NuCana (NCNA) director Leperlier details long-dated option grants

Rhea-AI Filing Summary

NuCana plc director Cyrille Leperlier reports existing stock option holdings over the company’s ordinary shares. The options are structured in four grants, each referencing ordinary shares with very low exercise prices between 0.0004 and 0.004 Pounds Sterling per share.

According to the terms, some grants are already fully vested and expire on June 20, 2035 and January 14, 2036. Other grants will vest in full on June 20, 2026 and January 14, 2027, provided Leperlier continues to serve with NuCana through those vesting dates.

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Leperlier Cyrille

(Last) (First) (Middle)

C/O NUCANA PLC

3 LOCHSIDE WAY

(Street)

EDINBURGH UNITED KINGDOM EH12 9DT

(City) (State) (Zip)

UNITED KINGDOM

(Country)

2. Date of Event Requiring Statement (Month/Day/Year)
03/18/2026

3. Issuer Name and Ticker or Trading Symbol
NuCana plc [ NCNA ]

3a. Foreign Trading Symbol

5. If Amendment, Date of Original Filed (Month/Day/Year)

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Options	(1)	(1)	Ordinary Shares	32,823,199	(1)	D
Options	(2)	(2)	Ordinary Shares	32,823,199	(2)	D
Options	(3)	(3)	Ordinary Shares	39,466,743	(3)	D
Options	(4)	(4)	Ordinary Shares	39,466,743	(4)	D

Explanation of Responses:

1. The ordinary shares, nominal value 0.0004 Pounds Sterling per share (the "Ordinary Shares"), of NuCana plc (the "Company") underlying this option have an exercise price of 0.004 Pounds Sterling, completed vesting on June 20, 2025 and expire June 20, 2035.

2. The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest in full on June 20, 2026, subject to the Reporting Person's continued service with the Company through the applicable vesting date.

3. The Ordinary Shares underlying this option have an exercise price of 0.0005 Pounds Sterling, completed vesting on January 14, 2026 and expire January 14, 2036.

4. The Ordinary Shares underlying this option have an exercise price of 0.0004 Pounds Sterling and will vest in full on January 14, 2027, subject to the Reporting Person's continued service with the Company through the applicable vesting date.

Remarks:

Exhibit 24.1 - Power of Attorney

	/s/ Ian Webster, Attorney-in-Fact for Cyrille Leperlier	03/18/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 3: SEC 1473 (03-26)

FAQ

What does NuCana (NCNA) director Cyrille Leperlier report in this Form 3?

Cyrille Leperlier reports existing holdings of stock options linked to NuCana’s ordinary shares. The filing lists four option grants with specified exercise prices, vesting schedules, and expiration dates, but does not show any new purchases or sales of shares.

What are the exercise prices of the NuCana (NCNA) options reported by Cyrille Leperlier?

The options have exercise prices between 0.0004 and 0.004 Pounds Sterling per share. One grant carries a 0.004 price, others are at 0.0004 or 0.0005 Pounds, reflecting low-cost options on NuCana’s ordinary shares.

When do Cyrille Leperlier’s NuCana (NCNA) option grants vest and expire?

Some options are already fully vested, with expirations in 2035 and 2036. Other grants will vest in full on June 20, 2026 and January 14, 2027, contingent on continued service with NuCana through those specific vesting dates.

Does this NuCana (NCNA) Form 3 show insider buying or selling of shares?

The filing shows holdings only, with no reported open-market buying or selling. All entries are option positions classified as holdings, and the summary fields indicate no buy, sell, exercise, gift, or tax-withholding transactions.

What type of security is covered by Cyrille Leperlier’s NuCana (NCNA) Form 3?

The Form 3 covers derivative securities in the form of stock options. Each option grant is tied to NuCana’s ordinary shares as the underlying security, with explicitly stated exercise prices, vesting dates, and long-dated expiration terms into 2035 and 2036.