Septerna director receives 15,000 stock options

Septerna, Inc. director Alan Ezekowitz received a grant of stock options as part of his compensation.

Rhea-AI Filing Summary

Septerna, Inc. director Alan Ezekowitz received a grant of stock options as part of his compensation. The award covers 15,000 options to acquire Septerna common stock at an exercise price of $37.34 per share, with the option term running until June 25, 2036.

These options vest in full on the earlier of June 26, 2027 or the date of Septerna’s next annual meeting of stockholders, provided he continues to serve the company through the vesting date. Following this grant, his directly held option position from this award totals 15,000 shares underlying common stock.

Insider Trade Summary

Grant/Award: 15,000 shares

Grant/Award 1 txn

Insider Ezekowitz Alan

Role Director

Type	Security	Shares	Price	Value
Grant/Award	Stock Option (Right to Buy)	15,000	$0.00	$0.00

Holdings After Transaction: Stock Option (Right to Buy) — 15,000 contracts (Direct)

Footnotes (1)

1. F1. The shares underlying the stock option vest in full upon the earlier of (i) June 26, 2027 or (ii) the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Key Figures

Option grant size: 15,000 options Exercise price: $37.34 per share Underlying shares: 15,000 shares +3 more

6 metrics

Option grant size 15,000 options Stock Option (Right to Buy) awarded to director

Exercise price $37.34 per share Conversion or exercise price of stock option

Underlying shares 15,000 shares Common Stock underlying the option grant

Post-grant option holdings from award 15,000 options Total shares following transaction for this grant

Option expiration date June 25, 2036 Expiration date of stock option grant

Latest vesting date June 26, 2027 Vests earlier of this date or next annual meeting

Key Terms

Stock Option (Right to Buy), Common Stock, vest in full, annual meeting of stockholders, +1 more

5 terms

Stock Option (Right to Buy) financial

"security_title: Stock Option (Right to Buy)"

Common Stock financial

"underlying_security_title: Common Stock"

Common stock represents ownership shares in a company, giving investors a stake in its success and a say in important decisions through voting rights. It is the most common type of stock traded on markets and can provide income through dividends, as well as potential for value growth. For investors, holding common stock means sharing in the company’s profits and risks.

vest in full financial

"The shares underlying the stock option vest in full upon the earlier of"

annual meeting of stockholders financial

"the date of the Issuer's next annual meeting of stockholders, subject to"

Grant, award, or other acquisition financial

"transaction_code_description: Grant, award, or other acquisition"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did Septerna (SEPN) report for Alan Ezekowitz?

Septerna reported that director Alan Ezekowitz received a grant of 15,000 stock options. These options give him the right to buy Septerna common shares at a fixed exercise price as part of his director compensation package, rather than reflecting an open-market stock purchase or sale.

How many Septerna (SEPN) shares are covered by Alan Ezekowitz’s new stock options?

The new option grant to Alan Ezekowitz covers 15,000 shares of Septerna common stock. Each option represents the right to buy one share when exercised, subject to vesting conditions and the stated exercise price in the award’s terms.

What is the exercise price of Alan Ezekowitz’s Septerna (SEPN) stock options?

The stock options granted to Alan Ezekowitz carry an exercise price of $37.34 per share. This means he can purchase Septerna common stock at $37.34 once the options vest and as long as they are exercised before the option expiration date.

When do Alan Ezekowitz’s Septerna (SEPN) stock options vest?

The options vest in full on the earlier of June 26, 2027 or Septerna’s next annual meeting of stockholders. Vesting is contingent on his continued service to the company through the applicable vesting date detailed in the award footnote.

When do Alan Ezekowitz’s Septerna (SEPN) stock options expire?

Alan Ezekowitz’s stock options are scheduled to expire on June 25, 2036. He must exercise any vested options before that expiration date; otherwise, the right to purchase the underlying Septerna common shares under this grant will lapse.

Is Alan Ezekowitz buying or selling Septerna (SEPN) stock in this Form 4?

The Form 4 reports a grant of stock options, not an open-market stock trade. Ezekowitz is receiving options as compensation, classified as an acquisition of derivative securities, rather than buying or selling Septerna shares in the market.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 06/30/2026 - 07:00 PM EDT Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Ezekowitz Alan

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
06/26/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$37.34	06/26/2026		A		15,000		(1)	06/25/2036	Common Stock	15,000	$0	15,000	D

Explanation of Responses:

1. The shares underlying the stock option vest in full upon the earlier of (i) June 26, 2027 or (ii) the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person's continued service to the Issuer through such vesting date.

Remarks:

Exhibit 24.2 - Substitute Power of Attorney

	/s/ Mark A. Wilson, Attorney-in-Fact	06/30/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)