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Rhythm Pharma CEO exercises, sells 50K shares

Rhythm Pharmaceuticals’ CEO exercised long‑standing stock options and sold 50,000 shares in pre‑planned trades under a Rule 10b5‑1 plan.

(Neutral)
(Neutral)
Form Type
4

Rhea-AI Filing Summary

For Rhythm Pharmaceuticals, Inc. (RYTM), President and CEO David P. Meeker reported exercising options for 50,000 shares of common stock at an exercise price of $6.05 per share on September 14, 2026, and selling 50,000 shares in multiple transactions on the same day. The option exercise relates to awards granted in February 2017, and the exercise and sales were carried out under a Rule 10b5-1 trading plan adopted on June 15, 2026.

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Insider Meeker David P
Role President and CEO
Sold 50,000 shs ($5.13M)
Approx. gross sale proceeds $5.13M
Approx. exercise cost $303K
Approx. pre-tax spread $4.83M
Type Security Shares Price Value
Exercise Employee Stock Option (Right to Buy) F8 50,000 $0.00 $0.00
Exercise Common Stock F1, F2 50,000 $6.05 $303K
Sale Common Stock F1, F3 6,439 $101.7464 $655K
Sale Common Stock F1, F4 30,746 $102.347 $3.15M
Sale Common Stock F1, F5 8,698 $103.43 $900K
Sale Common Stock F1, F6 1,817 $104.5487 $190K
Sale Common Stock F1, F7 2,300 $105.19 $242K
Holdings After Transaction: Employee Stock Option (Right to Buy) — 15,431 contracts (Direct); Common Stock — 239,258 shares (Direct)
Footnotes (8)
  1. F1. The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 15, 2026.
  2. F2. Includes 242 shares acquired under the Rhythm Pharmaceuticals, Inc. employee stock purchase plan on 2-28-2026.
  3. F3. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $100.96 to $101.95 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
  4. F4. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $101.96 to $102.94 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
  5. F5. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $102.97 to $103.96 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
  6. F6. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $103.97 to $104.94 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
  7. F7. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $105.00 to $105.31 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
  8. F8. The stock options were granted on February 8, 2017 and vested and became exercisable in three equal annual installments measured from January 6, 2017.
Options exercised 50,000 shares Options for Rhythm Pharmaceuticals common stock exercised on September 14, 2026
Exercise price $6.05 per share Exercise price of options exercised for 50,000 shares
Shares sold 50,000 shares Total Rhythm Pharmaceuticals shares sold in multiple transactions on September 14, 2026
Weighted average sale price (first tranche) $101.7464 per share 6,439 shares sold with trades in the range $100.96–$101.95
Weighted average sale price (largest tranche) $102.3470 per share 30,746 shares sold with trades in the range $101.96–$102.94
Highest weighted average sale price $105.1900 per share 2,300 shares sold with trades in the range $105.00–$105.31
Remaining derivative securities 15,431 options Options of the same type directly held after the reported exercise
ESPP shares included 242 shares Common shares acquired under the employee stock purchase plan on February 28, 2026
Rule 10b5-1 trading plan regulatory
"The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 15, 2026."
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
weighted average price financial
"The price reported in Column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
employee stock purchase plan financial
"Includes 242 shares acquired under the Rhythm Pharmaceuticals, Inc. employee stock purchase plan on 2-28-2026."
An employee stock purchase plan is a company program that lets workers buy shares through small payroll deductions, often at a discount to the market price and after a set offering period. Think of it like a workplace savings plan that turns into ownership: it encourages employees to share in the company’s success and can create predictable buying or selling of stock that investors watch because it affects supply, demand and employee incentives.
employee stock option financial
"The stock options were granted on February 8, 2017 and vested and became exercisable in three equal annual installments measured from January 6, 2017."
An employee stock option is a promise that lets a worker buy company shares later at a predetermined price, often after they stay for a certain period or meet performance goals — think of it like a coupon that locks in today's price for a future purchase. It matters to investors because options align employees’ incentives with company performance, can increase the number of shares outstanding (dilution) when exercised, and represent a compensation cost that affects reported profits and shareholder value.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did RYTM’s CEO report on September 14, 2026?

David P. Meeker reported exercising 50,000 stock options for Rhythm Pharmaceuticals common stock at an exercise price of $6.05 per share and selling 50,000 shares of common stock in multiple transactions on September 14, 2026.

At what prices were the RYTM shares sold by the CEO?

The 50,000 Rhythm Pharmaceuticals shares were sold in several groups at weighted average prices of $101.7464, $102.3470, $103.4300, $104.5487, and $105.1900 per share, with each group executed over price ranges disclosed in the filing footnotes.

Were the RYTM CEO’s transactions made under a Rule 10b5-1 plan?

Yes. The filing states that the option exercise and related sales were effected pursuant to a Rule 10b5-1 trading plan adopted by David P. Meeker on June 15, 2026.

What stock options did the RYTM CEO exercise in this Form 4?

David P. Meeker exercised options for 50,000 shares of Rhythm Pharmaceuticals common stock at an exercise price of $6.05 per share. These options were granted on February 8, 2017 and vested in three equal annual installments measured from January 6, 2017.

How many derivative securities remain after the RYTM CEO’s option exercise?

After exercising 50,000 options, the filing reports that 15,431 derivative securities of the same option type remain directly held by David P. Meeker.

Does the RYTM Form 4 mention purchases under an employee stock purchase plan?

Yes. A footnote states that the reported holdings include 242 shares acquired under the Rhythm Pharmaceuticals, Inc. employee stock purchase plan on February 28, 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Meeker David P

(Last)(First)(Middle)
C/O RHYTHM PHARMACEUTICALS, INC.
222 BERKELEY STREET, 12TH FLOOR

(Street)
BOSTON MASSACHUSETTS 02116

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
RHYTHM PHARMACEUTICALS, INC. [ RYTM ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
XOfficer (give title below)Other (specify below)
President and CEO
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/14/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/14/2026M(1)50,000A$6.05289,258(2)D
Common Stock09/14/2026S(1)6,439D$101.7464(3)282,819D
Common Stock09/14/2026S(1)30,746D$102.347(4)252,073D
Common Stock09/14/2026S(1)8,698D$103.43(5)243,375D
Common Stock09/14/2026S(1)1,817D$104.5487(6)241,558D
Common Stock09/14/2026S(1)2,300D$105.19(7)239,258D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Employee Stock Option (Right to Buy)$6.0509/14/2026M50,000 (8)02/07/2027Common Stock50,000$015,431D
Explanation of Responses:
1. The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 15, 2026.
2. Includes 242 shares acquired under the Rhythm Pharmaceuticals, Inc. employee stock purchase plan on 2-28-2026.
3. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $100.96 to $101.95 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
4. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $101.96 to $102.94 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
5. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $102.97 to $103.96 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
6. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $103.97 to $104.94 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
7. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $105.00 to $105.31 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
8. The stock options were granted on February 8, 2017 and vested and became exercisable in three equal annual installments measured from January 6, 2017.
/s/ Stephen Vander Stoep, attorney-in-fact for David P. Meeker09/14/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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