BeOne Medicines (ONC) COO sells 16,009 ADS at $350–$381

BeOne Medicines Ltd. (ONC) reported insider transactions by its President and COO.

Rhea-AI Filing Summary

BeOne Medicines Ltd. (ONC) reported insider transactions by its President and COO. The reporting person sold 16,009 American Depositary Shares (ADS) on 11/12/2025 and 11/13/2025 at weighted average prices with trade ranges from $350.00 to $381.50, as detailed in the footnotes.

After these sales, the reporting person held 0 ADS directly. Beneficial ownership also includes 1,020,861 ordinary shares and 4,000 ADS held indirectly by spouse. Each ADS represents 13 ordinary shares. One footnote states that the ordinary share total includes 650 ordinary shares acquired under the company’s employee share purchase plan.

Insider Trade Summary

Net Seller: 16,009 shares

Net Sell 13 txns

Insider Wu Xiaobin

Role President and COO

Sold 16,009 shs ($5.85M)

Type	Security	Shares	Price	Value
Sale	American Depositary Shares	4,240	$380.3261	$1.61M
Sale	American Depositary Shares	1,769	$381.0497	$674K
Sale	American Depositary Shares	500	$350.441	$175K
Sale	American Depositary Shares	3,240	$351.4102	$1.14M
Sale	American Depositary Shares	789	$352.7773	$278K
Sale	American Depositary Shares	251	$354.1964	$89K
Sale	American Depositary Shares	120	$355.00	$43K
Sale	American Depositary Shares	100	$357.4318	$36K
Sale	American Depositary Shares	4,846	$360.0958	$1.75M
Sale	American Depositary Shares	154	$362.0719	$56K
holding	Ordinary Shares	--	--	--
holding	American Depositary Shares	--	--	--
holding	American Depositary Shares	--	--	--

Holdings After Transaction: American Depositary Shares — 12,365 shares (Direct); Ordinary Shares — 1,020,861 shares (Direct); American Depositary Shares — 4,000 shares (Indirect, By Wife)

Footnotes (11)

1. F1. Includes 650 ordinary shares acquired pursuant to the Company's Fourth Amended and Restated 2018 Employee Share Purchase Plan.
2. F2. Each American Depositary Share represents 13 Ordinary Shares.
3. F3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $350.00 to $350.93, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
4. F4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.05 to $351.52, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
5. F5. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $352.28 to $353.10, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
6. F6. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.59 to $354.585, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
7. F7. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.385 to $357.70, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
8. F8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.00 to $360.945, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
9. F9. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.00 to $362.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
10. F10. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $380.00 to $380.75, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.
11. F11. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $381.00 to $381.50, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did ONC’s President and COO report on Form 4?

Sales of 16,009 ADS on 11/12/2025 and 11/13/2025 at weighted average prices within stated ranges.

What prices were the ONC ADS sold at?

Weighted average prices with transaction ranges from $350.00 to $381.50, per footnotes (3)–(11).

How many ONC ADS does the insider hold after the sales?

Direct ADS holdings are 0 following the reported transactions; 4,000 ADS are held indirectly by spouse.

What are the insider’s ordinary share holdings at ONC?

Beneficial ownership includes 1,020,861 ordinary shares; this includes 650 ordinary shares from the employee share purchase plan.

How do ONC ADS relate to ordinary shares?

Each American Depositary Share represents 13 ordinary shares.

Were all transactions single-price trades?

No. The filing notes weighted average prices with multiple trades executed within specified price ranges on each date.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Form 4 Insider Transactions: What Each Field Means →

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Accepted by SEC EDGAR 11/14/2025 - 05:35 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Wu Xiaobin

(Last) (First) (Middle)

C/O BEONE MEDICINES I GMBH

AESCHENGRABEN 27, 21ST FLOOR

(Street)

BASEL V8 4051

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
BeOne Medicines Ltd. [ ONC ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	President and COO

3. Date of Earliest Transaction (Month/Day/Year)
11/12/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Ordinary Shares								1,020,861(1)	D
American Depositary Shares(2)								12,365	D
American Depositary Shares(2)								4,000	I	By Wife
American Depositary Shares(2)	11/12/2025		S		500	D	$350.441(3)	15,509	D
American Depositary Shares(2)	11/12/2025		S		3,240	D	$351.4102(4)	12,269	D
American Depositary Shares(2)	11/12/2025		S		789	D	$352.7773(5)	11,480	D
American Depositary Shares(2)	11/12/2025		S		251	D	$354.1964(6)	11,229	D
American Depositary Shares(2)	11/12/2025		S		120	D	$355	11,109	D
American Depositary Shares(2)	11/12/2025		S		100	D	$357.4318(7)	11,009	D
American Depositary Shares(2)	11/12/2025		S		4,846	D	$360.0958(8)	6,163	D
American Depositary Shares(2)	11/12/2025		S		154	D	$362.0719(9)	6,009	D
American Depositary Shares(2)	11/13/2025		S		4,240	D	$380.3261(10)	1,769	D
American Depositary Shares(2)	11/13/2025		S		1,769	D	$381.0497(11)	0	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Includes 650 ordinary shares acquired pursuant to the Company's Fourth Amended and Restated 2018 Employee Share Purchase Plan.

2. Each American Depositary Share represents 13 Ordinary Shares.

3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $350.00 to $350.93, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.05 to $351.52, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

5. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $352.28 to $353.10, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

6. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.59 to $354.585, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

7. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.385 to $357.70, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

8. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.00 to $360.945, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

9. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.00 to $362.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

10. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $380.00 to $380.75, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

11. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $381.00 to $381.50, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price.

Remarks:

	/s/ Qing Nian, as Attorney-in-Fact	11/14/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.