[SCHEDULE 13G] PALISADE BIO, INC. SEC Filing

Rhea-AI Filing Summary

Perceptive Advisors LLC, its founder Joseph Edelman and Perceptive Life Sciences Master Fund, Ltd. reported beneficial ownership of 12,243,018 shares of Palisade Bio, Inc. common stock, representing 9.99% of the class on a fully considered basis. The calculation uses 96,645,431 reported outstanding shares plus 25,714,285 shares from the underwriters' over-allotment and assumes exercise of Pre-Funded Warrants for 193,018 shares permitted under a stated Beneficial Ownership Limitation. The Master Fund directly holds 12,050,000 shares and 5,185,714 Pre-Funded Warrants, and Perceptive Advisors acts as investment manager; Mr. Edelman is the managing member. The filing states the position was not acquired to influence control.

Positive

• Material stake disclosed: Combined ownership of 12,243,018 shares representing 9.99%
• Regulatory compliance: Timely Schedule 13G filing with clear breakdown of direct holdings and warrants
• Structured warrant limit: Beneficial Ownership Limitation prevents accidental ownership above 9.99%

Negative

• Near-threshold concentration: Position sits immediately below the 10% level, which could limit future automatic exercises
• Shared voting/dispositive power only: Reported sole voting and dispositive power are 0, indicating decisions are not claimed as sole control

Insights

Institutional Ownership Analyst

Large passive stake disclosed just below the 10% regulatory threshold.

The filing shows a coordinated reporting group holding 12,243,018 shares, equal to 9.99%, which is material for investors because it signals a significant concentrated position without crossing the 10% reporting/beneficial ownership trigger. The position combines direct shares and Pre-Funded Warrants limited by a Beneficial Ownership Limitation that caps exercisable warrants at 193,018 shares.

This structure means further automatic exercise into additional shares is constrained unless circumstances change; monitor any changes to the Beneficial Ownership Limitation or subsequent filings for increases in ownership or changes in voting/dispositive power within the next few reporting cycles, including any amendments or Schedule 13D filings if intentions shift.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

PALISADE BIO, INC.

(Name of Issuer)

Common Stock, $0.01 par value

(Title of Class of Securities)

696389402

(CUSIP Number)

10/02/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 696389402

1

Names of Reporting Persons

Perceptive Advisors LLC

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 12,243,018.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 12,243,018.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

12,243,018.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.99 %

12

Type of Reporting Person (See Instructions)

IA

SCHEDULE 13G

CUSIP No. 696389402

1

Names of Reporting Persons

Joseph Edelman

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 12,243,018.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 12,243,018.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

12,243,018.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.99 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

CUSIP No. 696389402

1

Names of Reporting Persons

Perceptive Life Sciences Master Fund, Ltd.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

CAYMAN ISLANDS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 12,243,018.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 12,243,018.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

12,243,018.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.99 %

12

Type of Reporting Person (See Instructions)

CO

SCHEDULE 13G

Item 1.
(a)	Name of issuer: PALISADE BIO, INC.
(b)	Address of issuer's principal executive offices: 1902 Wright Place, Suite 200 Carlsbad, California 92008
Item 2.
(a)	Name of person filing: The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.01 per share (the "Common Stock") of PALISADE BIO, INC. (the "Issuer") are: Perceptive Advisors LLC ("Perceptive Advisors") Joseph Edelman ("Mr. Edelman") Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund")
(b)	Address or principal business office or, if none, residence: The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor New York, NY 10003
(c)	Citizenship: Perceptive Advisors is a Delaware limited liability company Mr. Edelman is a United States citizen The Master Fund is a Cayman Islands corporation
(d)	Title of class of securities: Common Stock, $0.01 par value
(e)	CUSIP No.: 696389402
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 96,645,431 outstanding shares of Common Stock as reported by the Issuer in its prospectus supplement filed pursuant to Rule 424(b)(4) with the Securities and Exchange Commission on October 2, 2025, plus 25,714,285 additional shares of Common Stock issued upon the underwriters' exercise of their over-allotment option on October 6, 2025, and assume the exercise of Pre-Funded Warrants held by the Reporting Persons for 193,018 shares of Common Stock (the "Pre-Funded Warrants"). Neither Perceptive Advisors nor Mr. Edelman directly hold any shares of Common Stock or any Pre-Funded Warrants. The Master Fund directly holds 12,050,000 shares of Common Stock and 5,185,714 Pre-Funded Warrants immediately exercisable for shares of Common Stock at an exercise price of $0.0001 per share, subject to the Beneficial Ownership Limitation (as defined below). The terms of the Pre-Funded Warrants provide that the Pre-Funded Warrants may not be exercised if, after such exercise, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) if the Securities Exchange Act of 1934, as amended, more than 9.99% of the shares of Common Stock then issued and outstanding (the "Beneficial Ownership Limitation"). As of the date hereof, the Beneficial Ownership Limitation permits the Reporting Persons to exercise Pre-Funded Warrants for an aggregate of not more than 193,018 shares of Common Stock. In providing the beneficial ownership information set forth herein, the Reporting Persons have assumed that the aggregate remaining Pre-Funded Warrants held by the Reporting Persons are not exercisable due to the Beneficial Ownership Limitation. Perceptive Advisors serves as the investment manager to the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors.
(b)	Percent of class: Perceptive Advisors: 9.99% Mr. Edelman: 9.99% Master Fund: 9.99%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0
	(ii) Shared power to vote or to direct the vote: Perceptive Advisors: 12,243,018 Mr. Edelman: 12,243,018 Master Fund: 12,243,018
	(iii) Sole power to dispose or to direct the disposition of: Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0
	(iv) Shared power to dispose or to direct the disposition of: Perceptive Advisors: 12,243,018 Mr. Edelman: 12,243,018 Master Fund: 12,243,018
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Perceptive Advisors LLC

Signature:	/s/ Joseph Edelman
Name/Title:	Joseph Edelman, Managing Member
Date:	10/09/2025

Joseph Edelman

Signature:	/s/ Joseph Edelman
Name/Title:	Joseph Edelman
Date:	10/09/2025

Perceptive Life Sciences Master Fund, Ltd.

Signature:	/s/ Joseph Edelman
Name/Title:	Joseph Edelman, Managing Member
Date:	10/09/2025

FAQ

What stake did Perceptive report in Palisade Bio (PALI)?

Perceptive Advisors, Joseph Edelman and Perceptive Life Sciences Master Fund reported beneficial ownership of 12,243,018 shares, equal to 9.99%.

How is the 9.99% ownership percentage calculated?

The percentage is based on 96,645,431 outstanding shares reported by the issuer plus 25,714,285 over-allotment shares and assumes exercise of Pre-Funded Warrants for 193,018 shares permitted under the Beneficial Ownership Limitation.

Does the filing indicate control of Palisade Bio?

No; the certifying statement says the securities were not acquired to change or influence control, and each Reporting Person reports 0 sole voting power and 0 sole dispositive power.

What are the Pre-Funded Warrants disclosed?

The Master Fund directly holds 5,185,714 Pre-Funded Warrants exercisable for common stock at $0.0001 per share, subject to the Beneficial Ownership Limitation which currently permits exercise for up to 193,018 shares.

Who signs the Schedule 13G for these filings?

The Schedule is signed by Joseph Edelman as Managing Member of Perceptive Advisors and on behalf of the Master Fund, dated 10/09/2025.