[Form 4] Inmune Bio, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Inmune Bio (INMB) reported a Form 4 filing for its Chief Scientific Officer, Mark William Lowdell, reflecting a one-time repricing of certain outstanding stock options. Effective as of November 18, 2025, stockholders approved reducing the exercise price of these options granted under the 2017, 2019 and Second Amended and Restated 2021 Stock Incentive Plans to $1.50, equal to the Nasdaq Capital Market closing price of the company’s common stock on that date. The table shows multiple existing stock option grants being adjusted from higher exercise prices to $1.50 while keeping the same share amounts and expiration dates. All other terms, including vesting and option terms, remain in full force and effect, so the change mainly affects the price at which these options can be exercised.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Lowdell Mark William

(Last) (First) (Middle)

C/O INMUNE BIO INC.

225 NE MIZNER BLVD., SUITE 640

(Street)

BOCA RATON FL 33432

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Inmune Bio, Inc. [ INMB ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Scientific Officer

3. Date of Earliest Transaction (Month/Day/Year)
11/18/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (right to buy)	$7.8	11/18/2025		D(1)			400,000	(2)	01/01/2028	Common Stock	400,000	(1)	0	D
Stock Option (right to buy)	$1.5	11/18/2025		A(1)		400,000		(2)	01/01/2028	Common Stock	400,000	(1)	400,000	D
Stock Option (right to buy)	$3.91	11/18/2025		D(1)			180,000	(2)	11/24/2029	Common Stock	180,000	(1)	0	D
Stock Option (right to buy)	$1.5	11/18/2025		A(1)		180,000		(2)	11/24/2029	Common Stock	180,000	(1)	180,000	D
Stock Option (right to buy)	$7.92	11/18/2025		D(1)			104,000	(2)	03/20/2032	Common Stock	104,000	(1)	0	D
Stock Option (right to buy)	$1.5	11/18/2025		A(1)		104,000		(2)	03/20/2032	Common Stock	104,000	(1)	104,000	D
Stock Option (right to buy)	$5.05	11/18/2025		D(1)			140,000	(2)	12/04/2034	Common Stock	140,000	(1)	0	D
Stock Option (right to buy)	$1.5	11/18/2025		A(1)		140,000		(2)	12/04/2034	Common Stock	140,000	(1)	140,000	D
Stock Option (right to buy)	$9.92	11/18/2025		D(1)			100,000	(2)	05/13/2034	Common Stock	100,000	(1)	0	D
Stock Option (right to buy)	$1.5	11/18/2025		A(1)		100,000		(2)	05/13/2034	Common Stock	100,000	(1)	100,000	D

Explanation of Responses:

1. Effective as of November 18, 2025 (the "Repricing Date"), the Issuer's stockholders approved a one-time repricing of certain outstanding stock options (the "Repriced Options") granted under the Issuer's 2017 Stock Incentive Plan (the "2017 Plan"), 2019 Stock Incentive Plan (the "2019 Plan"), and Second Amended and Restated 2021 Stock Incentive Plan (as may be amended, restated or otherwise modified from time to time in accordance with its terms, the "2021 Plan") , which reduced the per share exercise price of each Repriced Option to $1.50, representing the closing price of the Issuer's common stock on The Nasdaq Capital Market on the Repricing Date (the "Option Repricing"). Except as modified by the Option Repricing, all other terms and conditions of the Repriced Options, including, without limitation, any provisions with respect to vesting and term of the Repriced Options, remain in full force and effect.

2. This stock option award was issued pursuant to the 2017 Plan, 2019 Plan and/or the 2021 Plan, as applicable, and becomes exercisable in accordance with the vesting schedule specified in the award agreement and as previously reported on applicable Form 4, subject to the Reporting Person's continued service with the Issuer as of the applicable vesting date.

	/s/ Mark William Lowdell	11/18/2025
	** Signature of Reporting Person	Date
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