Vanguard disaggregates holdings after realignment; KRYS shows 0% ownership (KRYS)

Rhea-AI Filing Summary

Krystal Biotech Inc filing shows an amended Schedule 13G/A by The Vanguard Group reporting 0 shares and 0% beneficial ownership as of the filing; the amendment documents an internal realignment effective January 12, 2026 that disaggregated certain Vanguard subsidiaries for SEC reporting. The form is signed on 03/27/2026.

Insights

Institutional Ownership Analyst

Vanguard reports no beneficial stake in KRYS after internal realignment.

The amendment states 0 shares and 0% beneficial ownership as reported on 03/27/2026. It also records an internal reorganization dated January 12, 2026 that caused previously aggregated holdings to be reported separately by subsidiaries.

This filing clarifies reporting structure rather than indicating active buying or selling; subsequent filings from Vanguard subsidiaries may show holdings if tied to the realignment.

Securities Compliance Counsel

Amendment cites SEC Release No. 34-39538 to justify disaggregated reporting.

The disclosure references January 12, 1998 SEC Release No. 34-39538 and explains that certain subsidiaries will report beneficial ownership separately after Vanguard's internal realignment on January 12, 2026. The filing affirms that Vanguard no longer is deemed to beneficially own securities held by those subsidiaries.

Signatures show the form was executed on 03/27/2026; future Schedule 13 filings from related Vanguard entities could reflect any holdings.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Accepted by SEC EDGAR 03/27/2026 - 10:19 AM Learn about SEC filing dates

FAQ

What stake does The Vanguard Group report in KRYS?

The filing reports 0 shares and 0% beneficial ownership as stated in Item 4. The Schedule 13G/A is signed on 03/27/2026 and reflects Vanguard's reporting after an internal realignment.

Why does Vanguard say it no longer beneficially owns certain securities?

Vanguard cites SEC Release No. 34-39538 and an internal realignment on January 12, 2026. The amendment explains certain subsidiaries will report holdings separately from The Vanguard Group.

When was this Schedule 13G/A amendment signed?

The document is signed by Ashley Grim, Head of Global Fund Administration, on 03/27/2026. That date appears as the execution date for the amended filing.

Does this filing show any shares held indirectly by Vanguard?

The filing states Vanguard, including investment companies and managed accounts, may have rights to dividends or proceeds but reports 0 shares beneficially owned in Item 4 on this Schedule 13G/A.

Will separate Vanguard subsidiaries report holdings for KRYS?

Yes; the amendment states certain subsidiaries or business divisions will report beneficial ownership separately following the January 12, 2026 realignment, per SEC Release No. 34-39538.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)

Krystal Biotech Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

501147102

(CUSIP Number)

03/13/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 501147102

1

Names of Reporting Persons

The Vanguard Group

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

0.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: On January 12, 2026, The Vanguard Group, Inc. went through an internal realignment. In accordance with SEC Release No. 34-39538 (January 12, 1998), certain subsidiaries or business divisions of subsidiaries of The Vanguard Group, Inc., that formerly had, or were deemed to have, beneficial ownership with The Vanguard Group, Inc., will report beneficial ownership separately (on a disaggregated basis) from The Vanguard Group, Inc. in reliance on such release. These subsidiaries and/or business divisions pursue the same investment strategies as previously pursued by The Vanguard Group, Inc. prior to the realignment. Further in accordance with SEC Release No. 34-39538 (January 12, 1998), The Vanguard Group, Inc. no longer has, or is deemed to have, beneficial ownership over securities beneficially owned by such subsidiaries and/or business divisions.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Krystal Biotech Inc
(b)	Address of issuer's principal executive offices: 2100 Wharton Street, Suite 701, Pittsburgh, PA, 15203
Item 2.
(a)	Name of person filing: The Vanguard Group
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd.,, Malvern, PA, 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.:
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 0
(b)	Percent of class: 0 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. The Vanguard Group, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein.No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

The Vanguard Group

Signature:	Ashley Grim
Name/Title:	Head of Global Fund Administration
Date:	03/27/2026