SEPN insider grant: CFO awarded 37,500 options at $11.70; vesting schedule disclosed

Rhea-AI Filing Summary

Septerna, Inc. Form 4 reports that Chief Financial Officer Gil M. Labrucherie acquired a stock option on 08/07/2025 to purchase 37,500 shares of common stock at an exercise price of $11.70 per share. The option is recorded as an acquisition and held directly by the reporting person.

The grant includes a service-based vesting schedule: 6/48th of the option shares vest on February 1, 2026, with the remaining shares vesting in 42 substantially equal monthly installments thereafter, subject to continuous service. The option shows an expiration/related date of 08/06/2035 and 37,500 shares are reported as beneficially owned following the transaction.

Positive

• Reporting person is identified as Chief Financial Officer Gil M. Labrucherie
• Grant is explicit: stock option to purchase 37,500 shares at $11.70 with a defined vesting schedule

Negative

• Options are not fully vested immediately: initial vesting on Feb 1, 2026 followed by 42 monthly installments
• The option represents future issuance of 37,500 shares upon exercise, which would increase outstanding shares if exercised

Insights

Financial Analyst

TL;DR: CFO received a routine option grant for 37,500 shares at $11.70; vesting ties value to continued service.

The Form 4 documents a standard executive equity award rather than an open-market purchase or disposition. Key metrics are a 37,500-share option with a stated exercise price of $11.70 and a multi-year vesting schedule (6/48th on Feb 1, 2026, then 42 monthly installments). Without the company’s current share count or market price in this filing, the immediate impact on per-share value cannot be quantified, but the grant is consistent with retention-focused compensation.

Corporate Governance Expert

TL;DR: Grant follows a time-based vesting pattern and is reported under Section 16; disclosure appears complete for the transaction.

The disclosure identifies the reporting person as the Chief Financial Officer and records the transaction as an acquisition under Form 4, showing direct beneficial ownership of the option. The explicit vesting schedule and the option's expiration-related date (08/06/2035) are provided, which supports transparency on executive compensation timing. This filing documents a compensation event but does not itself indicate any governance violation.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Labrucherie Gil M

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Financial Officer

3. Date of Earliest Transaction (Month/Day/Year)
08/07/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$11.7	08/07/2025		A		37,500		(1)	08/06/2035	Common Stock	37,500	$0	37,500	D

Explanation of Responses:

1. 6/48th of the shares subject to such option shall vest and become exercisable on February 1, 2026 and the remaining shares subject to the option shall vest in 42 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

	/s/ Ran Xiao, Attorney-in-Fact	08/11/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did the SEPN Form 4 disclose?

It discloses a stock option grant to CFO Gil M. Labrucherie to purchase 37,500 shares at an exercise price of $11.70 per share, recorded as an acquisition on 08/07/2025.

Who is the reporting person on the Form 4 for SEPN?

Gil M. Labrucherie, identified as the Chief Financial Officer of Septerna, Inc.

What are the key economic terms of the option grant (SEPN)?

Option to buy 37,500 shares with an exercise price of $11.70; the derivative security price is shown as $0 in the filing, and 37,500 shares are reported as beneficially owned after the transaction.

What is the vesting schedule for the SEPN option grant?

6/48th of the shares vest on February 1, 2026, with the remaining shares vesting in 42 substantially equal monthly installments thereafter, subject to continuous service.

When does the option lapse or have an associated expiration-related date?

The filing shows an associated date of 08/06/2035 related to the derivative security information in Table II.

How many shares does the reporting person beneficially own after this transaction?

The Form 4 reports 37,500 shares beneficially owned following the reported transaction, held directly.