Septerna CPO exercises options, sells 11,798 shares

Septerna, Inc. Chief People Officer Samira Shaikhly reported an option exercise and related share sale.

Rhea-AI Filing Summary

Septerna, Inc. Chief People Officer Samira Shaikhly reported an option exercise and related share sale. She exercised stock options to acquire 11,798 shares of common stock at an exercise price of $6.81 per share, then sold 11,798 shares in open-market transactions at a weighted average price of $30.0607 per share.

The sales were made under a pre-arranged Rule 10b5-1 sales plan adopted on October 31, 2025, and executed in multiple trades between $30.00 and $30.24 per share. After these transactions, she directly owned 793 shares of Septerna common stock.

Insider Trade Summary 10b5-1

Exercise and Sale: 11,798 shares ($274K approx. pre-tax spread)

Exercise and Sale 3 txns

Insider Shaikhly Samira

Role Chief People Officer

Sold 11,798 shs ($355K)

Approx. gross sale proceeds $355K

Approx. exercise cost $80K

Approx. pre-tax spread $274K

Type	Security	Shares	Price	Value
Exercise	Stock Option (Right to Buy)	11,798	$0.00	$0.00
Exercise	Common Stock	11,798	$6.81	$80K
Sale	Common Stock	11,798	$30.0607	$355K

Holdings After Transaction: Stock Option (Right to Buy) — 23,043 contracts (Direct); Common Stock — 793 shares (Direct)

Footnotes (3)

1. F1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.
2. F2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.00 to $30.24. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
3. F3. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

Key Figures

Shares sold: 11,798 shares Weighted average sale price: $30.0607 per share Option exercise price: $6.81 per share +4 more

7 metrics

Shares sold 11,798 shares Open-market sale of common stock on May 26, 2026

Weighted average sale price $30.0607 per share Sale of Septerna common stock in multiple transactions

Option exercise price $6.81 per share Stock Option (Right to Buy) conversion price

Shares acquired via exercise 11,798 shares Common stock received from option exercise

Shares owned after transaction 793 shares Direct common stock holdings following transactions

Option expiration date September 22, 2034 Stock Option (Right to Buy) term

10b5-1 plan adoption date October 31, 2025 Rule 10b5-1 sales plan governing the sale

Key Terms

Rule 10b5-1 sales plan, weighted average price, Stock Option (Right to Buy), exercise or conversion of derivative security, +1 more

5 terms

Rule 10b5-1 sales plan regulatory

"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."

weighted average price financial

"The price reported in Column 4 is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

Stock Option (Right to Buy) financial

"Stock Option (Right to Buy) with a conversion or exercise price of 6.8100."

exercise or conversion of derivative security financial

"Transaction code description: Exercise or conversion of derivative security."

vest and become exercisable financial

"1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments."

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did Septerna (SEPN) report for Samira Shaikhly?

Septerna reported that Chief People Officer Samira Shaikhly exercised options for 11,798 common shares and sold 11,798 shares in open-market transactions. The filing shows this as an option exercise followed by a sale on the same date.

At what prices did Samira Shaikhly sell Septerna (SEPN) shares?

The shares were sold at a weighted average price of $30.0607 per share. According to the filing, the individual trades occurred in a price range from $30.00 to $30.24 per share in multiple transactions.

What was the option exercise price in the Septerna (SEPN) Form 4 filing?

The Form 4 shows Samira Shaikhly exercised stock options with a conversion or exercise price of $6.81 per share. These options related to 11,798 underlying shares of Septerna common stock exercised on the reported transaction date.

How many Septerna (SEPN) shares does Samira Shaikhly hold after the transaction?

After the reported transactions, Samira Shaikhly directly owned 793 shares of Septerna common stock. This post-transaction holding reflects the sale of 11,798 shares following the exercise of stock options for the same number of shares.

Was the Septerna (SEPN) insider sale under a Rule 10b5-1 plan?

Yes. The filing states the sale was effected pursuant to a Rule 10b5-1 sales plan adopted on October 31, 2025. Such plans allow pre-scheduled trading, reducing the significance of trade timing as a discretionary decision.

What are the key terms of the stock option in Septerna (SEPN)’s Form 4?

The stock option is described as a “Stock Option (Right to Buy)” with a conversion price of $6.81 per share and an expiration date of September 22, 2034, relating to 11,798 underlying shares of Septerna common stock.

How does the Septerna (SEPN) Form 4 describe vesting of the option?

The footnote explains that one-forty-eighth of the shares subject to the option vest monthly. Vesting occurs on each monthly anniversary of October 28, 2024, contingent on Samira Shaikhly’s continuous service to Septerna on each vesting date.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 05/28/2026 - 07:02 PM EDT Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Shaikhly Samira

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief People Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
05/26/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	05/26/2026		M		11,798	A	$6.81	12,591	D
Common Stock	05/26/2026		S(1)		11,798	D	$30.0607(2)	793	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$6.81	05/26/2026		M			11,798	(3)	09/22/2034	Common Stock	11,798	$0	23,043	D

Explanation of Responses:

1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.00 to $30.24. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

3. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

	/s/ Mark A. Wilson, Attorney-in-Fact	05/28/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)