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Sol-Gel holder Opaleye buys 3,124 shares at $66

A ten percent owner of SLGL reported modest open-market share purchases and updated indirect holdings through a fund and a managed account.

(Moderate)
(Positive)
Form Type
4

Rhea-AI Filing Summary

Sol-Gel Technologies Ltd. (SLGL) reports that Opaleye Management Inc., a ten percent owner, indirectly purchased 3,124 ordinary shares in open-market transactions on September 10–11, 2026 through Opaleye, L.P. A separately managed account for which Opaleye Management acts as portfolio manager held 15,000 ordinary shares as of September 10, 2026. Opaleye Management may be deemed to beneficially own these securities but disclaims beneficial ownership except to the extent of its pecuniary interest.

Positive

  • None.

Negative

  • None.
Insider Opaleye Management Inc.
Role 10% Owner
Bought 3,124 shs ($207K)
Type Security Shares Price Value
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F3 1,493 $65.945 $98K
Purchase Ordinary Shares, par value NIS 1.00 per share F1, F3 1,631 $66.795 $109K
holding Ordinary Shares, par value NIS 1.00 per share F2, F3 -- -- --
Holdings After Transaction: Ordinary Shares, par value NIS 1.00 per share — 540,000 shares (Indirect, By Opaleye, L.P.); Ordinary Shares, par value NIS 1.00 per share — 15,000 shares (Indirect, By Managed Account)
Footnotes (3)
  1. F1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
  2. F2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
  3. F3. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Shares purchased September 11, 2026 1,493 shares Ordinary shares bought indirectly through Opaleye, L.P.
Purchase price September 11, 2026 $65.945 per share Open-market or private purchase of SLGL ordinary shares
Shares purchased September 10, 2026 1,631 shares Ordinary shares bought indirectly through Opaleye, L.P.
Purchase price September 10, 2026 $66.795 per share Open-market or private purchase of SLGL ordinary shares
Total shares purchased 3,124 shares Net buy volume across reported transactions
Managed account holdings 15,000 shares Ordinary shares held indirectly via a separately managed account as of September 10, 2026
ten percent owner regulatory
"Opaleye Management Inc. is identified as a ten percent owner"
separately managed account financial
"Securities owned by a separately managed account (the "Managed Account")"
A separately managed account (SMA) is a personalized investment portfolio owned by a single investor and run by a professional manager who buys and sells securities on that investor’s behalf. It matters to investors because an SMA offers tailored asset selection, tax handling, and transparency—like hiring a personal chef who prepares meals to your dietary needs rather than sharing a set menu—so you can align holdings with your goals and see exactly what you own.
beneficially own regulatory
"may be deemed to beneficially own the securities owned directly"
Beneficially own means having the economic rights and risks of a security—such as the right to receive dividends, sell the shares, or profit from price changes—whether or not your name appears on the official share register. Think of it like renting a car: you use it and reap the benefits even if the title lists someone else. Investors care because beneficial ownership determines who truly controls value, must be disclosed under securities rules, and can signal potential influence or trading activity that affects a stock’s price.
pecuniary interest financial
"disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transactions in SLGL did Opaleye Management report on this Form 4?

The filing reports open-market purchases totaling 3,124 ordinary shares of Sol-Gel Technologies Ltd. on September 10–11, 2026, made indirectly through Opaleye, L.P., for which Opaleye Management Inc. serves as investment manager.

At what prices were the SLGL shares purchased according to this Form 4?

Opaleye, L.P. purchased 1,493 SLGL ordinary shares at $65.945 per share on September 11, 2026 and 1,631 shares at $66.795 per share on September 10, 2026, as reported in the Form 4.

How many SLGL shares are held in the managed account linked to Opaleye Management?

A separately managed account for which Opaleye Management Inc. is portfolio manager held 15,000 ordinary shares of Sol-Gel Technologies Ltd. as of September 10, 2026, reported as indirect ownership by a managed account.

Does Opaleye Management claim full beneficial ownership of the reported SLGL shares?

No. Opaleye Management Inc. states it may be deemed to beneficially own shares held by Opaleye, L.P. and the managed account, but it disclaims beneficial ownership of the shares reported except to the extent of its pecuniary interest.

Were the reported SLGL transactions made under a Rule 10b5-1 trading plan?

The Form 4’s Rule 10b5-1 checkbox is not marked as affirming a trading plan, and there is no footnote stating that these transactions were executed pursuant to a Rule 10b5-1 or similar pre-arranged trading arrangement.

What type of ownership does Opaleye Management report for these SLGL shares?

All reported positions are classified as indirect ownership: the purchased shares are owned directly by Opaleye, L.P., and additional shares are owned by a separately managed account, with Opaleye Management acting as investment manager or portfolio manager.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Opaleye Management Inc.

(Last)(First)(Middle)
ONE BOSTON PLACE, 26TH FLOOR

(Street)
BOSTON MASSACHUSETTS 02108

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Sol-Gel Technologies Ltd. [ SLGL ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
DirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/10/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Ordinary Shares, par value NIS 1.00 per share09/10/2026P1,631A$66.795538,507IBy Opaleye, L.P.(1)(3)
Ordinary Shares, par value NIS 1.00 per share09/11/2026P1,493A$65.945540,000IBy Opaleye, L.P.(1)(3)
Ordinary Shares, par value NIS 1.00 per share15,000IBy Managed Account(2)(3)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Fund.
2. Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye Management, Inc. may be deemed to beneficially own the securities owned directly by the Managed Account.
3. Opaleye Management, Inc. disclaims beneficial ownership of the shares reported herein except to the extent of its pecuniary interest therein, and the filing of this Form 4 shall not be construed as an admission that Opaleye Management, Inc. is the beneficial owner of any such shares for purposes of Section 16(a) of the Securities Exchange Act of 1934, as amended, or for any other purpose.
Opaleye Management, Inc., By: /s/ James Silverman, President09/14/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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