months after closing. A registration rights agreement requires Gyre to file a resale registration statement for Cullgen holders’ shares and related conversion shares within 45 days of closing and to use reasonable best efforts to have it declared effective within specified timeframes.

Positive

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Insights

Amended 13D details an 8.6% stake tied to a $300M all‑stock Cullgen acquisition.

Ying Luo and Ping Lan disclose beneficial ownership of 10,211,387 Gyre Therapeutics shares, or 8.6% of common stock. The stake combines directly held shares and options exercisable within 60 days, based on a total of 119,080,374 shares outstanding or issuable as defined in the filing.

The amendment explains Gyre’s all‑stock acquisition of Cullgen Inc., valuing Cullgen at about $300 million. Cullgen holders received Gyre common stock or Series B Preferred Stock, with each preferred share convertible into five common shares after stockholder approval of a Conversion Proposal, subject to a 19.99% cap and individual beneficial ownership limits.

Lock‑up agreements restrict transfers of one‑third of covered shares for 180 days, one‑third for 12 months, and one‑third for 18 months after the May 4, 2026 merger closing. A registration rights agreement requires a resale registration statement within 45 days and sets targeted effectiveness within 90 business days (or 120 days after a full SEC review). Overall, this amendment primarily clarifies ownership and structural terms rather than introducing new financial performance information.

Beneficial ownership 10,211,387 shares Common stock beneficially owned by Ying Luo and Ping Lan
Ownership percentage 8.6% of class Percent of Gyre common stock represented by 10,211,387 shares
Cullgen valuation $300 million Approximate value of Cullgen in all‑stock acquisition
Total shares baseline 119,080,374 shares Shares used to calculate ownership percentage
Merger share issuance 14,450,527 shares Gyre common stock issued in the Cullgen merger
Options baseline 7,635,846 shares Shares underlying options held by Luo and Lan, exercisable within 60 days
Exchange ratio 0.4753 Shares of Gyre stock per Cullgen common share
Preferred conversion ratio cap 5 common per preferred Series B Preferred convertible into five common shares after approval
Series B Preferred Stock financial
"Each share of Series B Preferred Stock received in the Merger is convertible into five shares of Company Common Stock"
Series B preferred stock is a type of ownership share issued by a company that offers certain advantages over common stock, such as priority in receiving dividends or assets if the company is sold or liquidated. It is typically issued after an initial round of funding, making it a way for investors to support a company's growth while gaining some protections and benefits. This stock matters to investors because it often provides a more secure investment position with potential for future growth.
Exchange Ratio financial
"for each share of Cullgen common stock held by such holders, a number of shares of the Series B Preferred Stock, equal to (x) 0.4753 (the "Exchange Ratio")"
The exchange ratio is the number used to decide how many shares of one company you get for each share you own in another company during a merger or acquisition. It’s like a recipe that tells you how to swap shares fairly, ensuring both companies’ values are balanced. This ratio matters because it determines how ownership divides between the companies' shareholders.
Conversion Proposal financial
"the approval of the conversion of the Series B Preferred Stock into shares of Company Common Stock in accordance with certain of the rules of the Nasdaq Stock Market LLC (the "Conversion Proposal")"
Lock-Up Agreements financial
"certain executive officers, directors and stockholders of the Company and Cullgen have entered into lock-up agreements (the "Lock-Up Agreements")"
A lock-up agreement is a contract that prevents company insiders—founders, employees, and early investors—from selling their shares for a set period after a public stock offering. It matters to investors because it keeps a large block of shares off the market temporarily; when the lock-up ends, those holders can sell and this increased supply can cause the stock price to fall, similar to a timed release that suddenly opens a valve.
Registration Rights Agreement financial
"the Company entered into a Registration Rights Agreement (the "Registration Rights Agreement") with Cullgen and certain holders of shares of Cullgen Capital Stock"
A registration rights agreement is a contract that gives investors the option to have their ownership stakes officially registered with the government, making it easier to sell their shares later. This agreement matters because it provides investors with a clearer path to cash out their investments if they choose, offering more liquidity and confidence in their ability to sell their holdings when desired.
Fundamental Transaction financial
"consummate a Fundamental Transaction (as defined in the Certificate of Designation) or any merger or consolidation of the Company"

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

How many Gyre Therapeutics (GYRE) shares do Ying Luo and Ping Lan beneficially own?

They beneficially own 10,211,387 shares of Gyre Therapeutics common stock, representing 8.6% of the class. This total combines options held by Ying Luo, shares directly held by Ping Lan, and additional options held by Ping Lan that are exercisable within 60 days of the filing date.

What ownership percentage of Gyre Therapeutics (GYRE) is reported in this Schedule 13D/A amendment?

The filing reports beneficial ownership of 8.6% of Gyre Therapeutics’ common stock. This percentage is calculated using 119,080,374 shares, including outstanding common shares, merger‑issued shares, and options held by Ying Luo and Ping Lan that are exercisable within 60 days, as detailed in the amendment.

How did the Cullgen acquisition affect Gyre Therapeutics (GYRE) share count and ownership?

Gyre acquired Cullgen in an all‑stock transaction valued at approximately $300 million. The deal added 14,450,527 new Gyre common shares issued in the merger and contributed to the 119,080,374 shares used to compute Ying Luo and Ping Lan’s 8.6% beneficial ownership stake in the company.

What are the key terms of Gyre Therapeutics’ (GYRE) Series B Preferred Stock from the Cullgen deal?

Series B Preferred Stock pays dividends on an as‑converted basis and carries voting rights. After approval of a Conversion Proposal, each share becomes convertible into five common shares, subject to a 19.99% overall cap and a holder‑selected beneficial ownership limit between 0% and 19.99% of outstanding common shares.

What lock-up restrictions apply to certain Gyre Therapeutics (GYRE) and Cullgen holders after the merger?

Certain executives, directors and stockholders entered lock-up agreements restricting transfers of one-third of their Gyre shares for 180 days, one-third for 12 months, and one-third for 18 months after the May 4, 2026 closing. These staggered periods limit immediate post‑merger share sales and structure potential selling over time.

What does the registration rights agreement mean for former Cullgen holders in Gyre Therapeutics (GYRE)?

The registration rights agreement requires Gyre to file a resale registration statement within 45 days of the merger closing. Gyre must use reasonable best efforts to have it declared effective within 90 business days, or 120 days after a full SEC review, covering common and conversion shares held by designated Cullgen holders.





403783103

(CUSIP Number)
Ying Luo, Ph.D.
12770 High Bluff Drive, Suite 150
San Diego, CA, 92130
(858) 567-7770

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
05/04/2026

(Date of Event Which Requires Filing of This Statement)


If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).




schemaVersion:


SCHEDULE 13D




Comment for Type of Reporting Person:
Represents (i) 5,373,091 shares underlying the options directly held by Ying Luo ("Mr. Luo") that are exercisable within 60 days after the date hereof, (ii) 2,575,541 shares directly held by Ping Lan ("Ms. Lan"), the spouse of Mr. Luo, and (iii) 2,262,755 shares underlying the options directly held by Ms. Lan that are exercisable within 60 days after the date hereof. All percentage calculations herein are based on 119,080,374 shares of Company Common Stock, consisting of (i) 96,994,001 shares of Company Common Stock outstanding as of April 16, 2026, as disclosed in the Issuer's Definitive Proxy Statement on DEF 14A filed with the U.S. Securities and Exchange Commission (the "SEC") on April 27, 2026 (the "Proxy Statement"), (ii) 14,450,527 shares of Company Common Stock issued in the Merger (as defined below) and (iii) 7,635,846 shares underlying the options directly held by Mr. Luo and Ms. Lan that are exercisable within 60 days after the date hereof.


SCHEDULE 13D




Comment for Type of Reporting Person:
Represents (i) 5,373,091 shares underlying the options directly held by Mr. Luo that are exercisable within 60 days after the date hereof, (ii) 2,575,541 shares directly held by Ping Lan ("Ms. Lan"), the spouse of Mr. Luo, and (iii) 2,262,755 shares underlying the options directly held by Ms. Lan that are exercisable within 60 days after the date hereof. All percentage calculations herein are based on 119,080,374 shares of Company Common Stock, consisting of (i) 96,994,001 shares of Company Common Stock outstanding as of April 16, 2026, as disclosed in the Proxy Statement, (ii) 14,450,527 shares of Company Common Stock issued in the Merger and (iii) 7,635,846 shares underlying the options directly held by Mr. Luo and Ms. Lan that are exercisable within 60 days after the date hereof.


SCHEDULE 13D


Ying Luo
Signature:/s/ Ying Luo
Name/Title:Ying Luo
Date:05/06/2026
Ping Lan
Signature:/s/ Ping Lan
Name/Title:Ping Lan
Date:05/06/2026