Septerna (SEPN) awards 80,000 stock options to Chief People Officer

Rhea-AI Filing Summary

Septerna, Inc. reported that Chief People Officer Samira Shaikhly received a new stock option grant. On February 6, 2026, she was awarded options to purchase 80,000 shares of Septerna common stock at an exercise price of $25.41 per share, held as direct ownership.

According to the vesting terms, 2/48 of the option will vest and become exercisable on March 1, 2026. The remaining portion will vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, contingent on her continued service. The option is scheduled to expire on February 5, 2036.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Shaikhly Samira

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief People Officer

3. Date of Earliest Transaction (Month/Day/Year)
02/06/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$25.41	02/06/2026		A		80,000		(1)	02/05/2036	Common Stock	80,000	$0	80,000	D

Explanation of Responses:

1. 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Remarks:

Exhibit 24.2 - Substitute Power of Attorney

	/s/ Mark A. Wilson, Attorney-in-Fact	02/10/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Septerna (SEPN) disclose about Samira Shaikhly in this Form 4?

Septerna disclosed that Chief People Officer Samira Shaikhly received a stock option grant for 80,000 shares. The options have an exercise price of $25.41 per share, vest over time, and are held as direct ownership by the reporting person.

How many Septerna (SEPN) stock options were granted to Samira Shaikhly?

Samira Shaikhly was granted stock options covering 80,000 shares of Septerna common stock. These options were reported as a derivative security, with all 80,000 options beneficially owned following the transaction and subject to the stated vesting schedule and expiration terms.

What is the exercise price and expiration date of the Septerna (SEPN) options?

The stock options have an exercise price of $25.41 per share and an expiration date of February 5, 2036. This means they can be exercised at $25.41, subject to vesting, until they expire on that stated expiration date.

How do the Septerna (SEPN) stock options granted to Samira Shaikhly vest?

The options vest over time: 2/48 of the shares vest and become exercisable on March 1, 2026. The remaining shares vest in 46 substantially equal monthly installments, each tied to her continued service with Septerna on the relevant vesting dates.

Is the Septerna (SEPN) stock option grant to Samira Shaikhly direct or indirect ownership?

The filing shows the 80,000 stock options as directly owned by Samira Shaikhly. The ownership form is marked as “D” for direct, with no separate entity or indirect beneficial ownership structure described in the accompanying disclosure or footnote.

What type of security is reported in this Septerna (SEPN) Form 4 filing?

The filing reports a derivative security described as a “Stock Option (Right to Buy).” Each option represents the right to purchase one share of Septerna common stock, subject to the stated exercise price, vesting schedule, and expiration date disclosed in the filing.