STOCK TITAN

BeOne Medicines (ONC) CEO sells 145,861 ADSs after option exercises

Filing Impact
(Very High)
Filing Sentiment
(Very Negative)
Form Type
4

Rhea-AI Filing Summary

BeOne Medicines Ltd. Chief Executive Officer John Oyler reported both option exercises and share sales. On July 14, 2026 he exercised options covering 1,736,800 ordinary shares and sold 145,861 American Depositary Shares at prices between $302.48 and $307.87 per ADS under a Rule 10b5-1 trading plan. After these transactions he holds 5,445,917 ordinary shares directly, additional indirect interests through trusts and a Roth IRA, and 462,866 remaining share options.

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Insider OYLER JOHN
Role Chief Executive Officer
Sold 145,861 shs ($44.63M)
Type Security Shares Price Value
Exercise Share Option (Right to Buy) 1,264,666 $0.00 --
Exercise Share Option (Right to Buy) 472,134 $0.00 --
Sale American Depositary Shares 4,139 $303.0687 $1.25M
Sale American Depositary Shares 8,122 $303.9264 $2.47M
Exercise American Depositary Shares 97,282 $36.90 $3.59M
Exercise American Depositary Shares 36,318 $100.04 $3.63M
Sale American Depositary Shares 39,090 $305.0207 $11.92M
Sale American Depositary Shares 45,895 $306.2126 $14.05M
Sale American Depositary Shares 40,781 $306.9349 $12.52M
Sale American Depositary Shares 7,834 $307.5739 $2.41M
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
Holdings After Transaction: Share Option (Right to Buy) — 0 shares (Direct); American Depositary Shares — 8,122 shares (Direct); Ordinary Shares — 5,445,917 shares (Direct); Ordinary Shares — 481,533 shares (Indirect, See Footnote)
Footnotes (1)
  1. These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership. Each American Depositary Share represents 13 Ordinary Shares. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.48 to $303.46, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.54 to $304.43, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.45 to $305.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.455 to $306.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.455 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.46 to $307.87, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares. These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.
ADS sold 145,861 American Depositary Shares Total open-market or private sales on July 14, 2026
Shares from option exercises 1,736,800 ordinary shares Total underlying ordinary shares from option exercises on July 14, 2026
Direct ordinary share holdings 5,445,917 ordinary shares Ordinary shares held directly after the reported transactions
Remaining share options 462,866 share options Options with $7.7000 exercise price expiring 2027-09-26 remaining after partial exercise
Option exercise price $7.7000 per ordinary share Exercise price for options on 472,134 underlying ordinary shares
Option exercise price $2.8400 per ordinary share Exercise price for options on 1,264,666 underlying ordinary shares
ADS to ordinary share ratio 1 ADS : 13 ordinary shares Each American Depositary Share represents 13 ordinary shares
Rule 10b5-1 trading plan regulatory
"The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person."
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
grantor retained annuity trust financial
"These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee."
A grantor retained annuity trust (GRAT) is an estate-planning tool where the person who creates the trust transfers assets into it but receives fixed cash payments (an annuity) from the trust for a set number of years; whatever remains after that term passes to designated beneficiaries. It matters to investors because it can shift future appreciation of assets out of the creator’s taxable estate—like putting an asset into a timed vending machine that pays you fixed amounts while any extra value that grows inside the machine goes to heirs with reduced gift or estate tax consequences.
American Depositary Shares financial
"Each American Depositary Share represents 13 Ordinary Shares."
American depositary shares (ADSs) are a way for investors in the United States to buy shares of foreign companies without dealing with international markets directly. They represent ownership in a foreign company's stock and are traded on U.S. stock exchanges, making it easier for American investors to buy, sell, and own parts of companies from around the world.
beneficial ownership regulatory
"The beneficiaries include the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership."
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
Roth IRA financial
"These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account."
A Roth IRA is a retirement savings account you fund with money that’s already been taxed, and withdrawals taken in retirement under the account rules are tax-free. It matters to investors because it shifts the tax bill to today instead of retirement, potentially increasing after-tax income later—think of it like paying for a lifetime subscription now so you can use it without extra charges in the future—helpful for long-term tax planning and flexibility.
Share Option (Right to Buy) financial
"Share Option (Right to Buy) with the number of securities and exercise price in ordinary shares."

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What insider transactions did BeOne Medicines (ONC) CEO John Oyler report?

John Oyler reported exercising share options and selling American Depositary Shares. On July 14, 2026 he exercised options covering 1,736,800 ordinary shares and sold 145,861 ADSs in open‑market transactions, combining derivative exercises with cash sales.

How many BeOne Medicines (ONC) ADSs did John Oyler sell and at what prices?

He sold a total of 145,861 American Depositary Shares. The weighted‑average sale prices for the various tranches ranged between approximately $302.48 and $307.87 per ADS, across multiple open‑market transactions on July 14, 2026.

What share options did BeOne Medicines (ONC) CEO John Oyler exercise?

Oyler exercised options over 472,134 ordinary shares at an exercise price of $7.7000 and 1,264,666 ordinary shares at an exercise price of $2.8400, both converting into ordinary shares of BeOne Medicines.

What BeOne Medicines (ONC) holdings does John Oyler retain after these trades?

Following the reported transactions, Oyler directly holds 5,445,917 ordinary shares and 462,866 remaining share options. He also has indirect interests via several trusts and a Roth IRA, while disclaiming beneficial ownership of certain trust‑held shares.

Were John Oyler’s BeOne Medicines (ONC) sales made under a Rule 10b5-1 plan?

Yes. A footnote states the sales were effected pursuant to a Rule 10b5-1 trading plan adopted by Oyler on March 10, 2026, indicating the transactions were pre‑arranged rather than opportunistic trades based on short‑term market movements.

How are John Oyler’s indirect BeOne Medicines (ONC) holdings structured?

Indirect holdings are spread across the P&O Trust, a grantor retained annuity trust, Oyler Investment LLC, and The John Oyler Legacy Trust, plus a Roth IRA. Oyler disclaims beneficial ownership of several trust‑held positions benefiting family members.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
OYLER JOHN

(Last)(First)(Middle)
C/O BEONE MEDICINES I GMBH
AESCHENGRABEN 27, 21ST FLOOR

(Street)
BASEL4051

(City)(State)(Zip)

SWITZERLAND

(Country)
2. Issuer Name and Ticker or Trading Symbol
BeOne Medicines Ltd. [ ONC ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
Chief Executive Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
07/14/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Ordinary Shares5,445,917D
Ordinary Shares481,533ISee Footnote(1)
Ordinary Shares7,699,158ISee Footnote(2)
Ordinary Shares28,204,115ISee Footnote(3)
Ordinary Shares9,545,000ISee Footnote(4)
Ordinary Shares102,188ISee Footnote(5)
American Depositary Shares(6)07/14/2026S(7)4,139D$303.0687(8)8,122D
American Depositary Shares(6)07/14/2026S(7)8,122D$303.9264(9)0D
American Depositary Shares(6)07/14/2026M97,282A$36.997,282D
American Depositary Shares(6)07/14/2026M36,318A$100.04133,600D
American Depositary Shares(6)07/14/2026S(7)39,090D$305.0207(10)94,510D
American Depositary Shares(6)07/14/2026S(7)45,895D$306.2126(11)48,615D
American Depositary Shares(6)07/14/2026S(7)40,781D$306.9349(12)7,834D
American Depositary Shares(6)07/14/2026S(7)7,834D$307.5739(13)0D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Share Option (Right to Buy)$2.84(14)07/14/2026M1,264,666 (15)11/15/2026Ordinary Shares1,264,666$00D
Share Option (Right to Buy)$7.7(16)07/14/2026M472,134 (17)09/26/2027Ordinary Shares472,134$0462,866D
Explanation of Responses:
1. These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.
2. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
3. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
4. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.
5. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.
6. Each American Depositary Share represents 13 Ordinary Shares.
7. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.
8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.48 to $303.46, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
9. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.54 to $304.43, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
10. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.45 to $305.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
11. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.455 to $306.45, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
12. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.455 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
13. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.46 to $307.87, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
14. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.
15. These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events.
16. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. The exercise price is equal to 1/13 of the closing price of our American Depositary Shares ("ADSs") on the date of grant, as each ADS represents 13 ordinary shares.
17. These securities vest over a four-year period as follows: 25% on June 30, 2018, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares are subject to accelerated vesting upon a change in control or certain termination events.
Remarks:
/s/ Frank Collazo, as Attorney-in-Fact07/14/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)