Vanguard reports 4.11% stake in Niagen Bioscience

The Vanguard Group filed an amended Schedule 13G reporting its beneficial ownership in Niagen Bioscience Inc. The firm reports beneficial ownership of 3,286,498 shares of Niagen Bioscience common stock, representing 4.11% of the class.

Rhea-AI Filing Summary

The Vanguard Group filed an amended Schedule 13G reporting its beneficial ownership in Niagen Bioscience Inc.

The firm reports beneficial ownership of 3,286,498 shares of Niagen Bioscience common stock, representing 4.11% of the class. It has shared voting power over 446,427 shares and shared dispositive power over 3,286,498 shares, with no sole voting or dispositive power.

The filing notes that Vanguard’s clients have the right to receive dividends and sale proceeds from these securities, and that no single client holds more than 5% of the class. Vanguard states the shares are held in the ordinary course of business and not for the purpose of changing or influencing control of Niagen Bioscience.

The document also explains that, following an internal realignment on January 12, 2026, certain Vanguard subsidiaries or business divisions are expected to report beneficial ownership separately on a disaggregated basis while pursuing the same investment strategies as before the realignment.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What ownership stake does The Vanguard Group report in Niagen Bioscience (NAGE)?

The Vanguard Group reports beneficial ownership of 3,286,498 shares of Niagen Bioscience common stock, representing 4.11% of the outstanding class. This stake is disclosed in an amended Schedule 13G as of the relevant ownership date.

How much voting and dispositive power does Vanguard have over Niagen Bioscience (NAGE) shares?

Vanguard reports shared voting power over 446,427 shares and shared dispositive power over 3,286,498 shares, with no sole voting or dispositive power. This means voting and sale decisions are shared, typically with its clients or affiliated entities.

Why is The Vanguard Group filing an amended Schedule 13G for Niagen Bioscience (NAGE)?

The amended Schedule 13G updates Vanguard’s beneficial ownership in Niagen Bioscience and reflects a reported 4.11% stake. It also aligns disclosure with an internal realignment under which certain subsidiaries or business divisions may report holdings separately going forward.

Does The Vanguard Group intend to influence control of Niagen Bioscience (NAGE)?

Vanguard certifies the Niagen Bioscience shares were acquired and are held in the ordinary course of business, not to change or influence control. It also states the holdings are not part of any transaction designed to affect control of the company.

Who ultimately benefits from the Niagen Bioscience (NAGE) shares managed by Vanguard?

The filing states that Vanguard’s clients, including registered investment companies and other managed accounts, have the right to receive dividends and sale proceeds. No single other person’s interest in the reported securities exceeds 5% of the class.

What internal changes at The Vanguard Group are mentioned in relation to Niagen Bioscience (NAGE)?

The document explains that on January 12, 2026, Vanguard underwent an internal realignment. After this, it no longer performs portfolio management or proxy voting, and certain subsidiaries or business divisions are expected to report beneficial ownership separately while following the same strategies.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 01/30/2026 - 02:16 PM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

Niagen Bioscience Inc

(Name of Issuer)

Common Stock

(Title of Class of Securities)

171077407

(CUSIP Number)

12/31/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 171077407

1

Names of Reporting Persons

The Vanguard Group

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 446,427.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 3,286,498.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,286,498.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

4.11 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: On January 12, 2026, The Vanguard Group, Inc. went through an internal realignment. As of that date, The Vanguard Group, Inc. no longer performs portfolio management services or administers proxy voting. In accordance with SEC Release No. 34-39538 (January 12, 1998), The Vanguard Group, Inc. anticipates that certain subsidiaries or business divisions of subsidiaries of The Vanguard Group, Inc., that currently have, or are deemed to have, beneficial ownership with The Vanguard Group, Inc., will report beneficial ownership separately (on a disaggregated basis) from The Vanguard Group, Inc. in reliance on such release. These subsidiaries and/or business divisions pursue the same investment strategies as previously pursued by The Vanguard Group, Inc. prior to the realignment.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Niagen Bioscience Inc
(b)	Address of issuer's principal executive offices: 10900 Wilshire Blvd, Suite 600, Los Angeles, CA, 90024
Item 2.
(a)	Name of person filing: The Vanguard Group
(b)	Address or principal business office or, if none, residence: 100 Vanguard Blvd., Malvern, PA 19355
(c)	Citizenship: PA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 171077407
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 3286498
(b)	Percent of class: 4.11 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 446427
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 3286498
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. The Vanguard Group, Inc.'s clients, including investment companies registered under the Investment Company Act of 1940 and other managed accounts, have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the securities reported herein. No one other person's interest in the securities reported herein is more than 5%.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

The Vanguard Group

Signature:	Ashley Grim
Name/Title:	Head of Global Fund Administration
Date:	01/30/2026