MDxHealth holder Lytton reports 19.5% stake

MDxHealth SA shareholders Laurence W. Lytton and the Lytton-Kambara Foundation report beneficial ownership of 18,558,988 and 11,583,098 Ordinary Shares, respectively.

Rhea-AI Filing Summary

MDxHealth SA shareholders Laurence W. Lytton and the Lytton-Kambara Foundation report beneficial ownership of 18,558,988 and 11,583,098 Ordinary Shares, respectively. These positions represent 19.5% and 12.1% of the Ordinary Shares outstanding, based on 95,417,382 shares outstanding as of August 13, 2026.

Lytton reports 3,933,448 shares with sole voting and dispositive power and 14,625,540 shares with shared voting and dispositive power. The Foundation reports 11,583,098 shares with shared voting and dispositive power and no sole voting or dispositive power. Lytton and the Foundation have agreed to a joint filing of this Schedule 13G/A.

Key Figures

Shares outstanding: 95,417,382 Ordinary Shares Lytton beneficial ownership: 18,558,988 Ordinary Shares Lytton ownership percentage: 19.5% +5 more

8 metrics

Shares outstanding 95,417,382 Ordinary Shares Ordinary Shares outstanding as of August 13, 2026

Lytton beneficial ownership 18,558,988 Ordinary Shares Amount beneficially owned by Laurence W. Lytton

Lytton ownership percentage 19.5% Percent of MDxHealth Ordinary Shares beneficially owned by Lytton

Foundation beneficial ownership 11,583,098 Ordinary Shares Amount beneficially owned by Lytton-Kambara Foundation

Foundation ownership percentage 12.1% Percent of MDxHealth Ordinary Shares beneficially owned by the Foundation

Lytton sole voting power 3,933,448 Ordinary Shares Shares over which Lytton has sole power to vote

Lytton shared voting power 14,625,540 Ordinary Shares Shares over which Lytton has shared power to vote

Foundation shared voting power 11,583,098 Ordinary Shares Shares over which the Foundation has shared voting and dispositive power

Key Terms

beneficially owned, Sole Voting Power, Shared Dispositive Power, Schedule 13D or 13G

4 terms

beneficially owned financial

"Amount beneficially owned: Lytton: 18,558,988 Foundation: 11,583,098"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

Sole Voting Power financial

"5 | Sole Voting Power 3,933,448.00 6 | Shared Voting Power 14,625,540.00"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

Shared Dispositive Power financial

"8 | Shared Dispositive Power 14,625,540.00"

Schedule 13D or 13G regulatory

"AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What percentage of MDXH does Laurence W. Lytton report owning in this Schedule 13G/A?

Laurence W. Lytton reports beneficial ownership of 19.5% of MDxHealth SA (MDXH) Ordinary Shares. This corresponds to 18,558,988 shares, calculated against 95,417,382 Ordinary Shares outstanding as of August 13, 2026.

How many MDXH shares does the Lytton-Kambara Foundation beneficially own?

The Lytton-Kambara Foundation beneficially owns 11,583,098 MDxHealth SA (MDXH) Ordinary Shares. This represents 12.1% of the class, based on 95,417,382 Ordinary Shares outstanding as of August 13, 2026.

What voting powers over MDXH shares does Laurence W. Lytton report?

Laurence W. Lytton reports 3,933,448 MDXH shares with sole voting power and 14,625,540 shares with shared voting power. These figures reflect how many shares he alone can vote versus those voted jointly with others.

What dispositive powers over MDXH shares are reported for the Lytton-Kambara Foundation?

The Lytton-Kambara Foundation reports 0 MDXH shares with sole dispositive power and 11,583,098 shares with shared dispositive power. Shared dispositive power means decisions to sell or transfer those shares are made jointly with others.

On what share count is the reported MDXH ownership percentage based?

Both reporting persons calculate their MDxHealth SA (MDXH) ownership percentages using 95,417,382 Ordinary Shares outstanding. This outstanding share figure is as of August 13, 2026, as reported by the issuer in a Form 6-K.

Are Laurence W. Lytton and the Lytton-Kambara Foundation filing jointly for MDXH?

Yes. Laurence W. Lytton and the Lytton-Kambara Foundation have an Agreement Regarding Joint Filing of a statement on Schedule 13D or 13G. This formalizes their decision to report their MDXH holdings together in a single filing.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 08/17/2026 - 04:07 PM Accepted by SEC EDGAR 08/17/2026 - 04:06 PM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 4)

MDxHealth SA

(Name of Issuer)

Ordinary Shares

(Title of Class of Securities)

B5950S113

(CUSIP Number)

08/13/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): B5950S113

1

Names of Reporting Persons

Laurence W. Lytton

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 3,933,448.00
6	Shared Voting Power 14,625,540.00
7	Sole Dispositive Power 3,933,448.00
8	Shared Dispositive Power 14,625,540.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

18,558,988.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

19.5 %

12

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person: Percentage calculated based on 95,417,382 Ordinary Shares outstanding as of August 13, 2026, as reported in the Form 6-K filed by the Issuer on August 13, 2026.

SCHEDULE 13G

CUSIP Number(s): B5950S113

1

Names of Reporting Persons

Lytton-Kambara Foundation

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 11,583,098.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 11,583,098.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

11,583,098.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

12.1 %

12

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person: Percentage calculated based on 95,417,382 Ordinary Shares outstanding as of August 13, 2026, as reported in the Form 6-K filed by the Issuer on August 13, 2026.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: MDxHealth SA
(b)	Address of issuer's principal executive offices: CAP Business Center, Zone Industrielle des Hauts-Sarts, 4040 Herstal, Belgium
Item 2.
(a)	Name of person filing: Laurence W. Lytton Lytton-Kambara Foundation (Foundation)
(b)	Address or principal business office or, if none, residence: 467 Central Park West New York, NY 10025
(c)	Citizenship: See cover page for each reporting person.
(d)	Title of class of securities: Ordinary Shares
(e)	CUSIP No.: B5950S113
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: Lytton: 18,558,988 Foundation: 11,583,098
(b)	Percent of class: Lytton: 19.5% Foundation: 12.1%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Lytton: 3,933,448 Foundation: 0
	(ii) Shared power to vote or to direct the vote: Lytton: 14,625,540 Foundation: 11,583,098
	(iii) Sole power to dispose or to direct the disposition of: Lytton: 3,933,448 Foundation: 0
	(iv) Shared power to dispose or to direct the disposition of: Lytton: 14,625,540 Foundation: 11,583,098
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Laurence W. Lytton

Signature:	/s/ Laurence W. Lytton
Name/Title:	Reporting person
Date:	08/17/2026

Lytton-Kambara Foundation

Signature:	/s/ Laurence W. Lytton
Name/Title:	President
Date:	08/17/2026

Exhibit Information

EXHIBIT 99.1 - AGREEMENT REGARDING JOINT FILING OF STATEMENT ON SCHEDULE 13D OR 13G