[Form 3] HYPERION DEFI, INC. Initial Statement of Beneficial Ownership

Rhea-AI Filing Summary

David R. Knox, serving as Chief Financial Officer and a director of Hyperion DeFi, Inc. (ticker: HYPD), filed an initial Form 3 reporting his status as an officer and director. The reporting event date is 09/29/2025. The filing lists Mr. Knox's address in Laguna Hills, CA and includes a Power of Attorney as Exhibit 24.

The Form 3 discloses that no securities are beneficially owned by Mr. Knox at the time of filing. The document is signed by Mr. Knox on 10/01/2025. This Form 3 is a routine Section 16 filing notifying the market of an officer/director relationship and the absence of any current direct or indirect equity holdings in the issuer.

Insights

Corporate Governance Expert

TL;DR: Routine initial Section 16 filing by an officer/director showing no current equity holdings.

This Form 3 accurately notifies investors and regulators that David R. Knox is an officer and director of Hyperion DeFi, Inc. and currently holds no beneficial ownership in the company's securities. As an initial statement, it establishes a baseline for future Section 16 reporting of transactions and holdings. The inclusion of Exhibit 24 (Power of Attorney) and the manual signature meet standard procedural expectations for such filings.

Securities Compliance Analyst

TL;DR: Compliance filing appears complete and routine; no reportable holdings or transactions are listed.

The Form 3 contains required identification details, the role of the reporting person as CFO and director, the event date, and an explicit statement that no securities are beneficially owned. The signature and exhibit note support formal compliance. This filing does not itself create disclosure risk but sets the reporting baseline for future Section 16 transaction reporting obligations.

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Knox David R.

(Last) (First) (Middle)

C/O HYPERION DEFI, INC.

23461 SOUTH POINTE DRIVE, SUITE 390

(Street)

LAGUNA HILLS CA 92653

(City) (State) (Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
09/29/2025

3. Issuer Name and Ticker or Trading Symbol
HYPERION DEFI, INC. [ HYPD ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Financial Officer

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

Remarks:

Exhibit List - Exhibit 24 - Power of Attorney

No securities are beneficially owned.

	/s/ David R. Knox	10/01/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What does the Form 3 filed for HYPD by David R. Knox report?

The Form 3 reports that David R. Knox is an officer (Chief Financial Officer) and director of Hyperion DeFi, Inc. (HYPD) and that he owns no beneficial securities at the time of filing.

When is the event date and signature date on the HYPD Form 3?

The event requiring the statement is dated 09/29/2025 and the Form 3 is signed by David R. Knox on 10/01/2025.

Does the Form 3 include any exhibits or supporting documents?

Yes. The filing lists Exhibit 24 (Power of Attorney) and contains a manual signature by the reporting person.

Does this Form 3 show any direct or indirect ownership of HYPD securities?

No. The filing explicitly states that no securities are beneficially owned by the reporting person.

What is the address listed for the reporting person on the Form 3?

The address listed is 23461 South Pointe Drive, Suite 390, Laguna Hills, CA 92653.