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Lyell Immunopharma, Inc. SEC Filings

LYEL NASDAQ

Welcome to our dedicated page for Lyell Immunopharma SEC filings (Ticker: LYEL), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.

Lyell Immunopharma’s 10-K isn’t light reading—it weaves T-cell exhaustion science, clinical-trial minutiae and collaboration agreements into hundreds of pages. Investors hunting for cash-runway updates or pipeline milestones often struggle to find them quickly. If you’ve typed “Lyell Immunopharma SEC filings explained simply” into a search bar, you already know the challenge. Stock Titan turns that frustration into clarity by decoding the biology behind LYL845, LYL797 and other engineered T-cell programs.

The annual report section on our platform—Lyell Immunopharma annual report 10-K simplified—highlights R&D spend and trial timelines in plain language. Need quarter-over-quarter burn rates? The Lyell Immunopharma quarterly earnings report 10-Q filing pairs updated cash balances with AI commentary on clinical progress. Material announcements such as new data from the LYL119 solid-tumor study appear first in Lyell Immunopharma 8-K material events explained. Curious about management’s moves? Lyell Immunopharma insider trading Form 4 transactions and Lyell Immunopharma Form 4 insider transactions real-time alerts surface executive buys and sells within minutes, while the Lyell Immunopharma proxy statement executive compensation section maps incentives to pipeline success.

With AI-powered summaries, keyword search across every footnote, and side-by-side Lyell Immunopharma earnings report filing analysis, understanding Lyell Immunopharma SEC documents with AI becomes effortless. Our engine streams Lyell Immunopharma executive stock transactions Form 4 the moment they hit EDGAR, then ties them to upcoming catalysts. Whether you’re modelling potential royalties, tracking cash runway, or watching insider sentiment, Stock Titan delivers every disclosure you need—fast, clear and in one place.

Rhea-AI Summary

Lyell Immunopharma (Nasdaq:LYEL) filed an 8-K (Item 3.02) disclosing that the clinical milestone embedded in its October 2024 ImmPACT Bio merger has been met. The achievement obligates Lyell to issue 625,000 unregistered common shares (post 1-for-20 reverse split) to former ImmPACT securityholders in a private placement relying on the Section 4(a)(2) exemption.

The shares represent additional equity consideration; no cash will be paid. While the filing does not quantify the percentage of outstanding stock, the issuance will incrementally dilute current holders. The milestone confirms progress for ImmPACT’s next-generation CAR T-cell candidate, potentially accelerating Lyell’s cell-therapy pipeline.

  • Shares are restricted and cannot be publicly resold without registration or another exemption.
  • No other material items were reported.
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FAQ

What is the current stock price of Lyell Immunopharma (LYEL)?

The current stock price of Lyell Immunopharma (LYEL) is $8.94 as of June 28, 2025.

What is the market cap of Lyell Immunopharma (LYEL)?

The market cap of Lyell Immunopharma (LYEL) is approximately 133.1M.

What is the core focus of Lyell Immunopharma, Inc.?

Lyell Immunopharma is dedicated to developing clinical-stage cell therapies for cancer, with a particular focus on innovative CAR T-cell technology and reprogramming approaches to treat solid tumors and hematologic malignancies.

How does Lyell’s technology address T-cell exhaustion?

The company uses proprietary ex vivo genetic and epigenetic reprogramming techniques to enhance T-cell stemness and durability, thereby reducing exhaustion and improving the antitumor response.

What product candidates are included in Lyell’s pipeline?

Lyell’s portfolio features multiple candidates including ROR1-targeted CAR T-cell products like LYL797 and LYL119, a tumor infiltrating lymphocyte candidate (LYL845), and IMPT-314, a dual-targeting CAR T-cell product for hematologic malignancies acquired through ImmPACT.

What distinguishes Lyell from other cell therapy companies?

Lyell distinguishes itself through its integration of multi-layered reprogramming technologies that target T-cell exhaustion and enhance durable responses, a strategy that is particularly focused on addressing the challenges associated with solid tumor therapies.

How does the acquisition of ImmPACT Bio USA Inc. impact Lyell’s pipeline?

The acquisition expands Lyell’s pipeline to include next-generation CAR T-cell therapies for hematologic malignancies, notably enhancing their capability to develop dual-targeting approaches for aggressive B-cell lymphomas.

What is the significance of targeting ROR1 in cancer therapy?

ROR1 is a fetal protein re-expressed in certain cancers and is associated with poor prognosis. Targeting ROR1 allows for a more selective treatment strategy, potentially improving outcomes by directing T-cell therapies against a specific, pathogenic target.

What role do genetic and epigenetic reprogramming play in Lyell's approach?

These reprogramming techniques are central to enhancing the functional qualities of T cells. They ensure the cells remain potent, maintain a stem-like phenotype, and achieve sustained tumor cytotoxicity, which are crucial for effective immunotherapy.

How does Lyell ensure transparency in its clinical development process?

Lyell provides regular updates on clinical trial progress, detailed disclosures on its manufacturing protocols, and clear explanations of its technological innovations, reinforcing its commitment to transparency and scientific rigor.
Lyell Immunopharma, Inc.

NASDAQ:LYEL

LYEL Rankings

LYEL Stock Data

133.12M
11.43M
13.73%
65.93%
2.77%
Biotechnology
Pharmaceutical Preparations
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United States
SOUTH SAN FRANCISCO