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Krystal Biotech R&D chief sells 25K shares

Krystal Biotech’s President of R&D and ten percent owner sold 25,000 shares under a completed Rule 10b5-1 trading plan while retaining significant trust-held positions.

(Very High)
(Negative)
Form Type
4

Rhea-AI Filing Summary

Krystal Biotech, Inc. (KRYS) insider Suma Krishnan, a director, President of R&D, and ten percent owner, reported open-market sales of 25,000 shares of common stock on September 4, 2026. The sales were executed in multiple trades at prices within ranges from $353.98 to $366.91 per share and were made under a Rule 10b5-1 trading plan adopted on September 4, 2025, which has now reached its maximum share amount and terminated. Following these transactions, Krishnan continues to hold shares indirectly through several family trusts, including 90,000 shares held by the Krishnan Spousal Trust, 51,010 shares held by the Suma Mani Krishnan Trust, and 50,000 shares held by the Krishnan Family Trust.

Positive

  • None.

Negative

  • None.

Insights

Analyzing...

Insider Krishnan Suma
Role President, R&D
Sold 25,000 shs ($8.98M)
Type Security Shares Price Value
Sale Common Stock F1, F2, F3 520 $354.54 $184K
Sale Common Stock F4 2,006 $355.5719 $713K
Sale Common Stock F5 3,267 $356.3679 $1.16M
Sale Common Stock F6 3,962 $357.5742 $1.42M
Sale Common Stock F7 3,180 $358.4203 $1.14M
Sale Common Stock F8 3,392 $359.3862 $1.22M
Sale Common Stock F9 2,320 $360.466 $836K
Sale Common Stock F10 1,242 $361.61 $449K
Sale Common Stock F11 1,992 $362.6527 $722K
Sale Common Stock F12 565 $363.3404 $205K
Sale Common Stock F13 1,329 $364.4771 $484K
Sale Common Stock F14 826 $365.4139 $302K
Sale Common Stock F15 399 $366.556 $146K
holding Common Stock F16 -- -- --
holding Common Stock F17 -- -- --
holding Common Stock F18 -- -- --
Holdings After Transaction: Common Stock — 1,302,145 shares (Direct); Common Stock — 90,000 shares (Indirect, By Krishnan Spousal Trust); Common Stock — 51,010 shares (Indirect, By Suma Mani Krishnan Trust); Common Stock — 50,000 shares (Indirect, By Krishnan Family Trust)
Footnotes (18)
  1. F1. The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Krish S. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by her spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.
  2. F2. The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.
  3. F3. The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  4. F4. The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  5. F5. The transaction was executed in multiple trades ranging from $355.98 to $356.96. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  6. F6. The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  7. F7. The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  8. F8. The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  9. F9. The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  10. F10. The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  11. F11. The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  12. F12. The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  13. F13. The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  14. F14. The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  15. F15. The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  16. F16. Held by the Krishnan Spousal Trust, an irrevocable trust established by Mr. Krishnan for the benefit of Mrs. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.
  17. F17. Held by the Suma Mani Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.
  18. F18. Held by the Krishnan Family Trust. The Reporting Person and her spouse are each joint beneficial owners of the trust with joint voting and investment control.
Shares sold 25,000 shares Total common shares sold by Suma Krishnan on September 4, 2026
Lowest reported trade range price $353.98 per share Lowest price in disclosed trade ranges for the September 4, 2026 sales
Highest reported trade range price $366.91 per share Highest price in disclosed trade ranges for the September 4, 2026 sales
Krishnan Spousal Trust holdings 90,000 shares Common stock held indirectly by the Krishnan Spousal Trust after the reported date
Suma Mani Krishnan Trust holdings 51,010 shares Common stock held indirectly by the Suma Mani Krishnan Trust after the reported date
Krishnan Family Trust holdings 50,000 shares Common stock held indirectly by the Krishnan Family Trust after the reported date
Rule 10b5-1 plan adoption date September 4, 2025 Date Suma Krishnan adopted the trading plan used for these sales
Rule 10b5-1 trading plan regulatory
"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average sale price financial
"The price reported above reflects the weighted average sale price"
beneficially own regulatory
"The Reporting Person may be deemed to beneficially own shares"
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
pecuniary interest financial
"disclaims beneficial ownership of such shares except to the extent of her pecuniary interest"
irrevocable trust other
"Held by the Krishnan Spousal Trust, an irrevocable trust established"
An irrevocable trust is a legal arrangement where an owner transfers assets into a separate entity managed by a trustee and gives up the power to modify or reclaim those assets. For investors it matters because putting stock or other holdings into such a trust can change who controls and benefits from the assets, affect taxes and creditor protection, and influence how easy it is to sell or value those holdings—like placing valuables in a locked safe overseen by someone else.

FAQ

What insider transaction did KRYS report for Suma Krishnan on September 4, 2026?

KRYS reported that Suma Krishnan sold 25,000 shares of common stock on September 4, 2026 in a series of open-market transactions at various prices, as disclosed in a Form 4 filing.

What prices were the 25,000 KRYS shares sold for by Suma Krishnan?

The 25,000 KRYS shares were sold in multiple trades, with price ranges in the reported transactions spanning from $353.98 to $366.91 per share, with each line item showing a weighted average sale price within those ranges.

Were Suma Krishnan’s KRYS stock sales made under a Rule 10b5-1 plan?

Yes. The filing states the sales were made under a Rule 10b5-1 trading plan adopted by Suma Krishnan on September 4, 2025. The plan has reached its maximum number of shares to be sold and has terminated.

How many KRYS shares does Suma Krishnan still hold indirectly after these sales?

After the reported sales, indirect holdings disclosed include 90,000 shares held by the Krishnan Spousal Trust, 51,010 shares held by the Suma Mani Krishnan Trust, and 50,000 shares held by the Krishnan Family Trust.

Do the KRYS Form 4 figures include shares held directly by Suma Krishnan’s spouse?

No. A footnote explains that shares directly owned, and transactions made, by Krish S. Krishnan are not included in this Form 4 and are reported separately on a Form 4 filed by the spouse. Suma Krishnan disclaims beneficial ownership except for any pecuniary interest.

What roles does Suma Krishnan hold at Krystal Biotech (KRYS)?

The reporting person, Suma Krishnan, is identified as a director, an officer with the title President, R&D, and a ten percent owner of Krystal Biotech, Inc.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Krishnan Suma

(Last)(First)(Middle)
C/O KRYSTAL BIOTECH, INC.
2100 WHARTON STREET, SUITE 701

(Street)
PITTSBURGH PENNSYLVANIA 15203

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Krystal Biotech, Inc. [ KRYS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirectorX10% Owner
XOfficer (give title below)Other (specify below)
President, R&D
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/04/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/04/2026S(1)520D$354.54(2)(3)1,326,625D
Common Stock09/04/2026S2,006D$355.5719(4)1,324,619D
Common Stock09/04/2026S3,267D$356.3679(5)1,321,352D
Common Stock09/04/2026S3,962D$357.5742(6)1,317,390D
Common Stock09/04/2026S3,180D$358.4203(7)1,314,210D
Common Stock09/04/2026S3,392D$359.3862(8)1,310,818D
Common Stock09/04/2026S2,320D$360.466(9)1,308,498D
Common Stock09/04/2026S1,242D$361.61(10)1,307,256D
Common Stock09/04/2026S1,992D$362.6527(11)1,305,264D
Common Stock09/04/2026S565D$363.3404(12)1,304,699D
Common Stock09/04/2026S1,329D$364.4771(13)1,303,370D
Common Stock09/04/2026S826D$365.4139(14)1,302,544D
Common Stock09/04/2026S399D$366.556(15)1,302,145D
Common Stock90,000IBy Krishnan Spousal Trust(16)
Common Stock51,010IBy Suma Mani Krishnan Trust(17)
Common Stock50,000IBy Krishnan Family Trust(18)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Krish S. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by her spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of her pecuniary interest therein.
2. The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.
3. The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
4. The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
5. The transaction was executed in multiple trades ranging from $355.98 to $356.96. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
6. The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
7. The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
8. The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
9. The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
10. The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
11. The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
12. The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
13. The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
14. The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
15. The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
16. Held by the Krishnan Spousal Trust, an irrevocable trust established by Mr. Krishnan for the benefit of Mrs. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.
17. Held by the Suma Mani Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.
18. Held by the Krishnan Family Trust. The Reporting Person and her spouse are each joint beneficial owners of the trust with joint voting and investment control.
Remarks:
/s/ Suma M. Krishnan09/04/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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