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Krystal Biotech CEO sells 25K shares in plan

(Very High)
(Negative)
Form Type
4

Rhea-AI Filing Summary

Krystal Biotech, Inc. (KRYS) reports that President and CEO, director, and more-than-10% owner Krishnan Krish S sold 25,000 shares of common stock on September 4, 2026 in multiple open-market transactions around the mid-$350s per share, under a Rule 10b5-1 trading plan adopted September 4, 2025 that has now reached its maximum and terminated. He continues to hold shares indirectly through family trusts, including 90,000, 77,710, and 50,000 shares, respectively.

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Insider Krishnan Krish S
Role President and CEO
Sold 25,000 shs ($8.98M)
Type Security Shares Price Value
Sale Common Stock F1, F2, F3 520 $354.54 $184K
Sale Common Stock F4 2,029 $355.5719 $721K
Sale Common Stock F5 3,297 $356.3687 $1.17M
Sale Common Stock F6 3,981 $357.5738 $1.42M
Sale Common Stock F7 3,143 $358.4182 $1.13M
Sale Common Stock F8 3,357 $359.3861 $1.21M
Sale Common Stock F9 2,266 $360.463 $817K
Sale Common Stock F10 1,214 $361.6091 $439K
Sale Common Stock F11 2,010 $362.6504 $729K
Sale Common Stock F12 573 $363.3424 $208K
Sale Common Stock F13 1,358 $364.4794 $495K
Sale Common Stock F14 847 $365.4163 $310K
Sale Common Stock F15 405 $366.5567 $148K
holding Common Stock F16 -- -- --
holding Common Stock F17 -- -- --
holding Common Stock F18 -- -- --
Holdings After Transaction: Common Stock — 1,347,543 shares (Direct); Common Stock — 90,000 shares (Indirect, By SMK Trust FBO KSK); Common Stock — 77,710 shares (Indirect, By Krish Srinivas Krishnan Trust); Common Stock — 50,000 shares (Indirect, By Krishnan Family Trust)
Footnotes (18)
  1. F1. The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.
  2. F2. The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.
  3. F3. The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  4. F4. The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  5. F5. The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  6. F6. The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  7. F7. The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  8. F8. The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  9. F9. The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  10. F10. The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  11. F11. The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  12. F12. The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  13. F13. The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  14. F14. The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  15. F15. The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
  16. F16. Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.
  17. F17. Held by the Krish Srinivas Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.
  18. F18. Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.
Shares sold 25,000 shares Total common shares sold by Krishnan Krish S on September 4, 2026
Sale price example $354.54 per share One reported weighted average sale price tranche on September 4, 2026
Highest trade range price $366.91 per share Upper end of the disclosed intraday price range in footnote F15
Lowest trade range price $353.98 per share Lower end of the disclosed intraday price range in footnote F3
SMK Trust FBO KSK holdings 90,000 shares Indirect KRYS common stock held through SMK Trust FBO KSK
Krish Srinivas Krishnan Trust holdings 77,710 shares Indirect KRYS common stock held through Krish Srinivas Krishnan Trust
Krishnan Family Trust holdings 50,000 shares Indirect KRYS common stock held through Krishnan Family Trust
Rule 10b5-1 plan adoption date September 4, 2025 Date the CEO’s trading plan for these sales was adopted
Rule 10b5-1 trading plan regulatory
"The sales reported were pursuant to a Rule 10b5-1 trading plan adopted"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average sale price financial
"The price reported above reflects the weighted average sale price"
beneficial ownership financial
"The Reporting Person may be deemed to beneficially own shares"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
pecuniary interest financial
"disclaims beneficial ownership of such shares except to the extent of his pecuniary interest"
irrevocable trust financial
"an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan"
An irrevocable trust is a legal arrangement where an owner transfers assets into a separate entity managed by a trustee and gives up the power to modify or reclaim those assets. For investors it matters because putting stock or other holdings into such a trust can change who controls and benefits from the assets, affect taxes and creditor protection, and influence how easy it is to sell or value those holdings—like placing valuables in a locked safe overseen by someone else.
voting and investment power financial
"shares voting and investment power with a 3rd party co-trustee"

FAQ

What insider transaction did KRYS disclose for Krishnan Krish S?

Krystal Biotech disclosed that President and CEO Krishnan Krish S sold 25,000 shares of KRYS common stock on September 4, 2026 in a series of open-market transactions, as reported on a Form 4 filing.

At what prices did the KRYS CEO sell shares on September 4, 2026?

The reported KRYS sales on September 4, 2026 were executed in multiple trades with weighted average prices per tranche ranging from about $354.54 to $366.56 per share, with underlying trade ranges from $353.98 up to $366.91, according to the Form 4 footnotes.

Was the KRYS CEO’s 25,000-share sale under a Rule 10b5-1 trading plan?

Yes. The Form 4 states the sales were made pursuant to a Rule 10b5-1 trading plan adopted on September 4, 2025. The footnote explains that this plan has reached the maximum number of shares to be sold and has terminated.

How many KRYS shares does the CEO hold indirectly after these transactions?

The filing reports indirect holdings of 90,000 shares held by SMK Trust FBO KSK, 77,710 shares held by the Krish Srinivas Krishnan Trust, and 50,000 shares held by the Krishnan Family Trust, all as of September 4, 2026.

Are the KRYS CEO’s spouse’s shares included in this Form 4?

No. A footnote states that shares directly owned by his spouse Suma M. Krishnan and her transactions are not included in this Form 4 and are reported separately. He disclaims beneficial ownership of those shares except to the extent of his pecuniary interest.

What is the CEO’s role in the trusts holding KRYS shares?

The Form 4 explains that he is a co-trustee sharing voting and investment power for the SMK Trust FBO KSK, and is grantor and trustee with revocation power for the Krish Srinivas Krishnan Trust. For the Krishnan Family Trust, he and his spouse are joint beneficial owners with joint voting and investment control.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Krishnan Krish S

(Last)(First)(Middle)
C/O KRYSTAL BIOTECH, INC.
2100 WHARTON STREET, SUITE 701

(Street)
PITTSBURGH PENNSYLVANIA 15203

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Krystal Biotech, Inc. [ KRYS ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirectorX10% Owner
XOfficer (give title below)Other (specify below)
President and CEO
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/04/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/04/2026S(1)520D$354.54(2)(3)1,372,023D
Common Stock09/04/2026S2,029D$355.5719(4)1,369,994D
Common Stock09/04/2026S3,297D$356.3687(5)1,366,697D
Common Stock09/04/2026S3,981D$357.5738(6)1,362,716D
Common Stock09/04/2026S3,143D$358.4182(7)1,359,573D
Common Stock09/04/2026S3,357D$359.3861(8)1,356,216D
Common Stock09/04/2026S2,266D$360.463(9)1,353,950D
Common Stock09/04/2026S1,214D$361.6091(10)1,352,736D
Common Stock09/04/2026S2,010D$362.6504(11)1,350,726D
Common Stock09/04/2026S573D$363.3424(12)1,350,153D
Common Stock09/04/2026S1,358D$364.4794(13)1,348,795D
Common Stock09/04/2026S847D$365.4163(14)1,347,948D
Common Stock09/04/2026S405D$366.5567(15)1,347,543D
Common Stock90,000IBy SMK Trust FBO KSK(16)
Common Stock77,710IBy Krish Srinivas Krishnan Trust(17)
Common Stock50,000IBy Krishnan Family Trust(18)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. The Reporting Person may be deemed to beneficially own shares of the Issuer's common stock directly owned by the Reporting Person's spouse, Suma M. Krishnan. Such shares and transactions by the Reporting Person's spouse are not included in this Form 4, as they are being reported separately on a Form 4 filed by his spouse. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.
2. The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.
3. The transaction was executed in multiple trades ranging from $353.98 to $354.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
4. The transaction was executed in multiple trades ranging from $354.98 to $355.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
5. The transaction was executed in multiple trades ranging from $355.98 to $356.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
6. The transaction was executed in multiple trades ranging from $356.99 to $357.97. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
7. The transaction was executed in multiple trades ranging from $357.99 to $358.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
8. The transaction was executed in multiple trades ranging from $358.99 to $359.98. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
9. The transaction was executed in multiple trades ranging from $360.01 to $361.005. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
10. The transaction was executed in multiple trades ranging from $361.02 to $362.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
11. The transaction was executed in multiple trades ranging from $362.02 to $363.00. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
12. The transaction was executed in multiple trades ranging from $363.05 to $364.01. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
13. The transaction was executed in multiple trades ranging from $364.07 to $365.05. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
14. The transaction was executed in multiple trades ranging from $365.07 to $366.03. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
15. The transaction was executed in multiple trades ranging from $366.39 to $366.91. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.
16. Held by SMK Trust FBO KSK, an irrevocable trust established by Mrs. Krishnan for the benefit of Mr. Krishnan who serves as a co-trustee and shares voting and investment power with a 3rd party co-trustee.
17. Held by the Krish Srinivas Krishnan Trust dated July 7, 2026. The Reporting Person is the grantor and trustee of the trust, has the power to revoke the trust, and has voting and investment power with respect to the shares held by the trust.
18. Held by the Krishnan Family Trust. The Reporting Person and his spouse are each joint beneficial owners of the trust with joint voting and investment control.
Remarks:
/s/ Krish S. Krishnan09/04/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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