Septerna (SEPN) CFO receives 125,000-share stock option grant with 2036 expiry

Rhea-AI Filing Summary

Septerna, Inc.'s Chief Financial Officer, Gil M. Labrucherie, received a grant of stock options on 125,000 shares of common stock on February 6, 2026, with an exercise price of $25.41 per share and direct ownership.

According to the vesting terms, 2/48 of the option vests and becomes exercisable on March 1, 2026. The remaining shares vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, as long as the executive remains in continuous service with Septerna. The options expire on February 5, 2036.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Labrucherie Gil M

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Financial Officer

3. Date of Earliest Transaction (Month/Day/Year)
02/06/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$25.41	02/06/2026		A		125,000		02/06/2026(1)	02/05/2036	Common Stock	125,000	$0	125,000	D

Explanation of Responses:

1. 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Remarks:

Exhibit 24.2 - Substitute Power of Attorney

	/s/ Mark A. Wilson, Attorney-in-Fact	02/10/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Septerna (SEPN) disclose in this Form 4 filing?

Septerna reported that its Chief Financial Officer, Gil M. Labrucherie, received a stock option grant for 125,000 shares of common stock on February 6, 2026, reflecting equity-based compensation aligned with continued service at the company.

How many Septerna (SEPN) shares are covered by the new stock option?

The stock option granted to Septerna’s Chief Financial Officer covers 125,000 shares of the company’s common stock. This option represents a potential future ownership interest, subject to the vesting schedule and the executive electing to exercise the option at the set price.

What is the exercise price of the Septerna (SEPN) CFO’s stock option?

The exercise price of the stock option granted to Septerna’s Chief Financial Officer is $25.41 per share. This is the price at which the executive can buy Septerna common stock upon exercising vested portions of the option during the option term.

When do the Septerna (SEPN) CFO’s stock options start vesting?

The vesting of the CFO’s stock options begins on March 1, 2026, when 2/48 of the total grant vests. The remaining shares vest in 46 substantially equal monthly installments on each monthly anniversary, conditioned on continuous service with Septerna.

What is the expiration date of the Septerna (SEPN) CFO’s stock option grant?

The stock option granted to Septerna’s Chief Financial Officer expires on February 5, 2036. After this expiration date, any unexercised portion of the option can no longer be used to purchase Septerna common stock under the grant terms.

Is the Septerna (SEPN) CFO’s stock option held directly or indirectly?

The Form 4 indicates that the 125,000 stock options are held with direct ownership by the Chief Financial Officer. This means the reporting person is shown as the direct holder of the derivative security, rather than through an intermediary entity or account.