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OPKO HEALTH, INC. director Uppaluri Subbarao V received a grant of stock options covering 50,000 shares of common stock. The options have an exercise price of $1.17 per share and were awarded at no cost to the director. According to the filing, these options become exercisable on March 18, 2027 and expire on March 17, 2036. Following this grant, the director holds stock options for 50,000 underlying shares.
OPKO HEALTH, INC. director Dr. Uppaluri Subbarao V filed an initial Form 3 reporting his ownership of the company’s common stock. He reports direct ownership of 622,817 shares and several indirect interests through family-related entities and trusts.
One indirect position is held by Uppaluri Investments, LLC, which is owned equally by the Uppaluri 2012 Family Trust and the Ajay Uppaluri 2020 Gift Trust. Additional indirect holdings are reported through the 2020 Trust and shares owned by his spouse. For each of these indirect positions, Dr. Uppaluri disclaims beneficial ownership except to the extent of his pecuniary interest.
OPKO Health, Inc. has appointed Subbarao V. Uppaluri, Ph.D. as a new independent director, effective March 18, 2026. He will serve until the 2026 Annual Meeting of Stockholders and is expected to join the Compensation Committee.
Dr. Uppaluri previously served as OPKO’s Senior Vice President and Chief Financial Officer from 2007 to 2012 and later as a consultant. The board cites his independence under SEC and Nasdaq rules and notes there are no related-party transactions requiring disclosure. He fills a vacancy created by the passing of longtime director Dr. Richard Krasno and will receive the company’s standard non-employee director compensation and indemnification protections.
OPKO Health files its annual report detailing a diversified healthcare business spanning pharmaceuticals and diagnostics. The company highlights NGENLA®, a once-weekly growth hormone partnered with Pfizer, which generated $31.9 million in 2025 royalty and profit-share payments and is approved in more than 50 countries.
OPKO emphasizes Rayaldee, an FDA‑approved treatment for secondary hyperparathyroidism, now launched or authorized across multiple international markets through partners VFMCRP and Nicoya. Its ModeX subsidiary is advancing multispecific antibody and vaccine platforms, supported by BARDA funding and collaborations with Merck and Regeneron.
In diagnostics, OPKO reshaped BioReference by divesting non-core assets to Labcorp for up to $462.5 million, cutting annual revenue by about $200 million but reducing headcount from roughly 3,300 to 1,373 and refocusing on New York/New Jersey clinical testing and the 4Kscore® prostate cancer test, whose revenue grew more than 13% in 2025.
OPKO Health reported weaker results for the quarter and year ended December 31, 2025, while highlighting major new partnerships and a deepening pipeline. Fourth quarter revenue was $148.5 million versus $183.6 million a year earlier, with a net loss of $31.3 million, or $0.04 per share, compared with net income of $14.0 million in 2024.
For full year 2025, revenue fell to $606.9 million from $713.1 million, and net loss widened to $225.7 million from $53.2 million. The company signed a Regeneron collaboration with potential milestones exceeding $200 million per program and overall value above $1 billion, and reported progress across multiple ModeX antibody programs. Cash, cash equivalents and restricted cash were $369.1 million at year-end 2025. OPKO issued 2026 guidance calling for total revenue of $530–$560 million and total costs and expenses of $725–$750 million.
OPKO Health (OPK) CEO and Chairman Phillip Frost, M.D., reported multiple open-market purchases of OPKO common stock. On 11/21/2025, he bought blocks of 102,371, 3,894, 89,375, 191,490 and 192,870 shares at prices ranging from $1.30 to $1.335 per share. After these transactions, one line shows 216,706,448 shares of common stock beneficially owned indirectly as indicated in footnote (1). Separate lines show 3,568,951 shares held directly and 30,127,177 shares held indirectly as described in footnote (2).
Footnote (1) explains that certain shares are held by Frost Gamma Investments Trust and related entities, and footnote (2) explains holdings in Frost Nevada Investments Trust and related entities. In both cases, the reporting person disclaims beneficial ownership of these securities except to the extent of any pecuniary interest.
OPKO Health (OPK) insider trading report: Phillip Frost, M.D., who serves as CEO, Chairman, director and a 10% owner of OPKO Health, reported a series of open-market purchases of the company’s common stock. On 11/20/2025, he bought a total of 580,000 common shares in multiple trades at prices ranging from $1.32 to $1.35 per share, all reported as indirect ownership through Frost Gamma Investments Trust. After these transactions, one reported indirect position shows 216,126,448 shares beneficially owned. The filing also lists 3,568,951 shares held directly and an additional 30,127,177 shares held indirectly through Frost Nevada Investments Trust. The report states that beneficial ownership is disclaimed except to the extent of any pecuniary interest.
OPKO Health (OPK) insider Phillip Frost, M.D., who serves as CEO, Chairman and a 10% owner, reported multiple open market purchases of the company’s common stock. On 11/19/2025, he bought a total of 580,000 shares in several transactions at prices ranging from $1.28 to $1.32 per share. Following these transactions, he was reported as indirectly beneficially owning 215,546,448 shares through Frost Gamma Investments Trust, with additional holdings of 3,568,951 shares directly and 30,127,177 shares indirectly through Frost Nevada entities, while expressly disclaiming beneficial ownership beyond his pecuniary interest.
OPKO Health (OPK) CEO and Chairman Phillip Frost, M.D. reported multiple purchases of OPKO common stock on 11/18/2025. The transactions, coded as open-market or private purchases, ranged from $1.245 to $1.29 per share across several small trades.
Following these transactions, Frost is shown as beneficially owning 214,966,448 OPKO shares indirectly, as noted in a footnote describing Frost Gamma Investments Trust and related entities. Additional holdings of 3,568,951 shares are listed as directly owned, and 30,127,177 shares as indirectly owned through Frost Nevada Investments Trust, with both positions also accompanied by detailed ownership-disclaimer language. Frost is identified as a director, 10% owner, CEO and Chairman of OPKO Health.
OPKO Health (OPK): Phillip Frost, M.D., the company’s CEO, Chairman, Director and a 10% owner, reported an open‑market purchase of 150,000 shares of common stock on 10/31/2025 at a weighted average price of $1.4229. The price reflects multiple trades between $1.415 and $1.4299.
Following the transaction, reported beneficial ownership includes 3,568,951 shares direct, 214,386,448 shares indirect held by Frost Gamma Investments Trust, and 30,127,177 shares indirect held by Frost Nevada Investments Trust. The filing notes trust structures and standard beneficial ownership disclaimers.