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BeOne Medicines (ONC) CEO sells 60,218 ADS under 10b5-1 plan

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4

Rhea-AI Filing Summary

BeOne Medicines Ltd. CEO John Oyler exercised options for 60,218 American Depositary Shares at $36.90 and sold 60,218 ADS in open‑market trades in July 2026 at weighted‑average prices between $295.66 and $307.44 under a Rule 10b5‑1 plan, leaving no directly held ADS. The filing also lists 5,605,310 ordinary shares held directly as of July 10, 2026 and additional ordinary shares recorded as indirectly held through various trusts and a Roth IRA, with beneficial ownership disclaimed for several trust positions.

Positive

  • None.

Negative

  • None.
Insider OYLER JOHN
Role Chief Executive Officer
Sold 60,218 shs ($18.26M)
Type Security Shares Price Value
Exercise Share Option (Right to Buy) 630,760 $0.00 --
Exercise American Depositary Shares 48,520 $36.90 $1.79M
Sale American Depositary Shares 798 $301.9364 $241K
Sale American Depositary Shares 4,584 $302.7881 $1.39M
Sale American Depositary Shares 26,294 $303.8251 $7.99M
Sale American Depositary Shares 8,438 $304.6803 $2.57M
Sale American Depositary Shares 846 $305.5654 $259K
Sale American Depositary Shares 7,240 $306.8245 $2.22M
Sale American Depositary Shares 320 $307.405 $98K
Exercise Share Option (Right to Buy) 152,074 $0.00 --
Exercise American Depositary Shares 11,698 $36.90 $432K
Sale American Depositary Shares 1,493 $296.0672 $442K
Sale American Depositary Shares 1,314 $297.2303 $391K
Sale American Depositary Shares 3,074 $298.3516 $917K
Sale American Depositary Shares 5,143 $298.9362 $1.54M
Sale American Depositary Shares 370 $300.1199 $111K
Sale American Depositary Shares 150 $301.1828 $45K
Sale American Depositary Shares 136 $302.1911 $41K
Sale American Depositary Shares 18 $303.03 $5K
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
holding Ordinary Shares -- -- --
Holdings After Transaction: Share Option (Right to Buy) — 1,264,666 shares (Direct); American Depositary Shares — 48,520 shares (Direct); Ordinary Shares — 5,605,310 shares (Direct); Ordinary Shares — 481,533 shares (Indirect, See Footnote)
Footnotes (1)
  1. These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership. Each American Depositary Share represents 13 Ordinary Shares. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $295.66 to $296.65, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $296.66 to $297.64, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $297.67 to $298.66, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $298.68 to $299.59, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $299.68 to $300.61, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $300.69 to $301.47, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.95 to $302.25, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.23 to $302.19, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.29 to $303.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.30 to $304.29, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.30 to $305.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.30 to $306.23, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.32 to $307.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.35 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events.
American Depositary Shares sold 60218 American Depositary Shares Total open-market sales reported on 2026-07-10 and 2026-07-13
ADS option exercise price $36.90 per American Depositary Share Exercise price for ADS options exercised in July 2026
Sale price range low $295.66 per American Depositary Share Lowest weighted-average sale price range disclosed in footnotes
Sale price range high $307.44 per American Depositary Share Highest weighted-average sale price range disclosed in footnotes
Underlying shares in derivative exercises 782834 Ordinary Shares Total underlying ordinary shares for derivative option exercises at $2.84
Direct ordinary share holding 5605310 Ordinary Shares Direct ownership recorded as of 2026-07-10
ADS to ordinary share ratio 1 American Depositary Share = 13 Ordinary Shares Stated relationship between ADS and Ordinary Shares
American Depositary Shares financial
"Each American Depositary Share represents 13 Ordinary Shares."
American depositary shares (ADSs) are a way for investors in the United States to buy shares of foreign companies without dealing with international markets directly. They represent ownership in a foreign company's stock and are traded on U.S. stock exchanges, making it easier for American investors to buy, sell, and own parts of companies from around the world.
Rule 10b5-1 trading plan regulatory
"The sale was effected pursuant to a Rule 10b5-1 trading plan adopted"
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
grantor retained annuity trust financial
"These securities are held in a grantor retained annuity trust, of which"
A grantor retained annuity trust (GRAT) is an estate-planning tool where the person who creates the trust transfers assets into it but receives fixed cash payments (an annuity) from the trust for a set number of years; whatever remains after that term passes to designated beneficiaries. It matters to investors because it can shift future appreciation of assets out of the creator’s taxable estate—like putting an asset into a timed vending machine that pays you fixed amounts while any extra value that grows inside the machine goes to heirs with reduced gift or estate tax consequences.
beneficial ownership regulatory
"for which the Reporting Person disclaims beneficial ownership."
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
weighted average price financial
"The price reported in Column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
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FAQ

What insider stock activity did BeOne Medicines (ONC) report for its CEO?

BeOne Medicines CEO John Oyler reported an exercise-and-sale pattern involving American Depositary Shares. He exercised options for 60,218 ADS at $36.90 and sold 60,218 ADS in open-market trades in July 2026 at weighted-average prices between $295.66 and $307.44.

How many American Depositary Shares did ONC's CEO sell, and at what prices?

John Oyler sold 60,218 American Depositary Shares of BeOne Medicines in open-market transactions. Footnotes show weighted-average sale prices in multiple ranges, with individual trades occurring between $295.66 and $307.44 per ADS across the reported transactions.

What option exercises by the BeOne Medicines (ONC) CEO are disclosed?

The filing shows Oyler exercising options into American Depositary Shares at $36.90 per ADS and separate derivative option exercises covering 782,834 underlying ordinary shares at $2.84 per share, with those options having an expiration date of November 15, 2026.

What shareholdings does John Oyler retain in BeOne Medicines (ONC) after these trades?

The report records Oyler with 5,605,310 ordinary shares held directly as of July 10, 2026. It also lists substantial ordinary-share positions held indirectly through various trusts, an LLC and a Roth IRA, with beneficial ownership disclaimed for several trust-related holdings.

Were the ONC CEO's share sales made under a trading plan?

Yes. A footnote states the sale was effected under a Rule 10b5-1 trading plan adopted by John Oyler on March 10, 2026. Such plans are pre-arranged trading programs that systematically execute transactions according to preset instructions.
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
OYLER JOHN

(Last)(First)(Middle)
C/O BEONE MEDICINES I GMBH
AESCHENGRABEN 27, 21ST FLOOR

(Street)
BASEL4051

(City)(State)(Zip)

SWITZERLAND

(Country)
2. Issuer Name and Ticker or Trading Symbol
BeOne Medicines Ltd. [ ONC ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
Chief Executive Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
07/10/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Ordinary Shares5,605,310D
Ordinary Shares481,533ISee Footnote(1)
Ordinary Shares7,699,158ISee Footnote(2)
Ordinary Shares28,204,115ISee Footnote(3)
Ordinary Shares9,545,000ISee Footnote(4)
Ordinary Shares102,188ISee Footnote(5)
American Depositary Shares(6)07/10/2026M11,698A$36.911,698D
American Depositary Shares(6)07/10/2026S(7)1,493D$296.0672(8)10,205D
American Depositary Shares(6)07/10/2026S(7)1,314D$297.2303(9)8,891D
American Depositary Shares(6)07/10/2026S(7)3,074D$298.3516(10)5,817D
American Depositary Shares(6)07/10/2026S(7)5,143D$298.9362(11)674D
American Depositary Shares(6)07/10/2026S(7)370D$300.1199(12)304D
American Depositary Shares(6)07/10/2026S(7)150D$301.1828(13)154D
American Depositary Shares(6)07/10/2026S(7)136D$302.1911(14)18D
American Depositary Shares(6)07/10/2026S(7)18D$303.030D
American Depositary Shares(6)07/13/2026M48,520A$36.948,520D
American Depositary Shares(6)07/13/2026S(7)798D$301.9364(15)47,722D
American Depositary Shares(6)07/13/2026S(7)4,584D$302.7881(16)43,138D
American Depositary Shares(6)07/13/2026S(7)26,294D$303.8251(17)16,844D
American Depositary Shares(6)07/13/2026S(7)8,438D$304.6803(18)8,406D
American Depositary Shares(6)07/13/2026S(7)846D$305.5654(19)7,560D
American Depositary Shares(6)07/13/2026S(7)7,240D$306.8245(20)320D
American Depositary Shares(6)07/13/2026S(7)320D$307.405(21)0D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Share Option (Right to Buy)$2.84(22)07/10/2026M152,074 (23)11/15/2026Ordinary Shares152,074$01,895,426D
Share Option (Right to Buy)$2.84(22)07/13/2026M630,760 (23)11/15/2026Ordinary Shares630,760$01,264,666D
Explanation of Responses:
1. These securities are held by the P&O Trust, the beneficiaries of which include the Reporting Person's child and others, for which the Reporting Person disclaims beneficial ownership.
2. These securities are held in a grantor retained annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
3. These securities are held by Oyler Investment LLC, of which 99% of the the limited liability company interests are owned by a grantor retain annuity trust, of which the Reporting Person's father is a trustee, for which the Reporting Person disclaims beneficial ownership.
4. These securities are held for the benefit of the Reporting Person in a Roth IRA PENSCO trust account.
5. These securities are held by The John Oyler Legacy Trust for the benefit of the Reporting Person's child, for which the Reporting Person disclaims beneficial ownership.
6. Each American Depositary Share represents 13 Ordinary Shares.
7. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 10, 2026.
8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $295.66 to $296.65, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
9. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $296.66 to $297.64, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
10. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $297.67 to $298.66, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
11. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $298.68 to $299.59, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
12. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $299.68 to $300.61, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
13. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $300.69 to $301.47, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
14. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.95 to $302.25, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
15. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $301.23 to $302.19, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
16. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $302.29 to $303.27, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
17. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $303.30 to $304.29, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
18. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $304.30 to $305.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
19. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $305.30 to $306.23, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
20. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $306.32 to $307.26, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
21. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $307.35 to $307.44, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
22. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares.
23. These securities vest over a four-year period as follows: 25% on July 13, 2017, and the remaining in 36 successive equal monthly installments, subject to continued service. Unvested shares subject to this option are subject to accelerated vesting upon a change in control or certain termination events.
Remarks:
Exhibit List - Exhibit 24.1 - Power of Attorney
/s/ Frank Collazo, as Attorney-in-Fact07/14/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)