Prosight entities report 2.4% OnKure Therapeutics (OKUR) stake in 13G/A

Rhea-AI Filing Summary

OnKure Therapeutics, Inc. is the subject of an amended Schedule 13G filed by Prosight Management, LP and related entities, together with W. Lawrence Hawkins, reporting beneficial ownership of the company’s Class A Common Stock. Prosight Management, certain Prosight funds, separate managed accounts, Prosight Partners, LLC, and Hawkins (collectively the reporting persons) may be deemed to beneficially own 978,992 shares of Class A Common Stock, representing 2.4% of the class, based on 40,395,480 shares outstanding as of May 4, 2026. The reported holdings are held with shared voting and dispositive power and no sole power. Individual fund positions include 45,771 shares (0.1%) for Prosight Fund, LP and 219,725 shares (0.5%) for Prosight Plus Fund, LP. The reporting persons include extensive disclaimers of beneficial ownership and state that ownership is 5% or less of the class.

Key Figures

Prosight aggregate beneficial ownership: 978,992 shares Prosight ownership percentage: 2.4% Shares outstanding: 40,395,480 shares +3 more

6 metrics

Prosight aggregate beneficial ownership 978,992 shares Class A Common Stock beneficially owned by reporting persons, representing 2.4% of the class

Prosight ownership percentage 2.4% Percentage of OnKure Class A Common Stock based on 40,395,480 shares outstanding as of May 4, 2026

Shares outstanding 40,395,480 shares OnKure Common Stock outstanding as of May 4, 2026, per Form 10-Q

Prosight Fund, LP holdings 45,771 shares OnKure Class A Common Stock, equal to 0.1% of the class

Prosight Plus Fund, LP holdings 219,725 shares OnKure Class A Common Stock, equal to 0.5% of the class

Shared voting power 978,992 shares Shares over which reporting persons have shared voting and dispositive power and no sole power

Key Terms

beneficially own, shared voting power, dispositive power, separate managed accounts, +2 more

6 terms

beneficially own financial

"may be deemed to indirectly beneficially own securities owned by"

Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.

shared voting power financial

"Shared Voting Power 978,992.00"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

dispositive power financial

"Shared Dispositive Power 978,992.00"

Dispositive power is the authority to decide the final outcome of an asset, legal claim, contract, or corporate action — in effect the power to dispose of or resolve something. For investors it matters because whoever holds that authority can determine who gets paid, who controls an asset or vote, and how risks and returns are allocated; think of it like holding the key that lets you lock in the winner or loser in a deal.

separate managed accounts financial

"sub-advisor for certain separate managed accounts (collectively, the "Managed Accounts")"

Section 13(d) or 13(g) regulatory

"for the purposes of Section 13(d) or 13(g) of the Securities Exchange Act"

Schedule 13G regulatory

"Each Reporting Person may be deemed to be a member of a group with respect to the Issuer"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

FAQ

What ownership stake in OnKure Therapeutics (OKUR) does Prosight report?

Prosight-related entities and W. Lawrence Hawkins report beneficial ownership of 978,992 shares of OnKure Therapeutics Class A Common Stock, representing 2.4% of the outstanding shares based on 40,395,480 shares outstanding as of May 4, 2026.

How many OnKure (OKUR) shares does Prosight Fund, LP hold?

Prosight Fund, LP reports beneficial ownership of 45,771 shares of OnKure Therapeutics Class A Common Stock, equal to 0.1% of the class, calculated using 40,395,480 outstanding shares as of May 4, 2026, as disclosed by the issuer.

What is Prosight Plus Fund, LP’s position in OnKure (OKUR)?

Prosight Plus Fund, LP reports beneficial ownership of 219,725 shares of OnKure Therapeutics Class A Common Stock, representing 0.5% of the class, using the issuer’s reported 40,395,480 outstanding shares as of May 4, 2026 for the percentage calculation.

Does Prosight have sole or shared voting power over its OnKure (OKUR) shares?

The reporting persons disclose 0 shares with sole voting or dispositive power and 978,992 shares with shared voting and shared dispositive power, reflecting that control over these OnKure Therapeutics shares is exercised jointly rather than individually.

Why does the Schedule 13G/A for OnKure (OKUR) reference 40,395,480 shares?

The 40,395,480 shares figure is the number of OnKure Therapeutics Common Stock shares outstanding as of May 4, 2026, disclosed in the company’s Form 10-Q filed May 5, 2026, and is used as the denominator for Prosight’s ownership percentages.

Do the Prosight reporting persons claim to be a group in holding OnKure (OKUR) stock?

The reporting persons state they may be deemed members of a group under Section 13(d) or 13(g) but expressly declare that the filing should not be construed as an admission that they are acting as a group or are beneficial owners for any purpose.

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Available on EDGAR 08/10/2026 - 08:52 AM Accepted by SEC EDGAR 08/10/2026 - 08:51 AM Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

OnKure Therapeutics, Inc.

(Name of Issuer)

Class A Common Stock, par value $0.0001 per share

(Title of Class of Securities)

68277Q105

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 68277Q105

1

Names of Reporting Persons

Prosight Management, LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 978,992.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 978,992.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

978,992.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.4 %

12

Type of Reporting Person (See Instructions)

IA

Comment for Type of Reporting Person: The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026.

SCHEDULE 13G

CUSIP Number(s): 68277Q105

1

Names of Reporting Persons

Prosight Fund, LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 45,771.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 45,771.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

45,771.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0.1 %

12

Type of Reporting Person (See Instructions)

PN

Comment for Type of Reporting Person: The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026.

SCHEDULE 13G

CUSIP Number(s): 68277Q105

1

Names of Reporting Persons

Prosight Plus Fund, LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 219,725.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 219,725.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

219,725.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

0.5 %

12

Type of Reporting Person (See Instructions)

PN

Comment for Type of Reporting Person: The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026.

SCHEDULE 13G

CUSIP Number(s): 68277Q105

1

Names of Reporting Persons

Prosight Partners, LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 978,992.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 978,992.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

978,992.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.4 %

12

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person: The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026.

SCHEDULE 13G

CUSIP Number(s): 68277Q105

1

Names of Reporting Persons

W. Lawrence Hawkins

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 978,992.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 978,992.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

978,992.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

2.4 %

12

Type of Reporting Person (See Instructions)

HC, IN

Comment for Type of Reporting Person: The figure in Item 11 is based upon 40,395,480 shares of Common Stock of the Issuer outstanding as of May 4th, 2026, as disclosed in the Issuer's Form 10-Q, filed with the SEC on May 5, 2026.

SCHEDULE 13G

Item 1.
(a)	Name of issuer: OnKure Therapeutics, Inc.
(b)	Address of issuer's principal executive offices: 6707 WINCHESTER CIRCLE, SUITE 400, BOULDER, COLORADO, 80301
Item 2.
(a)	Name of person filing: This statement is jointly filed by and on behalf of each of Prosight Management, LP, a Delaware limited partnership ("Prosight Management"), Prosight Fund, LP, a Delaware limited partnership ("Prosight Fund"), Prosight Plus Fund, LP, a Delaware limited partnership ("Prosight Plus Fund"), Prosight Partners, LLC, a Delaware limited liability company ("Prosight Partners"), and W. Lawrence Hawkins (collectively referred herein as the "Reporting Persons"). Prosight Management is the general partner and investment manager of, and may be deemed to indirectly beneficially own securities owned by, Prosight Fund and Prosight Plus Fund. Prosight Management is a sub-advisor for certain separate managed accounts (collectively, the "Managed Accounts") and may be deemed to indirectly beneficially own securities owned by the Managed Accounts. Prosight Partners is the general partner of, and may be deemed to beneficially own, securities beneficially owned by Prosight Management. Mr. Hawkins is the sole manager of, and may be deemed to beneficially own securities beneficially owned by, Prosight Partners. Prosight Fund, Prosight Plus Fund, and the Managed Accounts are the record and direct beneficial owner of the securities of the Issuer covered by this statement. Prosight Fund disclaims beneficial ownership of the securities of the Issuer held by each of the Managed Accounts and Prosight Plus Fund. Prosight Plus Fund disclaims beneficial ownership of the securities of the Issuer held by each of the Managed Accounts and Prosight Fund. Each Reporting Person declares that neither the filing of this statement nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Securities Exchange Act of 1934, as amended (the "Act") or any other purpose, the beneficial owner of any securities covered by this statement. Each Reporting Person may be deemed to be a member of a group with respect to the Issuer or securities of the Issuer for the purpose of Section 13(d) or 13(g) of the Act. Each of the Reporting Persons declares that neither the filing of this statement nor anything herein shall be construed as an admission that such person is, for the purpose of Section 13(d) or 13(g) of the Act or any other purpose, (i) acting (or has agreed or is agreeing to act together with any other person) as a partnership, limited partnership, syndicate, or other group for the purpose of acquiring, holding, or disposing of securities of the Issuer or otherwise with respect to the Issuer or any securities of the Issuer or (ii) a member of any group with respect to the Issuer or any securities of the Issuer.
(b)	Address or principal business office or, if none, residence: The address of the principal business office of each of the Reporting Persons is c/o Prosight Management, LP, 5956 Sherry Lane, Suite 1365, Dallas, Texas 75225.
(c)	Citizenship: See Item 4 on the cover page(s) hereto.
(d)	Title of class of securities: Class A Common Stock, par value $0.0001 per share
(e)	CUSIP No.: 68277Q105
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: See Item 9 on the cover pages hereto.
(b)	Percent of class: See Item 11 on the cover pages hereto.
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: See Item 5 on the cover pages hereto.
	(ii) Shared power to vote or to direct the vote: See Item 6 on the cover pages hereto.
	(iii) Sole power to dispose or to direct the disposition of: See Item 7 on the cover pages hereto.
	(iv) Shared power to dispose or to direct the disposition of: See Item 8 on the cover pages hereto.
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Prosight Management, LP

Signature:	W. Lawrence Hawkins
Name/Title:	Sole Manager of the General Partner
Date:	08/10/2026

Prosight Fund, LP

Signature:	W. Lawrence Hawkins
Name/Title:	Sole Manager of the General Partner of the General Partner
Date:	08/10/2026

Prosight Plus Fund, LP

Signature:	W. Lawrence Hawkins
Name/Title:	Sole Manager of the General Partner of the General Partner
Date:	08/10/2026

Prosight Partners, LLC

Signature:	W. Lawrence Hawkins
Name/Title:	Sole Manager
Date:	08/10/2026

W. Lawrence Hawkins

Signature:	W. Lawrence Hawkins
Name/Title:	W. Lawrence Hawkins
Date:	08/10/2026