Recursion prices 61.5M-share offering at $3.25
Preliminary cash and expected net offering proceeds are projected to fund operating expenses and capital expenditures into 2029.
Sentiment and the balance of points
Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.
Form Type
8-K
Rhea-AI Filing Summary
Recursion Pharmaceuticals, Inc. (RXRX) priced a company-issued offering of 61,540,000 Class A common shares at $3.25 per share, with gross proceeds expected to be approximately $200 million before underwriting discounts, commissions and expenses. Closing is expected October 16, 2026, subject to customary conditions.
Preliminary cash, cash equivalents and restricted cash were approximately $561 million as of September 30, 2026, including approximately $86 million of net proceeds from the at-the-market program during the quarter. Recursion expects cash, including the offering’s net proceeds, to fund operating expenses and capital expenditures into 2029.
Sanofi optioned its first candidate from the collaboration, triggering a $10 million milestone and bringing total upfront and milestone payments to $144 million. Recursion remains eligible for more than $300 million in additional program milestones and an average of low double-digit royalties on net product sales if successfully commercialized; Sanofi will fund and lead development, with Phase 1 expected in 2027. REC-4881 showed a 47% median polyp-burden reduction after 12 weeks; 85% remained below baseline after 12 weeks off treatment. For REC-1245, 11 of 12 patients starting at 45 mg or 65 mg had disease control at eight weeks. The 45 mg expansion dose was selected; at 65 mg, 3 of 4 patients evaluable for dose-limiting toxicities had them, and the maximum tolerated dose was exceeded.
Positive
- Minor pointSanofi’s candidate option triggered a $10 million milestone payment.
- Minor pointREC-4881: 47% median polyp-burden reduction at Week 13.
Negative
- Minor pointREC-1245: 3 of 4 patients had dose-limiting toxicities at 65 mg.
Filing Explained
If the offering closes, its 61,540,000 shares sold by Recursion would increase the share count and reduce existing holders’ percentage ownership, absent offsetting changes; closing was expected
8-K Event Classification
5 items: 1.01, 2.02, 7.01, 8.01, 9.01
5 items
Item 1.01
Entry into a Material Definitive Agreement
Business
The company signed a significant contract such as a merger agreement, credit facility, or major partnership.
Item 2.02
Results of Operations and Financial Condition
Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 7.01
Regulation FD Disclosure
Disclosure
Material non-public information disclosed under Regulation Fair Disclosure, often investor presentations or guidance.
Item 8.01
Other Events
Other
Voluntary disclosure of events the company deems important to shareholders but not covered by other items.
Item 9.01
Financial Statements and Exhibits
Exhibits
Financial statements, pro forma financial information, or exhibit attachments filed with this report.
Key Figures
Class A common shares in offering: 61,540,000 shares
Offering price: $3.25 per share
Expected gross proceeds: Approximately $200 million
+5 more
8 metrics
Class A common shares in offering
61,540,000 shares
Company-issued offering
Offering price
$3.25 per share
Class A common stock
Expected gross proceeds
Approximately $200 million
Before underwriting discounts, commissions and estimated offering expenses
Preliminary cash, cash equivalents and restricted cash
Approximately $561 million
As of September 30, 2026; preliminary and unaudited
Sanofi milestone payment
$10 million
Triggered by Sanofi’s option on the development candidate
Additional Sanofi program milestones
More than $300 million
Further milestones Recursion remains eligible to receive
REC-4881 median polyp-burden reduction
47%
After 12 weeks of treatment
REC-1245 disease control
91.7% (11 of 12 patients)
At eight weeks among patients starting at 45 mg or 65 mg
Key Terms
underwriting agreement, at-the-market program, milestone payment, efficacy-evaluable, +2 more
6 terms
underwriting agreement financial
"entered into an underwriting agreement"
An underwriting agreement is a contract where a company selling new stocks or bonds hires financial firms to buy those securities and resell them to investors. It matters because the agreement sets the offering price, number of securities, fees and which party bears the risk if sales fall short—think of it as a promise that the sale will happen and a roadmap investors can use to understand how the new securities reach the market.
at-the-market program financial
"shares under our at-the-market program"
An at-the-market program is a way for a company to sell new shares of its stock gradually over time directly into the stock market, rather than all at once. This approach allows the company to raise money as needed while giving investors the opportunity to buy shares at current market prices. It helps manage the timing and price of new stock offerings, providing flexibility for both the company and investors.
milestone payment financial
"The option triggered a $10 million milestone payment"
A milestone payment is a pre-agreed cash amount paid when a company reaches a specific, measurable achievement in a partnership, such as completing a clinical trial stage, receiving regulatory approval, or hitting a sales target. For investors it signals how future revenue and risk are shared — like progress payments on a construction project, these payments can unlock value and affect a company’s cash flow and valuation as each milestone is met.
efficacy-evaluable medical
"16 efficacy-evaluable patients"
dose-limiting toxicities medical
"three of four DLT-evaluable patients experienced DLTs"
Dose-limiting toxicities are the harmful side effects seen in early clinical trials that are severe enough to stop researchers from raising a drug’s dose. Like a car’s speed limiter marking the safe top speed, DLTs define the maximum tolerable dose, and they matter to investors because they determine whether a medicine can reach effective levels, influence development timelines, costs, and regulatory chances, and thus affect a drug’s commercial prospects.
molecular glue degrader technical
"REC-1245, a potential first-in-class oral molecular glue degrader"
A molecular glue degrader is a small drug-like molecule that acts like a tiny adhesive, sticking a specific disease-related protein to the cell’s natural disposal machinery so the protein is destroyed rather than merely blocked. Investors watch these compounds because they can turn previously untreatable targets into removable liabilities, potentially creating breakthrough therapies, shifting development risk, and offering strong commercial upside if clinical results and regulatory approval follow.
FAQ
AI-generated questions and answers. How Rhea-AI works. Not financial advice.
What is RXRX’s cash balance and expected runway?
Recursion estimated preliminary, unaudited cash, cash equivalents and restricted cash of approximately $561 million as of September 30, 2026. The estimate includes approximately $86 million in net proceeds from its at-the-market program during the quarter. Including net offering proceeds, the company expects to fund operating expenses and capital expenditures into 2029.
What did RXRX report about REC-4881?
REC-4881 showed a 47% median reduction in total polyp burden after 12 weeks, and 85% of patients remained below baseline after 12 weeks off treatment. Recursion anticipates initiating a registrational trial in 2027, pending ongoing discussions with the FDA.
What did RXRX report about REC-1245 and its selected dose?
At eight weeks, 11 of 12 patients who started at 45 mg or 65 mg had disease control; three partial responses were reported, two confirmed and one unconfirmed. Recursion selected 45 mg once daily for expansion cohorts. At 65 mg, three of four dose-limiting-toxicity-evaluable patients experienced dose-limiting toxicities, and the maximum tolerated dose was exceeded.
What are the financial terms of RXRX’s Sanofi collaboration update?
Sanofi’s option on the first development candidate triggered a $10 million milestone payment, bringing total upfront and milestone payments under the collaboration to $144 million. Recursion remains eligible for more than $300 million in additional milestones for the program and an average of low double-digit royalties on net product sales if successfully commercialized.
AI-generated analysis. How Rhea-AI works. Not financial advice.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 OR 15(d)
of The Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): October 15, 2026
(Exact name of registrant as specified in its charter)
| (State or other jurisdiction of incorporation) | (Commission File Number) | (I.R.S. Employer Identification No.) | ||||||||||||
(Address of principal executive offices) (Zip code)
(385 ) 269 - 0203
(Registrant’s telephone number, including area code)
Not Applicable
(Former name or former address, if changed since last report.)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
Securities registered pursuant to Section 12(b) of the Act:
| Title of each class | Trading symbol(s) | Name of each exchange on which registered | ||||||
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 1.01. Entry into a Material Definitive Agreement.
On October 15, 2026, Recursion Pharmaceuticals, Inc. (the “Company” or “Recursion”) entered into an underwriting agreement (the “Underwriting Agreement”) with Leerink Partners LLC, Goldman Sachs & Co. LLC, Morgan Stanley & Co. LLC and Evercore Group L.L.C. as representatives of the several underwriters named therein (collectively, the “Underwriters”), relating to the offering of 61,540,000 shares of its Class A common stock, par value $0.00001 per share (the “Class A Common Stock”, and the offering of such shares, the “Offering”), at a price of $3.25 per share. All of the shares of Class A Common Stock are to be sold by the Company. The gross proceeds to the Company from the offering are expected to be approximately $200 million before deducting underwriting discounts and commissions and other estimated offering expenses payable by the Company. The offering is expected to close on October 16, 2026, subject to the satisfaction of customary closing conditions.
The Underwriting Agreement contains customary representations, warranties and agreements by the Company, customary conditions to closing, indemnification obligations of the Company and the Underwriters, including for liabilities under the Securities Act of 1933, as amended, other obligations of the parties and termination provisions. The representations, warranties and covenants contained in the Underwriting Agreement were made only for purposes of such agreement and as of specific dates, were solely for the benefit of the parties to such agreement, and may be subject to limitations agreed upon by such parties. In addition, pursuant to the terms of the Underwriting Agreement, the executive officers and directors of the Company and certain related entities have entered into “lock-up” arrangements with the Underwriters, which generally prohibit the sale, transfer or other disposition of securities of the Company for a 45-day period, subject to certain exceptions.
The offering is being made pursuant to the Company's effective registration statement on Form S-3ASR (File No. 333-284878) (the "Registration Statement") and a related prospectus supplement and the accompanying prospectus, in each case filed with the Securities and Exchange Commission ("SEC").
The description of the Underwriting Agreement set forth above is qualified in its entirety by reference to the Underwriting Agreement, a copy of which is filed as Exhibit 1.1 hereto and is incorporated herein by reference.
A copy of the opinion of Wilson Sonsini Goodrich & Rosati, P.C. relating to the validity of the shares of Class A Common Stock sold by the Company is filed as Exhibit 5.1 hereto and is incorporated by reference into the Registration Statement.
Item 2.02. Results of Operations and Financial Condition.
Financial Update
On October 15, 2026, the Company estimated that its cash, cash equivalents, and restricted cash balance as of September 30, 2026 was approximately $561 million. Following this offering, we expect our existing cash, cash equivalents and restricted cash will enable us to fund our operating expenses and capital expenditure requirements into 2029. The preliminary cash balance includes approximately $86 million in net proceeds from the sale of 23,696,330 shares of Class A Common Stock under our at-the-market program with TD Securities (USA) LLC during the quarter ended September 30, 2026.
The Company’s consolidated financial statements for the three months ended September 30, 2026 are not yet available. Accordingly, the information presented above reflects the Company’s preliminary estimates subject to the completion of the Company’s financial closing procedures and any adjustments that may result from the completion of the quarterly review of the Company’s consolidated financial statements. As a result, these preliminary estimates may differ from the actual results that will be reflected in the Company’s consolidated financial statements for the quarter when they are completed and publicly disclosed. These preliminary estimates may change and those changes may be material.
The Company’s expectations with respect to its unaudited results for the period discussed above are based upon management estimates and are the responsibility of management. The Company’s independent registered public accounting firm has not audited, reviewed or performed any procedures with respect to these preliminary results and, accordingly, does not express an opinion or any other form of assurance about them.
Item 7.01. Regulation FD Disclosure.
Also on October 15, 2026, the Company issued a press release announcing that Sanofi has optioned the development candidate described in Item 8.01 below. The press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.
Also on October 15, 2026, the Company issued a press release with a general corporate update. The press release is attached as Exhibit 99.2 to this Current Report on Form 8-K and is incorporated herein by reference.
Also on October 15, 2026, the Company posted an updated corporate presentation to the investor section of the Company’s website. A copy of this presentation is attached as Exhibit 99.3 to this Current Report on Form 8-K and is incorporated herein by reference.
The information contained in the slides is summary information that is intended to be considered in the context of the more complete information included in the Company’s filings with the SEC and other public announcements that the Company has made and may make from time to time by press release or otherwise. The Company undertakes no duty or obligation to update or revise the information contained in the presentation in this Current Report on Form 8-K, although it may do so from time to time as its management believes is appropriate. Any such update may be made through the filing of other reports or documents with the SEC.
The information in this Item 7.01, including Exhibit 99.1, Exhibit 99.2, Exhibit 99.3, and Exhibit 99.4 attached hereto, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, except as expressly set forth by specific reference in such filing.
Item 8.01. Other Events.
Offering Update
The Company issued a press release on October 15, 2026 announcing the pricing of the Offering, which press release is attached as Exhibit 99.4 to this Current Report on Form 8-K and is incorporated herein by reference.
Partner Update
On October 15, 2026, Recursion announced that Sanofi has optioned the first development candidate from the two companies’ multi-program research collaboration. The potential first-in-class oral small molecule was designed to achieve a differentiated profile against a challenging dual target implicated in inflammatory disease, and was delivered by the combination of Recursion’s integrated AI-enabled drug design platform and small-molecule chemistry capabilities with Sanofi’s deep expertise in drug discovery and immunology.
The candidate has now been added to Sanofi’s development pipeline and is expected to enter phase 1 clinical trials in 2027, with Sanofi funding and leading further development and commercialization. The option triggered a $10 million milestone payment to Recursion, bringing total upfront and milestone payments under the collaboration to $144 million to date. Recursion remains eligible for more than $300 million in additional milestones for this program, with an average of low double-digit royalties on net product sales if successfully commercialized. With the first development candidate optioned, the collaboration has now achieved six progress-based milestones across five programs.
REC-4881 Phase 1b/2 Study
On October 15, 2026, we announced updated topline data from our Phase 1b/2 TUPELO study of REC-4881, an investigational MEK1/2 inhibitor for familial adenomatous polyposis (FAP) that targets both Wnt/β-catenin initiation and MAPK evolution pathways via a mechanism identified by Recursion's AI discovery platform. REC-4881 is a potential first-in-class oral therapy granted FDA Orphan Drug and Fast Track designations.
FAP is a genetically defined driver of GI cancer with no approved therapies that affects more than 50,000 patients, 35,000 of which are post-colectomy, in the US and EU5, representing a roughly $15 billion overall addressable market opportunity. In these patients, upper GI (UGI) polyps represent the highest unmet need in FAP due to higher rates of complications such as bleeding and perforations from surgical procedures used to manage the disease.
Study Design and Population
We are conducting a multi-center, open-label trial of REC-4881 in genetically confirmed FAP patients age 18 and over with no active cancer and polyps in the upper or lower GI tracts. Patients are given 4 mg once daily for twelve weeks followed by no treatment for twelve weeks. Polyp burden was defined as the sum of all polyp diameters and evaluated at baseline and weeks 13 and 25. With a data cutoff of September 10, 2026, we reported on sixteen (16) efficacy-evaluable patients, defined as participants with measurable disease (non-zero polyp burden) at baseline endoscopy, who received at least 75% of study drug, and had at least one post-baseline on-study endoscopic assessment. These 16 reflect 4 additional efficacy-evaluable patients from the last update. We also reported on 26 safety evaluable patients, 5 from the Phase 1b and 21 from the Phase 2 portion of the TUPELO study.
Results
Of the 16 efficacy-evaluable patients, 87% of patients achieved reductions in total polyp burden, with a 47% median reduction in total polyp burden at week 13, consistent with the 43% (n=12) reported previously. Of the four additional patients, all had reductions in overall polyp burden. In the upper GI tract, 92% of 13 evaluable patients experienced reductions, with 46% achieving equal to or greater than a 65% reduction. Two patients achieved reductions in the UGI of equal to or greater than 98%.
After twelve weeks off treatment, 85% of patients remained below their overall baseline polyp burden (n=11/13). In the UGI tract, 92% of patients remained below baseline, with 6 out of 11 with equal or greater reductions from their 13 week assessments. We view the durability results as potentially allowing for dosing flexibility, which may be important for long term disease management.
Half of patients showed Spigelman downstaging at week 13 (n=12), which is in line with our expectation given the 55% median reduction in upper GI polyp burden. Of the 6 patients downstaged at week 13, 4 maintained the greater than or equal to one stage improvement after twelve weeks off treatment; the remaining two were not assessed.
The safety profile remains favorable and supports the potential for chronic dosing. Of 26 safety-evaluable patients, 21 (80.8%) patients had treatment related adverse events (TRAEs) less than or equal to Grade 2, which were consistent with MEK1/2 inhibition and included dermatitis acneiform, CPK increases, rash, diarrhea, and left ventricular ejection fraction (LVEF) decrease. Of those who experienced LVEF, they were asymptomatic and the decrease was reversible, with one patient lost to follow up. Of 4 reports of Grade 3 TRAEs, two were dermatitis acneiform and rash and 2 were a blood CPK increase. None of the patients with Grade 3 TRAEs discontinued and three of the four resolved prior to the data cutoff. No Grade 4 or 5 TRAEs were reported.
The full Phase 1b/2 trial dataset will be presented at the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC) Annual Meeting on Monday, November 2 presented by Lisa Boardman, M.D., Mayo Clinic.
FDA Next Steps
Recursion has had conversations with the FDA for initiating a registrational trial. Pending the outcome of ongoing discussion with the FDA, the Company anticipates initiating a registrational trial in 2027 and will provide additional details later this year.
REC-1245 Phase 1/2 Study
On October 15, 2026, Recursion announced initial data from the Phase 1 monotherapy dose escalation portion of DAHLIA, our ongoing open-label Phase 1/2 clinical trial of REC-1245, a potential first-in-class oral molecular glue degrader designed to exploit a synthetic-lethal vulnerability in genomically unstable cancers by degrading RBM39, a splicing factor that regulates genes involved in DNA repair and stress response. The target emerged from Recursion’s platform, which found that degrading RBM39 mimics the loss of CDK12, a cancer vulnerability that has been difficult to target selectively because of its close similarity to CDK13, whose co-inhibition risks added toxicity. We estimate the total addressable patients for the therapy, should it be approved, to be greater than 100,000 in the US and EU5.
Study Design and Population
The dose escalation portion of DAHLIA enrolled patients with unresectable, locally recurrent or metastatic select solid tumors, or select relapsed or refractory lymphoma, who had progressed following, or were intolerant to, available standard-of-care treatments. Patients received REC-1245 on a continuous once-daily basis at escalating dose levels. The primary objectives of the phase 1 portion of the trial are safety and determining an MTD and/or recommended phase 2 dose, and the secondary objectives are pharmacokinetics and anti-tumor activity. As of the data cutoff date, 30 patients across all dose levels were safety-evaluable, and 12 patients who started treatment at 45 mg (dose level 4) or 65 mg (dose level 5) were efficacy-evaluable. Patients who had not yet reached their first efficacy assessment were excluded from the efficacy-evaluable population.
The data reflect a data cutoff date of August 21, 2026.
Dose Escalation Results
Among the 12 efficacy-evaluable patients who started treatment at 45 mg or 65 mg, 11 patients (91.7%) achieved disease control (complete response, partial response or stable disease) at eight weeks. Across all dose levels, 14 of 21 efficacy-evaluable patients (66.7%) achieved disease control at week 9.
Among the patients who started treatment at 45 mg or 65 mg, three patients achieved a partial response (PR) as measured by target lesion change under RECIST 1.1 criteria, two with endometrial cancer and one with hepatocellular carcinoma (HCC). Two of the responses have been confirmed. One patient with endometrial cancer, who started treatment at 65 mg and was reduced to 45 mg after six days of dosing (90% of dosing was 45 mg), achieved a PR with a 32.3% reduction in target lesions at Week 9, which was confirmed at Week 17 with a 48.9% reduction. A second patient with endometrial cancer, who started treatment at 45 mg, achieved a PR with a 33.9% reduction at Week 9 and a 38.2% reduction at Week 13. Both patients remained on treatment at 45 mg as of the data cutoff date. The patient with HCC, who started treatment at 65 mg, achieved an unconfirmed PR with a 55.9% reduction at Week 9, but withdrew from the trial due to toxicity, including Grade 3 stomatitis, Grade 4 thrombocytopenia and febrile neutropenia.
Safety and Tolerability Results
Across all dose levels, 22 of 30 patients (73.3%) experienced treatment related adverse events (TRAEs) of any grade, and eight patients (26.7%) experienced Grade 3 or higher TRAEs. The most common TRAEs were fatigue (30%), anemia (30%), nausea (20%), thrombocytopenia (20%) and stomatitis (16.7%). Grade 3 or higher TRAEs included anemia (10%), thrombocytopenia (10%), stomatitis (10%) and nausea (3.3%). At the 45 mg dosing level, 70% of patients experienced TRAEs (fatigue and anemia (30% each), all of which were Grade 1 or 2) with two patients (20%) experienced Grade 3 TRAEs, consisting of elevated creatinine and hypokalemia. No dose limiting toxicities (DLTs) or serious TRAEs were observed at that dose. At 65 mg, three of four DLT-evaluable patients experienced DLTs, including stomatitis, neutropenia or febrile neutropenia, and thrombocytopenia, and the MTD was exceeded.
Next Steps
Based on these data, we selected 45 mg once daily as the dose for monotherapy expansion cohorts, including in endometrial cancer, where second-line treatment options are limited and expect preliminary data in the second half of 2027. We are exploring additional tumor types for dose expansion. Additional Phase 1 data from DAHLIA are anticipated in the second half of 2026.
Forward-Looking Statements
The Company warns that statements in this report may contain information that includes or is based upon “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including, without limitation, statements regarding the expected completion and timing of closing of the offering, the anticipated total gross proceeds from the offering; the Company’s preliminary estimate of its cash and cash equivalents as of September 30, 2026; the Company’s expectations regarding its cash runway, including its believe that its existing cash, cash equivalents and restricted cash as of September 30, 2026, together with the net proceeds from the offering, will be sufficient to fund its operating expenses and capital expenditure requirements into 2029; the expected timing of the initiation of phase 1 clinical trials for the development candidate optioned by Sanofi; Recursion’s eligibility to receive future milestone payments and royalties under its collaboration with Sanofi; the potential of REC-1245 and REC-4881, including as first-in-class therapies, and their potential safety, efficacy, tolerability, durability of response, dosing flexibility and suitability for chronic dosing; the planned monotherapy expansion cohorts for REC-1245 and the exploration of additional tumor types; the expected timing of additional data readouts and presentations, including additional Phase 1 data for REC-1245 in the second half of 2026, expansion cohort data for REC-1245 in the second half of 2027, and the presentation of REC-4881 data at the CGA-IGC Annual Meeting; Recursion’s plans to initiate a pivotal trial of REC-4881 in 2027 and to provide additional details regarding such trial; Recursion’s estimates of addressable patient populations and market opportunities; and all other statements that are not statements of historical facts. Forward-looking statements may or may not include identifying words such as “intend,” “plan,” “will,” “expect,” “anticipate,” “believe,” “potential,” “continue,” “may,” “could,” “estimate,” “designed to,” and similar terms. These statements are subject to known and unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to:
prevailing market conditions; the satisfaction of customary closing conditions; the completion of the Company’s financial closing procedures and quarterly review, and the risk that final results may differ materially from the Company’s preliminary estimates; general economic, industry or political conditions; challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; the risk that initial, interim or topline clinical data, including the REC-1245 and REC-4881 data described in this report, may not be indicative of final results and may change as more patient data become available or additional analyses are performed; the risk that the FDA or other regulatory authorities may not agree with Recursion’s proposed pivotal trial design or development plans; Recursion’s ability to leverage and enhance its drug discovery platform; Recursion’s ability to obtain financing for development activities and other corporate purposes; the success of Recursion’s collaboration activities, including Recursion’s reliance on Sanofi for the further development and commercialization of the optioned development candidate and the achievement of milestones under the collaboration; Recursion’s ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; the accuracy of Recursion’s estimates of addressable patient populations and market opportunities; Recursion’s ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to Recursion’s technology systems; Recursion’s ability to attract, motivate, and retain key employees and manage its growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading “Risk Factors” in the preliminary prospectus supplement related to the offering and the accompanying prospectus filed with the SEC on October 15, 2026, and in Recursion’s filings with the SEC, including its most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q. All forward-looking statements are based on management’s current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.
Item 9.01. Financial Statements and Exhibits.
(d) Exhibits
| Exhibit Number | Description | ||||
| 1.1 | Underwriting Agreement, dated as of October 15, 2026 by and between Recursion Pharmaceuticals, Inc., and Leerink Partners LLC, Goldman Sachs & Co. LLC, Morgan Stanley & Co. LLC,, and Evercore Group L.L.C. as representatives of the several underwriters named therein. | ||||
| 5.1 | Opinion of Wilson Sonsini Goodrich & Rosati. | ||||
| 23.1 | Consent of Wilson Sonsini Goodrich & Rosati (included in Exhibit 5.1). | ||||
| 99.1 | Press Release of Recursion Pharmaceuticals, Inc. dated October 15, 2026. | ||||
| 99.2 | Press Release of Recursion Pharmaceuticals, Inc. dated October 15, 2026. | ||||
| 99.3 | Corporate Presentation of Recursion Pharmaceuticals, Inc. dated October 15, 2026. | ||||
| 99.4 | Press Release of Recursion Pharmaceuticals, Inc. dated October 15, 2026. | ||||
| 104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) | ||||
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized on October 15, 2026.
| RECURSION PHARMACEUTICALS, INC. | ||||||||
| By: | /s/ Ben Taylor | |||||||
Ben Taylor | ||||||||
| Chief Financial Officer | ||||||||
Exhibit 99.1
Recursion Announces Sanofi Options Potential First-in-Class Immunology Development Candidate from Their Collaboration
Potential first-in-class dual targeting inhibitor oral small molecule to enter Sanofi’s development pipeline, with phase 1 clinical study currently planned to begin in 2027
Salt Lake City, UT, Oct 15, 2026 (GLOBE NEWSWIRE) -- Recursion (Nasdaq: RXRX), a leading clinical-stage TechBio company decoding biology to radically improve lives, today announced that Sanofi has optioned the first development candidate from the two companies’ multi-program research collaboration.
The option triggered a $10 million milestone payment to Recursion, bringing total upfront and milestone payments received from Sanofi under the collaboration to $144 million; Recursion is eligible for more than $300 million in additional milestones under the program, with double digit royalties on net product sales, if approved.
“The most important test of any technology platform in drug discovery is whether it can translate into differentiated medicines,” said Najat Khan, Ph.D., President and Chief Executive Officer of Recursion. “Together with Sanofi, we tackled a difficult design problem against a dual target product profile with high potential and delivered a molecule that Sanofi has now selected for its development pipeline. With additional programs advancing across our collaboration, this milestone is another important demonstration of how our platform can translate computational capabilities into differentiated medicines — and do so repeatedly.”
The potential first-in-class oral small molecule was designed to achieve a differentiated profile against a challenging dual target implicated in inflammatory disease. Optimizing for this target pair required navigating complex and competing chemistry constraints to achieve the desired balance of drug-like properties. The candidate was delivered by the combination of Recursion’s integrated AI-enabled drug design platform and small-molecule chemistry capabilities with Sanofi’s deep expertise in drug discovery and immunology. Recursion applied multiple computational design approaches across iterative cycles of prediction, chemical design, synthesis, and experimental validation to rapidly explore and optimize a complex chemical space.
“By combining Sanofi's drug discovery and clinical and translational knowledge in Immunology with Recursion's AI-driven platform, we were able to move with speed and precision in a space where that balance is notoriously hard to achieve,” said Alyssa Johnsen, Therapeutic Area Head, Development, Immunology & Inflammation, Sanofi. “This new development candidate has potential to deliver a differentiated oral medicine with highly selective dual targeting that could be a meaningful advance for people living with inflammatory diseases who still lack adequate treatment options.”The candidate has now been added to Sanofi’s development pipeline and is
expected to enter phase 1 clinical trials in 2027, with Sanofi funding and leading further development and commercialization to advance the program toward patients.
Building a growing portfolio through the Recursion-Sanofi collaboration
The Recursion-Sanofi collaboration was established to discover and advance a portfolio of potentially first- and best-in-class small molecule medicines across immunology and oncology by combining Sanofi’s deep therapeutic-area and drug-development expertise with Recursion’s integrated capabilities across biology, AI-enabled molecular design and chemistry.
With the first development candidate optioned, the collaboration has now achieved six progress-based milestones across five programs. Sanofi’s selection of the development candidate triggered a $10 million milestone payment to Recursion, bringing total upfront and milestone payments under the collaboration to $144 million to date.
Recursion remains eligible for more than $300 million in additional milestones for this program, with an average of low double-digit royalties on net product sales if successfully commercialized. The $10 million milestone payment will be recognized as revenue in the third quarter of 2026, and ends Recursion’s operational requirements related to this candidate, with all future payments resulting in profit to Recursion.
Additional programs across the collaboration continue to advance. Over the next 12 months, other programs in the joint portfolio have the potential to reach development candidate and other progress-based milestones.
About Recursion
Recursion (NASDAQ: RXRX) a leading clinical-stage company pioneering AI-enabled drug discovery and development decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the Recursion OS is designed to translate complex science into medicines that matter — faster, better, and at scale — for patients who are waiting.
Recursion's platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation.
Media Contact
media@recursion.com
Investor Contact
investor@recursion.com
Forward-Looking Statements
This document contains information that includes or is based upon "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, without limitation, those regarding the expected timing of the initiation of phase 1 clinical trials for the development candidate optioned by Sanofi; the potential of such development candidate, including its potential to be a first-in-class, differentiated oral medicine for inflammatory diseases; Sanofi’s funding and leadership of further development and commercialization of such development candidate; Recursion’s eligibility to receive future milestone payments and royalties under its collaboration with Sanofi, and the expected timing of revenue recognition for the $10 million milestone payment; the potential for additional programs in the collaboration to reach development candidate and other progress-based milestones over the next 12 months; the ability of Recursion’s platform to repeatedly translate computational capabilities into differentiated medicines; and all other statements that are not historical facts. Forward-looking statements may or may not include identifying words such as "plan," "will," "may," "could," "should," "expect," "anticipate," "intend," "believe," "estimate," "project," "designed to," "potential," "continue," and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; our ability to leverage and enhance our drug discovery platform; the performance and limitations of our artificial intelligence and machine learning models and the data on which they are trained; our reliance on third parties, including collaborators, contract research organizations, and manufacturers; our ability to initiate clinical trials and enroll patients on expected timelines; competition from other therapies and platforms; our ability to obtain financing for development activities and other corporate purposes; the success of our collaboration activities and our collaborators' discretion over option exercises, program advancement, and funding, including the risk that Sanofi may delay, deprioritize, or discontinue development of the optioned development candidate; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading "Risk Factors" in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K and our subsequent Quarterly Reports on Form 10-Q. All forward-looking statements speak only as of the date of this document and are based on management's current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or
update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.
Exhibit 99.2
Recursion Announces $200 Million Oversubscribed Follow-On Offering, Clinical Data Updates, and Partnership Milestone
-Leading Healthcare Investors, including Adage, ARK, Driehaus, Invus, Janus Henderson Investors, Longaeva, and multiple prominent mutual funds invest $200 million in Recursion
-REC-4881 Phase 1b/2 Data Update: Deep, durable polyp burden reductions reproduced in the expanded adult FAP population (18+), with a 47% median reduction after 12 weeks of treatment and 85% maintaining reductions below baseline after 12 weeks off treatment. New upper GI data, addressing the area of greatest unmet medical need, demonstrated a 55% median reduction, with 92% of patients responding, two patients with ≥98% polyp burden reduction, and 92% maintaining reductions below baseline after 12 weeks off treatment. Registrational trial initiation targeted for 2H 2027, pending FDA discussions
-REC-1245 Phase 1 Data Update: Encouraging monotherapy activity with 2 confirmed partial responses in endometrial cancer, 1 unconfirmed response in liver cancer, and a 91.7% disease control rate (11/12) at doses ≥45 mg; 45 mg selected for expansion based on acceptable safety profile
-Partnership Update: Recursion announces Sanofi options potential first-in-class oral small molecule development candidate from their collaboration, designed to achieve a differentiated profile against a challenging dual target implicated in inflammatory disease
-Expected Cash Runway Extended into 2029, including proceeds from the concurrently announced offering
SALT LAKE CITY, UT, Oct. 15, 2026 (GLOBE NEWSWIRE) -- Recursion (Nasdaq: RXRX), a leading clinical-stage company pioneering AI-enabled drug discovery and development decoding biology to radically improve lives, today announced a $200 million underwritten offering of common stock with leading healthcare and institutional investors, including Adage, ARK, Driehaus, Invus, Janus Henderson Investors and other prominent mutual funds as well as business and clinical updates across its pipeline, including updated Phase 1b/2 data for REC-4881 in Familial Adenomatous Polyposis (FAP), promising early data in the Phase 1 DAHLIA trial for REC-1245, and a key milestone with Sanofi optioning a potential first-in-class immunology development candidate from their collaboration.
“Over the past 18 months, we've fundamentally transformed Recursion with a clear ambition: to repeatedly translate AI-driven discoveries into differentiated medicines for patients. And we're delivering. The proof points are stacking up — with REC-4881, we've demonstrated deep, durable reductions in precancerous polyps, particularly in the upper GI, where the unmet medical need is greatest, in a lifelong disease with no approved pharmacologic therapies. We're also seeing encouraging responses in heavily pretreated cancer patients with REC-1245, alongside continued validation of our platform through global pharma partnerships,” said Najat Khan, Ph.D., President and Chief Executive Officer of Recursion. “Importantly, these are independent proof points emerging from the same integrated engine. This financing strengthens our ability to build on that momentum, advance our highest-conviction programs, deliver on upcoming clinical milestones, and build long-term value with focus and discipline.”
Updates on our clinical programs are summarized below.
REC-4881 (in FAP) Phase 1b/2: Rapid and Durable Treatment Effect Across GI Tract, Polyp Reduction in Upper GI
FAP is a genetically defined driver of GI cancer, affecting >50,000 patients in the US and EU5 who face major surgeries and life-long surveillance with no approved therapies, representing a potential $15 billion opportunity, based on Company estimates. Among the approximately 35,000 post-colectomy patients, upper GI disease represents the highest unmet need in FAP, due to risks of bleeding and perforation from polyp removal, high complication rates from surgery, and higher cancer risk.
REC-4881, a potential first-in-class oral therapy granted FDA Orphan Drug and Fast Track designations, is designed to address both Wnt/β-catenin initiation and MAPK evolution pathways. The opportunity was identified through unbiased phenotypic screening on Recursion’s AI foundation models, which showed that MEK1/2 inhibition could potentially reverse the cellular effects of APC loss.
Topline data from the Phase 1b/2 TUPELO study of REC-4881 4 mg once daily, including the expanded adult (18+) FAP population (data cutoff: September 10, 2026):
-Total GI tract: After 12 weeks of treatment, 87% of patients (13 of 15) had reductions in total polyp burden, with a 47% median reduction
-1 in 3 patients (5 of 15) achieved a reduction of 65% or more
-At Week 25, after a 12-week off-treatment follow-up, 85% (11 of 13) were still below baseline
-Upper GI tract: After 12 weeks of treatment, 92% of patients had reductions in upper GI polyp burden
-Nearly half (6 of 13) achieved a reduction of 65% or more
-Two patients achieved a reduction of ≥98% polyp burden reduction in the upper GI
-50% (6 of 12) improved by at least one Spigelman stage at Week 13
-At Week 25, after a 12-week off-treatment follow-up, 92% (11 of 12) were still below baseline
-Favorable safety profile supports potential for chronic dosing: No TRAEs above Grade 3 were observed. Most patients (21 of 26; 80.8%) had TRAEs of Grade 2 or lower, consistent with MEK1/2 inhibition, including dermatitis acneiform, rash, CPK increase, diarrhea, and asymptomatic LVEF decrease. Grade 3 TRAEs occurred in 4 patients. Four patients discontinued due to AEs, none because of a Grade 3 TRAE.
The Company anticipates initiating a registrational trial in the second half of 2027, pending the outcome of ongoing FDA discussions, and will provide additional details later this year.
Additional REC-4881 Phase 1b/2 data as of September 10, 2026 will be presented at the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer (CGA-IGC) Annual Meeting on Monday, November 2.
REC-1245 Phase 1 Update: Monotherapy Partial Responses Observed and Expansion Dose for Cohorts, including Endometrial Cancer, Selected
REC-1245 is a potential first-in-class oral molecular glue designed to exploit a synthetic-lethal vulnerability in cancers by degrading RBM39, a splicing factor that regulates genes involved in DNA repair and stress response. The target emerged from Recursion’s platform, which found that degrading RBM39
mimics the loss of CDK12, while sparing CDK13-associated liabilities. REC-1245 was identified within 18 months after synthesizing only 204 compounds using Recursion’s design platform. Additional Phase 1 monotherapy data are expected in the second half of 2026, and preliminary dose expansion data in endometrial cancer are expected in the second half of 2027. Dose escalation will also continue in other solid tumors.
Early data from the Phase 1 dose-escalation portion of DAHLIA, our ongoing open-label Phase 1/2 study of REC-1245, show the following (data cutoff: August 21, 2026):
●Three partial responses per RECIST 1.1 criteria (2 confirmed, 1 unconfirmed) in heavily pretreated patients with endometrial cancer and hepatocellular carcinoma, all at doses of 45 mg once daily (QD) or higher, with a disease control rate of 91.7% at those doses (n=12).
●Recursion has selected 45 mg QD for expansion cohorts, including endometrial cancer, where limited second-line treatments are approved; at the 45 mg QD dose (n=10), no dose-limiting toxicities or treatment-related serious adverse events were observed, and treatment-related adverse events were predominantly Grade 1 or 2. Most frequent TRAEs were Grade 1 or Grade 2 fatigue and anemia (30% each).
Recursion Announces Sanofi Options Potential First-in-Class Immunology Development Candidate
On October 15, 2026, Recursion announced that Sanofi has optioned the first development candidate from the two companies’ multi-program research collaboration. The potential first-in-class oral small molecule was designed to achieve a differentiated profile against a challenging dual target implicated in inflammatory disease and was delivered by the combination of Recursion’s integrated AI-enabled drug design platform and small-molecule chemistry capabilities with Sanofi’s deep expertise in drug discovery and immunology.
The candidate has now been added to Sanofi’s development pipeline and is expected to enter phase 1 clinical trials in 2027, with Sanofi funding and leading further development and commercialization. The option triggered a $10 million milestone payment to Recursion, bringing total upfront and milestone payments under the collaboration to $144 million to date. Recursion remains eligible for more than $300 million in additional milestones under the program, with an average of low double-digit royalties on net product sales if approved. With the first development candidate optioned, the collaboration has now achieved six progress-based milestones across five programs.
Additional programs across the collaboration continue to advance. In 2027, other programs in the joint portfolio have the potential to reach development candidate and other progress-based milestones.
Other Portfolio Updates
Given the promising data in REC-4881 and REC-1245, Recursion plans to continue to focus resources on its high-impact partnerships and internal pipeline including REC-4881, REC-1245 (RBM39 - endometrial cancer and other solid tumors), REC-4539 ( LSD1 - solid tumors and hematology), REC-7735 (PI3Kα H1047R - solid tumors) and REC-102 (ENPP1 - Hypophosphatasia). Recursion intends to pursue partnership opportunities to advance REC-617 (CDK7) and REC-3565 (MALT1).
Financial Update
●Cash position: As of September 30, 2026, we had cash, cash equivalents, and restricted cash of approximately $561 million, which figure is preliminary, unaudited and is subject to completion of
the Company’s quarter-end financial close procedures. We expect to receive total gross proceeds of approximately $200 million from our October 2026 underwritten offering.
●Cash runway: Recursion expects its cash, including the net proceeds from today’s concurrently announced offering, to meet the Company’s operational needs into 2029.
This press release is not an offer to sell, nor is it a solicitation of an offer to buy, any securities, nor shall there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any state or any jurisdiction.
About Recursion
Recursion (NASDAQ: RXRX) a leading clinical-stage company pioneering AI-enabled drug discovery and development decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the Recursion OS is designed to translate complex science into medicines that matter — faster, better, and at scale — for patients who are waiting.
Recursion's platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation.
Media Contact
media@recursion.com
Investor Contact
investor@recursion.com
Forward-Looking Statements
This document contains information that includes or is based upon "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, without limitation, those regarding the follow-on offering, including the expected gross proceeds, the anticipated closing and the intended use of proceeds; the timing and outcome of anticipated engagement with the FDA, including the definition of a registrational path for REC-4881, the timing of initiation of a registrational trial of REC-4881 in FAP, and the timing of additional details regarding such trial; the timing and content of data presentations, including at the CGA-IGC Annual Meeting; the potential of REC-4881 to address both drivers of FAP polyp growth and the durability, safety and efficacy of REC-4881; the planned expansion of REC-1245 into indication-specific cohorts, including endometrial cancer, at the selected expansion dose and the timing of additional REC-1245 data; expectations and developments with respect to licenses and collaborations, including Sanofi's development plans for the optioned candidate, the timing of any Phase 1 study, and the amount and timing of potential milestone payments and royalties; the occurrence or realization of potential milestones; plans to pursue partnership opportunities for REC-617 and REC-3565; financial position, including preliminary estimates of cash, cash equivalents and restricted cash as of September 30, 2026, and cash runway, including the expected impact of the offering; prospective
products and their potential future indications, differentiated profiles and market opportunities, including estimates of diagnosed patient populations; expectations relating to early and late stage discovery, preclinical, and clinical programs, including timelines for commencement of and enrollment in studies and data readouts; developments with Recursion OS, including the ability to discover and develop new medicines; and all other statements that are not historical facts. Forward-looking statements may or may not include identifying words such as "plan," "will," "may," "could," "should," "expect," "anticipate," "intend," "believe," "estimate," "project," "designed to," "potential," "continue," and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; the fact that interim and preliminary clinical data, including data from a small number of patients in a single-arm study, may not be predictive of final results; our ability to leverage and enhance our drug discovery platform; the performance and limitations of our artificial intelligence and machine learning models and the data on which they are trained; our reliance on third parties, including collaborators, contract research organizations, and manufacturers; our ability to initiate clinical trials and enroll patients on expected timelines; the outcome of our discussions with the FDA, which may result in changes to the design or timing of, or delays in, our planned registrational trial of REC-4881; competition from other therapies and platforms; our ability to obtain financing for development activities and other corporate purposes; the satisfaction of customary closing conditions for the offering; the possibility that our preliminary estimate of cash, cash equivalents and restricted cash may change upon completion of our quarter-end financial close procedures; the success of our collaboration activities and our collaborators' discretion over option exercises, program advancement, and funding; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading "Risk Factors" in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K and our subsequent Quarterly Reports on Form 10-Q. All forward-looking statements speak only as of the date of this document and are based on management's current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.
Recursion October 2026
Legal Disclaimer This presentation does not constitute an offer to sell or a solicitation of an offer to buy securities Recursion Pharmaceuticals, Inc. (“Recursion,” “we,” “us,” or “our”) or an invitation or inducement to engage in investment activity, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification of such securities under the securities law of any such jurisdiction. The Company has filed a shelf registration statement on Form S-3 with the SEC for the offering to which this presentation relates. Before you invest in any of the securities of the Company, you should read the prospectus in that registration statement, together with the information incorporated therein by reference, as well as any free writing prospectus provided in connection with the offering and any other documents the Company has filed with the SEC for more complete information about the Company and the offering. You may get these documents, and the prospectus supplement, when available, for free by visiting EDGAR on the SEC website at www.sec.gov. Alternatively, the Company, any underwriter or any dealer participating in the offering will arrange to send you the prospectus and accompanying prospectus supplement, if you request it by contacting: Leerink Partners LLC, Attention: Syndicate Department 53 State Street, 40th Floor, Boston, MA 02109, by telephone at 1-800-808- 7525 ex. 6105 or by email at syndicate@leerink.com; Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, New York 10282, telephone: 1-866-471-2526, facsimile: 212-902-9316, or email: prospectus-ny@ny.email.gs.com; or Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014, by phone: 1-866-718-1649 or by email: prospectus@morganstanley.com. This presentation is not a prospectus and is neither an offer to sell nor a solicitation of an offer to buy any securities, and shall not constitute an offer, solicitation or sale in any jurisdiction in which such offer, solicitation or sale is unlawful. Important Information 2
Forward Looking Information This presentation contains, and any accompanying discussion may contain, statements that are not historical facts may be considered forward-looking statements under federal securities laws. Such statements may be identified by words such as “anticipates,” “believes,” “estimates,” “expects,” “intends,” “plans,” “potential,” “predicts,” “projects,” “seeks,” “should,” “will,” or words of similar meaning and include, but are not limited to, statements regarding the impact of the acceptance of the target validated option milestone by Genentech on future developments and potential treatments; the possibility of targets and development candidates to be optioned by program partners; timing of future clinical and preclinical trials; the impact of REC-4881 trial on the Recursion OS and other clinical and preclinical programs; the anticipated benefits of our agentic AI tools, including expected improvements in scientific productivity, design and analysis cycle times, and clinical trial enrollment rates; financial position, cash runway, and ability to reduce our cash operating expense; our ability to use AI to translate complex science into medicines faster and better; Recursion’s OS industrializing first- and best-in-class drug discovery; our ability to industrialize clinical development and the effect of doing so on clinical trial outcomes; the occurrence or realization of potential milestones and their potential timing or amounts; current and future preclinical and clinical studies, including timelines for enrollment in studies, data readouts, progression toward IND-enabling and other potential studies, and engagement with the FDA; advancements of and other decisions regarding our pipeline, partnerships, and data strategies; the potential size of the market opportunity for our drug candidates; outcomes and benefits from licenses, partnerships and collaborations, including option exercises by partners; the initiation, timing, progress, results, and cost of our research and development programs; advancements of our Recursion OS; and many others. We have based these forward-looking statements largely on our current expectations and projections about our business, the industry in which we operate, and financial trends that we believe may affect our business, financial condition, results of operations, and prospects. These forward-looking statements are not guarantees of future performance or development. These statements speak only as of the date of this report and are subject to a number of risks, uncertainties and assumptions. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified, you should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. A further discussion of these and other important factors and information are contained in our most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and the Company’s other filings with the U.S. Securities and Exchange Commission (the “SEC”), which can be accessed at https://ir.recursion.com, or www.sec.gov. All forward-looking statements are qualified by these cautionary statements and apply only as of the date they are made. Except as required by applicable law, we undertake no obligation to update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, or otherwise. Important Information 3
Preliminary Financial Information This presentation also includes financial information that is presented as of September 30, 2026, which information is preliminary, has not been audited, reviewed or compiled by our independent registered public accounting firm and is subject to change. Our actual results remain subject to the completion of management's final review and our other closing procedures and may differ materially from such financial information included in this presentation due to the completion of our financial closing procedures, audit procedures and final adjustments. These preliminary estimates are not a comprehensive statement of our financial results for the quarter-ended September 30, 2026, and should not be viewed as a substitute for full financial statements prepared in accordance with US GAAP. In addition, these preliminary estimates are not necessarily indicative of the results to be achieved in any future period. Accordingly, you should not place undue reliance on these preliminary financial results. Non-GAAP Financial Measures This presentation includes certain unaudited financial measures not presented in accordance with generally accepted accounting principles in the United States (“GAAP”), and certain ratios and other metrics derived therefrom, including cash and cash operating expense, each of which are used by management as a supplemental measure, have certain limitations, and should not be construed as alternatives to financial measures determined in accordance with GAAP. Non- GAAP financial measures should not be construed as being more important than comparable GAAP measures. The non-GAAP measures as defined by us may not be comparable to similar non-GAAP financial measures presented by other companies, which could limit such measures’ usefulness as comparative measures. Our presentation of such measures, which may include adjustments to exclude unusual or non-recurring items, should not be construed as an inference that our future results will be unaffected by other unusual or non-recurring items. Such information may contain inaccuracies because of the assumptions used and is not necessarily indicative of future performance. A reconciliation to the most directly comparable GAAP measures is provided in the appendix of this presentation. Market and Industry Data Certain information contained in this presentation relates to or is based on studies, publications, surveys and other data obtained from third-party sources and the company’s own internal estimates and research. While the company believes these third-party sources to be reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third- party sources. In addition, all of the market data included in this presentation involves a number of assumptions and limitat ions, and there can be no guarantee as to the accuracy or reliability of such assumptions. Finally, while the company believes its own internal research is reliable, such research has not been verified by any independent source. Information contained in, or that can be accessed through our website is not a part of and is not incorporated into this presentation. Cross-trial or cross-candidate information about other investigational assets and drug candidates are not based on head-to-head studies and are presented for informational purposes; data presented are based on publicly available information for other clinical trials and other drug candidates. ® 2026 Recursion Pharmaceuticals, Inc. Recursion and its related logo are registered trademarks of Recursion Pharmaceuticals, Inc. All other trademarks are property of their respective owners. Important Information 4
Three critical capabilities define an AI-enabled therapeutics company Proprietary maps Uncovering new biology • REC-1245, REC-4881: Identified novel biology • Roche Genentech: First-in-class program with novel MOA against a previously “undruggable” oncology pathway (featured at Roche’s Investor Day) >10 Development candidate nominations • Internally discovered molecules • Sanofi: 5 milestones achieved 2 First-in-class oral medicines • REC-4881 (MEK1/2): First-in-class, oral FAP candidate, positive PoC • REC-1245 (RBM39): First-in-class, oral molecular glue degrader for solid tumors 1. Cash operating expense is a non-GAAP financial measure, which we calculate as Cash, excluding partnership inflows and transaction costs; see the appendix for a more detailed description. Based on 2026 OpEx YTD trends relative to comparable period in 2024. FY 2024 cash OpEx is adjusted to reflect change in cash for Exscientia during the comparable period in 2024. • 2H 2026: Potential for additional targets to be optioned by Roche Genentech • 2H 2026: Potential first-in-class development candidate to be optioned by Sanofi • 2H 2026: REC-4881 registrational update and Phase 2 data • 2H 2026: REC-1245 additional Phase 1 dataNear-term inflection points Near-term inflection points Near-term inflection points Uncovered novel, causal biology Discover Design Deliver Translated novel targets into differentiated molecules Emerging clinical evidence of meaningful patient impact 5 External validation: $525M+ partner inflows as of 30-Sep-26 Financial discipline: ~40% lower cash OpEx v. 20241 Milestones and near-term inflection on this slide reflect status as of 1H 2026
Proof points are stacking up: Compelling medicines emerging from a repeatable engine Uncovered novel, causal biology Discover Design Deliver Translated novel targets into differentiated molecules Emerging clinical evidence of meaningful patient impact 6 Selected from Recursion’s proprietary maps; joint small- molecule work progressing Dual targeting inhibitor in immunology Phase 1 planned for 2027 2H 2026 Genentech advances first unexplored neuroscience target 2H 2026 Sanofi opts in potential first-in- class oral inhibitor in I&I REC-4881 (MEK1/2 inhibitor): Deep, durable polyp reductions 2H 2026 REC-1245 (RBM39 degrader): Early monotherapy activity 3 partial responses reported to date1 in heavily pretreated patients Significant upper GI activity, including sustained reductions off treatment 2H 2026 1. Confirmed (n=2), unconfirmed (n=1); note that for one of 2 confirmed PRs, confirmatory scan has been reported by the site and entered into the EDC after the 21 August 2026 data cutoff; source data verification by the CRO is pending; All PRs observed at doses of ≥45 mg UPCOMING 2026 CATALYSTS REC-4881: CGA-IGC data (Nov 2nd) + FDA update (2H, 2026) | REC-1245: additional monotherapy data | Roche/Genentech: potential additional target
One connected AI engine. Continuously learning across biology, chemistry, and the clinic 7 PROPRIETARY DATA FACTORY Industrial-scale experiments Disease-relevant maps Purpose-built datasets 50+ PB proprietary data1 CONNECTED AI PRODUCT ENGINE Models guide experiments; new data refine models DIFFERENTIATED CLINICAL PIPELINE Potential first-in- class assets More informed patient selection Efficient clinical development Feedback: predictions → experiments → learning Every experiment and clinical insight feeds a connected learning system—improving decisions across the pipeline. BIOLOGY AI Discover novel targets DESIGN AI Create novel molecules CLINICAL AI Optimize development 1. As of 30-Sep-2026
REC-4881 MEK1/2 Translating proof to products
REC-4881: Potential to transform FAP care Deep upper GI reductions and durability off treatment support a potential new oral treatment approach 9 • Favorable safety profile4 with 15.4% Gr 3 TRAEs and no TRAEs above Gr3 • Durable benefit off therapy may allow for flexible dosing potential Oral therapy with a favorable safety profile • 87%1 with reductions in total polyp burden2 • 1 in 3 achieved ≥65% reduction after 12 weeks of treatment (47% median reduction) • 85% (11 of 13) maintained reductions below baseline after 12 weeks off-treatment Rapid reductions that persist off treatment On REC-4881’s rapid activity “I think it’s very impressive… there’s no study before that showed these kind of regressions.” - Gastroenterology physician-scientist, European AMC • 92% had reductions in upper GI polyp burden3 • ~1 in 2 achieved ≥65% reduction in upper GI polyp burden • 92% (11 of 12) maintained reductions below baseline 12 weeks off treatment Deep reductions in upper GI polyp burden On upper GI activity “This would make a big difference for the patient… it would lower the cancer risk, would lower the surgery risk and it would maybe lower the number of endoscopies.” - Practicing gastroenterologist, US AMC 1. Efficacy Evaluable (n=16); Efficacy-evaluable population defined as participants with measurable disease (non-zero polyp burden) at baseline endoscopy, who received at least 75% of study drug, and had at least one post-baseline on-study endoscopic assessment. At Week 13, n=15 efficacy evaluable patients, as 1 patient missed Week 13 screening. At Week 25, n=13 efficacy evaluable patients, as 2 patients did not have Week 25 results at the data cutoff, and 1 patient was lost to fo llow-up 2. Polyp burden defined as the sum of all polyp diameters; percent change from baseline is measured at the Week 13 and Week 25 endoscopies 3. Upper GI: n=13 2 patients had no upper GI disease. 4. Safety evaluable (n=26; 5 Ph I/ and 21 Ph 2. Of the 21 Ph 2, 16 are efficacy evaluable per the definition noted above
Improved data in the expanded population (N=4 additional efficacy evaluable patients, 16 total) DEC 2025 SEP 2026 Median total polyp burden reduction 43% → 47% Patients with ≥75% total burden reduction 9% → 20% Patients with Spigelman downstaging1 40% → 50% Patients with polyp burden below baseline 12 weeks off treatment 82% → 85% 38% achieved ≥75% polyp burden reduction 92% below baseline after 12 weeks off treatment Broader age eligibility Eligibility expanded to ages 18+; no discontinuations reported among newly enrolled patients 1. Secondary endpoint Percentages reflect endpoint-specific evaluable populations. Protocol expanded to patients ≥18 years; median age of new patients : 46. REC-4881: Expanded dataset reinforces favorable efficacy and durability New analyses reveal deep, durable upper GI activity Data Cutoff Date: 10-Sep-2026
EPIDEMIOLOGY UNMET NEED & BURDEN OF CARE >50K Diagnosed FAP patients US + EU55 Inherited APC-driven disease Characterized by precancerous polyps Real world data show persistent polyp growth over time 0 approved therapies No approved pharmacologic treatments for FAP-associated duodenal polyposis Lifelong chronic disease Most penetrant driver of GI cancer1 Multiple major surgeries and a lifetime of surveillance2 Upper GI: greatest unmet need Complex polyp removal; advanced disease may require major surgery Psychological burden Patients develop anxiety and/or PTSD, Ongoing cancer threat concerns, repeated procedures and life-altering interventions3 Amsterdam UMC registry (n=55, ~20-year follow-up)4 87% of evaluated patients had annual polyp- burden increase 1. Ferrandon et al, Fam Cancer. 2025; doi: 10.1007/s10689-025-00479-3, NCI BRCA1 and BRCA2: Cancer Risks and Management (PDQ®). 2. EMA/NORD and Orphanet based Epi estimate adjusted for colectomy rate (Syngal S, et al. Am J Gastroenterol 2015;110(2):223–62. DOI 10.1038/ajg.2014.435) and long term surveillance rate (Tatsuta et al. PLoS One. 2026 Feb 13;21(2):e0339401. 3. Mol MJ, et al. Psychooncology. 2025;34(5):e70176. 4. Natural History Analysis evaluated data from ~200 FAP patients; analysis shown represents a subset of patients who satisfy key inclusion criteria of TUPELO. Study is intended to contextualize the TUPELO single arm data, better understand background natural history of FAP disease progression. Study limitations include potential variabil ity in polyp count estimation between endoscopies; endoscopies are typically conducted annually in routine care, while the TUPELO data represent polyp burden at Week 13; 5. US: Burke et al. (2026). ACG Clinical Guideline: Diagnosis and Management of Adenomatous Colorectal Polyposis Syndromes. Range of [1 in 2,800 to 1 in 18,000] -> A sing le prevalence of 1 in 10,000 is applied to both the US and EU5. FAP shows no significant racial, ethnic or geographic variation (BMJ Best Practice), and no founder effect was found in population-based study (Gut 2002). Diagnosis rates: Danish diagnosed point prevalence d ivided by Danish birth frequency = 82.7%, Karstensen JG et al. Endoscopy 2019; 6. Based on company estimates, modeled total addressable market, pre and post colectomy FAP (not realized or forecasted sales): Based on rare-disease oral net price (benchmark GOMEKLI ~$30k/mo for adults); assumes 10% gross-to-net d iscount and EU5 price as 0.7x of US price ~$15B ’26 Total Addressable FAP market (US + EU5)6 FAP: a serious, lifelong chronic disease with zero approved therapies for FAP 11
“ Disease challenge: Upper GI is the greatest unmet need in FAP 1. Lim, C. H., & Cho, Y. S. (2016). Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management. World journal of gastroenterology 2. Lee, J.H., Chung, W.C. (2018). Duodenal Tumors. In: Chun, H., Yang, SK., Choi, MG. (eds) Clinical Gastrointestinal Endoscopy 3. Kuipers, E., Rösch, T. & Bretthauer, M. Colorectal cancer screening—optimizing current strategies and new directions. Nat Rev Clin Oncol 10, 130–142 (2013) No approved therapies Management relies on lifelong surveillance and repeated endoscopy, with frequency increasing as disease severity progresses Complex endoscopic polyp removal Thin duodenal walls and challenging anatomy increase the risk of bleeding and perforation during polyp removal1 High-morbidity, high-risk surgery Advanced disease may require removal of the duodenum, with high complication rates and prolonged recovery Highest cancer risk Upper GI cancers remain a major cause of cancer-related death after colectomy Polyp shape and thin duodenal walls complicate upper GI polyp removal Sessile polyp in upper GI2 Peduncular polyp in lower GI3 [Removal of the duodenum] has a lot of complications – way more than the colon… 50% got a severe complication… [hospital stays that] could be four months. So this is really surgery you want to prevent. - Gastroenterology physician-scientist, European AMC The majority of polyp burden in post-colectomy patients is found in the upper GI 12
Recursion’s platform uncovered a novel therapeutic opportunity in FAP 13 Sources: Fujishita T, et al. Cancer Sci. 2015;106(6):692–699; Blaj C, et al. Cancer Res. 2017;77(7):1763–1774; Guardavaccaro D, Clevers H. Sci Signal. 2012;5(219):pe15; Cheng YT, et al. Part Fibre Toxicol. 2026;23:4; Georgopoulos NT, et al. J Cell Sci. 2014;127(13):2967–2982. REC-4881 Similar Opposite Unbiased phenotypic screening Proprietary AI foundation models analyzed cellular images to identify relationships between genetic and compound perturbations Novel insight uncovered by platform Suppressing both pathways leads to polyp burden reduction Initiation pathway APC mutation β-catenin stabilization β-catenin → TCF/LEF txn. Evolution pathway Additional mutations (e.g., KRAS, BRAF, EGFR) MAPK signaling (MEK1/2) REC-4881 Cross-talk1 Direct inhibition 2 Mechanistic rationale for REC-4881 Unexpected biological insight MEK1/2 inhibition emerged as a potential way to reverse cellular phenotypes associated with APC loss – unappreciated synthetic rescue relationship
Week 13 polyp burden reduction | REC-4881 drives significant reductions in total polyp burden after 12 weeks of treatment 14 -11% -20% -37% -44% -47% -50% -59% -67% -70% -82% -89% -98% -100% -50% 0% 50% 100% -5% 59%2 33%3 Data Cutoff Date: 10-Sep-2026 87% Had a reduction in total polyp burden ≥65% Reduction in 1 in 3 patients 47% Median total polyp burden reduction Week 13 total polyp burden reduction relative to baseline (n=151; all patients completed treatment) 1. 15 of 16 efficacy evaluable patients are shown, as 1 patient was not screened at Week 13 2. The site corrected baseline polyp burden to exclude polyps excised for biopsy at screening; this correction revised the previously reported increase from 32% to 59% 3. Baseline polyp burden of 3 mm (2 polyps), increasing to 4 mm (1 polyp) at Week 13, all in the lower GI Note: Efficacy Evaluable (n=16); Efficacy-evaluable population: Patients with measurable baseline polyp burden, ≥75% study drug exposure, and ≥1 post-baseline endoscopic assessment Note: Results reflect the 10-Sep-2026 data cutoff. Data review since the last presentation also updated 2 patients after minor corrections of <5mm: -48% to -47% and -69% to -67% *** * *Additional patients since previously reported data cutoff (November 25, 2025)
Week 25 polyp burden reduction | Treatment effect persists after 12 weeks off treatment 15 12 weeks ON REC-4881 12 weeks OFF REC-4881 % change from baseline in total polyp burden in post- colectomy patients at Wk. 13 and Wk. 25 1. 15 of 16 efficacy-evaluable patients, 1 patient did not have a Week 13 endoscopy and is shown at Week 13 as an open square 2. 13 of 16 efficacy-evaluable patients, 2 patients did not have Week 25 results at the data cutoff, and 1 discontinued treatment after Week 13 Note: For any excisions at the week 13 endoscopy, the excised polyp burden was added back to the week 25 polyp burden before calculating the change from baseline -100% -80% -60% -40% -20% 0% 20% 40% 380% Baseline Week 13 (N=151) Week 25 (N=132) 11 of 13 patients remained below baseline at Week 25 Large % increase from baseline of 2 polyps (3mm) 11 of 13 patients remained below baseline after 12 weeks off treatment • Sustained activity despite 12 weeks without treatment • Durability may allow for dosing flexibility, which may be important in the context of long-term disease management 85% Data Cutoff Date: 10-Sep-2026
Week 13 - upper GI | Nearly 1 in 2 (46%) patients achieved ≥65% reductions in upper GI polyp burden 16 9% -11% -25% -34% -47% -55% -68% -75% -87% -88% -98% -100% -80% -60% -40% -20% 0% 20% -2% -100% Data Cutoff Date: 10-Sep-2026 Week 13 upper GI polyp burden reduction (n=131) “REC-4881’s upper GI efficacy has the potential to limit the need for life-altering surgeries.” - Practicing Gastroenterologist, US AMC *** * 92% Had a reduction in upper GI polyp burden ≥65% Reduction in ~1 in 2 patients 2 pts Achieved ≥98% reductions 1. Upper GI evaluable at week 13: n=13; 2 patients had no upper GI disease at baseline and 1 was missing endoscopy at week 13 *Additional patients since previously reported data cutoff (November 25, 2025)
17 Week 25 – upper GI | Polyp burden reductions persist after 12 weeks off treatment -100% -80% -60% -40% -20% 0% 20% 40% Baseline Week 13 (N=131) Week 25 (N=122) 11 of 12 patients remained below baseline at Week 25 11 of 12 patients remained below baseline after 12 weeks off treatment • Sustained activity in the upper GI, where unmet need is greatest • 6 of 11 patients with equal or greater reductions during the off-treatment period 92% 12 weeks ON REC-4881 12 weeks OFF REC-4881 % change from baseline in upper GI polyp burden in post-colectomy patients at Wk. 13 and Wk. 25 1. Upper GI evaluable at week 13: n=13; 2 patients had no upper GI disease at baseline and 1 was missing endoscopy at week 13 2. Upper GI evaluable at week 25: n=12; 2 patients had no upper GI disease at baseline and 2 did not have Week 25 results at the data cutoff Note: For any excisions at the week 13 endoscopy, the excised polyp burden was added back to the week 25 polyp burden before calculating the change from baseline. Data Cutoff Date: 10-Sep-2026
Total polyp burden (mm) 18 Additional detail on highest Week 13 responder 1,344 mm 32 mm ← 32 mm (2.4% of baseline) Baseline Week 13 96 1 at baseline at Week 13 Upper GI polyps > 5 mm 95 fewer polyps Note: Patient remains on study; Week 25 results were not available at the data cutoff (10-Sep-2026) Data Cutoff Date: 10-Sep-2026 The result presented here is only for one out of the 16 total efficacy evaluable patient population; this result is not representative of the overall efficacy of the evaluable patient population to date 98% reduction in total polyp burden from baseline to Week 13
Spigelman staging is used by clinicians to classify disease severity and inform need for interventions, including surgery 19 “Really what you're looking for is a drug … that can manage duodenal adenomas to the point where it decreases the need for surgical intervention—that's ideal.” - Practicing Gastroenterologist, US AMC Spigelman stage grades duodenal & ampullary disease; clinically, it drives how often patients are scoped and when surgery is needed >10mm sized polyp present >20 polyps High Grade Dysplasia (HGD) Stage IV 5-10mm sized polyp present >20 polyps Low Grade Dysplasia, at risk of HGD Stage III <5mm sized polyp only 5-20 polyps Low Grade Dysplasia, limited risk of HGD Stage II <5mm sized polyp only <5 polyps Low Grade Dysplasia, limited risk of HGD Stage I Yen T, Stanich PP, Axell L, et al. APC-Associated Polyposis Conditions. 1998 Dec 18 [Updated 2022 May 12] GeneReviews No polyps No Dysplasia Stage 0 Note: Stage is a points total across number, size, histology and dysplasia; boxes show typical findings
Week 13 Spigelman stage: 50% achieved Spigelman downstaging at Week 13, reflecting UGI disease improvement 20 1. Spigelman assessment not provided 2. Natural History Analysis evaluated data from ~200 FAP patients Note: N=14 efficacy evaluable for Spigelman staging; two patients did not have upper GI polyp burden at baseline assessment; AUMC: Amsterdam University Medical Center Data Cutoff Date: 10-Sep-2026 50% 4 of 6 Baseline Week 13 Week 25 III III III I N/A1 II III II II II II II III II II III II II III II N/A1 II 0 N/A1 IV IV IV III III III III III III III III N/A1 III N/A1 I IV II III 6 of 12 patients achieved ≥1-stage Spigelman downstaging Patients down-staged at week 13 maintained ≥1- stage improvement compared baseline, the other 2 were not assessed One additional patient was not assessed at Week 13 but showed a 2-stage decrease at Week 25 20% Experienced stage progression between annual endoscopies; no downstaging observed2 Patient had a 2- stage change at Week 25 Week 13 | ON TREATMENT Week 25 | 12 weeks OFF TREATMENT Natural history context
Favorable safety profile supports potential for chronic dosing 21 1. For 4 mg, N=5 patients in Phase 1b and N=21 patients in Phase 2 were dosed; safety data cutoff date of 2026-09-10 2. Patients were asymptomatic and decrease was reversible, 1 patient was lost to follow-up 3. Dermatitis acneiform/rash (n=1 each), blood CPK increase (n=2) 4. Discontinuations: Grade 1 (n=2): 1 diarrhea, 1 left atrial enlargement (present in medical history at baseline); Grade 2 (n=2): 1 retinopathy (present in medical history at baseline), 1 perineal rash • 21 of 26 (80.8%) patients had TRAEs ≤ Grade 2 consistent with mechanism of MEK1/2 inhibition: • E.g., Dermatitis acneiform, CPK increases, rash, diarrhea, LVEF decrease2 • Low rates of Grade 3 TRAEs (n=4)3 • No TRAEs >Grade 3 • AEs were manageable and most resolved within 12 weeks off treatment • Discontinuations due to AE (n=4)4 # Patients with events ≤2 3 4 5 0 0 TRAE grade Summary of treatment-related AEs (n=26 safety evaluable)1 21 4 0 10 20 30 40 Data Cutoff Date: 10-Sep-2026
US + EU5 FAP ADDRESSABLE MARKET1 POTENTIAL LIFETIME IMPACT OF REC-4881 Reduce repeated interventions Potential to reduce surveillance frequency and repeated endoscopic procedures Patient benefit Less treatment burden, travel and time away from work Avoid high-morbidity complications Potential to reduce major upper GI surgery, cancer, and complications associated with endoscopic resection System benefit Hospital capacity, caregiver burden and follow-up costs 1. US: Burke et al. (2026). ACG Clinical Guideline: Diagnosis and Management of Adenomatous Colorectal Polyposis Syndromes.Range of [1 in 2,800 to 1 in 18,000] -> A single prevalence of 1 in 10,000 is applied to both the US and EU5. FAP shows no significant racial, ethnic or geographic variation (BMJ Best Practice), and no founder effect was found in population-based study (Gut 2002). 2. Per company calculations, diagnosed share is calculated as Danish diagnosed point prevalence divided by Danish birth frequency: 6.11 per 100,000 ÷ 7.39 per 100,000 (1 in 13,528) = 82.7%, rounded to 83%; Karstensen JG et al. Colorectal cancer in individuals with familial adenomatous polyposis, based on analysis of the Danish Polyposis Registry. Endoscopy 2019;51(04):S127 3. Per company calculations, the post-colectomy share is the midpoint of the US rate and the Danish rate: (80.65% + 53%) ÷ 2 = 66.8%. The US rate averages two cohorts (82.7% and 78.6%); Feldman D et al. Dis Colon Rectum. 2025; J Gastrointest Surg. 2019, Utah registry; Beck SH et al. Am J Gastroenterol. 2024 4. Based on rare-disease oral net price (benchmark GOMEKLI ~$30k/mo for adults); assumes 10% gross-to-net discount and EU5 price as 0.7x of US price, per company calculations Estimated prevalence ~67,100 Diagnosed prevalence2 ~55,700 POST-COLECTOMY3 ~37,200 67% | Immediate focus PRE-COLECTOMY3 ~18,500 33% | Future expansion ~$10B4 Post-colectomy opportunity ~$5B4 Pre-colectomy expansion On REC-4881’s polyp burden reduction “This would make a big difference for the patient… it would lower the cancer risk, would lower the surgery risk and it would maybe lower the number of endoscopies.” - Practicing gastroenterologist, US AMC REC-4881 | Potential to transform $15B FAP market opportunity 22
REC-1245 First-in-class RBM39 degrader Translating proof to products
REC-1245: Novel biology with early clinical activity Phase 1 monotherapy results support expansion at 45 mg once daily 24 Oral RBM39 degrader targeting vulnerabilities in hard-to-treat cancers Disrupts splicing of transcripts associated with stress-response and DNA-repair 3 partial responses1 2 endometrial, 1 HCC Novel mechanism with broad potential Platform-derived biological insight Early clinical activity supports expansion cohort 1. PRs at doses ≥45 mg: Confirmed (n=2), unconfirmed (n=1); note that for one of 2 confirmed PRs, confirmatory scan has been reported by the site and entered into the EDC after the 21 August 2026 data cutoff; source data verification by the CRO is pending 2. Overall DCR at 8 weeks across doses: 66.7% (14/21). Note: N=30 safety evaluable across all dose groups; N=12 efficacy evaluable at doses ≥45 mg (participant in follow-up who haven't reached their first efficacy assessment are excluded) 91.7% DCR (11/12)2 At 8 weeks, doses ≥45 mg 45 mg QD selected for expansion cohort No serious TRAEs or dose reduction reported in the 45 mg cohort Data Cutoff Date: 2026-08-21 RBM39 phenocopies CDK12 loss while sparing CDK13-associated liabilities 204 compounds screened to development candidate in 18 months
• Potential first-in-class molecular glue degrader • Oral, highly bioavailable, and highly selective • Hits multiple oncogenic drivers achieving synthetic lethal cancer cell killing • Drives rapid and potent RBM39 degradation in human PBMCs within 24 hours and induces significant tumor regressions in multiple xenograft models driven by replication stress1 RBM39 Pre- mRNA RBM39-mediated mRNA splicing Spliced mRNA Cancer cells rely on accurate splicing of stress response and DNA repair genes for survival RBM39 ensures proper splicing of critical stress response and DNA repair genes RBM39 RBM39: Oncology target with broad potential based on highly relevant mechanism in multiple tumor types • Biological insight converted into a novel molecular glue degrader • RBM39 phenocopies CDK12 loss while sparing CDK13-associated liabilities • Advanced from 204 compounds to candidate in 18 months 25 Recursion OS Insight RBM39 is a master splicing factor REC-1245 RBM39 degradation disrupts RNA splicing and expression of stress response and DNA damage repair genes 1. Data available but not shown CDK12 RBM39CDK13 RBM39 CDK12 CDK13 REC-1245
Monotherapy Opportunity Combination Opportunity RBM39: A broad opportunity in hard-to-treat cancers Targeting RBM39 is relevant across multiple indications Hard to treat tumors Including endometrial, hepatocellular (HCC) and ovarian cancers Transcriptionally driven cancers Including pediatric tumors (Ewing sarcoma and neuroblastoma) >100k Total addressable patients/yr (US + EU5)1 Two complementary development strategies Intrinsically primed and vulnerable tumors 2,3 Create vulnerabilities and deepen efficacy in earlier lines with REC-1245 + SoC • Clinical status: Phase 1 dose escalation in multiple tumor types ongoing; dose expansion actively recruiting in endometrial cancer and other prioritized indications4 • Development strategy: Identify rational combinations with potential to support earlier-line use alongside SoC 1. Company estimate based on undisclosed solid tumor indications with strong mechanistic rationale, including some biomarker-defined populations. Addressable patients/year reflects estimated annual incidence of potentially relevant populations in the US and EU5 (UK, France, Germany, Italy and Spain) 2. Preclinical evidence: Kohsaka et al., npj Precis. Oncol. 2024;8:117. 3. Singh et al., Sci. Adv. 2021;7:eabj5405; Lyu et al., Eur. J. Med. Chem. 2026;314:118921. 4. DAHLIA Phase 1/2 study, NCT06678659. 26
Phase 1A monotherapy Continuous once-daily dosing Key inclusion criteria Unresectable, locally recurrent or metastatic select solid tumors, or select relapsed/refractory lymphoma Progressed following, or intolerant to, available standard-of-care treatments Primary objective PK and safety Secondary objective Anti-tumor activity *2 Confirmed (n=2), unconfirmed (n=1); note that for one of 2 confirmed PRs, confirmatory scan has been reported by the site and entered into the EDC after the 21 August 2026 data cutoff; source data verification by the CRO is pending 1. DL5 had DLTs, DL6 explored a dose between dose level 4 and 5 Data Cutoff Date: 2026-08-21 REC-1245 Phase 1 dose escalation update Early activity from monotherapy dose escalation 27 Emerging response and safety data • Multiple partial responses at doses ≥45 mg* • Activity across tumor types • Heavily pretreated population • 3 PRs (median 5 prior lines of therapy) • Data support expansion cohorts (45mg) • Monotherapy expansion at an active dose with an acceptable safety profile • First expansion into endometrial actively enrolling (45mg QD) Dose 1 QD Dose 2 QD Dose 3 QD Dose 4 QD (45mg) Dose 6 QD Dose 5 QD
REC-1245: Confirmed partial response in endometrial cancer 28 1. Prior medical history includes cataracts, neuropathy, compression fracture, and pulmonary embolism Response summary • Week 9 Radiographic Assessment: Achieved a partial response, 32.3% overall decrease. • Week 17 Radiographic Assessment: Verified a partial response, 48.9% overall decrease. Patient details1 • 70-year-old female with recurrent, progressive Stage IV high- grade serous carcinoma of the endometrium • p53-mutant / HER2 non-amplified, microsatellite stable • 4 lines of prior therapy including platinum chemotherapy, tyrosine kinase inhibitor, immunotherapy, and antibody-drug conjugate Dosing & clinical response • W1D1: Initiated DL5 @ 65mg • D6-D14: Interrupted due to G2 oral & abdominal pain • D15: Reduced to 45mg; tolerated extremely well, abdominal and oral pain resolved Patient is asymptomatic from disease and remains on treatment (45mg) L iv e r M e ts P e lv ic M a s s L u n g M e ts L iv e r M e ts Baseline CT Scan Week 9 CT Scan Week 17 CT Scan Data Cutoff Date: 2026-08-21
REC-1245: Confirmed1 partial response in endometrial cancer 29 1. Confirmatory scan reported by the site and entered into the EDC after the 21 August 2026 data cutoff; source data verification by the CRO is pending 2. Prior medical history includes Fatigue, Anorexia, Ascites, Pleural Effusions, Depression, Neuropathy, GERD Note: Images not at consistent scale; based on patient record provided from site Response summary • Week 9 Radiographic Assessment: Achieved a partial response, 33.9% overall decrease • Week 13 Radiographic Assessment: Verified a partial response, 38.2% overall decrease1 Patient details2 • 54-year-old female with recurrent, progressive Stage IV endometrioid carcinoma of the endometrium • p53-mutant / HER2 amplified, ER+, PR-, MMR proficient • 7 lines of prior therapy including, Platinum/taxane chemotherapy, VEGF inhibitor, HER2-targeted therapy, immune checkpoint inhibitor, tyrosine kinase Inhibitor, antibody-drug conjugate, investigational CAR-T therapy Dosing & clinical response • W1D1: Initiated Backfill DL4 at 45mg • W4D5: Interrupted dose due to missed MD appointment • W5D1: Patient restarted drug, tolerating well Patient remains on treatment (45mg) L N P e ri p o rt a l L N M e d ia st in a l Baseline CT Scan Week 9 CT Scan Data Cutoff Date: 2026-08-21
REC-1245: Unconfirmed partial response in Stage IV liver cancer 30 1. Prior medical history includes osteoporosis, anxiety, mouth sores, HTN, arthritis, paroxysmal atrial tachycardia, hyperlipidemia, hyperparathyroidism Response summary • Week 9 Radiographic Assessment: Achieved a partial response, 55.9% overall decrease. Patient details1 • 73-year-old female with recurrent, progressive Stage IV HCC; MSS, normal TMB • Partial hepatectomy (‘17) and subsequent tumor debulking (‘20) • 5 lines of prior therapy including, tyrosine kinase inhibitors, immune checkpoint inhibitor, and investigational immunotherapy agent Dosing & clinical response • W1D1: Initiated DL5 @ 65mg • W3D4: Interrupted due to G2->G3 stomatitis, G4 thrombocytopenia, and febrile neutropenia • W5D1: Patient withdrew from study due to toxicity Patient discontinued therapy due to AEs Baseline CT Scan L u n g M e ts L u n g M e ts Week 9 CT Scan Data Cutoff Date: 2026-08-21
Best overall response2 SD PD SD SD SD SD SD SD SD PR3 PR PR4 REC-1245: Three partial responses in endometrial and liver cancer 31 -60% -40% -20% 0% 20% 16.0% (BRCA) 8.9% (EC) 3.0% (LC) (EC) 1.5% 0.0% (EC) -3.6% (EC) -11.2% (HGSC) -24.6% (EC) -25.7% (EC) -38.2% (EC) -48.9% (EC) -55.9% (HCC) 45mg 65mg Data Cutoff Date: 2026-08-21 % c h a n g e f ro m b a se li n e Remains on-study Target lesion change by starting dose in response evaluable patients at 45mg and 65mg (N=12) -30% PR threshold 1. Days receiving 65 mg as a percentage of total elapsed treatment days, including treatment interruptions - remaining time includes lower doses and treatment holds; shown only for patients starting at 65mg 2. Best overall response is the best response recorded on study per RECIST 1.1, including unconfirmed responses 3. Confirmatory scan reported by the site and entered into the EDC after the 21 August 2026 data cutoff; source data verification by the CRO is pending 4. Unconfirmed partial response (PR with -48.9% change is confirmed) 5. Disease control rate (DCR) = complete response, partial response, or stable disease among efficacy-evaluable patients (11/12) 91.7% DCR at 8 weeks5 (11/12) Switched to 45mg after 6 days of dosing at 65mg; 90% of dosing at 45mg Starting dose
Dose reduced (Y/N)? N Y Y N N Y Y N N N Y N Dosing days at 45 mg (%)1 100% 43% 34% 100% 100% 54% 29% 100% 100% 100% 94% 0% REC-1245: Three partial responses in endometrial and liver cancer 32 -60% -40% -20% 0% 20% 16.0% (BRCA) 8.9% (EC) 3.0% (LC) (EC) 1.5% 0.0% (EC) -3.6% (EC) -11.2% (HGSC) -24.6% (EC) -25.7% (EC) -38.2% (EC) -48.9% (EC) -55.9% (HCC) 45mg 65mg Data Cutoff Date: 2026-08-21 % c h a n g e f ro m b a se li n e Remains on-study -30% PR threshold 1. Dosing days at 45mg is the % of total dosing days receiving 45mg; denominator excludes dose interruptions 2. Best overall response is the best response recorded on study per RECIST 1.1, including unconfirmed responses 3. Unconfirmed partial response; PR with -48.9% change is confirmed 4. Disease control rate (DCR) = complete response, partial response, or stable disease among efficacy-evaluable patients (11/12) 91.7% DCR at 8 weeks4 (11/12) Target lesion change by starting dose in response evaluable patients at 45mg and 65mg (N=12)
All doses (N=30) TRAE Any grade Grade ≥3 Any TRAE 22 (73.3%) 8 (26.7%) Fatigue 9 (30%) 0 Anemia 9 (30%) 3 (10%) Nausea 6 (20%) 1 (3.3%) Thrombocytopenia 6 (20%) 3 (10%) Stomatitis 5 (16.7%) 3 (10%) 45 mg QD / DL4 (N=10) TRAE Any grade Grade ≥3 Any TRAE 7 (70%) 2 (20%) Fatigue 3 (30%) 0 Anemia 3 (30%) 0 Nausea 2 (20%) 0 Thrombocytopenia 0 0 Stomatitis 1 (10%) 0 Data Cutoff Date: 2026-08-21 REC-1245: Safety & Treatment-Related Adverse Events (TRAEs) 33 Grade 3 TRAEs were elevated creatinine and hypokalemia 45mg once daily (N=10) • No dose-limiting toxicities (DLTs) • No serious TRAEs • Most frequent TRAEs: fatigue and anemia (30% each); all Grade 1–2 Dose escalation established the tolerability limit At 65 mg QD, 3 of 4 DLT-evaluable patients experienced dose-limiting toxicities • DLTs include stomatitis, neutropenia/febrile neutropenia, thrombocytopenia • MTD was exceeded
most common cancer in US women REC-1245: differentiated biology and development rationale: Disrupts DNA damage repair⁴ Potential immune priming⁵ Distinct mechanism from ADCs⁶ RBM39 degradation downregulates DNA-damage- response networks and cell- cycle checkpoints Missplicing-derived neoantigens provide a mechanistic rationale for immunotherapy combinations Target biology provides a rationale to evaluate activity following ADC progression 1. US cases and deaths, 2026 estimates: American Cancer Society, Cancer Facts & Figures 2026, endometrial cancer key statistics page, revised 14 January 2026; 2. Stage survival: SEER, as presented by ACS, for people diagnosed 2015 to 2021. based on SEER stage groups: https://www.cancer.org/cancer/types/endometrial-cancer/detection-diagnosis- staging/survival-rates.html; 3. Only HER2 ADC (for HER2 IHC2+ patients, ~25% of endometrial) currently approved. Lenvatinib + Pembro, dostarlimab often used in 2L but underperforms for patients who have relapsed on ICIs. ADCs such as like sac-TMT are expected to enter the market in the near term. 4. Xu et al, Cell Reports Volume 42, Issue 10, 2023; class evidence 5. Lu et al., Cell 2021, doi:10.1016/j.cell.2021.05.038: class evidence 6. Mechanistic hypothesis only. Post-ADC efficacy and absence of cross-resistance remain unestablished for REC-1245. REC-1245 is investigational. Significant opportunity for differentiated oral therapy in endometrial cancer 34 4th1 estimated new US cases in 2026 ~68K1 5-year relative survival with distant- stage disease ~20%2 for patients relapsing on IO. ADC currently approved only for HER2+ Limited treatment options in 2L+3 1 2 3 Actively enrolling in endometrial cancer, data expected in 2H27 Exploring additional tumor types in dose expansion
Partnerships Novel targets and programs Translating proof to products
Recursion Announces Sanofi Options Potential First-in-Class Immunology Development Candidate from Their Collaboration 1. The majority of the $10 million milestone payment will be recognized as revenue in the third quarter of 2026, and ends Recursion’s operational requirements related to this candidate, with all future payments resulting in profit to Recursion 2. Inclusive of latest achieved $10 million milestone payment Potential first-in-class, oral, dual-targeting inhibitor $10M1 Milestone payment achieved Double-digit royalties if approved 36 Sanofi “By combining Sanofi’s drug discovery and clinical and translational knowledge in Immunology with Recursion’s AI-driven platform, we were able to move with speed and precision in a space where that balance is notoriously hard to achieve.” Alyssa Johnsen, M.D., Ph.D., Therapeutic Area Head, Development, Immunology & Inflammation, Sanofi 6th milestone | $144M upfront & milestone inflows2 | $343M potential milestones per program Expected Phase 1 entry in 2027 Differentiated profile against a challenging dual target implicated in inflammatory disease Optimizing for this target pair required navigating complex and competing chemistry constraints to achieve the desired balance of drug-like properties.
Roche highlights our Biology Engine's role in finding a novel mechanism for an "undruggable" cancer pathway Presented at Roche Investor day on September 28th, 2026 37
Unexplored neuroscience target optioned by Genentech from the Recursion, Roche and Genentech partnership 38 Roche and Genentech Neuron AI biological map 3Q24 - $30M Roche and Genentech Microglia AI biological map 4Q25 - $30M ACCEPTED ACCEPTED More than $300M in development, commercialization, and net sales milestones for Recursion per small molecule program1 OPTIONED 2026 2025 2024 Roche and Genentech 1st unexplored NS target What’s next: Advancing into early discovery — applying Recursions AI-native chemistry engine to design a molecule against the validated target 1st unexplored target, validated and optioned in Neuroscience KEY MILESTONE 1. + tiered royalties up to high single digits $216 million in upfront and milestone payments achieved to date
Collaborative process to generate and validate neuroscience targets 39 1. Builds disease-relevant human models with high- dimensional data Output: Disease-relevant biology at unprecedented scale 4. Validates through experiments with Genentech Output: A target advanced into an early discovery program 2. Explores the human genome at scale Output: Unexplored biology emerges from maps, reviewed and prioritized by scientists 3. Navigates from known to unknown biology Output: A ranked list of potentially novel, biologically connected targets Next steps: • Advancing target to small molecule design/hit generation and validation • New potentially novel targets from reusable high- dimensional data/maps
Advancing a Focused Pipeline of AI-Enabled, Differentiated Programs 40 Platform capability utilized Platform capability not utilized Platform capability to be utilized further in development Disease indication(s) Addressable patients Next catalyst AI enabled differentiation Late discovery Preclinical Phase 1/2 Pivotal Familial adenomatous polyposis (FAP) >50,0001 Nov-26: CGA-IGC 2H26: FDA update Solid tumors (e.g., endometrial) >100,0002 2H26: Additional monotherapy data Solid tumors & hematology oncology ~45,0003 2H27: Mono – early safety and PK Solid tumors ~80,0004 2H26: IND cleared, FIH in 2H 2026 Hypophosphatasia (HPP) >7,8005 2H26: Completion of IND-enabling studies C L IN IC A L P R E - C L IN IC A L Design Clinical REC-4881 MEK1/2 (Oral) REC-1245 RBM39 (Oral) REC-4539 LSD1 (Oral) REC-7735 PI3Kα H1047R (Oral) REC-102 ENPP1 (Oral) Biology Novel disease-mechanism insight Novel target + novel degrader Hard to drug, enhanced TI, CNS penetrant Enhanced therapeutic index (Onc & non-Onc) Novel target + novel molecule We are increasing our investment in our pipeline while pursuing partnership opportunities for select programs6 1. Company estimate assuming FAP prevalence of 1 in 10,000 in the US and EU5 and an 82.7% diagnosis rate (Burke et al., 2026; Karstensen et al., 2019) 2. Company estimate of annual US and EU5 patients with selected solid tumors (e.g., endometrial), including biomarker-defined populations 3. Company estimate of annual patients in the US and EU5 with extensive-stage small-cell lung cancer eligible for treatment after progression on frontline therapy (EvaluatePharma Epidemiology, 2023); excludes hematologic indications (e.g., AML) 4. Company estimate of annual patients in the US and EU5 with PIK3CA H1047R-mutant breast (HR+/HER2-, HER2+, triple-negative), colorectal, endometrial, ovarian, and head and neck cancers, across early-stage (~57,000) and metastatic (~23,000) disease and including patients with diabetes; based on EvaluatePharma 2025 incidence and Tempus real-world H1047R mutation frequency (2026). Excludes PIK3CA-related overgrowth spectrum and vascular anomalies 5. Company estimate of diagnosed prevalent HPP patients in the US, based on ALPL gene variant prevalence in a European population and assumed diagnosis rates 6. REC-617 (CDK7) and REC-3565 (MALT1)
Sanofi: Planned Phase 1 start Continued momentum with upcoming catalysts 1. Registrational study initiation remains subject to regulatory alignment UP NEXT UP NEXT UP NEXT 2027 2027 2027 Potential additional candidate and program milestones 2H 2026 REC-4881: FDA update 2H 2027 REC-4881: Additional Phase 2 data 2H 2027 REC-4881: Planned registrational study start1 2H 2027 REC-1245: Preliminary data from dose expansion 2H 2027 REC-4539: Monotherapy dose escalation data Delivered Roche and Genentech First neuroscience target accepted Delivered Sanofi opt-in Oral dual-target inhibitor Delivered REC-4881 Deep, durable polyp reductions REC-1245 Early monotherapy responses Uncovered novel, causal biology Discover Design Translated novel targets into differentiated molecules Deliver Emerging clinical evidence of meaningful patient impact Roche Genentech – potential for: • Additional new targets • Additional programs advanced Additional internal & partnered maps 2027 2H 2026 REC-1245: Additional monotherapy data 2H 2026 REC-4881: Phase 2 data at CGA-IGC (02-Nov) 41
FINANCIAL STRENGTH & OPERATING DISCIPLINE $561M Cash as of September 30, 2026¹ ~40% Lower cash OpEx vs 2024² Cash runway into mid-2028³ WHERE WE ARE CONCENTRATING INVESTMENT Differentiated pipeline Prioritize clearly differentiated, wholly owned programs Value-creating partnerships Drive NPV growth while strengthening platform capabilities Proprietary data advantage Generate novel data that compounds long-term differentiation AI-enabled productivity Scale discovery and development through AI and automation A more focused Recursion Capital discipline to fund the highest-value opportunities 42 1. Preliminary, unaudited cash, cash equivalents and restricted cash 2. Based on 2026 OpEx YTD trends relative to comparable period in 2024. FY 2024 cash OpEx is adjusted to reflect change in cash for Exscientia during the comparable period in 2024. Cash operating expense is a non-GAAP measure; see appendix for a more detailed description 3. Runway includes risk-adjusted inflows from existing partnerships; excludes additional financing or new partnerships
Appendix Non-GAAP Financial Measure To supplement our financial statements prepared in accordance with U.S. GAAP, we monitor and consider operating cash expense, which is a non-GAAP financial measure. We define operating cash expense as the net cash used in operating activities, excluding non-ordinary course transaction costs and partnership cash inflows. This non-GAAP financial measure is not based on any standardized methodology prescribed by U.S. GAAP and is not necessarily comparable to similarly-titled measures presented by other companies. We believe operating cash expense to be a liquidity measure that provides useful information to management and investors about the amount of cash consumed by the operations of the business. A limitation of using this non-U.S. GAAP measure is that operating cash expense does not represent the total change in cash and cash equivalents for the period because it excludes cash provided by or used for other investing and financing activities. We account for this limitation by providing information about our capital expenditures and other investing and financing activities in the statements of cash flows in our financial statements. Additionally, we reconciled operating cash expense above to net cash used in operating activities, the most directly comparable U.S. GAAP financial measure. In addition, it is important to note that other companies, including companies in our industry, may not use operating cash expense, may calculate operating cash expense in a different manner than we do or may use other financial measures to evaluate their performance, all of which could reduce the usefulness of operating cash expense as a comparative measure. Because of these limitations, operating cash expense should not be considered in isolation from, or as a substitute for, financial information prepared in accordance with U.S. GAAP.
Exhibit 99.4
Recursion Announces Pricing of $200 Million Underwritten Offering of Class A Common Stock
Recursion Pharmaceuticals, Inc. (“Recursion”) (NASDAQ: RXRX), a leading clinical-stage company pioneering AI-enabled drug discovery and development decoding biology to radically improve lives, today announced the pricing of an underwritten offering of 61,540,000 shares of its Class A common stock at a price of $3.25 per share. All of the shares are to be sold by Recursion. Before deducting the underwriting discounts and commissions and estimated offering expenses, Recursion expects to receive total gross proceeds of approximately $200 million. The offering is expected to close on or about October 16, 2026, subject to satisfaction of customary closing conditions.
Leerink Partners, Goldman Sachs & Co. LLC, Morgan Stanley & Co. LLC and Evercore Group L.L.C. are acting as joint bookrunning managers for the offering. Needham & Company, LLC is acting as lead manager for the offering.
The financing included participation from leading healthcare and institutional investors, including Janus Henderson Investors, Invus, Longaeva Partners, ARK Invest, Driehaus Capital Management and other prominent healthcare specialists and mutual funds.
The shares are being offered by Recursion pursuant to a registration statement on Form S-3, which became automatically effective upon filing with the U.S. Securities and Exchange Commission (“SEC”) on February 12, 2025. The offering is being made solely by means of a written prospectus and a prospectus supplement that form a part of the registration statement. The preliminary prospectus supplement and accompanying prospectus relating to the offering was filed on October 15, 2026. A final prospectus supplement and accompanying prospectus relating to the offering will also be filed with the SEC. These documents can be accessed for free through the SEC’s website at www.sec.gov. Alternatively, a copy of the final prospectus supplement and accompanying prospectus relating to this offering may be obtained, when available, by contacting: Leerink Partners LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at (800) 808-7525 ext. 6105 or by email at syndicate@leerink.com; Goldman Sachs & Co. LLC, Attention: Prospectus Department, 200 West Street, New York, NY 10282, by telephone at (866) 471-2526 or by email at prospectus-ny@ny.email.gs.com; Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, NY 10014, by telephone at (866) 718-1649 or by email at prospectus@morganstanley.com; or Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 35th Floor, New York, NY 10055, by telephone at (888) 474-0200 or by email at ecm.prospectus@evercore.com.
This press release does not constitute an offer to sell or a solicitation of an offer to buy, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation, or sale would be unlawful before registration or qualification under the securities laws of that state or jurisdiction.
About Recursion
Recursion (NASDAQ: RXRX) is a leading clinical-stage company pioneering AI-enabled drug discovery and development decoding biology to radically improve lives. Recursion is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the Recursion OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the Recursion OS is designed to translate complex science into medicines that matter — faster, better, and at scale — for patients who are waiting.
Recursion's platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. Recursion also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation.
Forward-Looking Statements
This press release contains information that includes or is based upon “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including, without limitation, statements regarding
the expected completion and timing of closing of the offering, the anticipated total gross proceeds from the offering and all other statements that are not statements of historical facts. Forward-looking statements may or may not include identifying words such as “intend,” “plan,” “will,” “expect,” “anticipate,” “believe,” “potential,” “continue,” and similar terms. These statements are subject to known and unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: prevailing market conditions; the satisfaction of customary closing conditions; general economic, industry or political conditions; challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; the fact that interim and preliminary clinical data, including data from a small number of patients in a single-arm study, may not be predictive of final results; our ability to leverage and enhance our drug discovery platform; the performance and limitations of our artificial intelligence and machine learning models and the data on which they are trained; our reliance on third parties, including collaborators, contract research organizations, and manufacturers; our ability to initiate clinical trials and enroll patients on expected timelines; the outcome of our discussions with the FDA, which may result in changes to the design or timing of, or delays in, our planned registrational trial of REC-4881; competition from other therapies and platforms; our ability to obtain financing for development activities and other corporate purposes; the satisfaction of customary closing conditions for the offering; the possibility that our preliminary estimate of cash, cash equivalents and restricted cash may change upon completion of our quarter-end financial close procedures; the success of our collaboration activities and our collaborators' discretion over option exercises, program advancement, and funding; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading "Risk Factors" in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K and our subsequent Quarterly Reports on Form 10-Q. All forward-looking statements speak only as of the date of this document and are based on management's current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.
Investor Contact:
investor@recursion.com
Media Contact:
media@recursion.com