UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 6-K
REPORT OF FOREIGN PRIVATE ISSUER
PURSUANT TO RULE 13a-16 OR 15d-16
UNDER THE SECURITIES EXCHANGE ACT OF 1934
For the Month of April 2026
Commission File Number: 000-29962
Kazia Therapeutics Limited.
(Exact Name of Registrant as Specified in Its Charter)
Three International Towers Level 24 300 Barangaroo
Avenue Sydney NSW 2000
(Address of principal executive offices)
Indicate by check mark whether the registrant files or will file annual
reports under cover of Form 20-F or Form 40-F.
Form 20-F ☒
Form 40-F ☐
INFORMATION CONTAINED IN THIS FORM 6-K REPORT
Entry into Employment Agreement with Chief Scientific Officer
This report on Form 6-K (the “Report”) contains information
regarding the entry into a material employment agreement by Kazia Therapeutics Limited (the “Company”). On April 10, 2026,
the Company entered into an Employment Agreement (the “Agreement”) with Dr. Sudha Rao, pursuant to which Dr. Rao will serve
as the Company’s Chief Scientific Officer (“CSO”), effective April 13, 2026.
Under the terms of the Agreement, Dr. Rao will serve as Chief
Scientific Officer on a part-time basis (three days per week) and will receive an annual base salary of AUD$325,000. Dr. Rao is
eligible to receive an annual performance bonus with a target of 40% of her base salary, subject to the achievement of performance
objectives determined by the Company’s Board of Directors. The Agreement also provides for a grant of options to acquire
250,000 American Depositary Shares (“ADS”) of the Company, subject to approval by the Company’s Board of
Directors, with one-third vesting upon commencement of employment and the remaining two-thirds vesting in two equal annual
installments on the first and second anniversaries of the commencement date. The Agreement permits Dr. Rao to maintain concurrent
employment with QIMR Berghofer Medical Research Institute.
The foregoing description of the Agreement does not purport to be complete
and is qualified in its entirety by reference to the full text of the Agreement, which is filed as Exhibit 10.1 to this Report and is
incorporated herein by reference.
Press Release
The
Company is furnishing with this Report on Form 6-K a press release announcing the appointment of Dr. Sudha Rao as Chief Scientific Officer,
dated April 15, 2026, as Exhibit 99.1.
Incorporation by Reference
The Company hereby incorporates by reference the information contained
herein, including Exhibits 10.1 and 99.1, except for the quotes of Dr. John Friend, Chief Executive Officer of the Company, contained
in Exhibit 99.1, into the Company’s registration statements on Form F-3 (File Nos. 333-276091, 333-281937 and 333-294392).
The Company hereby incorporates by reference the information contained
under the heading “Departure of Director” in the Company’s report on Form 6-K furnished with the Securities and Exchange
Commission on March 31, 2026, but excluding any other information contained in such report, including Exhibits 99.1 and 99.2 thereto,
into the Company’s registration statements on Form F-3 (File Nos. 333-276091, 333-281937 and 333-294392).
EXHIBIT INDEX
| Exhibit |
|
Description |
| 10.1 |
|
Employment Agreement, dated as of April 10, 2026, by and between Kazia Therapeutics Limited and Dr. Sudha Rao. |
| 99.1 |
|
Press Release dated April 15, 2026. |
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
| |
Kazia Therapeutics Limited. |
| |
|
|
| |
By: |
/s/ John Friend |
| |
Name: |
John Friend |
| |
Title: |
Chief Executive Officer |
| |
|
|
| Date: April 15, 2026 |
|
|
Exhibit 99.1
Kazia Therapeutics Strengthens Scientific Leadership with Appointment
of Dr. Sudha Rao as Chief Scientific Officer to Lead Next-Generation Oncology Platform
Sydney, Australia – April 15, 2026 – Kazia Therapeutics
(NASDAQ: KZIA), a clinical-stage oncology company developing differentiated therapies for cancers with high unmet need, today announced
the appointment of Dr. Sudha Rao as Chief Scientific Officer (CSO).
Dr. Rao is the scientific originator of the epigenetic framework underlying
paxalisib and a pioneer in next-generation therapeutic platforms, including PD-L1 protein degradation and SETDB1-targeted chromatin modulation.
Her appointment brings deep expertise in translational epigenetics, AI-guided epi-drug discovery capability, liquid and spatial epigenetic
clinical biomarker precision medicine platforms, and early clinical development into Kazia’s executive leadership as the Company
advances its integrated oncology platform strategy.
Dr. Rao is a highly accomplished translational scientist and biotech
executive with more than 20 years of experience spanning pharmaceutical R&D, biotechnology, and early clinical development. She currently
holds a professorial appointment and leads the Gene Regulation and Translational Medicine Laboratory at QIMR Berghofer Medical Research
Institute and previously held senior scientific roles at Sanofi/Rhône-Poulenc in the UK, where she contributed to one of the earliest
clinical genomics platforms.
She is the founder and former Chief Scientific Officer of EpiAxis Therapeutics
and has advanced first-in-class epigenetic therapeutics from discovery through IND-enabling studies and into early clinical trials, including
the first Phase 1b study of an LSD1 inhibitor in metastatic breast cancer. Dr. Rao is lead inventor on 39 international patents and has
authored numerous high-impact publications in journals including Science, Nature, and Immunity.
At Kazia, Dr. Rao will lead all research and development activities,
advancing the Company’s pipeline and expanding its next-generation platform capabilities, including:
| ● | Paxalisib, a brain-penetrant dual PI3K/mTOR inhibitor being developed across oncology indications, including advanced breast cancer; |
| ● | NDL2, a novel PD-L1 protein degrader platform designed to target intracellular and nuclear PD-L1 biology; and |
| ● | MSETC, a first-in-class SETDB1-targeted epigenetic program aimed at reversing immune evasion at the chromatin level. |
Her scientific work has been central to advancing the concept of PI3K/mTOR
inhibition as a driver of epigenetic reprogramming, forming the foundation of Kazia’s strategy to move beyond pathway inhibition
toward therapeutic control of cancer’s regulatory drivers.
Dr. John Friend, CEO of Kazia Therapeutics, commented: “Dr. Rao
is a leading translational epigenetics scientist, a breast cancer researcher, and the lead inventor behind the intellectual property linking
PI3K/mTOR inhibition to epigenetic regulation. As the architect of much of our platform, including paxalisib, NDL2, and MSETC, her appointment
allows us to immediately strengthen execution while advancing a more integrated, platform-driven oncology strategy.”
“I am excited by the opportunity to advance a next-generation
oncology platform at Kazia. PI3K/mTOR is a key driver of tumour growth and a master regulator of epigenetic programs that shape tumour
behaviour, the tumour microenvironment (TME), and immune evasion,” stated Dr. Rao. “We are building a platform focused on
precision targeting and precision medicine, integrating spatial and liquid epigenomics and AI-driven drug discovery to accelerate novel
therapies. This includes paxalisib alongside emerging programs such as the PD-L1 degrader and SETDB1-targeting approaches. We aim to enable
patient selection, real-time target engagement, and a scalable pipeline with clear clinical translation.”
Dr. Rao will also play a key role in advancing Kazia’s biomarker
strategy, external collaborations, scientific publications, and strategic partnerships, while continuing to expand the Company’s
platform and pipeline.
About Kazia
Kazia Therapeutics Limited (NASDAQ: KZIA) is an oncology-focused drug
development company, based in Sydney, Australia. Our lead program is paxalisib, an investigational brain penetrant inhibitor of the PI3K
/ Akt / mTOR pathway, which is being developed to treat multiple forms of cancer. Licensed from Genentech in late 2016, paxalisib is or
has been the subject of ten clinical trials in this disease. A completed Phase 2/3 study in glioblastoma (GBM-Agile) was reported in 2024,
and discussions are ongoing for designing and executing a pivotal registrational study in pursuit of a standard approval. Other clinical
trials involving paxalisib are ongoing in advanced breast cancer, brain metastases, diffuse midline gliomas, and primary central nervous
system lymphoma, with several of these trials having reported encouraging interim data. Paxalisib was granted Orphan Drug Designation
for glioblastoma by the U.S. Food and Drug Administration (FDA) in February 2018, and Fast Track Designation (FTD) for glioblastoma by
the FDA in August 2020. Paxalisib was also granted FTD in July 2023 for the treatment of solid tumor brain metastases harboring PI3K pathway
mutations in combination with radiation therapy. In addition, paxalisib was granted Rare Pediatric Disease Designation and Orphan Drug
Designation by the FDA for diffuse intrinsic pontine glioma in August 2020, and for atypical teratoid / rhabdoid tumors in June 2022 and
July 2022, respectively. Kazia is also developing EVT801, a small molecule inhibitor of VEGFR3, which was licensed from Evotec SE in April
2021. In addition to its clinical-stage programs, Kazia is advancing NDL2, a potentially first-in-class nuclear PD-L1 protein degrader
program targeting a newly identified mechanism of immunotherapy resistance and metastatic progression, currently in preclinical development.
For more information, please visit www.kaziatherapeutics.com or follow us on X @KaziaTx.
Forward Looking Statements
This announcement may contain forward-looking statements, which can
generally be identified as such by the use of words such as “may,” “will,” “estimate,” “future,”
“forward,” “anticipate,” or other similar words. Any statement describing Kazia’s future plans, strategies, intentions,
expectations, objectives, goals or prospects, and other statements that are not historical facts, are also forward-looking statements,
including, but not limited to, statements regarding: the anticipated contributions of Dr. Sudha Rao as Chief Scientific Officer; expectations
regarding Dr. Rao’s leadership of Kazia’s research and development activities; the potential of Kazia’s three-platform
oncology strategy, including paxalisib, NDL2, and MSETC; expectations regarding the advancement of Kazia’s pipeline and platform
capabilities; the potential of paxalisib, including in advanced breast cancer and other oncology indications; the potential of NDL2 as
a PD-L1 protein degrader platform; the potential of MSETC as a SETDB1-targeted epigenetic program; expectations regarding Kazia’s
biomarker strategy, AI-driven drug discovery, and precision medicine capabilities; and Kazia’s broader pipeline strategy and anticipated
benefits of its integrated platform approach. Such statements are based on Kazia’s current expectations and projections about future events
and future trends affecting its business and are subject to certain risks and uncertainties that could cause actual results to differ
materially from those anticipated in the forward-looking statements, including risks and uncertainties associated with: the ability to
attract and retain key personnel, including Dr. Rao; the development of early-stage therapeutic programs; the risk that preclinical results
may not be predictive of clinical results; risks related to regulatory approvals; risks related to Kazia’s reliance on third-party collaborators;
risks related to intellectual property protection; risks related to the impact of global economic conditions; and risks related to Kazia’s
ability to maintain compliance with the applicable NASDAQ continued listing requirements and standards. These and other risks and uncertainties
are described more fully in Kazia’s Annual Report on Form 20-F filed with the SEC, and in subsequent filings with the United States Securities
and Exchange Commission. Kazia undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information,
future events, or otherwise, except as required under applicable law. You should not place undue reliance on these forward-looking statements,
which apply only as of the date of this announcement.