T. Rowe Price discloses 12.1% stake in Personalis (NASDAQ: PSNL)

Rhea-AI Filing Summary

T. Rowe Price Investment Management, Inc. filed a Schedule 13G reporting a significant passive stake in Personalis Inc. (PSNL). The firm reports beneficial ownership of 10,780,290 shares of Personalis common stock, representing 12.1% of the class as of the event date of 12/31/2025. T. Rowe Price Investment Management is identified as an investment adviser and reports sole voting and dispositive power over all of these shares, with no shared voting or dispositive power. The filing states that the securities were acquired and are held in the ordinary course of business and not for the purpose of changing or influencing control of Personalis, and it expressly denies that T. Rowe Price Investment Management should be deemed the beneficial owner of the securities.

Insights

Institutional ownership analyst

T. Rowe Price reports a 12.1% passive stake in Personalis.

T. Rowe Price Investment Management, Inc. discloses beneficial ownership of 10,780,290 shares of Personalis common stock, equal to 12.1% of the outstanding class as of 12/31/2025. The firm reports sole voting and dispositive power over this entire position, with no shared authority.

The filer classifies itself as an investment adviser and certifies that the shares were acquired and are held in the ordinary course of business, not to change or influence control of Personalis. It also states that the filing should not be construed as an admission that T. Rowe Price Investment Management is the beneficial owner of these securities, which it expressly denies.

This type of Schedule 13G indicates a sizable institutional position but characterizes it as passive rather than activist. Future ownership updates, if any, would typically appear in subsequent beneficial ownership filings should the percentage change enough to require another disclosure.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

PERSONALIS INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

71535D106

(CUSIP Number)

12/31/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 71535D106

1

Names of Reporting Persons

T. Rowe Price Investment Management, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MARYLAND

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 10,780,290.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 10,780,290.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

10,780,290.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

12.1 %

12

Type of Reporting Person (See Instructions)

IA

SCHEDULE 13G

Item 1.
(a)	Name of issuer: PERSONALIS INC
(b)	Address of issuer's principal executive offices: 6600 DUMBARTON CIRCLE, FREMONT, CA, 94555
Item 2.
(a)	Name of person filing: T. Rowe Price Investment Management, Inc.
(b)	Address or principal business office or, if none, residence: 1307 Point Street, Baltimore, MD 21231
(c)	Citizenship: Maryland
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP No.: 71535D106
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 10780290
(b)	Percent of class: 12.1 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 10780290
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 10780290
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. T. Rowe Price Investment Management, Inc. hereby declares and affirms that the filing of Schedule 13G shall not be construed as an admission that Price Investment Management is the beneficial owner of the securities referred to, which beneficial ownership is expressly denied.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

T. Rowe Price Investment Management, Inc.

Signature:	Ellen York
Name/Title:	Vice President
Date:	01/08/2026

FAQ

How many Personalis (PSNL) shares does T. Rowe Price Investment Management report owning?

T. Rowe Price Investment Management, Inc. reports beneficial ownership of 10,780,290 shares of Personalis Inc. common stock.

What percentage of Personalis (PSNL) does T. Rowe Price Investment Management hold?

The filing states that T. Rowe Price Investment Management's position represents 12.1% of the outstanding class of Personalis common stock.

Is T. Rowe Price Investment Management a passive or active investor in Personalis (PSNL)?

The firm certifies that the securities were acquired and are held in the ordinary course of business and not for the purpose of changing or influencing control of Personalis, indicating a passive stance under Schedule 13G.

What voting and dispositive powers does T. Rowe Price Investment Management have over its Personalis (PSNL) shares?

The filing reports sole power to vote and dispose of 10,780,290 shares, with no shared voting or dispositive power over Personalis common stock.

When was the ownership level that triggered this Personalis (PSNL) Schedule 13G measured?

The ownership information is reported as of the event date of 12/31/2025, which is the date cited as requiring the filing of this Schedule 13G.

Does T. Rowe Price Investment Management admit beneficial ownership of the Personalis (PSNL) shares?

No. The filing states that it shall not be construed as an admission that T. Rowe Price Investment Management is the beneficial owner of the securities and that such beneficial ownership is expressly denied.