State Street Corporation (NYSE: STT) discloses 5.5% Iovance Biotherapeutics stake

Rhea-AI Filing Summary

State Street Corporation reported beneficial ownership of common stock of Iovance Biotherapeutics, Inc. This filing states that State Street and certain investment adviser subsidiaries collectively beneficially own 24,478,268 shares of Iovance common stock, representing 5.5% of the class.

The group reports 0 shares with sole voting or dispositive power, and 23,483,868 shares with shared voting power and 24,478,268 shares with shared dispositive power. Subsidiaries listed include SSGA Funds Management, Inc. and several State Street Global Advisors entities.

Key Figures

Beneficially owned shares: 24,478,268 shares Percent of class: 5.5% Shared voting power: 23,483,868 shares +3 more

6 metrics

Beneficially owned shares 24,478,268 shares Common stock beneficially owned by State Street Corporation

Percent of class 5.5% Percentage of Iovance common stock class held by State Street

Shared voting power 23,483,868 shares Shares over which State Street has shared voting power

Shared dispositive power 24,478,268 shares Shares over which State Street has shared dispositive power

Sole voting power 0 shares Shares over which State Street has sole voting authority

Sole dispositive power 0 shares Shares over which State Street has sole dispositive authority

Key Terms

beneficially owned, shared voting power, shared dispositive power, Schedule 13G, +1 more

5 terms

beneficially owned financial

"Item 4. | Ownership (a) | Amount beneficially owned: 24478268.00"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

shared voting power financial

"Shared Voting Power 23,483,868.00"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

shared dispositive power financial

"Shared Dispositive Power 24,478,268.00"

Schedule 13G regulatory

"STATE STREET CORPORATION has filed this schedule, Schedule 13G"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

investment company financial

"shareholders of an investment company registered under the Investment Company Act of 1940"

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 08/07/2026 - 09:57 AM Accepted by SEC EDGAR 08/07/2026 - 09:56 AM Learn about SEC filing dates

FAQ

How many Iovance Biotherapeutics (IOVA) shares does State Street Corporation beneficially own?

State Street Corporation reports beneficial ownership of 24,478,268 shares of Iovance Biotherapeutics common stock, as disclosed in the Schedule 13G. This position reflects holdings managed through various State Street Global Advisors investment adviser subsidiaries.

What percentage of Iovance Biotherapeutics (IOVA) is held by State Street Corporation?

State Street Corporation reports holding 5.5% of the class of Iovance Biotherapeutics common stock. This percentage is based on the company’s outstanding shares and represents a significant institutional ownership stake.

Does State Street Corporation have sole or shared voting power over its Iovance (IOVA) shares?

State Street Corporation reports 0 shares with sole voting power and 23,483,868 shares with shared voting power. The filing indicates voting authority is shared, primarily through its investment adviser subsidiaries.

What is State Street Corporation’s dispositive power over Iovance Biotherapeutics (IOVA) shares?

The filing shows State Street has 0 shares with sole dispositive power and 24,478,268 shares with shared dispositive power. This means decisions to sell or otherwise dispose of these shares are made on a shared basis.

Which State Street subsidiaries are associated with the Iovance (IOVA) holdings?

Subsidiaries listed include SSGA Funds Management, Inc., State Street Global Advisors Europe Limited, State Street Global Advisors Limited, State Street Global Advisors Trust Company, and State Street Global Advisors, Ltd., all classified as investment advisers (IA).

Who signed the Schedule 13G filing for State Street’s Iovance (IOVA) holdings?

The Schedule 13G was signed by Elizabeth Schaefer, identified as Senior Vice President, Chief Accounting Officer of State Street Corporation, dated 08/07/2026.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

IOVANCE BIOTHERAPEUTICS INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

462260100

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 462260100

1

Names of Reporting Persons

STATE STREET CORPORATION

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 23,483,868.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 24,478,268.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

24,478,268.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.5 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: IOVANCE BIOTHERAPEUTICS INC
(b)	Address of issuer's principal executive offices: 999 SKYWAY ROAD SUITE 150, SAN CARLOS, CALIFORNIA, 94070
Item 2.
(a)	Name of person filing: STATE STREET CORPORATION;
(b)	Address or principal business office or, if none, residence: ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES
(c)	Citizenship: MA
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP Number(s): 462260100
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 24478268.00
(b)	Percent of class: 5.5 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 23,483,868
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 24,478,268
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. NOT APPLICABLE
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);STATE STREET GLOBAL ADVISORS, LTD. (IA);
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. NOT APPLICABLE
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. NOT APPLICABLE

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

STATE STREET CORPORATION

Signature:	ELIZABETH SCHAEFER
Name/Title:	SENIOR VICE PRESIDENT, CHIEF ACCOUNTING OFFICER
Date:	08/07/2026