Filed by ENDRA Life Sciences Inc.
pursuant to Rule 425 under the Securities
Act of 1933, as amended,
and deemed filed pursuant to Rule 14a-12
under the Securities Exchange Act of 1934, as
amended
Subject Company: ENDRA Life Sciences Inc. (File
No. 001-37969)
The following sets forth the transcript of a 30-second
national television advertisement, which will air from September 14, 2026 through October 9, 2026, relating to the proposed merger and
related transactions (the “Proposed Transactions”) involving Renergen Limited, a wholly owned subsidiary of ASP Isotopes,
Inc. (“Renergen”), Noble Africa LLC, a wholly owned subsidiary of ASP Isotopes, Inc. and holding company for Renergen (“Noble
Africa”), and ENDRA Life Sciences Inc. (“ENDRA”). ENDRA and persons authorized by ENDRA may also use the video or portions
thereof in social media posts, including on LinkedIn, Instagram, X and Facebook.

Transcript:
In March 2026, missile strikes on Qatar removed nearly one third
of the world's helium supply.
Important for America's national defense, helium is critical for
missiles, rockets, space, and satellites.
Now, meet Noble Africa, owners of one of the most prolific helium
assets in the world, now under development for US supply demands, anchored by funding from the US Development Finance Corporation. Recently
announced proposed merger with NASDAQ NDRA.
Cautionary Statement Regarding Forward-Looking Statements
This communication contains “forward-looking
statements” within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking
statements are neither historical facts nor assurances of future performance. Instead, they are based only on the current beliefs, expectations,
and assumptions of the parties regarding the future of the parties’ businesses, future plans and strategies, projections, anticipated
events and trends, the economy, and other future conditions. Forward-looking statements can be identified by words such as “anticipates,”
“believes,” “could,” “estimates,” “expects,” “intends,” “may,”
“might,” “plans,” “projects,” “will,” and words of a similar nature. Examples of forward-looking
statements include, but are not limited to, statements relating to the Proposed Transactions involving Renergen, Noble Africa and ENDRA;
the expected structure, timing and the completion of the Proposed Transactions and the expected effects, perceived benefits or opportunities
of the Proposed Transactions; the combined company’s listing on Nasdaq after the closing of the Proposed Transactions; the expected
executive officers and directors of the combined company; each company’s and the combined company’s expected cash position
at the closing of the Proposed Transactions and cash runway of the combined company following the Proposed Transactions; the future operations
and pipeline, estimates of financial position, competitive landscape, addressable market and strategic and financial initiatives of the
combined company; the nature, strategy and focus of the combined company; statements regarding the continuation of Renergen’s Virginia
Gas Project and its funding timeline and other statements that are not historical fact. Because forward-looking statements relate to the
future, they are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict, many of which are
outside our control. Actual results, financial condition, and events may differ materially from those indicated in the forward-looking
statements based upon a number of factors. Forward-looking statements are not a guarantee of future performance or developments. You are
strongly cautioned that reliance on any forward-looking statements involves known and unknown risks and uncertainties. Therefore, you
should not rely on any of these forward-looking statements.
There are many important factors that could cause
actual results and financial condition to differ materially from those indicated in the forward-looking statements, including, but not
limited to: the outcomes of various strategies and projects undertaken by Renergen; the potential impact of laws or government regulations
or policies in South Africa or elsewhere; Renergen’s future capital requirements and sources and uses of cash; Renergen’s
ability to obtain funding for its operations and future growth, including debt funding for Phase 2 of the Virginia Gas Project; Renergen’s
reliance on the efforts of third parties; Renergen’s ability to complete Phase 1 and 2 of the Virginia Gas Project; the financial
terms of any current and future commercial arrangements; Renergen’s ability to complete certain transactions and realize anticipated
benefits from acquisitions and contracts; Renergen’s ability to comply with the terms of the loan and credit facilities of Renergen’s
subsidiary Tetra4; the ability of Renergen and its subsidiaries to retain and hire key personnel; the volatility of LNG and liquid helium
prices; Renergen’s success in discovering, estimating and developing natural gas and helium reserves; actions of competitors or
regulators; limitations in the availability of, and costs of, supplies, materials, contractors and services that may delay the drilling
or completion of wells or make such wells more expensive; the amount and timing of future development costs; uncertainties inherent in
estimating quantities of natural gas and helium reserves and projecting future rates of production and timing of development activities;
risks relating to the lack of capital available on acceptable terms to finance the Renergen’s continued growth; the competitive
nature of Renergen’s industry; the risk that the conditions to the closing or consummation of the Proposed Transactions are not
satisfied, including the failure to timely obtain approval of the Proposed Transactions from ENDRA stockholders, if at all; the risk that
the proposed financings are not completed in a timely manner, if at all; uncertainties as to the timing of the consummation of the Proposed
Transactions and the ability of each of ENDRA and Noble Africa to consummate the Proposed Transactions; risks related to ENDRA’s
continued listing on Nasdaq until closing of the Proposed Transactions and the combined company’s ability to remain listed following
the closing of the Proposed Transactions; the ability to obtain debt financing on terms that are favorable, or at all; the risk that Renergen
does not receive funding from the U.S. DFC or SBSA or that such funding is delayed; risks related to ENDRA’s ability to correctly
estimate its respective operating expenses and its respective expenses associated with the Proposed Transactions, as applicable, pending
the closing of the Proposed Transactions, as well as uncertainties regarding the impact any delay in the closing would have on the anticipated
cash resources of ENDRA, and other events and unanticipated spending and costs that could reduce ENDRA’s cash resources; risks related
to the failure or delay in obtaining required approvals from any governmental or quasi-governmental entity necessary to consummate the
Proposed Transactions; the occurrence of any event, change or other circumstance or condition that could give rise to the termination
of the merger agreement; the effect of the announcement or pendency of the Proposed Transactions on ENDRA’s or Renergen’s
business relationships, operating results and business generally; costs related to the Proposed Transactions; risks related to the market
price of ENDRA’s common stock relative to the value suggested by the Proposed Transactions; the outcome of any legal proceedings
that may be instituted against ENDRA, Noble Africa or any of their respective directors, managers, or officers related to the Proposed
Transactions; costs of the Proposed Transactions and unexpected costs, charges or expenses resulting from the Proposed Transactions; changes
in regulatory requirements and government incentives; risks associated with the possible failure to realize, or that it may take longer
to realize than expected, certain anticipated benefits of the Proposed Transactions, including with respect to future financial and operating
results, legislative, regulatory, political and economic developments, and those uncertainties and factors; and the risk of involvement
in litigation, including securities class action litigation, that could divert the attention of the management of ENDRA or the combined
company, harm the combined company’s business and may not be sufficient for insurance coverage to cover all costs and damages, and
the other risks and uncertainties described in ENDRA’s filings with the U.S. Securities and Exchange Commission (the “SEC”),
and under the heading “Risk Factors” in its most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q, the
factors disclosed in Part I, Item 1A. “Risk Factors” of ASP Isotopes’ Annual Report on Form 10-K for the fiscal year
ended December 31, 2025 (as amended) and in ASP Isotopes’ subsequent reports filed with the SEC, each of which are available at
www.sec.gov, and in other filings that ENDRA and ASP Isotopes have made and will make with the SEC in connection with the Proposed Transactions,
including the Form S-4 and Proxy Statement described below under “Additional Information and Where to Find It”.
Any forward-looking statement made by the parties
in this communication is based only on information currently available to the parties and speaks only as of the date on which it is made.
The parties undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments
or otherwise. No information in this communication should be interpreted as an indication of future success, revenues, results of operations,
or stock price. All forward-looking statements herein are qualified by reference to the cautionary statements set forth herein and should
not be relied upon.
Important Additional Information and Where
to Find It
This communication relates to the Proposed Transactions
involving ENDRA, ASP Isotopes, Renergen and Noble Africa and may be deemed to be solicitation material in respect of the Proposed Transactions.
In connection with the Proposed Transactions, ENDRA intends to file relevant materials with the SEC, including a registration statement
on Form S-4 (the “Form S-4”) that will contain a proxy statement (the “Proxy Statement”) and prospectus. This
communication is not a substitute for the Form S-4, the Proxy Statement or for any other document that ENDRA may file with the SEC and/or
send to its stockholders in connection with the Proposed Transactions.
INVESTORS AND STOCKHOLDERS OF ENDRA ARE URGED
TO READ THE FORM S-4, THE PROXY STATEMENT AND ANY OTHER RELEVANT DOCUMENTS THAT MAY BE FILED WITH THE SEC, AS WELL AS ANY AMENDMENTS OR
SUPPLEMENTS TO THESE DOCUMENTS, CAREFULLY AND IN THEIR ENTIRETY IF AND WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT
INFORMATION ABOUT ENDRA, ASP ISOTOPES, RENERGEN, NOBLE AFRICA, THE PROPOSED TRANSACTIONS AND RELATED MATTERS.
Investors and stockholders will be able to obtain
free copies of the Form S-4, the Proxy Statement and other documents filed by ENDRA and ASP Isotopes with the SEC (when they become available)
through the website maintained by the SEC at www.sec.gov. ENDRA’s Internet website address is www.endrainc.com.
ENDRA’s Annual Report on Form 10-K, Quarterly
Reports on Form 10-Q, Current Reports on Form 8-K, including exhibits, and amendments to those reports filed or furnished pursuant to
Section 13(a) or 15(d) of the Exchange Act are available free of charge through the investor relations page of its Internet website as
soon as reasonably practicable after it electronically files such material with, or furnishes such material to, the SEC.
Participants in the Solicitation
ENDRA, ASP Isotopes, Renergen, Noble Africa, and
their respective directors and managers and certain of their executive officers and other members of management may be deemed to be participants
in the solicitation of proxies from ENDRA’s stockholders in connection with the Proposed Transactions under the rules of the SEC.
Information about ENDRA’s directors and
executive officers, including a description of their interests in ENDRA, is included in ENDRA’s most recent Annual Report on Form
10-K for the year ended December 31, 2025. Information about ASP Isotopes’ directors and executive officers, including a description
of their interests in ASP Isotopes, is included in ASP Isotopes’ most recent Annual Report on Form 10-K for the year ended December
31, 2025. Additional information regarding the persons who may be deemed participants in the proxy solicitations, including the directors
and executive officers of Renergen, and a description of their direct and indirect interests, by security holdings or otherwise, will
also be included in the Form S-4, the Proxy Statement and other relevant materials to be filed with the SEC when they become available.
These documents can be obtained free of charge from the sources indicated above.
No Offer or Solicitation
This communication is not intended to and does
not constitute a solicitation of a proxy, consent or approval with respect to any securities or in respect of the Proposed Transactions
or an offer to sell or the solicitation of an offer to subscribe for or buy or an invitation to purchase or subscribe for any securities
pursuant to the Proposed Transactions or otherwise, nor shall there be any sale, issuance or transfer of securities in any jurisdiction
in contravention of applicable law.
No offering of securities shall be made except by means of a prospectus
meeting the requirements of Section 10 of the Securities Act of 1933, as amended, and otherwise in accordance with applicable law, or
an exemption therefrom. Subject to certain exceptions to be approved by the relevant regulators or certain facts to be ascertained, the
public offer will not be made directly or indirectly, in or into any jurisdiction where to do so would constitute a violation of the laws
of such jurisdiction, or by use of the mails or by any means or instrumentality (including without limitation, facsimile transmission,
telephone and the internet) of interstate or foreign commerce, or any facility of a national securities exchange, of any such jurisdiction.